Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases
Tóm tắt
Từ khóa
Tài liệu tham khảo
Mittal, 2014, Reactive oxygen species in inflammation and tissue injury, Antioxid. Redox Signal., 20, 1126, 10.1089/ars.2012.5149
Nishikawa, 2000, KanedaY et al. normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage, Nature, 404, 787, 10.1038/35008121
Thomas, 2008, Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities, Antioxid. Redox Signal., 10, 1713, 10.1089/ars.2008.2027
Thannickal, 2000, Reactive oxygen species in cell signaling, Am. J. Phys. Lung Cell. Mol. Phys., 279, L1005
Dröge, 2002, Free radicals in the physiological control of cell function, Physiol. Rev., 82, 47, 10.1152/physrev.00018.2001
Sena, 2012, Physiological roles of mitochondrial reactive oxygen species, Mol. Cell, 48, 158, 10.1016/j.molcel.2012.09.025
Bretòn-Romero, 2014, Hydrogen peroxide signaling in vascular endothelial cells, Redox Biol., 2, 529, 10.1016/j.redox.2014.02.005
Uttara, 2009, Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options, Curr. Neuropharmacol., 7, 65, 10.2174/157015909787602823
Sosa, 2013, Oxidative stress and cancer: an overview, Ageing Res. Rev., 12, 376, 10.1016/j.arr.2012.10.004
Massy, 2002, Oxidative stress and chronic renal failure: markers and management, J. Nephrol., 15, 336
Park, 2006, Role of NADPH oxidase 4 in lipopolysaccharide-induced proinflammatory responses by human aortic endothelial cells, Cardiovasc. Res., 72, 447, 10.1016/j.cardiores.2006.09.012
Liao, 2013, Linking endothelial dysfunction with endothelial cell activation, J. Clin. Invest., 123, 540, 10.1172/JCI66843
Bulua, 2011, Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS), J. Exp. Med., 208, 519, 10.1084/jem.20102049
Nakahira, 2011, Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome, Nat. Immunol., 12, 222, 10.1038/ni.1980
Zhou, 2011, A role for mitochondria in NLRP3 inflammasome activation, Nature, 469, 221, 10.1038/nature09663
Landmesser, 2003, Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cellnitric oxide synthase in hypertension, J. Clin. Invest., 111, 1201, 10.1172/JCI200314172
Potenza, 2009, Endothelial dysfunction in diabetes: from mechanisms to therapeutic targets, Curr. Med. Chem., 16, 94, 10.2174/092986709787002853
Wolin, 2010, Oxidant-redox regulation of pulmonary vascular responses to hypoxia and nitric oxide-cGMP signaling, Cardiol. Rev., 18, 89, 10.1097/CRD.0b013e3181c9f088
Liaudet, 2009, Role of peroxynitrite in the redox regulation of cell signal transduction pathways, Front. Biosci. (Landmark Ed.), 14, 4809, 10.2741/3569
Radi, 2004, Nitric oxide, oxidants, and protein tyrosine nitration, Proc. Natl. Acad. Sci. U. S. A., 101, 4003, 10.1073/pnas.0307446101
Mathews, 2008, PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2, Arterioscler. Thromb. Vasc. Biol., 28, 711, 10.1161/ATVBAHA.107.156406
Dharmashankar, 2010, Vascular endothelial function and hypertension: insights and directions, Curr. Hypertens. Rep., 12, 448, 10.1007/s11906-010-0150-2
Toda, 2011, How mental stress affects endothelial function, Pflugers Arch., 462, 779, 10.1007/s00424-011-1022-6
Herrera, 2010, Endothelial dysfunction and aging: an update, Ageing Res. Rev., 9, 142, 10.1016/j.arr.2009.07.002
Soultati, 2012, Endothelial vascular toxicity from chemotherapeutic agents: preclinical evidence and clinical implications, Cancer Treat. Rev., 38, 473, 10.1016/j.ctrv.2011.09.002
Schwarz, 2014, The breathing heart- mitochondrial respiratory chain dysfunction in cardiac disease, Int. J. Cardiol., 171, 134, 10.1016/j.ijcard.2013.12.014
Tang, 2014, Mitochondria, endothelial cell function, and vascular diseases, Front. Physiol., 5, 175, 10.3389/fphys.2014.00175
Zorov, 2014, Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release, Physiol. Rev., 94, 909, 10.1152/physrev.00026.2013
Hernandez-Mijares, 2013, Human leukocyte/endothelial cell interactions and mitochondrial dysfunction in type 2 diabetic patients and their association with silent myocardial ischemia, Diabetes Care, 36, 1695, 10.2337/dc12-1224
Natalicchio, 2011, p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress, Arch. Physiol. Biochem., 117, 116, 10.3109/13813455.2011.562513
Orsini, 2004, The life span determinant p66shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential, J. Biol. Chem., 279, 25689, 10.1074/jbc.M401844200
Giorgio, 2005, Electron transfer between cytochrome c and p66shc generates reactive oxygen species that trigger mitochondrial apoptosis, Cell, 122, 221, 10.1016/j.cell.2005.05.011
Laviola, 2013, TNFα signals via p66(Shc) to induce E-selectin, promote leukocyte transmigration and enhance permeability in human endothelial cells, PLoS One, 8, 10.1371/journal.pone.0081930
Pagnin, 2005, Diabetes induces p66shc gene expression in human peripheral blood mononuclear cells relationship to oxidative stress, J. Clin. Endocrinol. Metab., 90, 1130, 10.1210/jc.2004-1283
Menini, 2006, Deletion of p66shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress, Diabetes, 55, 1642, 10.2337/db05-1477
Paneni, 2014, p66shc-induced redox changes drive endothelial insulin resistance, Atherosclerosis, 236, 426, 10.1016/j.atherosclerosis.2014.07.027
Bedard, 2007, The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology, Physiol. Rev., 87, 245, 10.1152/physrev.00044.2005
Panday, 2015, NADPH oxidases: an overview from structure to innate immunity-associated pathologies, Cell. Mol. Immunol., 12, 523, 10.1038/cmi.2014.89
Sorescu, 2002, Superoxide production and expression of Nox family proteins in human atherosclerosis, Circulation, 105, 1429, 10.1161/01.CIR.0000012917.74432.66
Datla, 2007, Important role of Nox4 type NADPH oxidase in angiogenic responses in human microvascular endothelial cells in vitro, Arterioscler. Thromb. Vasc. Biol., 27, 2319, 10.1161/ATVBAHA.107.149450
Chen, 2012, From form to function: the role of Nox4 in the cardiovascular system, Front. Physiol., 3, 412, 10.3389/fphys.2012.00412
Kim, 2014, Oxidative stress in angiogenesis and vascular disease, Blood, 123, 625, 10.1182/blood-2013-09-512749
Amara, 2010, NOX4/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGFbeta1-induced fibroblast differentiation into myofibroblasts, Thorax, 65, 733, 10.1136/thx.2009.113456
Pache, 2011, NOX-4 is expressed in thickened pulmonary arteries in idiopathic pulmonary fibrosis, Nat. Med., 17, 31, 10.1038/nm0111-31
Sedeek, 2010, Critical role of Nox4-based NADPH oxidase in glucose-induced oxidative stress in the kidney: implications in type 2 diabetic nephropathy, Am. J. Physiol. Ren. Physiol., 299, F1348, 10.1152/ajprenal.00028.2010
Schröder, 2012, Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase, Circ. Res., 110, 1217, 10.1161/CIRCRESAHA.112.267054
Ray, 2011, Endothelial Nox4 NADPH oxidase enhances vasodilatation and reduces blood pressure in vivo, Arterioscler. Thromb. Vasc. Biol., 31, 1368, 10.1161/ATVBAHA.110.219238
Touyz, 2012, Vascular Nox4 a multifarious NADPH oxidase, Circ. Res., 110, 1159, 10.1161/CIRCRESAHA.112.269068
Sorescu, 2004, Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase, Circ. Res., 95, 773, 10.1161/01.RES.0000145728.22878.45
Honjo, 2008, Essential role of NOXA1 in generation of reactive oxygen species induced by oxidized low-density lipoprotein in human vascular endothelial cells, Endothelium, 15, 137, 10.1080/10623320802125433
Drummond, 2014, Endothelial NADPH oxidases: which NOX to target in vascular disease?, Trends Endocrinol. Metab., 25, 452, 10.1016/j.tem.2014.06.012
Wind, 2010, Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibition, Hypertension, 56, 490, 10.1161/HYPERTENSIONAHA.109.149187
Niu, 2010, Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries, Circulation, 121, 549, 10.1161/CIRCULATIONAHA.109.908319
Wendt, 2005, Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4, Free Radic. Biol. Med., 39, 381, 10.1016/j.freeradbiomed.2005.03.020
Alderton, 2001, Nitric oxide synthases: structure, function and inhibition, Biochem. J., 357, 593, 10.1042/bj3570593
Balligand, 2009, eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues, Physiol. Rev., 89, 481, 10.1152/physrev.00042.2007
Alp, 2004, Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease, Arterioscler. Thromb. Vasc. Biol., 24, 413, 10.1161/01.ATV.0000110785.96039.f6
Diers, 2013, Nitrosative stress and redox-cycling agents synergize to cause mitochondrial dysfunction and cell death in endothelial cells, Redox Biol., 1, 1, 10.1016/j.redox.2012.11.003
Laursen, 2001, Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin, Circulation, 103, 1282, 10.1161/01.CIR.103.9.1282
Chalupsky, 2005, Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase, Proc. Natl. Acad. Sci. U. S. A., 102, 9056, 10.1073/pnas.0409594102
Heitzer, 2000, Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with type II diabetes mellitus, Diabetologia, 43, 1435, 10.1007/s001250051551
Higashi, 2002, Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals, Am. J. Hypertens., 15, 326, 10.1016/S0895-7061(01)02317-2
Stroes, 1997, Tetrahydrobiopterin restores endothelial function in hypercholesterolemia, J. Clin. Invest., 99, 41, 10.1172/JCI119131
Sud, 2008, Symmetric dimethylarginine inhibits HSP90 activityin pulmonary arterial endothelial cells: role of mitochondrial dysfunction, Am. J. Phys. Cell Phys., 294
Antoniades, 2009, Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis, Eur. Heart J., 30, 1142, 10.1093/eurheartj/ehp061
Vergnani, 2000, Effect of native and oxidized low-density lipoprotein on endothelial nitric oxide and superoxide production: key role of l-arginine availability, Circulation, 101, 1261, 10.1161/01.CIR.101.11.1261
Koshida, 2003, Angiostatin: a negative regulator of endothelial-dependent vasodilation, Circulation, 107, 803, 10.1161/01.CIR.0000057551.88851.09
Topal, 2004, Homocysteine induces oxidative stress by uncoupling of NO synthase activity through reduction of tetrahydrobiopterin, Free Radic. Biol. Med., 36, 1532, 10.1016/j.freeradbiomed.2004.03.019
Cosentino, 1997, High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells, Circulation, 96, 25, 10.1161/01.CIR.96.1.25
Zou, 2002, Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite, J. Clin. Invest., 109, 817, 10.1172/JCI0214442
Thum, 2007, Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes, Diabetes, 56, 666, 10.2337/db06-0699
Kuwabara, 2003, Unique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase, Proc. Natl. Acad. Sci. U. S. A., 100, 8170, 10.1073/pnas.1431485100
Nishino, 2008, Mammalian xanthine oxidoreductase- mechanism of transition from xanthine dehydrogenase to xanthine oxidase, FEBS J., 275, 3278, 10.1111/j.1742-4658.2008.06489.x
Nishino, 2005, Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase: identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant, J. Biol. Chem., 280, 24888, 10.1074/jbc.M501830200
Jankov, 2008, Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats, Am. J. Phys. Lung Cell. Mol. Phys., 294, L233
Desco, 2002, Xanthine oxidase is involved in free radical production in type 1 diabetes, Diabetes, 51, 1118, 10.2337/diabetes.51.4.1118
Kuppusamy, 2005, Glycaemic control in relation to xanthine oxidase and antioxidant indices in Malaysian Type 2 diabetes patients, Diabet. Med., 22, 1343, 10.1111/j.1464-5491.2005.01630.x
McNally, 2003, Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress, Am. J. Physiol. Heart Circ. Physiol., 285, H2290, 10.1152/ajpheart.00515.2003
Landmesser, 2007, Angiotensin ii induces endothelial xanthine oxidase activation. Role for endothelial dysfunction in patients with coronary disease, Arterioscler. Thromb. Vasc. Biol., 27, 943, 10.1161/01.ATV.0000258415.32883.bf
Battelli, 2014, Pathophysiology of circulating xanthine oxidoreductase: new emerging roles for a multi-tasking enzyme, Biochim. Biophys. Acta, 1842, 1502, 10.1016/j.bbadis.2014.05.022
Kelley, 2006, Moderate hypoxia induces xanthine oxidoreductase activity in arterial endothelial cells, Free Radic. Biol. Med., 40, 952, 10.1016/j.freeradbiomed.2005.11.008
Adachi, 1993, Binding of human xanthine oxidase to sulphated glycosaminoglycans on the endothelial cell surface, Biochem. J., 289, 523, 10.1042/bj2890523
Farquharson, 2002, Allopurinol improves endothelial dysfunction in chronic heart failure, Circulation, 106, 221, 10.1161/01.CIR.0000022140.61460.1D
Butler, 2000, Allopurinol normalizes endothelial dysfunction in Type 2 diabetics with mild hypertension, Hypertension, 35, 746, 10.1161/01.HYP.35.3.746
Fukai, 2002, Extracellular superoxide dismutase and cardiovascular disease, Cardiovasc. Res., 55, 239, 10.1016/S0008-6363(02)00328-0
Foresman, 2013, Extracellular but not cytosolic superoxide dismutase protects against oxidant-mediated endothelial dysfunction, Redox Biol., 1, 292, 10.1016/j.redox.2013.04.003
Juarez, 2008, Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling, Proc. Natl. Acad. Sci. U. S. A., 105, 7147, 10.1073/pnas.0709451105
Morikawa, 2003, Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization, J. Clin. Invest., 112, 1871, 10.1172/JCI200319351
Dromparis, 2013, Mitochondria in vascular health and disease, Annu. Rev. Physiol., 75, 95, 10.1146/annurev-physiol-030212-183804
Connor, 2005, Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation, J. Biol. Chem., 280, 16916, 10.1074/jbc.M410690200
He, 2004, Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase, Arterioscler. Thromb. Vasc. Biol., 24, 2021, 10.1161/01.ATV.0000142810.27849.8f
Ohashi, 2006, MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice, Arterioscler. Thromb. Vasc. Biol., 26, 2331, 10.1161/01.ATV.0000238347.77590.c9
Afolayan, 2012, Decreases in manganese superoxide dismutase expression and activity contribute to oxidative stress in persistent pulmonary hypertension of the newborn, Am. J. Phys. Lung Cell. Mol. Phys., 303, L870
Marrotte, 2010, Manganese superoxide dismutase expression in endothelial progenitor cells accelerates wound healing in diabetic mice, J. Clin. Invest., 120, 4207, 10.1172/JCI36858
Fukai, 2011, Superoxide dismutases: role in redox signaling, vascular function, and diseases, Antioxid. Redox Signal., 15, 1583, 10.1089/ars.2011.3999
Brown, 2006, Gene transfer of extracellular superoxide dismutase protects against vascular dysfunction with aging, Am. J. Physiol. Heart Circ. Physiol., 290, H2600, 10.1152/ajpheart.00676.2005
Fennell, 2002, Adenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension, Gene Ther., 9, 110, 10.1038/sj.gt.3301633
Iida, 2005, Gene transfer of extracellular superoxide dismutase improves endothelial function in rats with heart failure, Am. J. Physiol. Heart Circ. Physiol., 289, H525, 10.1152/ajpheart.00108.2005
Hwang, 2012, Catalase deficiency accelerates diabetic renal injury through peroxisomal dysfunction, Diabetes, 61, 728, 10.2337/db11-0584
Meilhac, 2000, Lipid peroxides induce expression of catalase in cultured vascular cells, J. Lipid Res., 41, 1205, 10.1016/S0022-2275(20)33427-1
Forgione, 2002, Cellular glutathione peroxidase deficiency and endothelial dysfunction, Am. J. Physiol. Heart Circ. Physiol., 282, H1255, 10.1152/ajpheart.00598.2001
Zhang, 2005, Adenosine dependent induction of glutathione peroxidase 1 in human primary endothelial cells and protection against oxidative stress, Circ. Res., 96, 8317, 10.1161/01.RES.0000164401.21929.CF
Oelze, 2014, Glutathione peroxidase1 deficiency potentiates dysregulatory modifications of endothelial nitric oxide synthase and vascular dysfunction in aging, Hypertension, 63, 390, 10.1161/HYPERTENSIONAHA.113.01602
La Sala, 2016, Oscillating glucose induces microRNA-185 and impairs an efficient antioxidant response in human endothelial cells, Cardiovasc. Diabetol., 15, 71, 10.1186/s12933-016-0390-9
Rhee, 2005, Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling, Free Radic. Biol. Med., 38, 1543, 10.1016/j.freeradbiomed.2005.02.026
Manevich, 2002, 1Cys peroxiredoxin overexpression protects cells against phospholipid peroxidation mediated membrane damage, Proc. Natl. Acad. Sci. U. S. A., v99, 11599, 10.1073/pnas.182384499
Wang, 2004, Adenovirus-mediated transfer of the 1cys peroxiredoxin gene to mouse lung protects against hyperoxic injury, Am. J. Phys. Lung Cell. Mol. Phys., 286, L1188
Pak, 2002, An antisense oligonucleotide to 1cys peroxiredoxin causes lipid peroxidation and apoptosis in lung epithelial cells, J. Biol. Chem., 277, 49927, 10.1074/jbc.M204222200
Kang, 2011, Peroxiredoxin II is an essential antioxidant enzyme that prevents the oxidative inactivation of VEGF receptor-2 in vascular endothelial cells, Mol. Cell, 44, 545, 10.1016/j.molcel.2011.08.040
Kümin, 2007, Peroxiredoxin 6 is required for blood vessel integrity in wounded skin, J. Cell Biol., 179, 747, 10.1083/jcb.200706090
Mowbray, 2008, Laminar shear stress up-regulates peroxiredoxins (PRX) in endothelial cells: PRX 1 as a mechanosensitive antioxidant, J. Biol. Chem., 283, 1622, 10.1074/jbc.M707985200
Haendeler, 2005, Cathepsin D and H2O2 stimulate degradation of thioredoxin-1: implication for endothelial cell apoptosis, Biol. Chem., 280, 42945, 10.1074/jbc.M506985200
Yamawaki, 2005, Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells, J. Clin. Invest., 115, 733, 10.1172/JCI200523001
Schroeder, 2007, Nuclear redox-signaling is essential for apoptosis inhibition in endothelial cells–important role for nuclear thioredoxin-1, Arterioscler. Thromb. Vasc. Biol., 27, 2325, 10.1161/ATVBAHA.107.149419
Devarajan, 2011, Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis, Antioxid. Redox Signal., 14, 341, 10.1089/ars.2010.3430
Ng, 2006, Paraoxonase2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase2, J. Biol. Chem., 281, 29491, 10.1074/jbc.M605379200
Cui, 2006, Expression modification of uncoupling proteins and MnSOD in retinal endothelial cells and pericytes induced by high glucose: the role of reactive oxygen species in diabetic retinopathy, Exp. Eye Res., 83, 807, 10.1016/j.exer.2006.03.024
Duval, 2002, Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells, Biochem. Cell Biol., 80, 757, 10.1139/o02-158
Sun, 2013, TRPV1-mediated UCP2 upregulation ameliorates hyperglycemia-induced endothelial dysfunction, Cardiovasc. Diabetol., 12, 69, 10.1186/1475-2840-12-69
Lee, 2005, Effects of recombinant adenovirus-mediated uncoupling protein 2 overexpression on endothelial function and apoptosis, Circ. Res., 96, 1200, 10.1161/01.RES.0000170075.73039.5b
Kluge, 2013, Mitochondria and endothelial function, Circ. Res., 112, 1171, 10.1161/CIRCRESAHA.111.300233
Potashnik, 2003, IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress, Diabetologia, 46, 639, 10.1007/s00125-003-1097-5
Tesfamariam, 1991, Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C, J. Clin. Invest., 87, 1643, 10.1172/JCI115179
Sheetz, 2002, Molecular understanding of hyperglycemia's adverse effects for diabetic complications, JAMA, 288, 2579, 10.1001/jama.288.20.2579
Lebiedzinska, 2010, Oxidative stress-dependent p66Shc phosphorylation in skin fibroblasts of children with mitochondrial disorders, Biochim. Biophys. Acta, 197, 952, 10.1016/j.bbabio.2010.03.005
Brownlee, 2001, Biochemistry and molecular cell biology of diabetic complications, Nature, 414, 813, 10.1038/414813a
Fu, 1996, The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions, J. Biol. Chem., 271, 9982, 10.1074/jbc.271.17.9982
Thornalley, 1999, Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose, Biochem. J., 344, 109, 10.1042/bj3440109
Wells-Knecht, 1995, Mechanism of autoxidative glycosylation: identification of glyoxal and arabinose as intermediates in the autoxidative modification of proteins by glucose, Biochemistry, 34, 3702, 10.1021/bi00011a027
Scheijen, 2014, Quantification of glyoxal, methylglyoxal and 3-deoxyglucosone in blood and plasma by ultra performance liquid chromatography tandem mass spectrometry: evaluation of blood specimen, Clin. Chem. Lab. Med., 52, 85, 10.1515/cclm-2012-0878
Goldin, 2006, Advanced glycation end products: sparking the development of diabetic vascular injury, Circulation, 114, 597, 10.1161/CIRCULATIONAHA.106.621854
Ishibashi, 2010, Glucagon-like peptide-1 (GLP-1) inhibits advanced glycation end product (AGE)-induced up-regulation of VCAM-1 mRNA levels in endothelial cells by suppressing AGE receptor (RAGE) expression, Biochem. Biophys. Res. Commun., 391, 1405, 10.1016/j.bbrc.2009.12.075
Phalitakul, 2013, Vaspin prevents methylglyoxal-induced apoptosis in human vascular endothelial cells by inhibiting reactive oxygen species generation, Acta Physiol. (Oxford), 209, 212
Zhan, 2012, Glucagonlike peptide-1(GLP-1) protects vascular endothelial cells against advanced glycation end products (AGEs)induced apoptosis, Med. Sci. Monit., 18, BR286, 10.12659/MSM.883207
Chu, 2016, Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway, Vasc. Pharmacol., pii, 30106
Wu, 2017, Propofol inhibits high glucose-induced PP2A expression in human umbilical vein endothelial cells, Vasc. Pharmacol., S1537
Weigert, 2004, Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB, J. Biol. Chem., 279, 23942, 10.1074/jbc.M312692200
Kim, 2005, Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta, Arterioscler. Thromb. Vasc. Biol., 25, 989, 10.1161/01.ATV.0000160549.60980.a8
Maloney, 2009, Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation, Arterioscler. Thromb. Vasc. Biol., 29, 1370, 10.1161/ATVBAHA.109.188813
Choi, 2007, Involvement of glycogen synthase kinase-3beta in palmitate-induced human umbilical vein endothelial cell apoptosis, J. Vasc. Res., 44, 365, 10.1159/000102321
Chai, 2007, p38 mitogen-activated protein kinase mediates palmitate-induced apoptosis but not inhibitor of nuclear factor-kappaB degradation in human coronary artery endothelial cells, Endocrinology, 148, 1622, 10.1210/en.2006-1068
Erdogdu, 2013, Exendin-4 protects endothelial cells from lipoapoptosis by PKA, PI3K, eNOS, p38 MAPK, and JNK pathways, J. Mol. Endocrinol., 50, 229, 10.1530/JME-12-0166
Jiang, 2010, Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways, Atherosclerosis, 210, 71, 10.1016/j.atherosclerosis.2009.10.032
Holland, 2008, Sphingolipids, insulin resistance, and metabolic disease: new insights from in vivo manipulation of sphingolipid metabolism, Endocr. Rev., 29, 381, 10.1210/er.2007-0025
Zhang, 2003, Ceramide-induced activation of NADPH oxidase and endothelial dysfunction in small coronary arteries, Am. J. Physiol. Heart Circ. Physiol., 284, H605, 10.1152/ajpheart.00697.2002
Li, 2002, Dual effect of ceramide on human endothelial cells: induction of oxidative stress and transcriptional upregulation of endothelial nitric oxide synthase, Circulation, 106, 2250, 10.1161/01.CIR.0000035650.05921.50
Li, 2011, Inhibition of ceramide synthesis reverses endothelial dysfunction and atherosclerosis in streptozotocin-induced diabetic rats, Diabetes Res. Clin. Pract., 93, 77, 10.1016/j.diabres.2011.03.017
Naik, 2011, Mitochondrial reactive oxygen species drive proinflammatory cytokine production, J. Exp. Med., 208, 417, 10.1084/jem.20110367
Martinon, 2008, The inflammasomes: guardians of the body, Annu. Rev. Immunol., 27, 229, 10.1146/annurev.immunol.021908.132715
Anderson, 2000, Posttranscriptional regulation of tumour necrosis factor alpha production, Ann. Rheum. Dis., 59, i3, 10.1136/ard.59.suppl_1.i3
DiMauro, 2003, Mitochondrial respiratorychain diseases, N. Engl. J. Med., 348, 2656, 10.1056/NEJMra022567
Nisoli, 2007, Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome?, Circ. Res., 100, 795, 10.1161/01.RES.0000259591.97107.6c
Patti, 2010, The role of mitochondria in the pathogenesis of type 2 diabetes, Endocr. Rev., 31, 364, 10.1210/er.2009-0027
Abderrazak, 2015, NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases, Redox Biol., 4, 296, 10.1016/j.redox.2015.01.008
Binder, 2002, Innate and acquired immunity in atherogenesis, Nat. Med., 8, 1218, 10.1038/nm1102-1218
Hansson, 2005, Inflammation, atherosclerosis, and coronary artery disease, N. Engl. J. Med., 352, 1685, 10.1056/NEJMra043430
Blankenberg, 2002, AtheroGene investigators. Interleukin-18 is a strong predictor of cardiovascular death in stable and unstable angina, Circulation, 106, 24, 10.1161/01.CIR.0000020546.30940.92
Mallat, 2001, Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability, Circulation, 104, 1598, 10.1161/hc3901.096721
Galea, 1996, Interleukin-1beta in coronary arteries of patients with ischemic heart disease, Arterioscler. Thromb. Vasc. Biol., 16, 1000, 10.1161/01.ATV.16.8.1000
Moyer, 1991, Synthesis of IL-1alpha and IL-1beta by arterial cells in atherosclerosis, Am. J. Pathol., 138, 951
Wallach, 1999, Tumor necrosis factor receptor and Fas signaling mechanisms, Annu. Rev. Immunol., 17, 331, 10.1146/annurev.immunol.17.1.331
Karsan, 1996, Endothelial cell death induced by tumor necrosis factor-alpha is inhibited by the Bcl-2 family member, A1, J. Biol. Chem., 271, 27201, 10.1074/jbc.271.44.27201
van der Poll, 1995, Tumor necrosis factor in sepsis: mediator of multiple organ failure or essential part of host defense?, Shock, 3, 1
Goossens, 1995, Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity, Proc. Natl. Acad. Sci. U. S. A., 92, 8115, 10.1073/pnas.92.18.8115
Schütze, 1992, TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced “acidic” sphingomyelin breakdown, Cell, 71, 765, 10.1016/0092-8674(92)90553-O
Schulze-Osthoff, 1993, Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF, EMBO J., 12, 3095, 10.1002/j.1460-2075.1993.tb05978.x
Corda, 2001, Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide, Am. J. Respir. Cell Mol. Biol., 24, 762, 10.1165/ajrcmb.24.6.4228
García-Ruiz, 1997, Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione, J. Biol. Chem., 272, 11369, 10.1074/jbc.272.17.11369
Zhang, 2002, Role of ceramide in TNF-alpha-induced impairment of endothelium-dependent vasorelaxation in coronary arteries, Am. J. Physiol. Heart Circ. Physiol., 283, H1785, 10.1152/ajpheart.00318.2002
Böse, 2007, Release of TNF-alpha during stent implantation into saphenous vein aortocoronary bypass grafts and its relation to plaque extrusion and restenosis, Am. J. Physiol. Heart Circ. Physiol., 292, H2295, 10.1152/ajpheart.01116.2006
Rowlands, 2011, Activation of TNFR1 ectodomain shedding by mitochondrial Ca2+ determines the severity of inflammation in mouse lung microvessels, J. Clin. Invest., 121, 1986, 10.1172/JCI43839
Li, 2013, Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers, J. Hematol. Oncol., 6, 19, 10.1186/1756-8722-6-19
Ouchi, 2011, Adipokines in inflammation and metabolic disease, Nat. Rev. Immunol., 11, 85, 10.1038/nri2921
Yamagishi, 2001, Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A, J. Biol. Chem., 276, 25096, 10.1074/jbc.M007383200
Chen, 2010, Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells, Am. J. Physiol. Heart Circ. Physiol., 299, H193, 10.1152/ajpheart.00431.2009
Woodfin, 2010, Recent developments and complexities in neutrophil transmigration, Curr. Opin. Hematol., 17, 9, 10.1097/MOH.0b013e3283333930
Zarbock, 2011, Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow, Blood, 118, 6743, 10.1182/blood-2011-07-343566
Haraldsen, 1996, Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human microvascular endothelial cells, J. Immunol., 156, 2558, 10.4049/jimmunol.156.7.2558
Griffin, 2012, IL-17 and TNF-α sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation, J. Immunol., 188, 6287, 10.4049/jimmunol.1200385
Hafezi-Moghadam, 2001, l-selectin shedding regulates leukocyte recruitment, Exp. Med., 193, 863, 10.1084/jem.193.7.863
Moore, 1994, The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine, J. Biol. Chem., 269, 23318, 10.1016/S0021-9258(17)31656-3
Steegmaier, 1995, The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor, Nature, 373, 615, 10.1038/373615a0
Zarbock, 2011, Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow, Blood, 118, 6743, 10.1182/blood-2011-07-343566
Zarbock, 2007, Galphai2 is required for chemokine-induced neutrophil arrest, Blood, 110, 3773, 10.1182/blood-2007-06-094565
Phillipson, 2006, Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade, J. Exp. Med., 203, 2569, 10.1084/jem.20060925
Borregaard, 2010, Neutrophils, from marrow to microbes, Immunity, 33, 657, 10.1016/j.immuni.2010.11.011
Mamdouh, 2003, Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis, Nature, 421, 748, 10.1038/nature01300
Bixel, 2007, A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo, Blood, 109, 5327, 10.1182/blood-2006-08-043109
Patel, 1991, Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils, J. Cell Biol., 112, 749, 10.1083/jcb.112.4.749
Gaboury, 1994, Molecular mechanisms involved in superoxide-induced leukocyte-endothelial cell interactions in vivo, Am. J. Phys., 266, H637
Narayanan, 1999, Ann. Clin. Lab. Sci., 29, 275
Sugama, 1992, Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion, J. Cell Biol., 119, 935, 10.1083/jcb.119.4.935
Roebuck, 1999, Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB (review), Int. J. Mol. Med., 4, 223
Ferran, 1995, Inhibition of NF-kappa B by pyrrolidine dithiocarbamate blocks endothelial cell activation, Biochem. Biophys. Res. Commun., 214, 212, 10.1006/bbrc.1995.2277
Ikeda, 1994, Suppressive effect of antioxidants on intercellular adhesion molecule-1 (ICAM-1) expression in human epidermal keratinocytes, J. Invest. Dermatol., 103, 791, 10.1111/1523-1747.ep12413176
Lo, 1993, Hydrogen peroxide-induced increase in endothelial adhesiveness is dependent on ICAM-1 activation, Am. J. Phys., 264, L406
Griendling, 2000, NAD(P)H oxidase: role in cardiovascular biology and disease, Circ. Res., 86, 494, 10.1161/01.RES.86.5.494
Fan, 2002, Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha-induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells, J. Biol. Chem., 277, 3404, 10.1074/jbc.M110054200
Chen, 2003, Rac1 and superoxide are required for the expression of cell adhesion molecules induced by tumor necrosis factor-alpha in endothelial cells, J. Pharmacol. Exp. Ther., 305, 573, 10.1124/jpet.102.047894
Gertzberg, 2004, NAD(P)H oxidase mediates the endothelial barrier dysfunction induced by TNF-alpha, Am. J. Phys. Lung Cell. Mol. Phys., 286, L37
Li, 2005, Acute tumor necrosis factor alpha signaling via NADPH oxidase in microvascular endothelial cells: role of p47phox phosphorylation and binding to TRAF4, Mol. Cell. Biol., 25, 2320, 10.1128/MCB.25.6.2320-2330.2005
Souza, 2009, Angiotensin II modulates CD40 expression in vascular smooth muscle cells, Clin. Sci. (Lond.), 116, 423, 10.1042/CS20080155
Hernández-Presa, 1997, Angiotensin-converting enzyme inhibition prevents arterial nuclear factor-kappa B activation, monocyte chemoattractant protein-1 expression, and macrophage infiltration in a rabbit model of early accelerated atherosclerosis, Circulation, 95, 1532, 10.1161/01.CIR.95.6.1532
Hernández-Presa, 1998, ACE inhibitor quinapril reduces the arterial expression of NF-kappaB-dependent proinflammatory factors but not of collagen I in a rabbit model of atherosclerosis, Am. J. Pathol., 153, 1825, 10.1016/S0002-9440(10)65697-0
Muller, 2000, Effect of bosentan on NF-kappaB, inflammation, and tissue factor in angiotensin II-induced end-organ damage, Hypertension, 36, 282, 10.1161/01.HYP.36.2.282
Libby, 2000, Coronary artery injury and the biology of atherosclerosis: inflammation, thrombosis, and stabilization, Am. J. Cardiol., 86, 3J, 10.1016/S0002-9149(00)01339-4
Costanzo, 2003, Endothelial activation by angiotensin II through NFkappaB and p38 pathways: involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin, J. Cell. Physiol., 195, 402, 10.1002/jcp.10191
Liu, 2004, Reoxygenation-induced constriction in murine coronary arteries: the role of endothelial NADPH oxidase (gp91phox) and intracellular superoxide, J. Biol. Chem., 279, 24493, 10.1074/jbc.M402920200
Pastore, 1999, Angiotensin II stimulates intercellular adhesion molecule-1 (ICAM-1) expression by human vascular endothelial cells and increases soluble ICAM-1 release in vivo, Circulation, 100, 1646, 10.1161/01.CIR.100.15.1646
Hwang, 2003, Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion, J. Biol. Chem., 278, 47291, 10.1074/jbc.M305150200
Cho, 2016, Lipopolysaccharide induces ICAM-1 expression via a c-Src/NADPH oxidase/ROS-dependent NF-κB pathway in human pulmonary alveolar epithelial cells, Am. J. Phys. Lung Cell. Mol. Phys., 310, L639
Lee, 2012, Role of TLR4/NADPH oxidase/ROS-activated p38 MAPK in VCAM-1 expression induced by lipopolysaccharide in human renal mesangial cells, Cell Commun. Signal, 10, 33, 10.1186/1478-811X-10-33
Kunsch, 1999, Oxidative stress as a regulator of gene expression in the vasculature, Circ. Res., 85, 753, 10.1161/01.RES.85.8.753
Cominacini, 2000, Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species, J. Biol. Chem., 275, 12633, 10.1074/jbc.275.17.12633
Cominacini, 1997, Antioxidants inhibit the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 induced by oxidized LDL on human umbilical vein endothelial cells, Free Radic. Biol. Med., 22, 117, 10.1016/S0891-5849(96)00271-7
Khan, 1995, Modified low density lipoprotein and its constituents augment cytokine-activated vascular cell adhesion molecule-1 gene expression in human vascular endothelial cells, J. Clin. Invest., 95, 1262, 10.1172/JCI117776
Chen, 2011, Inhibitory effect of delphinidin on monocyte-endothelial cell adhesion induced by oxidized low-density lipoprotein via ROS/p38MAPK/NF-κB pathway, Cell Biochem. Biophys., 61, 337, 10.1007/s12013-011-9216-2
Stielow, 2006, Novel Nox inhibitor of oxLDL-induced reactive oxygen species formation in human endothelial cells, Biochem. Biophys. Res. Commun., 344, 200, 10.1016/j.bbrc.2006.03.114
Ylä-Herttuala, 1991, Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts, J. Clin. Invest., 87, 1146, 10.1172/JCI115111
Reilly, 2004, 12/15-Lipoxygenase activity mediates inflammatory monocyte/endothelial interactions and atherosclerosis in vivo, J. Biol. Chem., 279, 9440, 10.1074/jbc.M303857200
Wölle, 1996, Transient overexpression of human 15-lipoxygenase in aortic endothelial cells enhances tumor necrosis factor-induced vascular cell adhesion molecule-1 gene expression, Biochem. Biophys. Res. Commun., 220, 310, 10.1006/bbrc.1996.0402
Folcik, 1997, Cytokine modulation of LDL oxidation by activated human monocytes, Arterioscler. Thromb. Vasc. Biol., 17, 1954, 10.1161/01.ATV.17.10.1954
Sukhanov, 2015, Insulin-like growth factor I reduces lipid oxidation and foam cell formation via downregulation of 12/15-lipoxygenase, Atherosclerosis, 238, 313, 10.1016/j.atherosclerosis.2014.12.024
Gustavsson, 2010, Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia, PLoS One, 5, 10.1371/journal.pone.0012699
Gearing, 1993, Circulating adhesion molecules in disease, Immunol. Today, 14, 506, 10.1016/0167-5699(93)90267-O
Pigott, 1992, Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells, Biochem. Biophys. Res. Commun., 187, 584, 10.1016/0006-291X(92)91234-H
Marfella, 2000, Circulating adhesion molecules in humans: role of hyperglycemia and hyperinsulinemia, Circulation, 101, 2247, 10.1161/01.CIR.101.19.2247
Boulbou, 2005, Circulating adhesion molecules levels in type 2 diabetes mellitus and hypertension, Int. J. Cardiol., 98, 39, 10.1016/j.ijcard.2003.07.037
Jude, 2002, Circulating cellular adhesion molecules ICAM-1, VCAM-1, P- and E-selectin in the prediction of cardiovascular disease in diabetes mellitus, Eur. J. Intern. Med., 13, 185, 10.1016/S0953-6205(02)00014-6
Blankenberg, 2003, Adhesion molecules and atherosclerosis, Atherosclerosis, 170, 191, 10.1016/S0021-9150(03)00097-2
Song, 2007, Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women, Diabetes, 56, 1898, 10.2337/db07-0250
Shalia, 2009, Circulating levels of cell adhesion molecules in hypertension, Indian J. Clin. Biochem., 24, 388, 10.1007/s12291-009-0070-6
Vallance, 2001, Importance of asymmetrical dimethylarginine in cardiovascular risk, Lancet, 358, 2096, 10.1016/S0140-6736(01)07229-4
Bonetti, 2003, Endothelial dysfunction: a marker of atherosclerotic risk, Arterioscler. Thromb. Vasc. Biol., 23, 168, 10.1161/01.ATV.0000051384.43104.FC
Sena, 2013, Endothelial dysfunction - a major mediator of diabetic vascular disease, Biochim. Biophys. Acta, 1832, 2216, 10.1016/j.bbadis.2013.08.006
Dhananjayan, 2016, Endothelial dysfunction in type 2 diabetes mellitus, Indian J. Clin. Biochem., 31, 372, 10.1007/s12291-015-0516-y
Verma, 2002, Fundamentals of endothelial function for the clinical cardiologist, Circulation, 105, 546, 10.1161/hc0502.104540
Mombouli, 1999, Endothelial dysfunction: from physiology to therapy, J. Mol. Cell. Cardiol., 31, 61, 10.1006/jmcc.1998.0844
Furchgott, 1996, Albert Lasker medical research awards. The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide, JAMA, 276, 1186, 10.1001/jama.1996.03540140074032
De Caterina, 1995, Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines, Clin. Investig., 96, 60, 10.1172/JCI118074
Zeiher, 1995, Nitric oxide modulates the expression of monocyte chemoattractant protein 1 in cultured human endothelial cells, Circ. Res., 76, 980, 10.1161/01.RES.76.6.980
Moncada, 2006, Nitric oxide and the vascular endothelium, Handb. Exp. Pharmacol., 213, 10.1007/3-540-32967-6_7
Wilcox, 1997, Expression of multiple isoforms of nitric oxide synthase in normal and atherosclerotic vessels, Arterioscler. Thromb. Vasc. Biol., 17, 2479, 10.1161/01.ATV.17.11.2479
Federici, 2002, Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells, Circulation, 106, 466, 10.1161/01.CIR.0000023043.02648.51
Siragusa, 2016, The eNOS signalosome and its link to endothelial dysfunction, Pflugers Arch., 468, 1125, 10.1007/s00424-016-1839-0
Kennard, 2016, TNFα reduces eNOS activity in endothelial cells through serine 116 phosphorylation and Pin1 binding: confirmation of a direct, inhibitory interaction of Pin1 with eNOS, Vasc. Pharmacol., 81, 61, 10.1016/j.vph.2016.04.003
Kojda, 1999, Interactions between NO and reactive oxygen species: pathophysiological importance in atherosclerosis, hypertension, diabetes and heart failure, Cardiovasc. Res., 43, 562, 10.1016/S0008-6363(99)00169-8
Widder, 2009, Attenuation of angiotensin II-induced vascular dysfunction and hypertension by overexpression of Thioredoxin 2, Hypertension, 54, 338, 10.1161/HYPERTENSIONAHA.108.127928
Vecchione, 2009, Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/betaPIX/Rac-1 pathway, Hypertension, 54, 1028, 10.1161/HYPERTENSIONAHA.109.136572
Dharmashankar, 2010, Vascular endothelial function and hypertension: insights and directions, Curr. Hypertens. Rep., 12, 448, 10.1007/s11906-010-0150-2
Magen, 2010, Potential link between C3a, C3b and endothelial progenitor cells in resistant hypertension, Am. J. Med. Sci., 339, 415, 10.1097/MAJ.0b013e3181d7d496
Hage, 2010, C-reactive protein-mediated vascular injury requires complement, Arterioscler. Thromb. Vasc. Biol., 30, 1189, 10.1161/ATVBAHA.110.205377
Ghiadoni, 2000, Mental stress induces transient endothelial dysfunction in humans, Circulation, 102, 2473, 10.1161/01.CIR.102.20.2473
Black, 2002, Stress, inflammation and cardiovascular disease, J. Psychosom. Res., 52, 1, 10.1016/S0022-3999(01)00302-6
García-Bueno, 2008, Stress as a neuroinflammatory condition in brain: damaging and protective mechanisms, Neurosci. Biobehav. Rev., 32, 1136, 10.1016/j.neubiorev.2008.04.001
Breitschopf, 2001, Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism, FEBS Lett., 493, 21, 10.1016/S0014-5793(01)02272-4
Pu, 2008, HDL slowing down endothelial progenitor cells senescence: a novel anti-atherogenic property of HDL, Med. Hypotheses, 70, 338, 10.1016/j.mehy.2007.05.025
Kujoth, 2005, Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging, Science, 309, 481, 10.1126/science.1112125
Matsushita, 2001, eNOS activity is reduced in senescent human endothelial cells: preservation by hTERT immortalization, Circ. Res., 89, 793, 10.1161/hh2101.098443
Kurosu, 2005, Suppression of aging in mice by the hormone Klotho, Science, 309, 1829, 10.1126/science.1112766
Schächinger, 2000, Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease, Circulation, 101, 1899, 10.1161/01.CIR.101.16.1899
Arrebola-Moreno, 2012, Noninvasive assessment of endothelial function in clinical practice, Rev. Esp. Cardiol. (Engl. Ed)., 65, 80, 10.1016/j.recesp.2011.09.012
Daiber, 2016, Targeting vascular (endothelial) dysfunction, Br. J. Pharmacol.
Hirata, 2010, Diagnosis and treatment of endothelial dysfunction in cardiovascular disease, Int. Heart J., 51, 1, 10.1536/ihj.51.1
Avogaro, 2011, Endothelial dysfunction in diabetes: the role of reparatory mechanisms, Diabetes Care, 34, S285, 10.2337/dc11-s239
Xu, 2016, miR-143 is involved in endothelial cell dysfunction through suppression of glycolysis and correlated with atherosclerotic plaques formation, Eur. Rev. Med. Pharmacol. Sci., 20, 4063
Liu, 2016, microRNA-181a is upregulated in human atherosclerosis plaques and involves in the oxidative stress-induced endothelial cell dysfunction through direct targeting Bcl-2, Eur. Rev. Med. Pharmacol. Sci., 20, 3092
Li, 2016, Inhibition of aberrant microRNA-133a expression in endothelial cells by statin prevents endothelial dysfunction by targeting GTP cyclohydrolase 1 in vivo, Circulation, 10.1161/CIRCULATIONAHA.116.017949
Loyer, 2014, Inhibition of microRNA-92a prevents endothelial dysfunction and atherosclerosis in mice, Circ. Res., 114, 434, 10.1161/CIRCRESAHA.114.302213
Daniel, 2014, Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury, Cardiovasc. Res., 103, 564, 10.1093/cvr/cvu162
Chen, 2008, Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription, J. Biol. Chem., 283, 16293, 10.1074/jbc.M801803200
Zhang, 2011, AMP-activated protein kinase suppresses endothelial cell inflammation through phosphorylation of transcriptional coactivator p300, Arterioscler. Thromb. Vasc. Biol., 31, 2897, 10.1161/ATVBAHA.111.237453
Hyndman, 2014, Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3, Am. J. Physiol. Heart Circ. Physiol., 307, H803, 10.1152/ajpheart.00243.2014
Pan, 2016, Resveratrol protects against TNF-α-induced injury in human umbilical endothelial cells through promoting Sirtuin-1-induced repression of NF-KB and p38 MAPK, PLoS One, 11, 10.1371/journal.pone.0147034
Balestrieri, 2015, Sirtuin 6 expression and inflammatory activity in diabetic atherosclerotic plaques: effects of incretin treatment, Diabetes, 64, 1395, 10.2337/db14-1149
Zhang, 2016, Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice, Sci Rep., 6, 23912, 10.1038/srep23912
Esposito, 2004, Effect of a mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial, JAMA, 292, 1440, 10.1001/jama.292.12.1440
Rallidis, 2009, Close adherence to a Mediterranean diet improves endothelialfunction in subjects with abdominal obesity, Am. J. Clin. Nutr., 90, 263, 10.3945/ajcn.2008.27290
Marin, 2011, Mediterranean diet reduces endothelial damage and improves the regenerative capacity of endothelium, Am. J. Clin. Nutr., 93, 267, 10.3945/ajcn.110.006866
Zamora-Ros, 2013, Mediterranean diet and non enzymatic antioxidant capacity in the PREDIMED study: evidence for a mechanism of antioxidant tuning, Nutr. Metab. Cardiovasc. Dis., 23, 1167, 10.1016/j.numecd.2012.12.008
Vilahur, 2015, Polyphenol-enriched diet prevents coronary endothelial dysfunctionby activating the Akt/eNOS pathway, Rev. Esp. Cardiol. (Engl. Ed.), 68, 216, 10.1016/j.recesp.2014.03.023
Scoditti, 2012, Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelialcells: a potentially protective mechanism in atherosclerotic vascular disease and cancer, Arch. Biochem. Biophys., 527, 81, 10.1016/j.abb.2012.05.003
Nascimento, 2006, Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide, Proc. Natl. Acad. Sci. U. S. A., 103, 218, 10.1073/pnas.0509779103