PTPL1: a large phosphatase with a split personality
Tóm tắt
Protein tyrosine phosphatase, PTPL1, (also known as PTPN13, FAP-1, PTP-BAS, PTP1E) is a non-receptor type PTP and, at 270 kDa, is the largest phosphatase within this group. In addition to the well-conserved PTP domain, PTPL1 contains at least 7 putative macromolecular interaction domains. This structural complexity indicates that PTPL1 may modulate diverse cellular functions, perhaps exerting both positive and negative effects. In accordance with this idea, while certain studies suggest that PTPL1 can act as a tumor-promoting gene other experimental studies have suggested that PTPL1 may function as a tumor suppressor. The role of PTPL1 in the cancer cell is therefore likely to be both complex and context dependent with possible roles including the modulation of growth, stress-response, and cytoskeletal remodeling pathways. Understanding the nature of molecular complexes containing PTPL1, its interaction partners, substrates, regulation and subcellular localization are key to unraveling the complex personality of this protein phosphatase.
Tài liệu tham khảo
citation_journal_title=Cell; citation_title=Protein tyrosine phosphatases in the human genome; citation_author=A. Alonso, J. Sasin, N. Bottini, I. Friedberg, A. Osterman, A. Godzik; citation_volume=117; citation_issue=6; citation_publication_date=2004; citation_pages=699-711; citation_doi=10.1016/j.cell.2004.05.018; citation_id=CR1
citation_journal_title=Biochimica et Biophysica Acta; citation_title=Involvement of the small protein tyrosine phosphatases TC-PTP and PTP1B in signal transduction and diseases: from diabetes, obesity to cell cycle, and cancer; citation_author=N. Dube, M. L. Tremblay; citation_volume=1754; citation_issue=1–2; citation_publication_date=2005; citation_pages=108-117; citation_id=CR2
citation_journal_title=Current Opinion in Genetics & Development; citation_title=The role of Shp2 (PTPN11) in cancer; citation_author=M. G. Mohi, B. G. Neel; citation_volume=17; citation_issue=1; citation_publication_date=2007; citation_pages=23-30; citation_doi=10.1016/j.gde.2006.12.011; citation_id=CR3
citation_journal_title=Nature Reviews Cancer; citation_title=Protein-tyrosine phosphatases and cancer; citation_author=A. Ostman, C. Hellberg, F. D. Bohmer; citation_volume=6; citation_issue=4; citation_publication_date=2006; citation_pages=307-320; citation_doi=10.1038/nrc1837; citation_id=CR4
citation_journal_title=Nature Reviews. Molecular Cell Biology; citation_title=Protein tyrosine phosphatases: from genes, to function, to disease; citation_author=N. K. Tonks; citation_volume=7; citation_issue=11; citation_publication_date=2006; citation_pages=833-846; citation_doi=10.1038/nrm2039; citation_id=CR5
citation_journal_title=Journal of Biological Chemistry; citation_title=A novel protein-tyrosine phosphatase with homology to both the cytoskeletal proteins of the band 4.1 family and junction-associated guanylate kinases; citation_author=D. Banville, S. Ahmad, R. Stocco, S. H. Shen; citation_volume=269; citation_issue=35; citation_publication_date=1994; citation_pages=22320-22327; citation_id=CR6
citation_journal_title=FEBS Letters; citation_title=Molecular cloning of a novel protein-tyrosine phosphatase containing a membrane-binding domain and GLGF repeats; citation_author=K. Maekawa, N. Imagawa, M. Nagamatsu, S. Harada; citation_volume=337; citation_issue=2; citation_publication_date=1994; citation_pages=200-206; citation_doi=10.1016/0014-5793(94)80273-4; citation_id=CR7
citation_journal_title=Journal of Biological Chemistry; citation_title=Cloning and characterization of PTPL1, a protein tyrosine phosphatase with similarities to cytoskeletal-associated proteins; citation_author=J. Saras, L. Claesson-Welsh, C. H. Heldin, L. J. Gonez; citation_volume=269; citation_issue=39; citation_publication_date=1994; citation_pages=24082-24089; citation_id=CR8
citation_journal_title=Science; citation_title=FAP-1: A protein tyrosine phosphatase that associates with Fas; citation_author=T. Sato, S. Irie, S. Kitada, J. C. Reed; citation_volume=268; citation_issue=5209; citation_publication_date=1995; citation_pages=411-415; citation_doi=10.1126/science.7536343; citation_id=CR9
citation_journal_title=FASEB Journal; citation_title=A genomic perspective on protein tyrosine phosphatases: Gene structure, pseudogenes, and genetic disease linkage; citation_author=J. N. Andersen, P. G. Jansen, S. M. Echwald, O. H. Mortensen, T. Fukada, R. Vecchio; citation_volume=18; citation_issue=1; citation_publication_date=2004; citation_pages=8-30; citation_doi=10.1096/fj.02-1212rev; citation_id=CR10
citation_journal_title=Trends in Biochemical Science; citation_title=The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane; citation_author=A. H. Chishti, A. C. Kim, S. M. Marfatia, M. Lutchman, M. Hanspal, H. Jindal; citation_volume=23; citation_issue=8; citation_publication_date=1998; citation_pages=281-282; citation_doi=10.1016/S0968-0004(98)01237-7; citation_id=CR11
citation_journal_title=Trends in Biochemical Science; citation_title=The KIND module: a putative signalling domain evolved from the C lobe of the protein kinase fold; citation_author=F. D. Ciccarelli, P. Bork, E. Kerkhoff; citation_volume=28; citation_issue=7; citation_publication_date=2003; citation_pages=349-352; citation_doi=10.1016/S0968-0004(03)00116-6; citation_id=CR12
citation_journal_title=Journal of Cell Science; citation_title=Membrane targeting of protein tyrosine phosphatase PTPL1 through its FERM domain via binding to phosphatidylinositol 4,5-biphosphate; citation_author=G. Bompard, M. Martin, C. Roy, F. Vignon, G. Freiss; citation_volume=116; citation_issue=Pt 12; citation_publication_date=2003; citation_pages=2519-2530; citation_doi=10.1242/jcs.00448; citation_id=CR13
citation_journal_title=Molecular Biology of the Cell; citation_title=The protein tyrosine phosphatase PTP-BL associates with the midbody and is involved in the regulation of cytokinesis; citation_author=L. Herrmann, T. Dittmar, K. S. Erdmann; citation_volume=14; citation_issue=1; citation_publication_date=2003; citation_pages=230-240; citation_doi=10.1091/mbc.E02-04-0191; citation_id=CR14
citation_journal_title=Molecular and Cellular Biology; citation_title=Structural and evolutionary relationships among protein tyrosine phosphatase domains; citation_author=J. N. Andersen, O. H. Mortensen, G. H. Peters, P. G. Drake, L. F. Iversen, O. H. Olsen; citation_volume=21; citation_issue=21; citation_publication_date=2001; citation_pages=7117-7136; citation_doi=10.1128/MCB.21.21.7117-7136.2001; citation_id=CR15
citation_journal_title=Journal of Biological Chemistry; citation_title=Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: Evidence for a second phosphotyrosine substrate recognition pocket; citation_author=F. Villa, M. Deak, G. B. Bloomberg, D. R. Alessi, D. M. Aalten; citation_volume=280; citation_issue=9; citation_publication_date=2005; citation_pages=8180-8187; citation_doi=10.1074/jbc.M412211200; citation_id=CR16
citation_journal_title=Journal of Human Genetics; citation_title=Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: Genomic structure and seven polymorphisms of the FAP-1 gene; citation_author=S. Yoshida, H. Harada, H. Nagai, K. Fukino, A. Teramoto, M. Emi; citation_volume=47; citation_issue=11; citation_publication_date=2002; citation_pages=614-619; citation_doi=10.1007/s100380200094; citation_id=CR17
citation_journal_title=DNA Sequence; citation_title=Identification of two Fas-associated phosphatase-1 (FAP-1) promoters in human cancer cells; citation_author=S. Irie, Y. Li, H. Kanki, T. Ohyama, L. L. Deaven, S. Somlo; citation_volume=11; citation_issue=6; citation_publication_date=2001; citation_pages=519-526; citation_doi=10.3109/10425170109041336; citation_id=CR18
citation_journal_title=Oncogene; citation_title=PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing’s Sarcoma tumorigenesis; citation_author=O. D. Abaan, A. Levenson, O. Khan, P. A. Furth, A. Uren, J. A. Toretsky; citation_volume=24; citation_issue=16; citation_publication_date=2005; citation_pages=2715-2722; citation_doi=10.1038/sj.onc.1208247; citation_id=CR19
citation_journal_title=Journal of Molecular Biology; citation_title=Structure determination and ligand interactions of the PDZ2b domain of PTP-Bas (hPTP1E): splicing-induced modulation of ligand specificity; citation_author=N. Kachel, K. S. Erdmann, W. Kremer, P. Wolff, W. Gronwald, R. Heumann; citation_volume=334; citation_issue=1; citation_publication_date=2003; citation_pages=143-155; citation_doi=10.1016/j.jmb.2003.09.026; citation_id=CR20
Zhu, J. H., Chen, R., Yi, W., Cantin, G. T., Fearns, C., Yang, Y., et al. (2008). Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling. Oncogene (in press).
citation_journal_title=Development; citation_title=Potential role of protein tyrosine phosphatase nonreceptor type 13 in the control of oocyte meiotic maturation; citation_author=T. Nedachi, M. Conti; citation_volume=131; citation_issue=20; citation_publication_date=2004; citation_pages=4987-4998; citation_doi=10.1242/dev.01368; citation_id=CR22
citation_journal_title=Cancer Research; citation_title=The putative tumor suppressor gene PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation; citation_author=M. Dromard, G. Bompard, M. Glondu-Lassis, C. Puech, D. Chalbos, G. Freiss; citation_volume=67; citation_issue=14; citation_publication_date=2007; citation_pages=6806-6813; citation_doi=10.1158/0008-5472.CAN-07-0513; citation_id=CR23
citation_journal_title=Journal of Cell Science; citation_title=Inositol–lipid binding motifs: signal integrators through protein–lipid and protein–protein interactions; citation_author=T. Balla; citation_volume=118; citation_issue=Pt 10; citation_publication_date=2005; citation_pages=2093-2104; citation_doi=10.1242/jcs.02387; citation_id=CR24
citation_journal_title=Biochemical Journal; citation_title=Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1; citation_author=W. A. Kimber, M. Deak, A. R. Prescott, D. R. Alessi; citation_volume=376; citation_issue=Pt 2; citation_publication_date=2003; citation_pages=525-535; citation_doi=10.1042/BJ20031154; citation_id=CR25
citation_journal_title=Biochemical Journal; citation_title=Association of protein-tyrosine phosphatase PTP-BAS with the transcription-factor-inhibitory protein IkappaBalpha through interaction between the PDZ1 domain and ankyrin repeats; citation_author=K. Maekawa, N. Imagawa, A. Naito, S. Harada, O. Yoshie, S. Takagi; citation_volume=337; citation_issue=Pt 2; citation_publication_date=1999; citation_pages=179-184; citation_doi=10.1042/0264-6021:3370179; citation_id=CR26
citation_journal_title=American Journal of Physiology Cell Physiology; citation_title=Regulation of the TRP channel TRPM2 by the tyrosine phosphatase PTPL1; citation_author=W. Zhang, Q. Tong, K. Conrad, J. Wozney, J. Cheung, B. A. Miller; citation_volume=292; citation_publication_date=2007; citation_pages=C1746-C1758; citation_doi=10.1152/ajpcell.00569.2006; citation_id=CR27
citation_journal_title=Journal of Biological Chemistry; citation_title=Characterization of the interactions between PDZ domains of the protein-tyrosine phosphatase PTPL1 and the carboxyl-terminal tail of Fas; citation_author=J. Saras, U. Engstrom, L. J. Gonez, C. H. Heldin; citation_volume=272; citation_issue=34; citation_publication_date=1997; citation_pages=20979-20981; citation_doi=10.1074/jbc.272.34.20979; citation_id=CR28
citation_journal_title=Journal of Biological Chemistry; citation_title=The molecular interaction of Fas and FAP-1. A tripeptide blocker of human Fas interaction with FAP-1 promotes Fas-induced apoptosis; citation_author=J. Yanagisawa, M. Takahashi, H. Kanki, H. Yano-Yanagisawa, T. Tazunoki, E. Sawa; citation_volume=272; citation_issue=13; citation_publication_date=1997; citation_pages=8539-8545; citation_doi=10.1074/jbc.272.13.8539; citation_id=CR29
citation_journal_title=FEBS Letters; citation_title=Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation; citation_author=S. Irie, T. Hachiya, S. Rabizadeh, W. Maruyama, J. Mukai, Y. Li; citation_volume=460; citation_issue=2; citation_publication_date=1999; citation_pages=191-198; citation_doi=10.1016/S0014-5793(99)01324-1; citation_id=CR30
citation_journal_title=Journal of Biological Chemistry; citation_title=ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E; citation_author=K. K. Murthy, K. Clark, Y. Fortin, S. H. Shen, D. Banville; citation_volume=274; citation_issue=29; citation_publication_date=1999; citation_pages=20679-20687; citation_doi=10.1074/jbc.274.29.20679; citation_id=CR31
citation_journal_title=Journal of Biological Chemistry; citation_title=A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1; citation_author=J. Saras, P. Franzen, P. Aspenstrom, U. Hellman, L. J. Gonez, C. H. Heldin; citation_volume=272; citation_issue=39; citation_publication_date=1997; citation_pages=24333-24338; citation_doi=10.1074/jbc.272.39.24333; citation_id=CR32
citation_journal_title=Journal of Biological Chemistry; citation_title=The carboxyl terminus of B class ephrins constitutes a PDZ domain binding motif; citation_author=D. Lin, G. D. Gish, Z. Songyang, T. Pawson; citation_volume=274; citation_issue=6; citation_publication_date=1999; citation_pages=3726-3733; citation_doi=10.1074/jbc.274.6.3726; citation_id=CR33
citation_journal_title=Proceedings of the National Academy of Sciences of the United States of America; citation_title=Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases; citation_author=A. J. Flint, T. Tiganis, D. Barford, N. K. Tonks; citation_volume=94; citation_issue=5; citation_publication_date=1997; citation_pages=1680-1685; citation_doi=10.1073/pnas.94.5.1680; citation_id=CR34
citation_journal_title=Biochemical Journal; citation_title=Protein tyrosine phosphatase function: the substrate perspective; citation_author=T. Tiganis, A. M. Bennett; citation_volume=402; citation_issue=1; citation_publication_date=2007; citation_pages=1-15; citation_doi=10.1042/BJ20061548; citation_id=CR35
citation_journal_title=European Journal of Biochemistry; citation_title=Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1; citation_author=Y. Nakai, S. Irie, T. A. Sato; citation_volume=267; citation_issue=24; citation_publication_date=2000; citation_pages=7170-7175; citation_doi=10.1046/j.1432-1327.2000.01818.x; citation_id=CR36
citation_journal_title=Immunity; citation_title=Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL; citation_author=M. Nakahira, T. Tanaka, B. E. Robson, J. P. Mizgerd, M. J. Grusby; citation_volume=26; citation_issue=2; citation_publication_date=2007; citation_pages=163-176; citation_doi=10.1016/j.immuni.2007.01.010; citation_id=CR37
citation_journal_title=Physiological Genomics; citation_title=Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity; citation_author=D. G. Wansink, W. Peters, I. Schaafsma, R. P. Sutmuller, F. Oerlemans, G. J. Adema; citation_volume=19; citation_issue=1; citation_publication_date=2004; citation_pages=50-60; citation_doi=10.1152/physiolgenomics.00079.2004; citation_id=CR38
citation_journal_title=European Journal of Neuroscience; citation_title=Effects of LAR and PTP-BL phosphatase deficiency on adult mouse retinal cells activated by lens injury; citation_author=B. Lorber, W. J. Hendriks, C. E. Zee, M. Berry, A. Logan; citation_volume=21; citation_issue=9; citation_publication_date=2005; citation_pages=2375-2383; citation_doi=10.1111/j.1460-9568.2005.04065.x; citation_id=CR39
citation_journal_title=Future Oncology; citation_title=Ewing’s sarcoma oncoprotein EWS-FLI1: The perfect target without a therapeutic agent; citation_author=A. Uren, J. A. Toretsky; citation_volume=1; citation_issue=4; citation_publication_date=2005; citation_pages=521-528; citation_doi=10.2217/14796694.1.4.521; citation_id=CR40
citation_journal_title=International Journal of Cancer; citation_title=Profiling and functional annotation of mRNA gene expression in pediatric rhabdomyosarcoma and Ewing’s sarcoma; citation_author=C. Baer, M. Nees, S. Breit, B. Selle, A. E. Kulozik, K. L. Schaefer; citation_volume=110; citation_issue=5; citation_publication_date=2004; citation_pages=687-694; citation_doi=10.1002/ijc.20171; citation_id=CR41
citation_journal_title=Nature Medicine; citation_title=Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks; citation_author=J. Khan, J. S. Wei, M. Ringner, L. H. Saal, M. Ladanyi, F. Westermann; citation_volume=7; citation_issue=6; citation_publication_date=2001; citation_pages=673-679; citation_doi=10.1038/89044; citation_id=CR42
citation_journal_title=Cancer Cell; citation_title=The Ewing’s sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts; citation_author=S. L. Lessnick, C. S. Dacwag, T. R. Golub; citation_volume=1; citation_issue=4; citation_publication_date=2002; citation_pages=393-401; citation_doi=10.1016/S1535-6108(02)00056-9; citation_id=CR43
citation_journal_title=Current Opinion in Pharmacology; citation_title=The Fas signalling pathway and its role in the pathogenesis of cancer; citation_author=A. Houston, J. O’Connell; citation_volume=4; citation_issue=4; citation_publication_date=2004; citation_pages=321-326; citation_doi=10.1016/j.coph.2004.03.008; citation_id=CR44
citation_journal_title=Cancer Research; citation_title=Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas-mediated apoptosis; citation_author=H. Ungefroren, M. Voss, M. Jansen, C. Roeder, D. Henne-Bruns, B. Kremer; citation_volume=58; citation_issue=8; citation_publication_date=1998; citation_pages=1741-1749; citation_id=CR45
citation_journal_title=Journal of Cell Science; citation_title=FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis; citation_author=H. Ungefroren, M. L. Kruse, A. Trauzold, S. Roeschmann, C. Roeder, A. Arlt; citation_volume=114; citation_issue=Pt 15; citation_publication_date=2001; citation_pages=2735-2746; citation_id=CR46
citation_journal_title=Molecular and Cellular Biology; citation_title=FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface; citation_author=V. N. Ivanov, P. Lopez Bergami, G. Maulit, T. A. Sato, D. Sassoon, Z. Ronai; citation_volume=23; citation_issue=10; citation_publication_date=2003; citation_pages=3623-3635; citation_doi=10.1128/MCB.23.10.3623-3635.2003; citation_id=CR47
citation_journal_title=American Journal of Pathology; citation_title=Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer; citation_author=I. Meinhold-Heerlein, F. Stenner-Liewen, H. Liewen, S. Kitada, M. Krajewska, S. Krajewski; citation_volume=158; citation_issue=4; citation_publication_date=2001; citation_pages=1335-1344; citation_id=CR48
citation_journal_title=British Journal of Cancer; citation_title=Expression of FAP-1 by human colon adenocarcinoma: implication for resistance against Fas-mediated apoptosis in cancer; citation_author=H. Yao, E. Song, J. Chen, P. Hamar; citation_volume=91; citation_issue=9; citation_publication_date=2004; citation_pages=1718-1725; citation_id=CR49
citation_journal_title=Journal of Cellular Biochemistry; citation_title=FAP-1-mediated activation of NF-kappaB induces resistance of head and neck cancer to Fas-induced apoptosis; citation_author=E. Wieckowski, Y. Atarashi, J. Stanson, T. A. Sato, T. L. Whiteside; citation_volume=100; citation_issue=1; citation_publication_date=2007; citation_pages=16-28; citation_doi=10.1002/jcb.20922; citation_id=CR50
citation_journal_title=Human Pathology; citation_title=Expression of Fas and Fas-related molecules in human hepatocellular carcinoma; citation_author=S. H. Lee, M. S. Shin, H. S. Lee, J. H. Bae, H. K. Lee, H. S. Kim; citation_volume=32; citation_issue=3; citation_publication_date=2001; citation_pages=250-256; citation_doi=10.1053/hupa.2001.22769; citation_id=CR51
citation_journal_title=Journal of Pathology; citation_title=In vivo expression of soluble Fas and FAP-1: possible mechanisms of Fas resistance in human hepatoblastomas; citation_author=S. H. Lee, M. S. Shin, J. Y. Lee, W. S. Park, S. Y. Kim, J. J. Jang; citation_volume=188; citation_issue=2; citation_publication_date=1999; citation_pages=207-212; citation_doi=10.1002/(SICI)1096-9896(199906)188:2<207::AID-PATH337>3.0.CO;2-8; citation_id=CR52
citation_journal_title=Hepatology; citation_title=Fluorescence resonance energy transfer analysis of proapoptotic CD95-EGF receptor interactions in Huh7 cells; citation_author=A. Eberle, R. Reinehr, S. Becker, D. Haussinger; citation_volume=41; citation_issue=2; citation_publication_date=2005; citation_pages=315-326; citation_doi=10.1002/hep.20564; citation_id=CR53
citation_journal_title=Neuron; citation_title=p75NTR is positively promiscuous: novel partners and new insights; citation_author=P. A. Barker; citation_volume=42; citation_issue=4; citation_publication_date=2004; citation_pages=529-533; citation_doi=10.1016/j.neuron.2004.04.001; citation_id=CR54
citation_journal_title=Journal of Neuroscience Research; citation_title=Dual role for p75(NTR) signaling in survival and cell death: Can intracellular mediators provide an explanation?; citation_author=V. Mamidipudi, M. W. Wooten; citation_volume=68; citation_issue=4; citation_publication_date=2002; citation_pages=373-384; citation_doi=10.1002/jnr.10244; citation_id=CR55
citation_journal_title=Cell Signal; citation_title=c-Cbl binds to tyrosine-phosphorylated neurotrophin receptor p75 and induces its ubiquitination; citation_author=T. Ohrt, A. Mancini, T. Tamura, R. Niedenthal; citation_volume=16; citation_issue=11; citation_publication_date=2004; citation_pages=1291-1298; citation_doi=10.1016/j.cellsig.2004.03.017; citation_id=CR56
citation_journal_title=Cell; citation_title=Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha; citation_author=V. Imbert, R. A. Rupec, A. Livolsi, H. L. Pahl, E. B. Traenckner, C. Mueller-Dieckmann; citation_volume=86; citation_issue=5; citation_publication_date=1996; citation_pages=787-798; citation_doi=10.1016/S0092-8674(00)80153-1; citation_id=CR57
citation_journal_title=Molecular and Cellular Biology; citation_title=Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl; citation_author=H. Kawai, L. Nie, Z. M. Yuan; citation_volume=22; citation_issue=17; citation_publication_date=2002; citation_pages=6079-6088; citation_doi=10.1128/MCB.22.17.6079-6088.2002; citation_id=CR58
citation_journal_title=Journal of Cell Science; citation_title=Temporal pattern of NF kappa B activation influences apoptotic cell fate in a stimuli-dependent fashion; citation_author=C. Fan, J. Yang, J. F. Engelhardt; citation_volume=115; citation_issue=24; citation_publication_date=2002; citation_pages=4843-4853; citation_doi=10.1242/jcs.00151; citation_id=CR59
citation_journal_title=Journal of Neurooncology; citation_title=FAS associated phosphatase (FAP-1) blocks apoptosis of astrocytomas through dephosphorylation of FAS; citation_author=E. D. Foehr, G. Lorente, V. Vincent, K. Nikolich, R. Urfer; citation_volume=74; citation_issue=3; citation_publication_date=2005; citation_pages=241-248; citation_doi=10.1007/s11060-004-7202-x; citation_id=CR60
citation_journal_title=Journal of Biological Chemistry; citation_title=The phosphoinositol 3,4-bisphosphate-binding protein TAPP1 interacts with syntrophins and regulates actin cytoskeletal organization; citation_author=A. Hogan, Y. Yakubchyk, J. Chabot, C. Obagi, E. Daher, K. Maekawa; citation_volume=279; citation_issue=51; citation_publication_date=2004; citation_pages=53717-53724; citation_doi=10.1074/jbc.M410654200; citation_id=CR61
citation_journal_title=Nature Reviews. Molecular and Cellular Biology; citation_title=Mechanisms and functions of Eph and ephrin signalling; citation_author=K. Kullander, R. Klein; citation_volume=3; citation_issue=7; citation_publication_date=2002; citation_pages=475-486; citation_doi=10.1038/nrm856; citation_id=CR62
citation_journal_title=Molecular Cell; citation_title=EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase; citation_author=A. Palmer, M. Zimmer, K. S. Erdmann, V. Eulenburg, A. Porthin, R. Heumann; citation_volume=9; citation_issue=4; citation_publication_date=2002; citation_pages=725-737; citation_doi=10.1016/S1097-2765(02)00488-4; citation_id=CR63
citation_journal_title=Biochemical and Biophysical Research Communications; citation_title=PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector; citation_author=B. E. Myagmar, M. Umikawa, T. Asato, K. Taira, M. Oshiro, A. Hino; citation_volume=329; citation_issue=3; citation_publication_date=2005; citation_pages=1046-1052; citation_doi=10.1016/j.bbrc.2005.02.069; citation_id=CR64
citation_journal_title=Journal of Biological Chemistry; citation_title=PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration; citation_author=Y. J. Lai, W. C. Lin, F. T. Lin; citation_volume=282; citation_issue=33; citation_publication_date=2007; citation_pages=24381-24387; citation_doi=10.1074/jbc.M701499200; citation_id=CR65
citation_journal_title=Journal of Gastroenterology and Hepatology; citation_title=Fas-associated phosphatase-1 promotes Fas-mediated apoptosis in human colon cancer cells: novel function of FAP-1; citation_author=T. Miyazaki, Y. Atarashi, S. Yasumura, I. Minatoya, K. Ogawa, M. Iwamoto; citation_volume=21; citation_issue=1 Pt 1; citation_publication_date=2006; citation_pages=84-91; citation_doi=10.1111/j.1440-1746.2005.04155.x; citation_id=CR66
citation_journal_title=Cell Death Differentiation; citation_title=Expression of genes that regulate Fas signalling and Fas-mediated apoptosis in colon carcinoma cells; citation_author=D. M. Tillman, F. G. Harwood, A. A. Gibson, J. A. Houghton; citation_volume=5; citation_issue=5; citation_publication_date=1998; citation_pages=450-457; citation_doi=10.1038/sj.cdd.4400369; citation_id=CR67
citation_journal_title=Leukemia; citation_title=Epigenetic disruption of two proapoptotic genes MAPK10/JNK3 and PTPN13/FAP-1 in multiple lymphomas and carcinomas through hypermethylation of a common bidirectional promoter; citation_author=J. Ying, H. Li, Y. Cui, A. H. Wong, C. Langford, Q. Tao; citation_volume=20; citation_issue=6; citation_publication_date=2006; citation_pages=1173-1175; citation_doi=10.1038/sj.leu.2404193; citation_id=CR68
citation_journal_title=Clinical Cancer Research; citation_title=Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma; citation_author=S. H. Yeh, D. C. Wu, C. Y. Tsai, T. J. Kuo, W. C. Yu, Y. S. Chang; citation_volume=12; citation_issue=4; citation_publication_date=2006; citation_pages=1097-1108; citation_doi=10.1158/1078-0432.CCR-05-1383; citation_id=CR69
citation_journal_title=Science; citation_title=Mutational analysis of the tyrosine phosphatome in colorectal cancers; citation_author=Z. Wang, D. Shen, D. W. Parsons, A. Bardelli, J. Sager, S. Szabo; citation_volume=304; citation_issue=5674; citation_publication_date=2004; citation_pages=1164-1166; citation_doi=10.1126/science.1096096; citation_id=CR70
citation_journal_title=Molecular Endocrinology; citation_title=Extinction of insulin-like growth factor-I mitogenic signaling by antiestrogen-stimulated Fas-associated protein tyrosine phosphatase-1 in human breast cancer cells; citation_author=G. Freiss, C. Puech, F. Vignon; citation_volume=12; citation_issue=4; citation_publication_date=1998; citation_pages=568-579; citation_doi=10.1210/me.12.4.568; citation_id=CR71
citation_journal_title=Journal of Biological Chemistry; citation_title=Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells; citation_author=G. Bompard, C. Puech, C. Prebois, F. Vignon, G. Freiss; citation_volume=277; citation_issue=49; citation_publication_date=2002; citation_pages=47861-47869; citation_doi=10.1074/jbc.M208950200; citation_id=CR72
citation_journal_title=Journal of Biological Chemistry; citation_title=No evidence for involvement of mouse protein-tyrosine phosphatase-BAS-like Fas-associated phosphatase-1 in Fas-mediated apoptosis; citation_author=E. Cuppen, S. Nagata, B. Wieringa, W. Hendriks; citation_volume=272; citation_issue=48; citation_publication_date=1997; citation_pages=30215-30220; citation_doi=10.1074/jbc.272.48.30215; citation_id=CR73
citation_journal_title=Chembiochem; citation_title=Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives; citation_author=M. Stuible, L. Zhao, I. Aubry, D. Schmidt-Arras, F. D. Bohmer, C. J. Li; citation_volume=8; citation_issue=2; citation_publication_date=2007; citation_pages=179-186; citation_doi=10.1002/cbic.200600287; citation_id=CR74