P2Y12 receptor upregulation in satellite glial cells is involved in neuropathic pain induced by HIV glycoprotein 120 and 2′,3′-dideoxycytidine

Hao S (2013) The molecular and pharmacological mechanisms of HIV-related neuropathic pain. Curr Neuropharmacol 11(5):499–512. https://doi.org/10.2174/1570159x11311050005 Parker R, Stein DJ, Jelsma J (2014) Pain in people living with HIV/AIDS: a systematic review. J Int AIDS Soc 17:18719. https://doi.org/10.7448/ias.17.1.18719 Schutz SG, Robinson-Papp J (2013) HIV-related neuropathy: current perspectives. HIV AIDS (Auckl) 5:243–251. https://doi.org/10.2147/hiv.s36674 Evans SR, Ellis RJ, Chen H, Yeh TM, Lee AJ, Schifitto G, Wu K, Bosch RJ, McArthur JC, Simpson DM, Clifford DB (2011) Peripheral neuropathy in HIV: prevalence and risk factors. Aids 25(7):919–928. https://doi.org/10.1097/QAD.0b013e328345889d Herzberg U, Sagen J (2001) Peripheral nerve exposure to HIV viral envelope protein gp120 induces neuropathic pain and spinal gliosis. J Neuroimmunol 116(1):29–39 Wallace VC, Blackbeard J, Pheby T, Segerdahl AR, Davies M, Hasnie F, Hall S, McMahon SB, Rice AS (2007) Pharmacological, behavioural and mechanistic analysis of HIV-1 gp120 induced painful neuropathy. Pain 133(1–3):47–63. https://doi.org/10.1016/j.pain.2007.02.015 Oshinaike O, Akinbami A, Ojo O, Ogbera A, Okubadejo N, Ojini F, Danesi M (2012) Influence of age and neurotoxic HAART use on frequency of HIV sensory neuropathy. AIDS Res Treat 2012:961510. https://doi.org/10.1155/2012/961510 Joseph EK, Chen X, Khasar SG, Levine JD (2004) Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat. Pain 107(1–2):147–158 Keswani SC, Jack C, Zhou C, Hoke A (2006) Establishment of a rodent model of HIV-associated sensory neuropathy. J Neurosci 26(40):10299–10304. https://doi.org/10.1523/jneurosci.3135-06.2006 Wallace VC, Blackbeard J, Segerdahl AR, Hasnie F, Pheby T, McMahon SB, Rice AS (2007) Characterization of rodent models of HIV-gp120 and anti-retroviral-associated neuropathic pain. Brain 130(Pt 10):2688–2702. https://doi.org/10.1093/brain/awm195 Takeda M, Takahashi M, Matsumoto S (2009) Contribution of the activation of satellite glia in sensory ganglia to pathological pain. Neurosci Biobehav Rev 33(6):784–792. https://doi.org/10.1016/j.neubiorev.2008.12.005 Costa FA, Moreira Neto FL (2015) Satellite glial cells in sensory ganglia: its role in pain. Rev Bras Anestesiol 65(1):73–81. https://doi.org/10.1016/j.bjan.2013.07.013 Hanani M (2005) Satellite glial cells in sensory ganglia: from form to function. Brain Res Brain Res Rev 48(3):457–476. https://doi.org/10.1016/j.brainresrev.2004.09.001 Blum E, Procacci P, Conte V, Sartori P, Hanani M (2017) Long term effects of lipopolysaccharide on satellite glial cells in mouse dorsal root ganglia. Exp Cell Res 350(1):236–241. https://doi.org/10.1016/j.yexcr.2016.11.026 Takeda M, Tanimoto T, Kadoi J, Nasu M, Takahashi M, Kitagawa J, Matsumoto S (2007) Enhanced excitability of nociceptive trigeminal ganglion neurons by satellite glial cytokine following peripheral inflammation. Pain 129(1–2):155–166. https://doi.org/10.1016/j.pain.2006.10.007 Fields R, Burnstock G (2006) Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci 276(6):423–436 Verderio C, Matteoli M (2011) ATP in neuron-glia bidirectional signalling. Brain Res Rev 66(1–2):106–114. https://doi.org/10.1016/j.brainresrev.2010.04.007 Zhang X, Chen Y, Wang C, Huang LY (2007) Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia. Proc Natl Acad Sci USA 104(23):9864–9869. https://doi.org/10.1073/pnas.0611048104 Katagiri A, Shinoda M, Honda K, Toyofuku A, Sessle BJ, Iwata K (2012) Satellite glial cell P2Y12 receptor in the trigeminal ganglion is involved in lingual neuropathic pain mechanisms in rats. Mol Pain 8:23. https://doi.org/10.1186/1744–8069–8-23 Kobayashi K, Yamanaka H, Noguchi K (2013) Expression of ATP receptors in the rat dorsal root ganglion and spinal cord. Anat Sci Int 88(1):10–16. https://doi.org/10.1007/s12565-012-0163-9 Yi Z, Rao S, Ouyang S, Bai Y, Yang J, Ma Y, Han X, Wu B, Zou L, Jia T, Zhao S, Hu X, Lei Q, Gao Y, Liu S, Xu H, Zhang C, Liang S, Li G (2017) A317491 relieved HIV gp120-associated neuropathic pain involved in P2X3 receptor in dorsal root ganglia. Brain Res Bull 130:81–89. https://doi.org/10.1016/j.brainresbull.2017.01.002 Nasirinezhad F, Jergova S, Pearson JP, Sagen J (2015) Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy. Neuropharmacology 95:100–109. https://doi.org/10.1016/j.neuropharm.2014.11.024 Lin J, Li G, Den X, Xu C, Liu S, Gao Y, Liu H, Zhang J, Li X, Liang S (2010) VEGF and its receptor-2 involved in neuropathic pain transmission mediated by P2X(2)(/)(3) receptor of primary sensory neurons. Brain Res Bull 83(5):284–291. https://doi.org/10.1016/j.brainresbull.2010.08.002 Zhang Z, Liu X, Lu S, Yu A, Fu Z (2013) Increased pain in response to mechanical or thermal stimulation in a rat model of incision-induced pain with nicotine dependence and withdrawal. Exp Ther Med 5(4):1063–1066. https://doi.org/10.3892/etm.2013.963 Tu G, Li G, Peng H, Hu J, Liu J, Kong F, Liu S, Gao Y, Xu C, Xu X, Qiu S, Fan B, Zhu Q, Yu S, Zheng C, Wu B, Peng L, Song M, Wu Q, Liang S (2013) P2X(7) inhibition in stellate ganglia prevents the increased sympathoexcitatory reflex via sensory-sympathetic coupling induced by myocardial ischemic injury. Brain Res Bull 96:71–85. https://doi.org/10.1016/j.brainresbull.2013.05.004 Feldman-Goriachnik R, Hanani M (2017) The effects of endothelin-1 on satellite glial cells in peripheral ganglia. Neuropeptides. https://doi.org/10.1016/j.npep.2017.03.002 Castillo C, Norcini M, Martin Hernandez LA, Correa G, Blanck TJ, Recio-Pinto E (2013) Satellite glia cells in dorsal root ganglia express functional NMDA receptors. Neuroscience 240:135–146. https://doi.org/10.1016/j.neuroscience.2013.02.031 Liu S, Zhang C, Shi Q, Li G, Song M, Gao Y, Xu C, Xu H, Fan B, Yu S, Zheng C, Zhu Q, Wu B, Peng L, Xiong H, Wu Q, Liang S (2014) Puerarin blocks the signaling transmission mediated by P2X3 in SG and DRG to relieve myocardial ischemic damage. Brain Res Bull 101:57–63. https://doi.org/10.1016/j.brainresbull.2014.01.001 Burnstock G (2013) Purinergic mechanisms and pain––an update. Eur J Pharmacol 716(1–3):24–40. https://doi.org/10.1016/j.ejphar.2013.01.078 Ying M, Liu H, Zhang T, Jiang C, Gong Y, Wu B, Zou L, Yi Z, Rao S, Li G, Zhang C, Jia T, Zhao S, Yuan H, Shi L, Li L, Liang S, Liu S (2017) Effect of artemisinin on neuropathic pain mediated by P2X4 receptor in dorsal root ganglia. Neurochem Int. https://doi.org/10.1016/j.neuint.2017.02.004 Yuan S, Shi Y, Chen J, Zhou X, Li G, Gelman BB, Lisinicchia JG, Carlton SM, Ferguson MR, Tan A (2014) Gp120 in the pathogenesis of human HIV-associated pain. Ann Neurol 75(6):837–850 Zheng W, Ouyang H, Zheng X, Liu S, Mata M, Fink DJ, Hao S (2011) Glial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in rats. Mol Pain 7:40. https://doi.org/10.1186/1744–8069–7-40 Yano R, Ma L, Nagai J, Ueda H (2013) Interleukin-1β plays key roles in LPA-induced amplification of LPA production in neuropathic pain model. Cell Mol Neurobiol 33(8):1033–1041. https://doi.org/10.1007/s10571-013-9970-3 Sommer C, Lindenlaub T, Teuteberg P, Schafers M, Hartung T, Toyka KV (2001) Anti-TNF-neutralizing antibodies reduce pain-related behavior in two different mouse models of painful mononeuropathy. Brain Res 913(1):86–89 Franke H, Verkhratsky A, Burnstock G, Illes P (2012) Pathophysiology of astroglial purinergic signalling. Purinergic Signal 8(3):629–657. https://doi.org/10.1007/s11302-012-9300-0 Horvath G, Goloncser F, Csolle C, Kiraly K, Ando RD, Baranyi M, Kovanyi B, Mate Z, Hoffmann K, Algaier I, Baqi Y, Muller CE, Von Kugelgen I, Sperlagh B (2014) Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents. Neurobiol Dis 70:162–178. https://doi.org/10.1016/j.nbd.2014.06.011 Taves S, Berta T, Liu DL, Gan S, Chen G, Kim YH, Van de Ven T, Laufer S, Ji RR (2016) Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: sex-dependent microglial signaling in the spinal cord. Brain Behav Immun 55:70–81. https://doi.org/10.1016/j.bbi.2015.10.006 Tatsumi E, Yamanaka H, Kobayashi K, Yagi H, Sakagami M, Noguchi K (2015) RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain. Glia 63(2):216–228. https://doi.org/10.1002/glia.22745 Kobayashi K, Yamanaka H, Fukuoka T, Dai Y, Obata K, Noguchi K (2008) P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain. J Neurosci 28(11):2892–2902. https://doi.org/10.1523/jneurosci.5589-07.2008 Pinheiro AR, Paramos-de-Carvalho D, Certal M, Costa C, Magalhaes-Cardoso MT, Ferreirinha F, Costa MA, Correia-de-Sa P (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11:70. https://doi.org/10.1186/1478-811x-11-70 Sachs D, Cunha FQ, Poole S, Ferreira SH (2002) Tumour necrosis factor-alpha, interleukin-1beta and interleukin-8 induce persistent mechanical nociceptor hypersensitivity. Pain 96(1–2):89–97 Pollock J, McFarlane SM, Connell MC, Zehavi U, Vandenabeele P, MacEwan DJ, Scott RH (2002) TNF-α receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones. Neuropharmacology 42(1):93–106 Schafers M, Lee DH, Brors D, Yaksh TL, Sorkin LS (2003) Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation. J Neurosci 23(7):3028–3038 Suadicani SO, Cherkas PS, Zuckerman J, Smith DN, Spray DC, Hanani M (2010) Bidirectional calcium signaling between satellite glial cells and neurons in cultured mouse trigeminal ganglia. Neuron Glia Biol 6(1):43–51. https://doi.org/10.1017/s1740925x09990408 Magni G, Ceruti S (2013) P2Y purinergic receptors: new targets for analgesic and antimigraine drugs. Biochem Pharmacol 85(4):466–477. https://doi.org/10.1016/j.bcp.2012.10.027 Ceruti S, Fumagalli M, Villa G, Verderio C, Abbracchio MP (2008) Purinoceptor-mediated calcium signaling in primary neuron-glia trigeminal cultures. Cell Calcium 43(6):576–590. https://doi.org/10.1016/j.ceca.2007.10.003