PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer

Cell Reports - Tập 25 - Trang 2972-2980.e5 - 2018
Liya Ding1,2, Hye-Jung Kim3, Qiwei Wang1,2, Michael Kearns1, Tao Jiang1, Carolynn E. Ohlson1, Ben B. Li1,2, Shaozhen Xie1, Joyce F. Liu4, Elizabeth H. Stover4, Brooke E. Howitt5, Roderick T. Bronson5, Suzan Lazo3, Thomas M. Roberts1,2, Gordon J. Freeman4, Panagiotis A. Konstantinopoulos4, Ursula A. Matulonis4, Jean J. Zhao1,2,6
1Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
2Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
3Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
5Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
6Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA

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Cell Reports

Tập 25

2972-2980.e5

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