Paeonol: pharmacological effects and mechanisms of action
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Shanghai First Pharmaceutical Factory, 1973, Development and clinical observation of Xu Changqing injection, Chin.Tradit.Herbal.Drugs., 7, 7
Harada, 1969, Pharmacological studies on the root bark of paeonia moutan. I. Central effects of paeonol, Yakugaku.Zasshi., 89, 1205, 10.1248/yakushi1947.89.9_1205
Himaya, 2012, Paeonol from Hippocampus kuda Bleeler suppressed the neuro-inflammatory responses in vitro via NF-kappaB and MAPK signaling pathways, Toxicol.In.Vitro., 26, 878, 10.1016/j.tiv.2012.04.022
Lei, 2016, Paeonol inhibits lipopolysaccharide-induced HMGB1 translocation from the nucleus to the cytoplasm in RAW264.7 cells, Inflammation, 39, 1177
Xu, 2018, Paeonol reduces the nucleocytoplasmic transportation of HMGB1 by upregulating HDAC3 in LPS-induced RAW264.7 cells, Inflammation, 1536, 10.1007/s10753-018-0800-0
Chen, 2014, Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock, Fundam.Clin.Pharmacol., 28, 268, 10.1111/fcp.12019
Jotanovic, 2012, Role of interleukin-1 inhibitors in osteoarthritis: an evidence-based review, Drugs.Aging., 29, 343, 10.2165/11599350-000000000-00000
Siebert, 2015, Cytokines as therapeutic targets in rheumatoid arthritis and other inflammatory diseases, Pharmacol.Rev., 67, 280, 10.1124/pr.114.009639
Lou, 2017, Paeonol inhibits IL-1beta-induced inflammation via PI3K/Akt/NF-kappaB pathways: in vivo and vitro studies, Inflammation, 40, 1698, 10.1007/s10753-017-0611-8
Liu, 2017, Paeonol alleviates interleukin-1beta-induced inflammatory responses in chondrocytes during osteoarthritis, Biomed.Pharmacother., 95, 914, 10.1016/j.biopha.2017.09.011
Zhai, 2017, Protective effects of paeonol on inflammatory response in IL-1beta-induced human fibroblast-like synoviocytes and rheumatoid arthritis progression via modulating NF-kappaB pathway, Inflammopharmacology, 25, 523, 10.1007/s10787-017-0385-5
Liu, 2017, Paeonol protects against TNF-alpha-induced proliferation and cytokine release of rheumatoid arthritis fibroblast-like synoviocytes by upregulating FOXO3 through inhibition of miR-155 expression, Inflamm.Res., 66, 603, 10.1007/s00011-017-1041-7
Li, 2014, Paeonol inhibited TNFalpha-induced GM-CSF expression in fibroblast-like synoviocytes, Int.J.Clin.Pharmacol.Ther., 52, 986, 10.5414/CP202127
Meng, 2017, Paeonol ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice by inhibiting the maturation and activation of dendritic cells, Int.J.Mol.Med., 39, 1101, 10.3892/ijmm.2017.2930
Sun, 2018, Paeonol extracted from Paeonia suffruticosa Andr. ameliorated UVB-induced skin photoaging via DLD/Nrf2/ARE and MAPK/AP-1 pathway, Phytother.Res., 32, 1741, 10.1002/ptr.6100
Xue, 2017, Paeonol suppresses solar ultraviolet-induced skin inflammation by targeting T-LAK cell-originated protein kinase, Oncotarget, 8, 27093, 10.18632/oncotarget.15636
Bu, 2008, Inhibition of MITF and tyrosinase by paeonol-stimulated JNK/SAPK to reduction of phosphorylated CREB, Am.J.Chin.Med., 36, 245, 10.1142/S0192415X08005758
Peng, 2013, Inhibitory effects of salidroside and paeonol on tyrosinase activity and melanin synthesis in mouse B16F10 melanoma cells and ultraviolet B-induced pigmentation in guinea pig skin, Phytomedicine, 20, 1082, 10.1016/j.phymed.2013.04.015
Li, 2018, Paeonol attenuates ligation-induced periodontitis in rats by inhibiting osteoclastogenesis via regulating Nrf2/NF-kappaB/NFATc1 signaling pathway, Biochimie, 156, 129, 10.1016/j.biochi.2018.09.004
Chang, 2014, Effect of paeonol on tissue destruction in experimental periodontitis of rats, Am.J.Chin.Med., 42, 361, 10.1142/S0192415X14500244
Zhu, 2017, Effects of paeonol on the function of bone marrow-derived macrophage from Porphyromonas gingivalis-induced mice, Hua.Xi.Kou.Qiang.Yi.Xue.Za.Zhi., 35, 139
Tsai, 2008, Paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38 and NF-kappaB pathway, Eur.J.Pharmacol., 588, 124, 10.1016/j.ejphar.2008.04.024
Kong, 2013, Paeonol inhibits hepatic fibrogenesis via disrupting nuclear factor-kappaB pathway in activated stellate cells: in vivo and in vitro studies, J.Gastroenterol.Hepatol., 28, 1223, 10.1111/jgh.12147
Liu, 2017, Prevention of bleomycin-induced pulmonary inflammation and fibrosis in mice by Paeonol, Front.Physiol., 8, 10.3389/fphys.2017.00193
Zhang, 2018, Paeonol ameliorates diabetic renal fibrosis through promoting the activation of the Nrf2/ARE pathway via up-regulating Sirt1, Front.Pharmacol., 9
Liu, 2014, Paeonol attenuates cigarette smoke-induced lung inflammation by inhibiting ROS-sensitive inflammatory signaling, Mediators.Inflamm., 2014, 651890, 10.1155/2014/651890
Fu, 2012, Anti-inflammatory and anticoagulative effects of paeonol on LPS-induced acute lung injury in rats, Evid.Based.Complement.Alternat.Med., 2012, 837513, 10.1155/2012/837513
Liu, 2018, Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock rats, Int.Immunopharmacol., 61, 169, 10.1016/j.intimp.2018.05.032
Du, 2010, Paeonol attenuates airway inflammation and hyperresponsiveness in a murine model of ovalbumin-induced asthma, Can.J.Physiol.Pharmacol., 88, 1010, 10.1139/Y10-077
Tang, 2018, Paeonol ameliorates ovalbumin-induced asthma through the inhibition of TLR4/NF-kappaB and MAPK signaling, Evid.Based.Complement.Alternat.Med., 2018, 3063145, 10.1155/2018/3063145
Ding, 2016, Attenuating oxidative stress by Paeonol protected against acetaminophen-induced hepatotoxicity in mice, PLoS.One., 11
Gong, 2017, Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice, Int.Immunopharmacol., 46, 124, 10.1016/j.intimp.2017.03.003
Sun, 2018, Paeonol alleviated acute alcohol-induced liver injury via SIRT1/Nrf2/NF-kappaB signaling pathway, Environ.Toxicol.Pharmacol., 60, 110, 10.1016/j.etap.2018.04.016
Hu, 2010, Paeonol, the main active principles of Paeonia moutan, ameliorates alcoholic steatohepatitis in mice, J.Ethnopharmacol., 128, 100, 10.1016/j.jep.2009.12.034
Liu, 2018, Role of AMPK pathway in lead-induced endoplasmic reticulum stress in kidney and in paeonol-induced protection in mice, Food.Chem.Toxicol., 122, 87, 10.1016/j.fct.2018.10.024
Fan, 2016, Paeonol protects endotoxin-induced acute kidney injury: potential mechanism of inhibiting TLR4-NF-kappaB signal pathway, Oncotarget, 7, 39497, 10.18632/oncotarget.8347
Zong, 2017, Study on the physicochemical properties and anti-inflammatory effects of paeonol in rats with TNBS-induced ulcerative colitis, Int.Immunopharmacol., 42, 32, 10.1016/j.intimp.2016.11.010
Jin, 2016, Anti-inflammatory and anti-oxidative activities of Paeonol and its metabolites through blocking MAPK/ERK/p38 signaling pathway, Inflammation, 39, 434, 10.1007/s10753-015-0265-3
Ishiguro, 2006, Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation, Toxicol.Appl.Pharmacol., 217, 35, 10.1016/j.taap.2006.07.002
Chen, 2010, Action potential bursts in central snail neurons elicited by paeonol: roles of ionic currents, Acta.Pharmacol.Sin., 31, 1553, 10.1038/aps.2010.156
Wu, 2008, Protective effects of paeonol on cultured rat hippocampal neurons against oxygen-glucose deprivation-induced injury, J.Neurol.Sci., 264, 50, 10.1016/j.jns.2007.06.057
Wang, 2015, Neuroprotective effects of paeonol in a cell model of Parkinson disease, Zhejiang.Da.Xue.Xue.Bao.Yi.Xue.Ban., 44, 30
Wang, 2011, Paeonol prevents excitotoxicity in rat pheochromocytoma PC12 cells via downregulation of ERK activation and inhibition of apoptosis, Planta.Med., 77, 1695, 10.1055/s-0030-1271033
Nam, 2013, Paeonol attenuates inflammation-mediated neurotoxicity and microglial activation, Neural.Regen.Res., 8, 1637, 10.4103/1673-5374.121567
Tseng, 2012, Paeonol attenuates microglia-mediated inflammation and oxidative stress-induced neurotoxicity in rat primary microglia and cortical neurons, Shock, 37, 312, 10.1097/SHK.0b013e31823fe939
Lin, 2015, Effects of paeonol on anti-neuroinflammatory responses in microglial cells, Int.J.Mol.Sci., 16, 8844, 10.3390/ijms16048844
He, 2016, Paeonol suppresses neuroinflammatory responses in LPS-activated microglia cells, Inflammation, 39, 1904, 10.1007/s10753-016-0426-z
Liu, 2013, Neuroprotective effect of paeonol on cognition deficits of diabetic encephalopathy in streptozotocin-induced diabetic rat, Neurosci.Lett., 549, 63, 10.1016/j.neulet.2013.06.002
Liu, 2013, Hypoglycemic and antioxidant activities of paeonol and its beneficial effect on diabetic encephalopathy in streptozotocin-induced diabetic rats, J.Med.Food., 16, 577, 10.1089/jmf.2012.2654
Yulug, 2018, Beyond the therapeutic effect of rTMS in Alzheimer's disease: a possible neuroprotective role of hippocampal BDNF?: a minireview, Mini.Rev.Med.Chem., 18, 1479, 10.2174/1389557517666170927162537
Liao, 2016, Neuroprotective effect of Paeonol mediates anti-inflammation via suppressing toll-like receptor 2 and toll-like receptor 4 signaling pathways in cerebral ischemia-reperfusion injured rats, Evid.Based.Complement.Alternat.Med., 2016, 10.1155/2016/3704647
Zhao, 2018, Protective effects of paeonol on subacute/chronic brain injury during cerebral ischemia in rats, Exp.Ther.Med., 15, 3836
Zhao, 2014, Paeonol pretreatment attenuates cerebral ischemic injury via upregulating expression of pAkt, Nrf2, HO-1 and ameliorating BBB permeability in mice, Brain.Res.Bull., 109, 61, 10.1016/j.brainresbull.2014.09.008
Zhong, 2009, Paeonol attenuates neurotoxicity and ameliorates cognitive impairment induced by d-galactose in ICR mice, J.Neurol.Sci., 277, 58, 10.1016/j.jns.2008.10.008
Jin, 2018, Paeonol attenuates isoflurane anesthesia-induced hippocampal neurotoxicity via modulation of JNK/ERK/P38MAPK pathway and regulates histone acetylation in neonatal rat, J.Matern.Fetal.Neonatal.Med., 1, 10.1080/14767058.2018.1487396
Yang, 2018, Paeonol promotes hippocampal synaptic transmission: the role of the Kv2.1 potassium channel, Eur.J.Pharmacol., 827, 227, 10.1016/j.ejphar.2018.03.020
Zhou, 2011, Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease, Brain.Res., 1388, 141, 10.1016/j.brainres.2011.02.064
Su, 2012, Paeonol protects memory after ischemic stroke via inhibiting beta-secretase and apoptosis, Evid.Based.Complement.Alternat.Med., 2012, 10.1155/2012/932823
Shi, 2016, Therapeutic effects of paeonol on methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-induced Parkinson's disease in mice, Mol.Med.Rep., 14, 2397, 10.3892/mmr.2016.5573
Miyazaki, 2017, Therapeutic strategy of targeting astrocytes for neuroprotection in Parkinson's disease, Curr.Pharm.Des., 23, 4936
Ye, 2017, Role of Paeonol in an astrocyte model of Parkinson's disease, Med.Sci.Monit., 23, 4740, 10.12659/MSM.906716
Chen, 2012, Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats, Molecules, 17, 4672, 10.3390/molecules17044672
Jamal, 2014, Paeonol protects against premature senescence in endothelial cells by modulating Sirtuin 1 pathway, J.Ethnopharmacol., 154, 428, 10.1016/j.jep.2014.04.025
Yang, 2018, Paeonol attenuates aging MRC-5 cells and inhibits epithelial-mesenchymal transition of premalignant HaCaT cells induced by aging MRC-5 cell-conditioned medium, Mol.Cell.Biochem., 439, 117, 10.1007/s11010-017-3141-7
Tao, 2016, Paeonol attenuates lipopolysaccharide-induced depressive-like behavior in mice, Psychiatry.Res., 238, 116, 10.1016/j.psychres.2016.02.033
Zhu, 2018, Novel antidepressant effects of Paeonol alleviate neuronal injury with concomitant alterations in BDNF, Rac1 and RhoA levels in chronic unpredictable mild stress rats, Psychopharmacology, 235, 1, 10.1007/s00213-018-4915-7
Zhang, 2015, Paeonol inhibits B16F10 melanoma metastasis in vitro and in vivo via disrupting proinflammatory cytokines-mediated NF-kappaB and STAT3 pathways, IUBMB.Life., 67, 778, 10.1002/iub.1435
Lyu, 2017, Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP2 and MMP9, Mol.Med.Rep., 16, 7513, 10.3892/mmr.2017.7576
Li, 2010, Paeonol inhibits tumor growth in gastric cancer in vitro and in vivo, World.J.Gastroenterol., 16, 4483, 10.3748/wjg.v16.i35.4483
Fu, 2018, Paeonol induces the apoptosis of the SGC7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NFkappaB signaling pathway, Int.J.Mol.Med., 42, 1473
Chung, 1999, Paeonol promotion of DNA adduct formation and arylamines N-acetyltransferase activity in human colon tumour cells, Food.Chem.Toxicol., 37, 327, 10.1016/S0278-6915(99)00011-3
Li, 2014, Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGE(2) synthesis and COX-2 expression, Oncol.Rep., 32, 2845, 10.3892/or.2014.3543
Li, 2013, Effects of paeonol on intracellular calcium concentration and expression of RUNX3 in LoVo human colon cancer cells, Mol.Med.Rep., 7, 1425, 10.3892/mmr.2013.1372
Ou, 2014, Antitumor and apoptosis induction effects of Paeonol on mice bearing EMT6 breast carcinoma, Biomol.Ther., 22, 341, 10.4062/biomolther.2013.106
Saahene, 2018, The antitumor mechanism of Paeonol on CXCL4/CXCR3-B signals in breast cancer through induction of tumor cell apoptosis, Cancer.Biother.Radiopharm., 33, 233, 10.1089/cbr.2018.2450
Chunhu, 2008, Antiproliferative and apoptotic effects of paeonol on human hepatocellular carcinoma cells, Anticancer.Drugs., 19, 401, 10.1097/CAD.0b013e3282f7f4eb
Sun, 2008, Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-alpha production, Eur.J.Pharmacol., 584, 246, 10.1016/j.ejphar.2008.02.016
Yin, 2013, Paeonol induces apoptosis in human ovarian cancer cells, Acta.Histochem., 115, 835, 10.1016/j.acthis.2013.04.004
Xu, 2017, Anti-proliferative effects of paeonol on human prostate cancer cell lines DU145 and PC-3, J.Physiol.Biochem., 73, 157, 10.1007/s13105-016-0537-x
Sun, 2008, Antiproliferation and apoptosis induction of paeonol in human esophageal cancer cell lines, Dis.Esophagus., 21, 723, 10.1111/j.1442-2050.2008.00840.x
Horng, 2014, Paeonol suppresses chondrosarcoma metastasis through up-regulation of miR-141 by modulating PKCdelta and c-Src signaling pathway, Int.J.Mol.Sci., 15, 11760, 10.3390/ijms150711760
Ramachandhiran, 2019, Paeonol exhibits anti-tumor effects by apoptotic and anti-inflammatory activities in 7,12-dimethylbenz(a)anthracene induced oral carcinogenesis, Biotech. Histochem., 94, 10, 10.1080/10520295.2018.1493221
Zhou, 2017, Paeonol enhances the sensitivity of human ovarian cancer cells to radiotherapy-induced apoptosis due to downregulation of the phosphatidylinositol-3-kinase/Akt/phosphatase and tensin homolog pathway and inhibition of vascular endothelial growth factor, Exp.Ther.Med., 14, 3213, 10.3892/etm.2017.4877
Lei, 2013, The radiosensitizing effect of Paeonol on lung adenocarcinoma by augmentation of radiation-induced apoptosis and inhibition of the PI3K/Akt pathway, Int.J.Radiat.Biol., 89, 1079, 10.3109/09553002.2013.825058
Wan, 2008, Synergistic effect of paeonol and cisplatin on oesophageal cancer cell lines, Dig.Liver.Dis., 40, 531, 10.1016/j.dld.2008.01.012
Xu, 2007, Synergistic effect of combining paeonol and cisplatin on apoptotic induction of human hepatoma cell lines, Acta.Pharmacol.Sin., 28, 869, 10.1111/j.1745-7254.2007.00564.x
Wu, 2016, Enhanced antitumor activity and attenuated cardiotoxicity of Epirubicin combined with Paeonol against breast cancer, Tumour.Biol., 37, 12301, 10.1007/s13277-016-5088-9
Zhang, 2015, Paclitaxel resistance in MCF-7/PTX cells is reversed by paeonol through suppression of the SET/phosphatidylinositol 3-kinase/Akt pathway, Mol.Med.Rep., 12, 1506, 10.3892/mmr.2015.3468
Cai, 2014, Paeonol reverses paclitaxel resistance in human breast cancer cells by regulating the expression of transgelin 2, Phytomedicine, 21, 984, 10.1016/j.phymed.2014.02.012
Fan, 2013, Endoplasmic reticulum stress-induced resistance to doxorubicin is reversed by paeonol treatment in human hepatocellular carcinoma cells, PLoS.One., 8
Wu, 2016, The protective effects of paeonol against epirubicin-induced hepatotoxicity in 4T1-tumor bearing mice via inhibition of the PI3K/Akt/NF-kB pathway, Chem.Biol.Interact., 244, 1, 10.1016/j.cbi.2015.11.025
Wu, 2017, Paeonol alleviates epirubicin-induced renal injury in mice by regulating Nrf2 and NF-kappaB pathways, Eur.J.Pharmacol., 795, 84, 10.1016/j.ejphar.2016.12.005
Wu, 2018, Cardioprotective effect of paeonol against epirubicin-induced heart injury via regulating miR-1 and PI3K/AKT pathway, Chem.Biol.Interact., 286, 17, 10.1016/j.cbi.2018.02.035
Lee, 2013, Paeonol, a major compound of moutan cortex, attenuates cisplatin-induced nephrotoxicity in mice, Evid.Based.Complement.Alternat.Med., 2013, 310989, 10.1155/2013/310989
J.R. Tang, L. Shi. The inhibitory effects of sodium paeonol sulfate on calcium influx in the cultured neonatal rat heart cells during calcium paradox. Yao.Xue.Xue.Bao. 26(1991)161–165. https//doi:10.16438/j.0513-4870.1991.03.001.
Zhang, 2003, Effect of paeonol on L-type calcium channel in rat ventricular myocytes, Methods.Find.Exp.Clin.Pharmacol., 25, 281, 10.1358/mf.2003.25.4.769676
Ma, 2006, The effects of paeonol on the electrophysiological properties of cardiac ventricular myocytes, Eur.J.Pharmacol., 545, 87, 10.1016/j.ejphar.2006.06.064
Li, 2010, Vascular dilation by paeonol--a mechanism study, Vascul.Pharmacol., 53, 169, 10.1016/j.vph.2010.07.001
Zhang, 2015, Effect of paeonol on blood pressure and blood flow in artery of spontaneously hypertensive rats and its mechanisms related on vasomotion, Zhongguo.Zhong.Yao.Za.Zhi., 40, 4903
Zhang, 2018, Paeonol regulates hypoxia-induced proliferation of pulmonary artery smooth muscle cells via EKR 1/2 signalling, Eur.J.Pharmacol., 834, 257, 10.1016/j.ejphar.2018.07.017
Tsai, 2010, EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1, Cardiovasc.Res., 88, 415, 10.1093/cvr/cvq226
Zhao, 2013, Novel effect of paeonol on the formation of foam cells: promotion of LXRalpha-ABCA1-dependent cholesterol efflux in macrophages, Am.J.Chin.Med., 41, 1079, 10.1142/S0192415X13500730
Li, 2015, Paeonol suppresses lipid accumulation in macrophages via upregulation of the ATPbinding cassette transporter A1 and downregulation of the cluster of differentiation 36, Int.J.Oncol., 46, 764, 10.3892/ijo.2014.2757
Bao, 2013, Paeonol suppresses oxidized low-density lipoprotein induced endothelial cell apoptosis via activation of LOX-1/p38MAPK/NF-kappaB pathway, J.Ethnopharmacol., 146, 543, 10.1016/j.jep.2013.01.019
Yuan, 2016, Paeonol promotes microRNA-126 expression to inhibit monocyte adhesion to ox-LDL-injured vascular endothelial cells and block the activation of the PI3K/Akt/NF-kappaB pathway, Int.J.Mol.Med., 38, 1871, 10.3892/ijmm.2016.2778
Li, 2018, Paeonol inhibits oxidized low-density lipoprotein-induced vascular endothelial cells autophagy by upregulating the expression of miRNA-30a, Front.Pharmacol., 9, 95, 10.3389/fphar.2018.00095
Liu, 2014, Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury in vitro via downregulating microRNA-21 expression and TNF-alpha release, Acta.Pharmacol.Sin., 35, 483, 10.1038/aps.2013.190
Chaabane, 2014, Smooth muscle cell phenotypic switch: implications for foam cell formation, Curr.Opin.Lipidol., 25, 374, 10.1097/MOL.0000000000000113
Wu, 2017, The anti-atherosclerotic effect of Paeonol against vascular smooth muscle cell proliferation by up-regulation of autophagy via the AMPK/mTOR signaling pathway, Front.Pharmacol., 8, 948, 10.3389/fphar.2017.00948
Meng, 2015, Paeonol inhibits the proliferation, invasion, and inflammatory reaction induced by TNF-alpha in vascular smooth muscle cells, Cell.Biochem.Biophys., 73, 495, 10.1007/s12013-015-0686-5
Chen, 2014, Paeonol inhibits proliferation of vascular smooth muscle cells stimulated by high glucose via Ras-Raf-ERK1/2 signaling pathway in Coculture model, Evid.Based.Complement.Alternat.Med., 2014, 10.1155/2014/484269
Pan, 2009, Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression, Phytomedicine, 16, 1027, 10.1016/j.phymed.2009.04.003
Liu, 2018, Paeonol attenuated inflammatory response of endothelial cells via stimulating monocytes-derived exosomal MicroRNA-223, Front.Pharmacol., 9, 1105, 10.3389/fphar.2018.01105
Nizamutdinova, 2007, Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways, Int.Immunopharmacol., 7, 343, 10.1016/j.intimp.2006.11.004
Choy, 2016, Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARdelta signaling pathway, Biochem.Pharmacol., 116, 51, 10.1016/j.bcp.2016.07.013
Choy, 2017, Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress, PLoS.One., 12, 10.1371/journal.pone.0178365
Choy, 2018, Paeonol attenuates LPS-induced endothelial dysfunction and apoptosis by inhibiting BMP4 and TLR4 signaling simultaneously but independently, J.Pharmacol.Exp.Ther., 364, 420, 10.1124/jpet.117.245217
Kim, 2009, Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases, Biol.Pharm.Bull., 32, 1142, 10.1248/bpb.32.1142
Ye, 2016, Paeonol enhances thrombus recanalization by inducing vascular endothelial growth factor 165 via ERK1/2 MAPK signaling pathway, Mol.Med.Rep., 13, 4853, 10.3892/mmr.2016.5135
Ma, 2016, Paeonol protects rat heart by improving regional blood perfusion during no-reflow, Front.Physiol., 7, 298, 10.3389/fphys.2016.00298
Nizamutdinova, 2008, Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats, Planta.Med., 74, 14, 10.1055/s-2007-993775
Kim, 2004, Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-alpha, Int.Immunopharmacol., 4, 279, 10.1016/j.intimp.2003.12.013
Terawaki, 2015, Keishibukuryogan, a traditional Japanese medicine, inhibits platelet aggregation in guinea pig whole blood, Evid.Based.Complement.Alternat.Med., 2015, 10.1155/2015/295706
Zhang, 2017, Local application of paeonol prevents early restenosis: a study with a rabbit vein graft model, J.Surg.Res., 212, 278, 10.1016/j.jss.2016.11.020
Wang, 2012, Synthesis and anti-tumor activity of paeonol and its derivatives, Yao.Xue.Xue.Bao., 47, 72
Huang, 2016, Synthesis and anti-inflammatory activity of paeonol analogues in the murine model of complete Freund's adjuvant induced arthritis, Bioorg.Med.Chem.Lett., 26, 5218, 10.1016/j.bmcl.2016.09.060
Jung, 2016, A tryptamine-paeonol hybridization compound inhibits LPS-mediated inflammation in BV2 cells, Neurochem.Int., 100, 35, 10.1016/j.neuint.2016.08.010
Fu, 2017, Evaluation of LPS-induced acute lung injury attenuation in rats by aminothiazole-Paeonol derivatives, Molecules, 22, 10.3390/molecules22101605
Zhu, 2013, Synthesis, characterization and biological evaluation of paeonol thiosemicarbazone analogues as mushroom tyrosinase inhibitors, Int.J.Biol.Macromol., 62, 589, 10.1016/j.ijbiomac.2013.09.056
Han, 2017, Novel derivative of Paeonol, Paeononlsilatie sodium, alleviates behavioral damage and hippocampal dendritic injury in Alzheimer's disease concurrent with cofilin1/phosphorylated-cofilin1 and RAC1/CDC42 alterations in rats, PLoS.One., 12, 10.1371/journal.pone.0185102
Zhou, 2015, Synthesis and evaluation of paeonol derivatives as potential multifunctional agents for the treatment of Alzheimer's disease, Molecules, 20, 1304, 10.3390/molecules20011304
Tsai, 2016, Synthesis and evaluation of aminothiazole-Paeonol derivatives as potential anticancer agents, Molecules, 21, 145, 10.3390/molecules21020145
Anh Hle, 2015, Synthesis of chromonylthiazolidines and their cytotoxicity to human cancer cell lines, Molecules, 20, 1151, 10.3390/molecules20011151
Huang, 2015, Design, synthesis, and bioevaluation of paeonol derivatives as potential anti-HBV agents, Eur.J.Med.Chem., 90, 428, 10.1016/j.ejmech.2014.11.050