PP2A inhibition with LB100 enhances cisplatin cytotoxicity and overcomes cisplatin resistance in medulloblastoma cells
Tóm tắt
Từ khóa
Tài liệu tham khảo
Kruchko, 2012, CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009, Neuro Oncol, 14, v1, 10.1093/neuonc/nos218
Gajjar, 2013, Survival, secondary tumors in children with medulloblastoma receiving radiotherapy and adjuvant chemotherapy: results of Children's Oncology Group trial A9961, Neuro-oncology, 15, 97, 10.1093/neuonc/nos267
Cole, 2014, Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group, Acta Neuropathol, 127, 189, 10.1007/s00401-013-1213-7
Orecchia, 2009, Pediatric medulloblastoma: toxicity of current treatment and potential role of protontherapy, Cancer Treat Rev, 35, 79, 10.1016/j.ctrv.2008.09.002
Doz, 2009, From childhood to adulthood: long-term outcome of medulloblastoma patients. The Institut Curie experience (1980-2000), J Neurooncol, 95, 271, 10.1007/s11060-009-9927-z
Finlay, 2010, High-dose carboplatin, thiotepa, and etoposide with autologous stem cell rescue for patients with previously irradiated recurrent medulloblastoma, Neuro Oncol, 12, 297, 10.1093/neuonc/nop031
von Bueren, 2012, Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas, Acta Neuropathol, 123, 473, 10.1007/s00401-012-0958-8
Packer, 2015, Medulloblastoma: toward biologically based management, Semin Pediatr Neurol, 22, 6, 10.1016/j.spen.2014.12.010
Zhuang, 2015, LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential, Cancer Biol Ther, 16, 821, 10.1080/15384047.2015.1040961
Neviani, 2013, Protein phosphatase 2A: a target for anticancer therapy, Lancet Oncol, 14, e229, 10.1016/S1470-2045(12)70558-2
Mumby, 2007, PP2A: unveiling a reluctant tumor suppressor, Cell, 130, 21, 10.1016/j.cell.2007.06.034
Zhuang, 2009, Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms, Proc Natl Acad Sci U S A, 106, 11697, 10.1073/pnas.0905930106
Vincent Chung, Fadi, Carlos, Donald. 2015. Phase I Study of LB-100 With Docetaxel in Solid Tumors.
Gottesman, 2015, The protein phosphatase 2A inhibitor LB100 sensitizes ovarian carcinoma cells to cisplatin-mediated cytotoxicity, Mol Cancer Ther, 14, 90, 10.1158/1535-7163.MCT-14-0496
Zhou, 2015, Inhibition of protein phosphatase 2A with the small molecule LB100 overcomes cell cycle arrest in osteosarcoma after cisplatin treatment, Cell Cycle, 14, 2100, 10.1080/15384101.2015.1041693
Liang, 2014, Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas, Mol Cancer Ther, 13, 2062, 10.1158/1535-7163.MCT-13-0800
Chen, 2015, Protein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma, Mol Cancer Ther, 14, 1540, 10.1158/1535-7163.MCT-14-0614
Zeng, 2014, Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair, Oncotarget, 5, 7512, 10.18632/oncotarget.2258
Morgan, 2013, Inhibition of protein phosphatase 2A radiosensitizes pancreatic cancers by modulating CDC25C/CDK1 and homologous recombination repair, Clin Cancer Res, 19, 4422, 10.1158/1078-0432.CCR-13-0788
Jove, 2014, Revisiting STAT3 signalling in cancer: new and unexpected biological functions, Nat Rev Cancer, 14, 736, 10.1038/nrc3818
Govoni, 1998, Variations in the levels of the JAK/STAT and ShcA proteins in human brain tumors, Anticancer Res, 18, 2381
Schaefer, 2002, Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2), Oncogene, 21, 2058, 10.1038/sj.onc.1205263
Jove, 2008, Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas, Mol Cancer Ther, 7, 3519, 10.1158/1535-7163.MCT-08-0138
Dilloo, 2014, In comparative analysis of multi-kinase inhibitors for targeted medulloblastoma therapy pazopanib exhibits promisingandefficacy, Oncotarget, 5, 7149, 10.18632/oncotarget.2240
Lin, 2015, A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells, J Biol Chem, 290, 3418, 10.1074/jbc.M114.616748
Yu, 2010, Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways, Mol Cancer Res, 8, 35, 10.1158/1541-7786.MCR-09-0220
Liu, 2012, Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells, Childs Nerv Syst, 28, 363, 10.1007/s00381-011-1672-x
Ma, 2014, Celecoxib suppresses the phosphorylation of STAT3 protein and can enhance the radiosensitivity of medulloblastoma-derived cancer stem-like cells, Int J Mol Sci, 15, 11013, 10.3390/ijms150611013
Odum, 1999, Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3, Proc Natl Acad Sci U S A, 96, 10620, 10.1073/pnas.96.19.10620
Kikuchi, 2005, Protein phosphatase type 2A, PP2A, is involved in degradation of gp130, Mol Cell Biochem, 269, 183, 10.1007/s11010-005-3089-x
Ghosh, 2014, Reduced phosphorylation of Stat3 at Ser-727 mediated by casein kinase 2 - protein phosphatase 2A enhances Stat3 Tyr-705 induced tumorigenic potential of glioma cells, Cell Signal, 26, 1725, 10.1016/j.cellsig.2014.04.003
Schmidt, 2013, Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma, Cell, 152, 1065, 10.1016/j.cell.2013.01.036
Bouffet, 2013, Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children, Cancer Res, 73, 6734, 10.1158/0008-5472.CAN-12-4331
Ma, 2015, Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells, Oncotarget, 6, 1750, 10.18632/oncotarget.2737
Cole, 2014, Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter, J Biol Chem, 289, 30880, 10.1074/jbc.R114.609248
Popovic, 2005, Survivin is a negative prognostic marker in medulloblastoma, Neuropathol Appl Neurobiol, 31, 422, 10.1111/j.1365-2990.2005.00664.x
Marshall, 2012, Subgroup-specific structural variation across 1,000 medulloblastoma genomes, Nature, 488, 49, 10.1038/nature11327
Bonavida, 2014, Central role of Snail1 in the regulation of EMT and resistance in cancer: a target for therapeutic intervention, J Exp Clin Cancer Res, 33, 62, 10.1186/s13046-014-0062-0
De Braganca, 2015, Medulloblastoma, J Child Neurol
Gottesman, 2012, Cisplatin resistance: a cellular self-defense mechanism resulting from multiple epigenetic and genetic changes, Pharmacol Rev, 64, 706, 10.1124/pr.111.005637