PPARα is a key regulator of hepatic FGF21
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Nishimura, 2000, Identification of a novel FGF, FGF-21, preferentially expressed in the liver, Biochim. Biophys. Acta, 1492, 203, 10.1016/S0167-4781(00)00067-1
Wente, 2006, Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways, Diabetes, 55, 2470, 10.2337/db05-1435
Kharitonenkov, 2007, The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21, Endocrinology, 148, 774, 10.1210/en.2006-1168
Kharitonenkov, 2005, FGF-21 as a novel metabolic regulator, J. Clin. Invest., 115, 1627, 10.1172/JCI23606
Moyers, 2007, Molecular determinants of FGF-21 activity-synergy and cross-talk with PPARgamma signaling, J. Cell. Physiol., 210, 1, 10.1002/jcp.20847
T. Lundasen, Studies on the hormonal regulation of bile acid synthesis Ph.D Thesis, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, 2007, 43 p, ISBN: 978-91-7357-053-4.
Mandard, 2004, Peroxisome proliferator-activated receptor alpha target genes, Cell. Mol. Life Sci., 61, 393, 10.1007/s00018-003-3216-3
Lee, 1995, Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators, Mol. Cell. Biol., 15, 3012, 10.1128/MCB.15.6.3012
Leone, 1999, A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders, Proc. Natl. Acad. Sci. USA, 96, 7473, 10.1073/pnas.96.13.7473
Kersten, 1999, Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting, J. Clin. Invest., 103, 1489, 10.1172/JCI6223
Stahlberg, 1995, Influence of bezafibrate on hepatic cholesterol metabolism in gallstone patients: reduced activity of cholesterol 7 alpha-hydroxylase, Hepatology, 21, 1025
Marrapodi, 2000, Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription, J. Lipid Res., 41, 514, 10.1016/S0022-2275(20)32398-1
Fazio, 2004, The role of fibrates in managing hyperlipidemia: mechanisms of action and clinical efficacy, Curr. Atheroscler. Rep., 6, 148, 10.1007/s11883-004-0104-8
Despres, 2004, Role of fibric acid derivatives in the management of risk factors for coronary heart disease, Drugs, 64, 2177, 10.2165/00003495-200464190-00003
Strom, 1996, Use of human hepatocytes to study P450 gene induction, Methods Enzymol., 272, 388, 10.1016/S0076-6879(96)72044-X
Gervois, 1999, Fibrates increase human REV-ERBalpha expression in liver via a novel peroxisome proliferator-activated receptor response element, Mol. Endocrinol., 13, 400
