PDK1 promotes tumor cell proliferation and migration by enhancing the Warburg effect in non-small cell lung cancer
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Reck, 2013, Management of non-small-cell lung cancer: Recent developments, Lancet, 382, 709, 10.1016/S0140-6736(13)61502-0
Gainor, 2013, ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: An analysis of 1,683 patients with non-small cell lung cancer, Clin Cancer Res, 19, 4273, 10.1158/1078-0432.CCR-13-0318
Gasparini, 2015, microRNA classifiers are powerful diagnostic/prognostic tools in ALK-, EGFR-, and KRAS-driven lung cancers, Proc Natl Acad Sci USA, 112, 14924, 10.1073/pnas.1520329112
Fong, 2015, Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis, Nat Cell Biol, 17, 183, 10.1038/ncb3094
Yang, 2012, ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect, Nat Cell Biol, 14, 1295, 10.1038/ncb2629
Meijer, 2012, Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy, Clin Cancer Res, 18, 5585, 10.1158/1078-0432.CCR-12-0858
Gilkes, 2013, Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts, J Biol Chem, 288, 10819, 10.1074/jbc.M112.442939
Li, 2014, Cbx4 governs HIF-1α to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity, Cancer Cell, 25, 118, 10.1016/j.ccr.2013.12.008
Pullamsetti, 2013, Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF, Oncogene, 32, 1121, 10.1038/onc.2012.136
Kaplon, 2013, A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence, Nature, 498, 109, 10.1038/nature12154
Sutendra, 2014, A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation, Cell, 158, 84, 10.1016/j.cell.2014.04.046
Sutendra, 2013, Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology, Front Oncol, 3, 38, 10.3389/fonc.2013.00038
Hur, 2013, Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target, Int J Oncol, 42, 44, 10.3892/ijo.2012.1687
Schell, 2014, A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth, Mol Cell, 56, 400, 10.1016/j.molcel.2014.09.026
Qin, 2016, Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth, Oncotarget, 7, 1395, 10.18632/oncotarget.6366
Koukourakis, 2005, Tumor and Angiogenesis Research Group: Pyruvate dehydrogenase and pyruvate dehydrogenase kinase expression in non small cell lung cancer and tumor-associated stroma, Neoplasia, 7, 1, 10.1593/neo.04373
Li, 2013, Genotyping and genomic profiling of non-small-cell lung cancer: Implications for current and future therapies, J Clin Oncol, 31, 1039, 10.1200/JCO.2012.45.3753
Cooper, 2013, Molecular biology of lung cancer, J Thorac Dis, 5, S479
Shimizu, 2014, Frequent alteration of the protein synthesis of enzymes for glucose metabolism in hepatocellular carcinomas, J Gastroenterol, 49, 1324, 10.1007/s00535-013-0895-x
Chiavarina, 2012, Metabolic reprogramming and two-compartment tumor metabolism: Opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells, Cell Cycle, 11, 3280, 10.4161/cc.21643
Hou, 2010, Gene expression-based classification of non-small cell lung carcinomas and survival prediction, PLoS One, 5, e10312, 10.1371/journal.pone.0010312
Landi, 2008, Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival, PLoS One, 3, e1651, 10.1371/journal.pone.0001651
Rousseaux, 2013, Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers, Sci Transl Med, 5, 10.1126/scitranslmed.3005723
Han, 2014, Prognostic potential of microRNA-138 and its target mRNA PDK1 in sera for patients with non-small cell lung cancer, Med Oncol, 31, 129, 10.1007/s12032-014-0129-y
Martelli, 2006, Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia, Leukemia, 20, 911, 10.1038/sj.leu.2404245
Kang, 2007, FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway, Cancer Cell, 12, 201, 10.1016/j.ccr.2007.08.003
Dann, 2007, mTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer, Trends Mol Med, 13, 252, 10.1016/j.molmed.2007.04.002
Heiden, 2009, Understanding the Warburg effect: The metabolic requirements of cell proliferation, Science, 324, 1029, 10.1126/science.1160809
Upadhyay, 2013, The Warburg effect: Insights from the past decade, Pharmacol Ther, 137, 318, 10.1016/j.pharmthera.2012.11.003