PGC1A driven enhanced mitochondrial DNA copy number predicts outcome in pediatric acute myeloid leukemia

Mitochondrion - Tập 58 - Trang 246-254 - 2021
Shilpi Chaudhary1, Shuvadeep Ganguly1, Jayanth Kumar Palanichamy2, Archna Singh2, Radhika Bakhshi3, Ayushi Jain2, Anita Chopra4, Sameer Bakhshi1
1Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India
2Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
3Shaheed Rajguru College of Applied Sciences for Women, University of Delhi, Delhi, India
4Department of Laboratory Oncology, Dr. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, India

Tài liệu tham khảo

Hao, 2020, Long-term outcome of childhood acute myeloid leukemia: A 10-year retrospective cohort study, Pediatr. Rep., 12, 22 Chaudhury, 2018, Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias, Nat. Commun., 9, 10.1038/s41467-018-07584-1 Wallace, 2012, Mitochondria and cancer, Nat. Rev. Cancer, 12, 685, 10.1038/nrc3365 Porporato, 2018, Mitochondrial metabolism and cancer, Cell Res., 28, 265, 10.1038/cr.2017.155 Chattopadhyay, 2017, Altered mitochondrial signalling and metabolism in cancer, Front Oncol., 10.3389/fonc.2017.00043 Wang, 2011, Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels, Mol. Oncol., 5, 399, 10.1016/j.molonc.2011.07.008 Lonetti, 2019, Targeted therapies for pediatric AML: gaps and perspective, Front. Pediatr., 7, 463, 10.3389/fped.2019.00463 Mercher, 2019, Pediatric acute myeloid leukemia (AML): from genes to models toward targeted therapeutic intervention, Front Pediatr., 7, 401, 10.3389/fped.2019.00401 Al, 2020, Alterations of mitochondria and related metabolic pathways in leukemia: a narrative review, Saudi J. Med. Med. Sci., 8, 3, 10.4103/sjmms.sjmms_112_18 Druzhyna, 2008, Mitochondrial DNA repair in aging and disease, Mech. Ageing Dev., 129, 383, 10.1016/j.mad.2008.03.002 Grzybowska-Szatkowska, 2012, Mitochondrial DNA and carcinogenesis (review), Mol. Med. Rep., 6, 923, 10.3892/mmr.2012.1027 Mi, 2015, The relationship between altered mitochondrial DNA copy number and cancer risk: a meta-analysis, Sci. Rep., 5, 10.1038/srep10039 Jain, 2018, Elevated mitochondrial DNA copy numbers in pediatric acute lymphoblastic leukemia: a potential biomarker for predicting inferior survival, Pediatr Blood Cancer., 65, e26874, 10.1002/pbc.26874 Tyagi, 2019, Expression of mitochondrial genes predicts survival in pediatric acute myeloid leukemia, Int. J. Hematol., 110, 205, 10.1007/s12185-019-02666-2 Wu, 2019, The mitochondrial transcription machinery genes are upregulated in acute myeloid leukemia and associated with poor clinical outcome, Metab. Open, 2, 100009, 10.1016/j.metop.2019.100009 Miller, 2012, c-Myc and cancer metabolism, Clin. Cancer Res., 18, 5546, 10.1158/1078-0432.CCR-12-0977 Bralha, 2015, Targeting mitochondrial RNA polymerase in acute myeloid leukemia, Oncotarget, 6, 37216, 10.18632/oncotarget.6129 Sriskanthadevan, S., Jeyaraju, D.V., Chung, T.E., et al. AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress. Blood. 2015;125(13):2120-2130. doi: 10.1182/blood-2014-08-594408. D’Andrea, 2016, The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas, Oncotarget, 7, 72415, 10.18632/oncotarget.11719 Škrtić, 2011, Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia, Cancer Cell, 20, 674, 10.1016/j.ccr.2011.10.015 Sharabi, 2017, Selective chemical inhibition of PGC-1α gluconeogenic activity ameliorates type 2 diabetes, Cell, 169, 148, 10.1016/j.cell.2017.03.001 Xiang, 2020, SR18292 exerts potent antitumor effects in multiple myeloma via inhibition of oxidative phosphorylation, Life Sci., 256, 117971, 10.1016/j.lfs.2020.117971 Kang, 2016, Clinicopathological implications of mitochondrial genome alterations in pediatric acute myeloid leukemia, Ann. Lab Med., 36, 101, 10.3343/alm.2016.36.2.101 Reznik, E., Miller, M.L., Şenbabaoğlu, Y., et al. Mitochondrial DNA copy number variation across human cancers. Elife. 2016;5(FEBRUARY2016). doi: 10.7554/eLife.10769. Lin, C.S., Lee, H.T., Lee, M.H., et al. Role of mitochondrial DNA copy number alteration in human renal cell carcinoma. Int. J. Mol. Sci. 2016;17(6). doi: 10.3390/ijms17060814. Kim, 2018, Spectrum of mitochondrial genome instability and implication of mitochondrial haplogroups in Korean patients with acute myeloid leukemia, Blood Res., 53, 240, 10.5045/br.2018.53.3.240 Vyas, 2016, Mitochondria and cancer, Cell, 166, 555, 10.1016/j.cell.2016.07.002 Morrish, F., Hockenbery, D., MYC and Mitochondrial Biogenesis. PubMed Commons. Cold Spring Harb Perspect Med. 2016;4(5):24789872. doi: 10.1101/cshperspect.a014225.MYC. Kühl, 2014, POLRMT does not transcribe nuclear genes, Nature, 514, E7, 10.1038/nature13690 Dang, 2011, Therapeutic targeting of Myc-reprogrammed cancer cell metabolism, Cold Spring Harb. Symp. Quant. Biol., 76, 369, 10.1101/sqb.2011.76.011296 Li, 2005, Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis, Mol. Cell Biol., 25, 6225, 10.1128/MCB.25.14.6225-6234.2005 Graves, 2012, Mitochondrial structure, function and dynamics are temporally controlled by c-Myc, PLoS One., 7, e37699, 10.1371/journal.pone.0037699 Fan, 2010, Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition, J. Biol. Chem., 285, 7324, 10.1074/jbc.M109.035584 Kim, J., Lee, J.H., Iyer, V.R., Global identification of Myc target genes reveals its direct role in mitochondrial biogenesis and its E-box usage in vivo. Fraser P, ed. PLoS One. 2008;3(3):e1798. doi: 10.1371/journal.pone.0001798. Ohanian, 2019, MYC protein expression is an important prognostic factor in acute myeloid leukemia, Leuk. Lymphoma, 60, 37, 10.1080/10428194.2018.1464158 Yun, 2019, Prognostic significance of MYC oncoprotein expression on survival outcome in patients with acute myeloid leukemia with myelodysplasia related changes (AML-MRC), Leuk. Res., 84, 106194, 10.1016/j.leukres.2019.106194 Marlein, 2018, PGC-1α driven mitochondrial biogenesis in stromal cells underpins mitochondrial trafficking to leukemic blasts, Leukemia, 32, 2073, 10.1038/s41375-018-0221-y Zhang, G., Frederick, D.T., Wu, L., et al. Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors. J. Clin. Invest., 2016;126(5):1834-1856. doi: 10.1172/JCI82661. Vazquez, 2013, PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress, Cancer Cell, 23, 287, 10.1016/j.ccr.2012.11.020 Sancho, P., Burgos-Ramos, E., Tavera, A., et al. MYC/PGC-1α balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells. Cell Metab., 2015;22(4):590-605. doi: 10.1016/j.cmet.2015.08.015.