PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease

Journal of Medicinal Chemistry - Tập 64 Số 1 - Trang 326-342 - 2021
Ariamala Gopalsamy1, Ann Aulabaugh2, Amey Barakat3, Kevin Beaumont4, Shawn Cabral2, Daniel P. Canterbury2, Agustin Casimiro‐Garcia1, Jeanne S. Chang2, Ming Z. Chen2, Chulho Choi2, Robert L. Dow1, Olugbeminiyi Fadeyi2, Xidong Feng2, Scott P. France2, Roger M. Howard2, Jay M. Janz3, J. Jasti2, Reema Jasuja3, Lyn H. Jones1, Amanda King‐Ahmad5, Kelly M. Knee3, Jeffrey T. Kohrt2, Chris Limberakis2, Spiros Liras1, Carlos A. Martínez6, Kim F. McClure1, Arjun Narayanan1, Jatin Narula4, Jonathan J. Novak5, Thomas N. O’Connell2, Mihir D. Parikh2, David W. Piotrowski2, Olga Plotnikova2, Ralph P. Robinson2, Parag V. Sahasrabudhe2, Raman Sharma5, Benjamin A. Thuma2, Dipy M. Vasa7, Liuqing Wei2, Anne Wenzel2, Jane M. Withka2, Jun Xiao2, Hatice G. Yayla2
1Pfizer Medicine Design, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States
2Pfizer Medicine Design, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States
3Rare Diseases Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States
4Primary Pharmacology Group, Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States
5Primary Pharmacology Group, Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States
6Medicinal Sciences, Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States
7Drug Product Design, Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States

Tóm tắt

Từ khóa


Tài liệu tham khảo

10.2471/BLT.06.036673

10.1016/S0140-6736(10)61029-X

10.1016/j.blre.2006.07.001

10.1056/NEJMra1510865

Adachi K., 1987, J. Biol. Chem., 262, 12920, 10.1016/S0021-9258(18)45145-9

10.1182/blood-2017-02-765891

10.1056/NEJMoa1715971

10.1056/NEJMoa1611770

10.1182/blood.V77.6.1334.1334

10.1182/blood.V120.21.3210.3210

10.1046/j.1365-2141.1996.d01-1744.x

10.1056/NEJMoa1903212

10.1002/ajh.23232

10.4314/gmj.v49i2.7

10.1016/j.hoc.2013.11.001

Gori A., 2004, Antivir Ther, 9, 603, 10.1177/135965350400900418

10.1111/j.1365-2125.1995.tb04465.x

10.1038/377071a0

10.1107/S0907444911036353

10.1021/jm0498001

10.1016/j.cbpa.2007.07.011

10.1021/ac500938y

10.1021/bi00335a003

10.1021/bi00263a029

10.1021/bi00467a027

10.1021/bi00759a023

10.1073/pnas.071493598

Wüthrich K., 1986, NMR of Proteins and Nucleic Acids, 10.1051/epn/19861701011

10.2210/pdb1hbs/pdb

10.1016/j.jsb.2016.04.003

10.1093/clinchem/20.1.83

Nakao, A.; Gotanda, K.; Aoki, K.; Hirano, S.; Hiruma, Y.; Shiiki, T. Cyclic Amine Compounds. US 8,173,631, 2012.

10.1002/anie.201405664

10.1111/bjh.14214

10.1021/acsmedchemlett.8b00466

10.1002/jps.22674

Atha D. H., 1976, J. Biol. Chem., 251, 5537, 10.1016/S0021-9258(17)33093-4

10.1016/S0006-3495(81)84788-1

Ip S., 1977, J. Biol. Chem., 252, 82, 10.1016/S0021-9258(17)32801-6

10.1021/bi00247a010

10.1021/ja500380e

10.1126/science.1131943

10.1021/acs.jmedchem.7b01788

10.1021/acs.jmedchem.9b01877

10.2174/156802606777951127

10.1182/blood-2006-02-004812

10.1021/acsmedchemlett.6b00491

10.1126/sciadv.1501240

10.1021/ja00031a017

10.1016/j.dmpk.2016.11.002

Bartels, B.; Dolente, C.; Guba, W.; Haap, W.; Obst Sander, U.; Peters, J.U.; Rogers-Evans, M.; Rombach, D.; Woltering, T. BACE1 Inhibitors. PCT Int. Appl. WO2016071211, 2016.

10.1023/B:COHC.0000028623.41308.e5

Pfizer, Study of Single and Multiple Ascending Doses of PF-07059013 in Healthy Adult Participants. NCT04323124. clinicaltrials.gov, 2020.

Thông tin
Thông tin xuất bản

Journal of Medicinal Chemistry

Tập 64 Số 1

326-342

Thông tin tác giả