P300 và việc giảm giá trị theo thời gian ở rối loạn ám ảnh cưỡng chế

Springer Science and Business Media LLC - Tập 272 - Trang 327-339 - 2021
Vera Flasbeck1, Björn Enzi1, Christina Andreou2, Georg Juckel1, Paraskevi Mavrogiorgou1
1Department of Psychiatry, LWL-University Hospital, Ruhr University Bochum, Bochum, Germany
2Department of Psychiatry and Psychotherapy, University Hospital Lübeck (UKSH), Lübeck, Germany

Tóm tắt

Nghiên cứu trước đây cho thấy rằng những rối loạn chức năng của các mạng lưới thần kinh trước-trstriatal có liên quan đến nội sinh bệnh lý của rối loạn ám ảnh cưỡng chế (OCD). Do đó, bệnh nhân OCD thể hiện những sự thay đổi trong quá trình ra quyết định. P300, được kích hoạt bởi các mô hình oddball, được cho là liên quan đến các quá trình chú ý và nhận thức và được tạo ra ở thùy thái dương giữa, vỏ não orbitofrontal và vỏ não cingulate, có đặc điểm quan trọng trong nghiên cứu OCD. Do đó, nghiên cứu này nhằm điều tra P300 ở OCD và các mối liên hệ của nó với hoạt động não trong quá trình ra quyết định: P300, được kích hoạt bởi một mô hình oddball âm thanh, đã được phân tích trên 19 bệnh nhân OCD và 19 người đối chứng khỏe mạnh liên quan đến độ trễ đỉnh, biên độ và mật độ nguồn năng lượng ở các vùng vỏ não chẩm bằng sLORETA. Sau đó, bằng cách sử dụng một mô hình fMRI, hình ảnh tương phản phụ thuộc vào mức độ oxy trong máu (BOLD) đã được thực hiện trong một mô hình giảm giá trị theo thời gian. Chúng tôi giả thuyết có sự khác biệt giữa các nhóm về các đặc điểm P300 và các mối liên hệ với hoạt động trước trong quá trình giảm giá trị theo thời gian. P300 không khác nhau giữa các nhóm, tuy nhiên, độ trễ P300 qua điện cực P4 có tương quan âm với điểm số NEO-FFI về sự cởi mở trải nghiệm ở bệnh nhân OCD. Ở những người đối chứng khỏe mạnh, mật độ nguồn năng lượng P300 có tương quan với hoạt động ở các vùng trán khi xử lý phần thưởng, một phát hiện không có ở bệnh nhân OCD. Kết luận là, các mối liên hệ của P300 với hoạt động não vùng trán trong quá trình giảm giá trị theo thời gian đã được tìm thấy, gợi ý rằng có sự đóng góp của các quá trình chú ý hoặc cập nhật ngữ cảnh. Vì mối liên hệ này không có ở bệnh nhân OCD, các phát hiện có thể được hiểu là có liên quan đến rối loạn chức năng của các mạng lưới thần kinh trước-trstriatal ở bệnh nhân OCD.

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