PH domain of ELMO functions in trans to regulate Rac activation via Dock180
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Cote, J.F. & Vuori, K. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. J. Cell Sci. 115, 4901–4913 (2002).
Brugnera, E. et al. Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex. Nat. Cell Biol. 4, 574–582 (2002).
Meller, N., Irani-Tehrani, M., Kiosses, W.B., Del Pozo, M.A. & Schwartz, M.A. Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins. Nat. Cell Biol. 4, 639–647 (2002).
Yajnik, V. et al. DOCK4, a GTPase activator, is disrupted during tumorigenesis. Cell 112, 637–684 (2003).
Fukui, Y. et al. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 412, 826–831 (2001).
Albert, M., Kim, J. & Birge, R. avb5 integrin recruits the CrkII–Dock180–Rac1 complex for phagocytosis of apoptotic cells. Nat. Cell Biol. 2, 899–905 (2000).
Gumienny, T.L. et al. CED-12/ELMO, a novel member of the crkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. Cell 107, 27–41 (2001).
Grimsley, C.M. et al. Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J Biol. Chem. 279, 6087–6097 (2004).
Kiyokawa, E. et al. Activation of Rac1 by a Crk SH3-binding protein, DOCK180. Genes Dev. 12, 3331–3336 (1998).
Duchek, P., Somogyi, K., Jekely, G., Beccari, S. & Rorth, P. Guidance of cell migration by the Drosophila pdgf/vegf receptor. Cell 107, 17–26 (2001).
Erickson, M.R., Galletta, B.J. & Abmayr, S.M. Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organization. J. Cell Biol. 138, 589–603 (1997).
Nolan, K.M. et al. Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processes. Genes Dev. 12, 3337–3342 (1998).
Reddien, P.W. & Horvitz, H.R. CED-12/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. Nat. Cell Biol. 2, 131–136 (2000).
Wu, Y.C. & Horvitz, H.R. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature 392, 501–504 (1998).
Lundquist, E.A., Reddien, P.W., Hartwieg, E., Horvirz, H.R. & Bargmann, C.I. Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis. Development 128, 4475–4488 (2001).
Wu, Y.C., Tsai, M.C., Cheng, L.C., Chou, C.J. & Weng, N.Y. C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment. Dev. Cell 1, 491–502 (2001).
Zhou, Z., Caron, E., Hartwieg, E., Hall, A. & Horvitz, H.R. The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signalling pathway. Dev. Cell 1, 477–489 (2001).
Schmidt, A. & Hall, A. Guanine nucleotide exchange factors for the Rho GTPases: Turning on the switch. Genes Dev. 16, 1587–1609 (2002).
Hoffman, G.R. & Cerione, R.A. Signaling to the Rho GTPases: networking with the DH domain. FEBS Lett. 513, 85–91 (2002).
Snyder, J.T. et al. Quantitative analysis of the effect of phosphoinositide interactions on the function of Dbl family proteins. J. Biol. Chem. 27, 27 (2001).
Worthylake, D.K., Rossman, K.L. & Sondek, J. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1. Nature 408, 682–688 (2000).
Rossman, K.L. et al. A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange. EMBO J. 21, 1315–1326 (2002).
Katoh, H. & Negishi, M. RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo. Nature 424, 461–464 (2003).
Sanui, T. et al. DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1. Blood 102, 2948–2950 (2003).
Nishihara, H. et al. Non-adherent cell-specific expression of DOCK2, a member of human CDM-family proteins. Biochim. Biophys. Acta 1452, 179–187 (1999).
Chen, Q., Kimura, H. & Schubert, D. A novel mechanism for the regulation of amyloid precursor protein metabolism. J. Cell Biol. 158, 79–89 (2002).
Namekata, K., Enokido, Y., Iwasawa, K. & Kimura, H. MOCA induces membrane spreading by activating Rac1. J. Biol. Chem. 279, 14331–14337 (2004).
Vetter, I.R., Arndt, A., Kutay, U., Gorlich, D. & Wittinghofer A structural view of the Ran-importin β interaction at 2.3 Å resolution. Cell 97, 635–646 (1999).
Snyder, J.T., Singer, A.U., Wing, M.R., Harden, T.K. & Sondek, J. The pleckstrin homology domain of phospholipase C-β2 as an effector site for Rac. J. Biol. Chem. 278, 21099–21104 (2003).
Mello, C.C., Kramer, J.M., Stinchcomb, D.T. & Ambros, V. Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959–3970 (1991).