PACAP attenuates hepatic lipid accumulation through the FAIM/AMPK/IRβ axis during overnutrition

Molecular Metabolism - Tập 65 - Trang 101584 - 2022
Wei Luo1, Jiaxin Dai1, Jianmin Liu1, Yongmei Huang1, Ziqiong Zheng1, Pei Xu1, Yi Ma1
1Department of Cellular Biology, Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Key Laboratory of Bioengineering Medicine of Guangdong Province, Jinan University, 601 Huangpu Ave. West, Guangzhou 510632, Guangdong Province, China

Tài liệu tham khảo

Samuel, 2018, Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases, Cell Metabolism, 27, 22, 10.1016/j.cmet.2017.08.002 Younossi, 2019, Non-alcoholic fatty liver disease - a global public health perspective, Journal of Hepatology, 70, 531, 10.1016/j.jhep.2018.10.033 Rotman, 2017, Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease, Gut, 66, 180, 10.1136/gutjnl-2016-312431 Estes, 2018, Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030, Journal of Hepatology, 69, 896, 10.1016/j.jhep.2018.05.036 Lambert, 2014, Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease, Gastroenterology, 146, 726, 10.1053/j.gastro.2013.11.049 Fabbrini, 2016, Physiological mechanisms of weight gain-induced steatosis in people with obesity, Gastroenterology, 150, 79, 10.1053/j.gastro.2015.09.003 Donnelly, 2005, Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease, Journal of Clinical Investigation, 115, 1343, 10.1172/JCI23621 Bozadjieva-Kramer, 2021, The role of mediobasal hypothalamic PACAP in the control of body weight and metabolism, Endocrinology, 162, 10.1210/endocr/bqab012 Rudecki, 2016, PACAP in the defense of energy homeostasis, Trends in Endocrinology and Metabolism, 27, 620, 10.1016/j.tem.2016.04.008 Gray, 2001, Targeted disruption of the pituitary adenylate cyclase-activating polypeptide gene results in early postnatal death associated with dysfunction of lipid and carbohydrate metabolism, Molecular Endocrinology, 15, 1739, 10.1210/mend.15.10.0705 Diané, 2014, PACAP is essential for the adaptive thermogenic response of brown adipose tissue to cold exposure, Journal of Endocrinology, 222, 327, 10.1530/JOE-14-0316 Chang, 2021, Pituitary adenylate cyclase-activating polypeptide excites proopiomelanocortin neurons: implications for the regulation of energy homeostasis, Neuroendocrinology, 111, 45, 10.1159/000506367 Resch, 2013, Intrahypothalamic pituitary adenylate cyclase-activating polypeptide regulates energy balance via site-specific actions on feeding and metabolism, American Journal of Physiology. Endocrinology and Metabolism, 305, E1452, 10.1152/ajpendo.00293.2013 Liu, 2019, PACAP stimulates insulin secretion by PAC(1) receptor and ion channels in β-cells, Cellular Signalling, 61, 48, 10.1016/j.cellsig.2019.05.006 Hurley, 2020, Acute blockade of PACAP-dependent activity in the ventromedial nucleus of the hypothalamus disrupts leptin-induced behavioral and molecular changes in rats, Neuroendocrinology, 110, 271, 10.1159/000501337 Xiao, 2019, PACAP ameliorates hepatic metabolism and inflammation through up-regulating FAIM in obesity, Journal of Cellular and Molecular Medicine, 23, 5970, 10.1111/jcmm.14453 Schneider, 1999, A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes, Journal of Experimental Medicine, 189, 949, 10.1084/jem.189.6.949 Huo, 2019, FAIM: an antagonist of fas-killing and beyond, Cells, 8, 10.3390/cells8060541 Kaku, 2020, FAIM is a non-redundant defender of cellular viability in the face of heat and oxidative stress and interferes with accumulation of stress-induced protein aggregates, Frontiers in Molecular Biosciences, 7, 32, 10.3389/fmolb.2020.00032 Han, 2021, FAIM regulates autophagy through glutaminolysis in lung adenocarcinoma, Autophagy, 1 Huo, 2016, Loss of Fas apoptosis inhibitory molecule leads to spontaneous obesity and hepatosteatosis, Cell Death & Disease, 7, 10.1038/cddis.2016.12 Charni-Natan, 2020, Protocol for primary mouse hepatocyte isolation, STAR Protocols, 1, 10.1016/j.xpro.2020.100086 Cabrera-Cruz, 2020, The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment, American Journal of Physiology. Endocrinology and Metabolism, 318, 10.1152/ajpendo.00162.2019 Yan, 2020, PACAP ameliorates fertility in obese male mice via PKA/CREB pathway-dependent Sirt1 activation and p53 deacetylation, Journal of Cellular Physiology, 235, 7465, 10.1002/jcp.29651 Abid, 2019, AMPK activation of PGC-1α/NRF-1-dependent SELENOT gene transcription promotes PACAP-induced neuroendocrine cell differentiation through tolerance to oxidative stress, Molecular Neurobiology, 56, 4086, 10.1007/s12035-018-1352-x Thomas-Chollier, 2011, Transcription factor binding predictions using TRAP for the analysis of ChIP-seq data and regulatory SNPs, Nature Protocols, 6, 1860, 10.1038/nprot.2011.409 Fornes, 2020, Jaspar 2020: update of the open-access database of transcription factor binding profiles, Nucleic Acids Research, 48, D87 Min, 2012, Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease, Cell Metabolism, 15, 665, 10.1016/j.cmet.2012.04.004 Akesson, 2003, Dual effects of pituitary adenylate cyclase-activating polypeptide and isoproterenol on lipid metabolism and signaling in primary rat adipocytes, Endocrinology, 144, 5293, 10.1210/en.2003-0364 Rasbach, 2019, PACAP deficiency aggravates atherosclerosis in ApoE deficient mice, Immunobiology, 224, 124, 10.1016/j.imbio.2018.09.008 Nakata, 2010, Intra-islet PACAP protects pancreatic β-cells against glucotoxicity and lipotoxicity, Journal of Molecular Neuroscience, 42, 404, 10.1007/s12031-010-9383-4 Yada, 2000, Intraperitoneal PACAP administration decreases blood glucose in GK rats, and in normal and high fat diet mice, Annals of the New York Academy of Sciences, 921, 259, 10.1111/j.1749-6632.2000.tb06974.x Vuppalanchi, 2021, Therapeutic pipeline in nonalcoholic steatohepatitis, Nature Reviews Gastroenterology & Hepatology, 18, 373, 10.1038/s41575-020-00408-y Baggio, 2021, Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease, Molecular Metabolism, 46, 10.1016/j.molmet.2020.101090 Newsome, 2021, A placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis, New England Journal of Medicine, 384, 1113, 10.1056/NEJMoa2028395 Capehorn, 2020, Efficacy and safety of once-weekly semaglutide 1.0mg vs once-daily liraglutide 1.2mg as add-on to 1-3 oral antidiabetic drugs in subjects with type 2 diabetes (SUSTAIN 10), Diabetes & Metabolism, 46, 100, 10.1016/j.diabet.2019.101117 Marso, 2016, Semaglutide and cardiovascular outcomes in patients with type 2 diabetes, New England Journal of Medicine, 375, 1834, 10.1056/NEJMoa1607141 Palmer, 2021, Sodium-glucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials, BMJ, 372, m4573, 10.1136/bmj.m4573 Rosenstock, 2021, Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial, Lancet, 398, 143, 10.1016/S0140-6736(21)01324-6 Karpiesiuk, 2021, Pituitary adenylate cyclase-activating polypeptide (PACAP) in physiological and pathological processes within the gastrointestinal tract: a review, International Journal of Molecular Sciences, 22, 10.3390/ijms22168682 Tsutsumi, 2002, A potent and highly selective VPAC2 agonist enhances glucose-induced insulin release and glucose disposal: a potential therapy for type 2 diabetes, Diabetes, 51, 1453, 10.2337/diabetes.51.5.1453 Ramos-Álvarez, 2015, A structure-function study of PACAP using conformationally restricted analogs: identification of PAC1 receptor-selective PACAP agonists, Peptides, 66, 26, 10.1016/j.peptides.2015.01.009 Bourgault, 2008, Novel stable PACAP analogs with potent activity towards the PAC1 receptor, Peptides, 29, 919, 10.1016/j.peptides.2008.01.022 Ma, 2015, A recombinant slow-release PACAP-derived peptide alleviates diabetes by promoting both insulin secretion and actions, Biomaterials, 51, 80, 10.1016/j.biomaterials.2015.01.064 Zhuang, 2019, SPION-decorated exosome delivered BAY55-9837 targeting the pancreas through magnetism to improve the blood GLC response, Small, 15, 10.1002/smll.201903135 Coccia, 2020, FAIM is regulated by MiR-206, MiR-1-3p and MiR-133b, Frontiers in Cell and Developmental Biology, 8, 10.3389/fcell.2020.584606 Wang, 2020, FAIM-S functions as a negative regulator of NF-κB pathway and blocks cell cycle progression in NSCLC cells, Cell Cycle, 19, 3458, 10.1080/15384101.2020.1843811 Sole, 2004, The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling, The Journal of Cell Biology, 167, 479, 10.1083/jcb.200403093 Kaku, 2009, Fas apoptosis inhibitory molecule enhances CD40 signaling in B cells and augments the plasma cell compartment, Journal of Immunology, 183, 1667, 10.4049/jimmunol.0900056 Herzig, 2018, AMPK: guardian of metabolism and mitochondrial homeostasis, Nature Reviews Molecular Cell Biology, 19, 121, 10.1038/nrm.2017.95 Mottillo, 2016, Lack of adipocyte AMPK exacerbates insulin resistance and hepatic steatosis through Brown and beige adipose tissue function, Cell Metabolism, 24, 118, 10.1016/j.cmet.2016.06.006 Li, 2020, Activation of the AMPK-SIRT1 pathway contributes to protective effects of Salvianolic acid A against lipotoxicity in hepatocytes and NAFLD in mice, Frontiers in Pharmacology, 11, 10.3389/fphar.2020.560905 Smith, 2016, Treatment of nonalcoholic fatty liver disease: role of AMPK, American Journal of Physiology. Endocrinology and Metabolism, 311, 10.1152/ajpendo.00225.2016 Lindholm, 2013, A high-fat diet decreases AMPK activity in multiple tissues in the absence of hyperglycemia or systemic inflammation in rats, Journal of Physiology & Biochemistry, 69, 165, 10.1007/s13105-012-0199-2 Huang, 2018, Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition, Journal of Clinical Investigation, 128, 5335, 10.1172/JCI63562