PGI2 as a regulator of CD4+ subset differentiation and function

Moncada, 1976, An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation, Nature, 263, 663, 10.1038/263663a0 Whittaker, 1976, The chemical structure of prostaglandin X (prostacyclin), Prostaglandins, 12, 915, 10.1016/0090-6980(76)90126-X Helliwell, 2004, Prostaglandin synthases: recent developments and a novel hypothesis, Prostaglandins Leukot Essent Fatty Acids, 70, 101, 10.1016/j.plefa.2003.04.002 Smyth, 2002, Human prostacyclin receptor, Vitam Horm, 65, 149, 10.1016/S0083-6729(02)65063-0 Szczeklik, 1980, Prostacyclin for pulmonary hypertension, Lancet, 2, 1076, 10.1016/S0140-6736(80)92291-6 Aronoff, 2007, Synthetic prostacyclin analogs differentially regulate macrophage function via distinct analog-receptor binding specificities, J Immunol, 178, 1628, 10.4049/jimmunol.178.3.1628 Zhou, 2007, Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells, J Immunol, 178, 702, 10.4049/jimmunol.178.2.702 Zhou, 2007, Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells, J Leukoc Biol, 81, 809, 10.1189/jlb.0606375 Lee, 2005, Human follicular dendritic cells express prostacyclin synthase: a novel mechanism to control T cell numbers in the germinal center, J Immunol, 175, 1658, 10.4049/jimmunol.175.3.1658 Gatto, 2010, The germinal center reaction, J Allergy Clin Immunol, 126, 898, 10.1016/j.jaci.2010.09.007 Abbas, 2003, The control of T cell activation vs. tolerance, Autoimmun Rev, 2, 115, 10.1016/S1568-9972(03)00028-4 Amsen, 2009, How are T(H)1 and T(H)2 effector cells made?, Curr Opin Immunol, 21, 153, 10.1016/j.coi.2009.03.010 Yang, 2011, Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5, Nat Immunol, 12, 247, 10.1038/ni.1995 Manel, 2008, The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat, Nat Immunol, 9, 641, 10.1038/ni.1610 Newcomb, 2011, Human Th17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A production, J Allergy Clin Immunol, 127, 1006, 10.1016/j.jaci.2010.11.043 Jager, 2010, Effector and regulatory T-cell subsets in autoimmunity and tissue inflammation, Scand J Immunol, 72, 173, 10.1111/j.1365-3083.2010.02432.x Nakajima, 2010, Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity, J Immunol, 184, 5595, 10.4049/jimmunol.0903260 Kuo, 2011, Effects of PGI2 analogues on Th1- and Th2-related chemokines in monocytes via epigenetic regulation, J Mol Med, 89, 29, 10.1007/s00109-010-0694-2 Hashimoto, 2004, Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness, J Virol, 78, 10303, 10.1128/JVI.78.19.10303-10309.2004 Graham, 2000, Immune-mediated disease pathogenesis in respiratory syncytial virus infection, Immunopharmacology, 48, 237, 10.1016/S0162-3109(00)00233-2 Takahashi, 2002, Augmentation of allergic inflammation in prostanoid IP receptor deficient mice, Br J Pharmacol, 137, 315, 10.1038/sj.bjp.0704872 Nagao, 2003, Role of prostaglandin I2 in airway remodeling induced by repeated allergen challenge in mice, Am J Respir Cell Mol Biol, 10.1165/rcmb.2003-0035OC Jaffar, 2002, A key role for prostaglandin I2 in limiting lung mucosal Th2, but not Th1, responses to inhaled allergen, J Immunol, 169, 5997, 10.4049/jimmunol.169.10.5997 Jaffar, 2007, Prostaglandin I2-IP signaling blocks allergic pulmonary inflammation by preventing recruitment of CD4+ Th2 cells into the airways in a mouse model of asthma, J Immunol, 179, 6193, 10.4049/jimmunol.179.9.6193 Idzko, 2007, Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function, J Clin Invest, 117, 464, 10.1172/JCI28949 Carey, 2003, Accentuated T helper type 2 airway response after allergen challenge in cyclooxygenase-1−/− but not cyclooxygenase-2−/− mice, Am J Respir Crit Care Med, 167, 1509, 10.1164/rccm.200211-1383OC Peebles, 2002, Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice, Am J Respir Crit Care Med, 165, 1154, 10.1164/ajrccm.165.8.2106025 Harrington, 2005, Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages, Nat Immunol, 6, 1123, 10.1038/ni1254 Newcomb, 2009, A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine production, J Immunol, 182, 5317, 10.4049/jimmunol.0803868 Li, 2011, Cyclooxygenase-2 (COX-2) regulates Th17 cell differentiation during allergic lung inflammation, Am J Respir Crit Care Med, 10.1164/rccm.201010-1637OC Iwakura, 2006, The IL-23/IL-17 axis in inflammation, J Clin Invest, 116, 1218, 10.1172/JCI28508 Zhou W, Huckabee MM, Dowell DR, et al. Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalitis. PLoS One, personal communication.