P2X7 receptor is required for the ototoxicity caused by aminoglycoside in developing cochlear hair cells

Neurobiology of Disease - Tập 183 - Trang 106176 - 2023
Cheng Cheng1, Jiaoyao Ma2, Xiaoling Lu2, Panpan Zhang3, Xiaohan Wang3, Luo Guo2, Peifan Li2, Ying Wei4,5, Geng-Lin Li2, Xia Gao1, Yuqiu Zhang6, Renjie Chai3,7,8,9,10, Huawei Li2,11,6, Shan Sun2
1Department of Otolaryngology Head and Neck Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Jiangsu Provincial Key Medical Discipline (Laboratory), No.321 Zhongshan Road,Nanjing 210008, China
2ENT Institute and Otorhinolaryngology Department of Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200031, China
3State Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, Advanced Institute for Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing 210096, China
4Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China
5Institutes of Integrative Medicine, Fudan University, Shanghai, China
6State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China
7Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China
8Department of Otolaryngology Head and Neck Surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China
9Institute for Stem Cell and Regeneration, Chinese Academy of Science, Beijing, China
10Beijing Key Laboratory of Neural Regeneration and Repair, Capital Medical University, 100069 Beijing, China
11Fudan University School of Basic Medical Sciences, NHC Key Laboratory of Hearing Medicine, Institutes of Biomedical Sciences, Shanghai, China

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