Ozonated oil effect for prevention of medication-related osteonecrosis of the jaw (MRONJ) in rats undergoing zoledronic acid therapy

Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O'Ryan F, American Association of Oral and Maxillofacial Surgeons (2014) American association of oral and maxillofacial surgeons special committee position paper on medication-related osteonecrosis of the jaw. J Oral Maxillofac Surg 72(10):1938–1956

Bartl R, Frisch B, von Tresckow E, Bartl C (2007) Bisphosphonates in medical practice actions, side effects, indications, strategies. Springer, Berlin/New York

Greenberg MS (2004) Intravenous bisphosphonates and osteonecrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98(3):259–260. https://doi.org/10.1016/j.tripleo.2010.04.015

Hughes DE, Wright KR, Uy HL, Sasaki A, Yoneda T, Roodman GD et al (1995) Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 10(10):1478–1487. https://doi.org/10.1002/jbmr.5650101008

Hughes DE, MacDonald BR, Russell RG, Gowen M (1989) Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow. J Clin Invest 83(6):1930–1935. https://doi.org/10.1172/JCI114100

Murakami H, Takahashi N, Sasaki T, Udagawa N, Tanaka S, Nakamura I, Zhang D, Barbier A, Suda T (1995) A possible mechanism of the specific action of bisphosphonates on osteoclasts: tiludronate preferentially affects polarized osteoclasts having ruffled borders. Bone 17(2):137–144. https://doi.org/10.1016/S8756-3282(95)00150-6

Ruggiero SL, Woo SB (2008) Biophosponate-related osteonecrosis of the jaws. Dent Clin N Am 52(1):111–128. https://doi.org/10.1016/j.cden.2007.09.002

Whyte MP, Wenkert D, Clements KL, McAlister WH, Mumm S (2003) Bisphosphonate-induced osteopetrosis. N Engl J Med 349(5):457–463. https://doi.org/10.1056/NEJMoa023110

Hoefert S, Eufinger H (2010) Sunitinib may raise the risk of bisphosphonate-related osteonecrosis of the jaw: presentation of three cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110(4):463–469. https://doi.org/10.1016/j.tripleo.2010.04.049

Marx RE (2003) Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 61(9):1115–1117. https://doi.org/10.1016/s0278-2391(03)00720-1

Bagan JV, Jimenez Y, Murillo J, Hernandez S, Poveda R, Sanchis JM, Diaz JM, Scully C (2006) Jaw osteonecrosis associated with bisphosphonates: multiple exposed areas and its relationship to teeth extractions. Study of 20 cases. Oral Oncol 42(3):327–329. https://doi.org/10.1016/j.oraloncology.2005.08.001

Coelho AI, Gomes PS, Fernandes MH (2010) Osteonecrose dos maxilares associada ao uso de bifosfonatos. parte II: inhas de orientação na consulta de medicina dentária. Rev Port Estomatol Med Dentária Cir Maxilofac 51(3):185–191. https://doi.org/10.1016/S1646-2890(10)70008-X

Ficarra G, Beninati F (2007) Bisphosphonate related osteonecrosis of the jaws: an update on clinical, pathological and management aspects. Head Neck Pathol 1(2):132–140. https://doi.org/10.1007/s12105-007-0033-2

Passeri LA, Bértolo MB, Abuabara A (2011) Osteonecrose dos maxilares associada ao uso de bisfosfonatos. Rev Bras Reumatol 51(4):404–407. https://doi.org/10.1590/S0482-50042011000400012

Vescovi P, Nammour S (2010) Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) therapy. A critical review. Minerva Stomatol 59(4):181–203 204-13

Agrillo A, Petrucci MT, Tedaldi M, Mustazza MC, Marino SMF, Gallucci C, Iannetti G (2006) New therapeutic protocol in the treatment of avascular necrosis of the jaws. J Craniofac Surg 17(6):1080–1083. https://doi.org/10.1097/01.scs.0000249350.59096.d0

Ripamonti CI, Cislaghi E, Mariani L, Maniezzo M (2011) Efficacy and safety of medical ozone (O3) delivered in oil suspension applications for the treatment of osteonecrosis of the jaw in patients with bone metastases treated with bisphosphonates: preliminary results of a phase I-II study. Oral Oncol 47(3):185–190. https://doi.org/10.1016/j.oraloncology.2011.01.002

Freiberger JJ, Padilla-Burgos R, Chhoeu AH, Kraft KH, Boneta O, Moon RE, Piantadosi CA (2007) Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series. J Oral Maxillofac Surg 65(7):1321–1327. https://doi.org/10.1016/j.joms.2007.03.019

Freiberger JJ (2009) Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg 67(5):96–106. https://doi.org/10.1016/j.joms.2008.12.003

Matsumoto AS, Sakurai N, Shinriki S et al (2000) Therapeutic effects of ozonized olive oil in the treatment of intractable fistula and wound after surgical operation. J Japan Surg Assoc 61(6):1383–1389. https://doi.org/10.3919/jjsa.61.1383

Skalska K, Ledakowicza S, Perkowskib J et al (2009) Germicidal properties of ozonated sunflower oil. Ozone Sci Eng 31(3):232–237. https://doi.org/10.1080/01919510902838669

Menéndez S, Falcón L, Simón DR, Landa N (2002) Efficacy of OLEOZON® in the treatment of tinea pedis. Mycoses 45(8):329–332. https://doi.org/10.1046/j.1439-0507.2002.00780.x

Abreu JM, Weisser MT, Cerero SM, Llanes LE, Domb W (2015) Efectos terapêuticos de la ozonioterapia en el tratamiento de la periodontitis del adulto, subtipo I y II. J Ozone Ther 1(1):Paper 2 (sp) pag 2

Sechi LA, Lezcano I, Nunez N, Espim M, Duprè I, Pinna A et al (2001) Antibacterial activity of ozonized sunflower oil (Oleozon). J Appl Microbiol 90:279–284. https://doi.org/10.1046/j.1365-2672.2001.01235.x

Hokugo A, Christensen R, Chung EM, Sung EC, Felsenfeld AL, Sayre JW, Garrett N, Adams JS, Nishimura I (2010) Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. J Bone Miner Res 25(6):1337–1349. https://doi.org/10.1002/jbmr.23

Gundersen HJG(1977) Notes on the estimation of the numerical of the numerical density of arbitrary profile: the edge effect. J.Microsc111(2)219–233. https://doi.org/10.1111/j.1365-2818.1977.tb00062.x

Kanyama M, Koboki T, Akiyama K et al (2003) Connective tissue growth factor expressed in ral alveolar bone regeneration sites after tooth extraction. Arch Oral Biol 48(10):723–730. https://doi.org/10.1016/S0003-9969(03)00153-5Get

Elsubeihia ES, Heersche JNM (2004) Quantitative assessment of post-extraction healing and alveolar ridge remodelling of the mandible in female rats. Arch Oral Biol 49(5):401–412. https://doi.org/10.1016/j.archoralbio.2003.12.003

Calixto RFE, Teo JM, Brentegani LM et al (2007) Grafting of tooth extraction socket with inorganic bovine bone or bioactive glass particles: comparative histometric study in rats. Implant Dent 16(3):260–269. https://doi.org/10.1097/ID.0b013e3180500b95

Bodner L, Kaffe I, Littner MM, Cohen J (1993) Extraction site healing in rats: a radiologic densitometric study. Oral Surg Oral Med Oral Pathol 75(3):367–372. https://doi.org/10.1016/0030-4220(93)90153-U

Iizuka T, Miller SC, Marks SC (1992) Alveolar bone remodeling after tooth extraction in normal and osteoporotic rats. J Oral Pathol Med 21(4):150–155. https://doi.org/10.1111/j.1600-0714.1992.tb00092.x

Trombelli L, Farina R, Marzola A, Bozzi L, Liljenberg B, Lindhe J (2008) Modeling and remodeling of human extraction sockets. J Clin Periodontol 35(7):630–639. https://doi.org/10.1111/j.1600-051X.2008.01246.x

Hansen T, Kunkel M, Weber A, James Kirkpatrick C (2006) Osteonecrosis of the jaws in patients treated with bisphosphonates: histomorphologic analysis in comparison with infected osteoradionecrosis. J Oral Pathol Med 35(3):155–160. https://doi.org/10.1111/j.1600-0714.2006.00391.x

Travagli V, Zanardi I, Valacchi G, Bocci V (2010) Ozone and ozonated oils in skin diseases: a review. Mediat Inflamm 9. https://doi.org/10.1155/2010/610418

Blanco P, Poznyak T, Chairez I (2015) Correlation of structural characterization and viscosity measurements with total unsaturation: an effective method for ozonation in the preparation of ozonated grape seed and sunflower oils. Eur J Lipid Sci Technol 117(7):988–998. https://doi.org/10.1002/ejlt.201400292

Valacchi G, Fortino V, Bocci V (2005) The dual action of ozone on the skin. Br J Dermatol 153(6):1096–1100. https://doi.org/10.1111/j.1365-2133.2005.06939.x

Valacchi G, Zanardi I, Lim Y, Belmonte G, Miracco C, Sticozzi C et al (2013) Ozonated oils as functional dermatological matrices: effects on the wound healing process using SKH1 mice. Int J Pharm 458(1):65–73. https://doi.org/10.1016/j.ijpharm.2013.09.039

Luvizuto ER, Queiroz TP, Dias SM, Okamoto T, Dornelles RC, Garcia IR Jr, Okamoto R (2010) Histomorphometric analysis and immunolocalization of RANKL and OPG during the alveolar healing process in female ovariectomized rats treated with oestrogen or raloxifene. Arch Oral Biol 55:52–59. https://doi.org/10.1016/j.archoralbio.2009.11.001

Okamoto T, Alves-Rezende MC, Claudio CC, Rodrigues T d S, Okamoto R (2006) Effects of Tissucol and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats. Braz Oral Res 20:33–39. https://doi.org/10.1590/S1806-83242006000100007

Ricieri CB, Sonoda CK, Aranega AM, Panzarini SR, Poi WR, Sundefeld ML, Okamoto T (2009) Healing process of incisor teeth of diabetic rats replanted after storage in milk. Dent Traumatol 25:284–289. https://doi.org/10.1111/j.1600-9657.2009.00767.x

Merzel J, Novaes PD (2006) Development of functional dentin incisors after a partial resection of the odontogenic organ of rat incisors. Arch Oral Biol 51:825–835. https://doi.org/10.1016/j.archoralbio.2006.03.010

Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B et al (2014) American Association of oral and maxillofacial surgeons special committee position paper on medication-related osteonecrosis of the jaw. J Oral Maxillofac Surg 72(10):1938–1956. https://doi.org/10.1016/j.joms.2014.04.031

Hidaka K, Mikuni-Takagaki Y, Wada-Takahashi S, Saita M, Kawamata R, Sato T, Kawata A, Miyamoto C, Maehata Y, Watabe H, Tani-Ishii N, Hamada N, Takahashi SS, Deguchi S, Takeuchi R (2019) Low-intensity pulsed ultrasound prevents development of bisphosphonate-related osteonecrosis of the jaw-like pathophysiology in a rat model. Ultrasound Med Biol 45(7):1721–1732. https://doi.org/10.1016/j.ultrasmedbio.2019.02.015

Sarkarat F, Modarresi A, Chiniforush N, Yazdanparast L, Rakhshan V (2018) Efficacy of photodynamic therapy in minimizing bisphosphonate-related osteonecrosis of the jaws after dental extraction: a preliminary animal study. J Oral Maxillofac Surg 77(2):307–314. https://doi.org/10.1016/j.joms.2018.09.036

Maahs MP, Azambuja AA, Campos MM, Salum FG, Cherubini K (2011) Association between bisphosphonates and jaw osteonecrosis: a study in Wistar rats. Head Neck 33:199–207. https://doi.org/10.1002/hed.21422

Monteiro CJ, Gama MS, Moura BF, Cabral-Oliveira GG, Mattos-Guaraldi AL, Carlos José Lima CJ, Lins RX (2020) In Vitro antimicrobial activity of ozonated sunflower oil against antibiotic-resistant Enterococcus faecalis isolated from endodontic infection. Ozone Sci Eng:1–6. https://doi.org/10.1080/01919512.2020.1822150