PHOTOPHYSICAL AND PHOTOSENSITIZING PROPERTIES OF BENZOPORPHYRIN DERIVATIVE MONOACID RING A (BPD‐MA)*

Photochemistry and Photobiology - Tập 59 Số 3 - Trang 328-335 - 1994
Béatrice M. Aveline1, Tayyaba Hasan1, Robert W. Redmond1
1Wellman Laboratories of Photomedicine, Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA

Tóm tắt

Abstract

The photophysical properties of benzoporphyrin derivative monoacid ring A (BPD‐MA), a second‐generation photosensitizer currently in phase II clinical trials, were investigated in homogeneous solution. Absorption, fluorescence, triplet‐state, singlet oxygen (O2(1Δg)) sensitization studies and photobleaching experiments are reported. The ground state of this chlorin‐type molecule shows a strong absorbance in the red (λ≈ 688 nm, ɛ≈ 33 000 M−1 cm−1 in organic solvents). For the singlet excited state the following data were determined in methanol: energy level, Es= 42.1 kcal mol−1, lifetime, Φf= 5.2 ns and fluorescence quantum yield, Φf= 0.05 in air‐saturated solution. The triplet state of BPD‐MA has a lifetime, τf >. 25 ns, an energy level, ET= 26.9 kcal mol−1 and the molar absorption coefficient is ɛT= 26 650 M−1 cm−1 at 720 nm. A dramatic effect of oxygen on the fluorescence (φf) and intersystem crossing (φT) quantum yields has been observed. The BPD‐MA presents rather high triplet (φT= 0.68 under N2‐saturated conditions) and singlet oxygen (φΔ= 0.78) quantum yields. On the other hand, the presence of oxygen does not significantly modify the photobleaching of this photostable compound, the photodegradation quantum yield (φPb) of which was found to be on the order of 5 × 10−5 in organic solvents.

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Photochemistry and Photobiology

Tập 59 Số 3

328-335

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