PPARγ Regulates Mouse Meibocyte Differentiation and Lipid Synthesis

Bron, 1997

Jester, 1981, Meibomian gland studies: histologic and ultrastructural investigations, Invest Ophthalmol Vis Sci, 20, 537

Mishima, 1961, The oily layer of the tear film and evaporation from the corneal surface, Exp Eye Res, 1, 39, 10.1016/S0014-4835(61)80006-7

Mathers, 1998, Meibomian gland lipids, evaporation, and tear film stability, Adv Exp Med Biol, 438, 349, 10.1007/978-1-4615-5359-5_50

Gilbard, 1989, Tear film and ocular surface changes after closure of the meibomian gland orifices in the rabbit, Ophthalmology, 96, 1180, 10.1016/S0161-6420(89)32753-9

Foulks, 2003, Meibomian gland dysfunction: a clinical scheme for description, diagnosis, classification, and grading, Ocul Surf, 1, 107, 10.1016/S1542-0124(12)70139-8

Lemp, 2009, Blepharitis in the United States 2009: a survey-based perspective on prevalence and treatment, Ocul Surf, 7, S1, 10.1016/S1542-0124(12)70620-1

Tong, 2010, Screening for meibomian gland disease: its relation to dry eye subtypes and symptoms in a tertiary referral clinic in singapore, Invest Ophthalmol Vis Sci, 51, 3449, 10.1167/iovs.09-4445

Viso, 2011, The association of meibomian gland dysfunction and other common ocular diseases with dry eye: a population-based study in Spain, Cornea, 30, 1, 10.1097/ICO.0b013e3181da5778

Nichols, 2011, The international workshop on meibomian gland dysfunction: executive summary, Invest Ophthalmol Vis Sci, 52, 1922, 10.1167/iovs.10-6997a

Knop, 2011, The international workshop on meibomian gland dysfunction: report of the subcommittee on anatomy, physiology, and pathophysiology of the meibomian gland, Invest Ophthalmol Vis Sci, 52, 1938, 10.1167/iovs.10-6997c

Jester, 1989, Meibomian gland dysfunction. II. The role of keratinization in a rabbit model of MGD, Invest Ophthalmol Vis Sci, 30, 936

Jester, 1988, Meibomian gland changes in the rhino (hrrhhrrh) mouse, Invest Ophthalmol Vis Sci, 29, 1190

Ohnishi, 1979, Polychlorinated biphenyls poisoning in monkey eye, Invest Ophthalmol Vis Sci, 18, 981

Sullivan, 2002, Complete androgen insensitivity syndrome: effect on human meibomian gland secretions, Arch Ophthalmol, 120, 1689, 10.1001/archopht.120.12.1689

Sullivan, 2006, Influence of aging on the polar and neutral lipid profiles in human meibomian gland secretions, Arch Ophthalmol, 124, 1286, 10.1001/archopht.124.9.1286

Ding, 2013, The influence of 13-cis retinoic acid on human meibomian gland epithelial cells, Invest Ophthalmol Vis Sci, 54, 4341, 10.1167/iovs.13-11863

Ding, 2014, The effects of insulin-like growth factor 1 and growth hormone on human meibomian gland epithelial cells, JAMA Ophthalmol, 132, 593, 10.1001/jamaophthalmol.2013.8295

Kam, 2011, Neurotransmitter influence on human meibomian gland epithelial cells, Invest Ophthalmol Vis Sci, 52, 8543, 10.1167/iovs.11-8113

Khandelwal, 2012, Androgen regulation of gene expression in human meibomian gland and conjunctival epithelial cells, Mol Vis, 18, 1055

Liu, 2010, Culture, immortalization, and characterization of human meibomian gland epithelial cells, Invest Ophthalmol Vis Sci, 51, 3993, 10.1167/iovs.09-5108

Liu, 2013, Effect of growth factors on the proliferation and gene expression of human meibomian gland epithelial cells, Invest Ophthalmol Vis Sci, 54, 2541, 10.1167/iovs.12-11221

Liu, 2014, Effect of azithromycin on lipid accumulation in immortalized human meibomian gland epithelial cells, JAMA Ophthalmol, 132, 226, 10.1001/jamaophthalmol.2013.6030

Liu, 2015, Can tetracycline antibiotics duplicate the ability of azithromycin to stimulate human meibomian gland epithelial cell differentiation?, Cornea, 34, 342, 10.1097/ICO.0000000000000351

Sullivan, 2014, Serum-induced differentiation of human meibomian gland epithelial cells, Invest Ophthalmol Vis Sci, 55, 3866, 10.1167/iovs.13-13407

Rosen, 2001, PPARgamma: a nuclear regulator of metabolism, differentiation, and cell growth, J Biol Chem, 276, 37731, 10.1074/jbc.R100034200

Fan, 2005, Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion, Diabetes, 54, 1000, 10.2337/diabetes.54.4.1000

Hammarstedt, 2005, The effect of PPARgamma ligands on the adipose tissue in insulin resistance, Prostaglandins Leukot Essent Fatty Acids, 73, 65, 10.1016/j.plefa.2005.04.008

Nien, 2010, The development of meibomian glands in mice, Mol Vis, 16, 1132

Nien, 2011, Effects of age and dysfunction on human meibomian glands, Arch Ophthalmol, 129, 462, 10.1001/archophthalmol.2011.69

Nien, 2009, Age-related changes in the meibomian gland, Exp Eye Res, 89, 1021, 10.1016/j.exer.2009.08.013

Jester, 2011, Volumetric reconstruction of the mouse meibomian gland using high-resolution nonlinear optical imaging, Anat Rec (Hoboken), 294, 185, 10.1002/ar.21305

Lin, 2011, Picosecond spectral coherent anti-Stokes Raman scattering imaging with principal component analysis of meibomian glands, J Biomed Opt, 16, 021104, 10.1117/1.3533716

Brown, 2004, Expression of neuregulin 1, a member of the epidermal growth factor family, is expressed as multiple splice variants in the adult human cornea, Invest Ophthalmol Vis Sci, 45, 3021, 10.1167/iovs.04-0229

Spirin, 1999, Analysis of gene expression in human bullous keratopathy corneas containing limiting amounts of RNA, Invest Ophthalmol Vis Sci, 40, 3108

Tontonoz, 2008, Fat and beyond: The diverse biology of PPARgamma, Ann Rev Biochem, 77, 289, 10.1146/annurev.biochem.77.061307.091829

Trivedi, 2006, Peroxisome proliferator-activated receptors increase human sebum production, J Invest Dermatol, 126, 2002, 10.1038/sj.jid.5700336

Adams, 1997, Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site, J Biol Chem, 272, 5128, 10.1074/jbc.272.8.5128

Hu, 1996, Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma, Science, 274, 21003, 10.1126/science.274.5295.2100

Geiss-Friedlander, 2007, Concepts in sumoylation: a decade on, Nat Rev Mol Cell Biol, 8, 947, 10.1038/nrm2293

Burgemeister, 2007, MAPK kinases as nucleo-cytoplasmic shuttles for PPARg, Cell Cycle, 6, 1539, 10.4161/cc.6.13.4453

van Beekum, 2009, Post translational modifications of PPAR-gamma: fine-tuning the metabolic master regulator, Obesity (Silver Spring), 17, 213, 10.1038/oby.2008.473

Makrantonaki, 2007, Testosterone metabolism to 5a-dihydrotestosterone and synthesis of sebaceous lipis is regulated by the peroxisome proliferator-activated receptor ligand linoleic acid in human sebocytes, Br J Dematol, 156, 428, 10.1111/j.1365-2133.2006.07671.x

Wrobel, 2003, Differentiation and apoptosis in human immortalized sebocytes, J Invest Dermatol, 120, 175, 10.1046/j.1523-1747.2003.12029.x

Xia, 2009, Culture of human sebocytes in vitro, Dermatoendocrinol, 1, 92, 10.4161/derm.1.2.8736

Zouboulis, 1999, Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95), J Invest Dermatol, 113, 1011, 10.1046/j.1523-1747.1999.00771.x

Robertson, 2005, Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line, Invest Ophthalmol Vis Sci, 46, 470, 10.1167/iovs.04-0528