Oxidative stress and metabolic disorders: Pathogenesis and therapeutic strategies
Tóm tắt
Từ khóa
Tài liệu tham khảo
Braun, 2011, The link between the metabolic syndrome and cancer, Int. J. Biol. Sci., 7, 1003, 10.7150/ijbs.7.1003
NHLBI Website: http://www.nhlbi.nih.gov/health/health-topics/topics/ms (accessed Jan 14, 2016).
WHO website: http://www.who.int/mediacentre/factsheets/fs311/en/ (accessed Jan 14, 2016).
Ng, 2014, Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the global burden of disease study 2013, Lancet, 384, 766, 10.1016/S0140-6736(14)60460-8
Ford, 2002, Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey, J. Am. Med. Assoc., 287, 356, 10.1001/jama.287.3.356
Calle, 2003, Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults, N. Engl. J. Med., 348, 1625, 10.1056/NEJMoa021423
Gallagher, 2010, 579
Gallagher, 2010, The pathway from diabetes and obesity to cancer, on the route to targeted therapy, Endocr. Pract., 16, 864, 10.4158/EP10098.RA
Gandhi, 2012, Assessment of DNA damage in obese individuals, Res. J. Biol., 2, 37
Al-Aubaidy, 2011, Oxidative DNA damage and obesity in type-2 diabetes mellitus, Eur. J. Endocrinol., 164, 899, 10.1530/EJE-11-0053
Reuter, 2010, Oxidative stress, inflammation, and cancer: how are they linked?, Free Radic. Biol. Med., 49, 1603, 10.1016/j.freeradbiomed.2010.09.006
Furukawa, 2004, Increased oxidative stress in obesity and its impact on metabolic syndrome, J. Clin. Invest., 114, 1752, 10.1172/JCI21625
Hansel, 2004, Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity, J. Clin. Endocrinol. Metab., 89, 4963, 10.1210/jc.2004-0305
Holvoet, 2008, Relations between metabolic syndrome, oxidative stress and inflammation and cardiovascular disease, Verh. K. Acad. Geneeskd. Belg., 70, 193
Marques de Mattos, 2012, Protein oxidative stress and dyslipidemia in dialysis patients, Ther. Apher. Dial., 16, 68, 10.1111/j.1744-9987.2011.01009.x
Zelzer, 2011, High density lipoprotein cholesterol level is a robust predictor of lipid peroxidation irrespective of gender, age, obesity, and inflammatory or metabolic biomarkers, Clin. Chim. Acta, 412, 1345, 10.1016/j.cca.2011.03.031
Holvoet, 2004, The metabolic syndrome, circulating oxidized LDL, and risk of myocardial infarction in well-functioning elderly people in the health, aging, and body composition cohort, Diabetes, 53, 1068, 10.2337/diabetes.53.4.1068
Fortuño, 2006, Phagocytic NADPH oxidase overactivity underlies oxidative stress in metabolic syndrome, Diabetes, 55, 209, 10.2337/diabetes.55.01.06.db05-0751
Murphy, 2009, How mitochondria produce reactive oxygen species, Biochem. J., 417, 1, 10.1042/BJ20081386
Hutcheson, 2012, The metabolic syndrome, oxidative stress, environment, and cardiovascular disease: the great exploration, Exp. Diabetes Res., 2012, 1, 10.1155/2012/271028
Davì, 1999, In vivo formation of 8-iso-prostaglandin f2 alpha and platelet activation in diabetes mellitus: effects of improved metabolic control and vitamin E supplementation, Circulation, 99, 224, 10.1161/01.CIR.99.2.224
Grattagliano, 2008, Oxidative stress-induced risk factors associated with the metabolic syndrome: a unifying hypothesis, J. Nutr. Biochem., 19, 491, 10.1016/j.jnutbio.2007.06.011
Yadav, 2015, Cysteinyl leukotrienes (CysLTs): role in obesity-induced asthma, Curr. Mol. Med., 15, 598, 10.2174/1566524015666150831130954
Jiang, 2011, Systemic upregulation of NADPH oxidase in diet-induced obesity in rats, Redox Rep., 16, 223, 10.1179/174329211X13049558293713
Beckman, 1996, Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly, Am. J. Physiol., 271, C1424, 10.1152/ajpcell.1996.271.5.C1424
Huang, 2005, Unraveling the links between diabetes, obesity, and cardiovascular disease, Circ. Res., 96, 1129, 10.1161/01.RES.0000170705.56583.45
Shishehbor, 2003, Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy, JAMA, 289, 1675, 10.1001/jama.289.13.1675
Ma, 2013, Obesity and risk of colorectal cancer: a systematic review of prospective studies, PLoS One, 8, 10.1371/journal.pone.0053916
Li, 2015, Relationship between body mass index and incidence of breast cancer, Int. J. Clin. Exp. Med., 8, 11549
De Pergola, 2013, Obesity as a major risk factor for cancer, J. Obes., 2013, 291546, 10.1155/2013/291546
van Kruijsdijk, 2009, Obesity and cancer: the role of dysfunctional adipose tissue, Cancer Epidemiol. Biomark. Prev., 18, 2569, 10.1158/1055-9965.EPI-09-0372
Fernández-Sánchez, 2011, Inflammation, oxidative stress, and obesity, Int. J. Mol. Sci., 12, 3117, 10.3390/ijms12053117
Khandrika, 2009, Oxidative stress in prostate cancer, Cancer Lett., 282, 125, 10.1016/j.canlet.2008.12.011
Grek, 2010, Redox metabolism and malignancy, Curr. Opin. Pharmacol., 10, 362, 10.1016/j.coph.2010.05.003
Kumar, 2008, Oxidative stress is B inherent in prostate cancer cells and is required for aggressive phenotype, Cancer Res., 68, 1777, 10.1158/0008-5472.CAN-07-5259
Dröse, 2012, Molecular mechanisms of superoxide production by the mitochondrial respiratory chain, 145
Martindale, 2002, Cellular response to oxidative stress: signaling for suicide and survival, J. Cell. Physiol., 192, 1, 10.1002/jcp.10119
Gorrini, 2013, Modulation of oxidative stress as an anticancer strategy, Nat. Rev. Drug Discov., 12, 931, 10.1038/nrd4002
Dupont, 2013, Obesity leads to higher risk of sperm DNA damage in infertile patients, Asian J. Androl., 15, 622, 10.1038/aja.2013.65
Nakabeppu, 2014, Cellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cells, Int. J. Mol. Sci., 15, 12543, 10.3390/ijms150712543
Toyokuni, 1995, Persistent oxidative stress in cancer, FEBS Lett., 358, 1, 10.1016/0014-5793(94)01368-B
Dahl, 2011, Advances in DNA methylation: 5-hydroxymethylcytosine revisited, Clin. Chim. Acta, 412, 831, 10.1016/j.cca.2011.02.013
Belot, 2013, CpG methylation changes within the IL2RA promoter in type 1 diabetes of childhood onset, PLoS One, 8, 10.1371/journal.pone.0068093
Ling, 2008, Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion, Diabetologia, 51, 615, 10.1007/s00125-007-0916-5
Hall, 2013, DNA methylation of the glucagon-like peptide 1 receptor (GLP1R) in human pancreatic islets, BMC Med. Genet., 14, 76, 10.1186/1471-2350-14-76
Campbell, 2013, Altered histone modifications in cancer, Adv. Exp. Med. Biol., 754, 81, 10.1007/978-1-4419-9967-2_4
Sawan, 2010, Histone modifications and cancer, Adv. Genet., 70, 57, 10.1016/B978-0-12-380866-0.60003-4
Monks, 2006, Ros-induced histone modifications and their role in cell survival and cell death, Drug Metab. Rev., 38, 755, 10.1080/03602530600959649
Afanas'ev, 2013, New nucleophilic mechanisms of ros-dependent epigenetic modifications: comparison of aging and cancer, Aging Dis., 5, 52, 10.14336/AD.2014.050052
Yahagi, 2004, p53 involvement in the pathogenesis of fatty liver disease, J. Biol. Chem., 279, 20571, 10.1074/jbc.M400884200
Tyner, 2002, p53 mutant mice that display early ageing-associated phenotypes, Nature, 415, 45, 10.1038/415045a
McNaughton, 2013, ‘Diabesity’ down under: overweight and obesity as cultural signifiers for type 2 diabetes mellitus, Crit. Public Health, 23, 274, 10.1080/09581596.2013.766671
Kaur, 2014, A comprehensive review on metabolic syndrome, Cardiol. Res. Pract., 2014, 943162, 10.1155/2014/943162
Warolin, 2013, The relationship of oxidative stress, adiposity and metabolic risk factors in healthy Black and White American youth, Pediatr. Obes., 9, 43, 10.1111/j.2047-6310.2012.00135.x
Karaouzene, 2011, Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young men, Nutr. Metab. Cardiovasc. Dis., 21, 792, 10.1016/j.numecd.2010.02.007
Savini, 2013, Obesity-associated oxidative stress: strategies finalized to improve redox state, Int. J. Mol. Sci., 14, 10497, 10.3390/ijms140510497
Codoñer-Franch, 2012, Elevated advanced oxidation protein products (AOPPs) indicate metabolic risk in severely obese children, Nutr. Metab. Cardiovasc. Dis., 22, 237, 10.1016/j.numecd.2010.06.002
Sies, 2005, Nutritional, dietary and postprandial oxidative stress, J. Nutr., 135, 969, 10.1093/jn/135.5.969
Dandona, 2010, Macronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance, Exp. Mol. Med., 42, 245, 10.3858/emm.2010.42.4.033
Lee, 2009, Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion, J. Biol. Chem., 284, 10601, 10.1074/jbc.M808742200
Tormos, 2011, Mitochondrial complex III ROS regulate adipocyte differentiation, Cell Metab., 14, 537, 10.1016/j.cmet.2011.08.007
Fajas, 2003, Adipogenesis: a cross-talk between cell proliferation and cell differentiation, Ann. Med., 35, 79, 10.1080/07853890310009999
Schröder, 2009, Nox4 acts as a switch between differentiation and proliferation in preadipocytes, Arterioscler. Thromb. Vasc. Biol., 29, 239, 10.1161/ATVBAHA.108.174219
Kanda, 2011, Reactive oxygen species mediate adipocyte differentiation in mesenchymal stem cells, Life Sci., 89, 250, 10.1016/j.lfs.2011.06.007
Monteiro, 2010, Chronic inflammation in obesity and the metabolic syndrome, Mediat. Inflamm., 2010, 289645, 10.1155/2010/289645
Malandrino, 2015, Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation, Am. J. Physiol. Endocrinol. Metab., 308, E756, 10.1152/ajpendo.00362.2014
Inoue, 2008, Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance, J. Biol. Chem., 283, 21220, 10.1074/jbc.M801824200
Macleod, 2008, The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system, Nat. Rev. Cancer, 8, 769, 10.1038/nrc2504
Fajas, 2002, E2Fs regulate adipocyte differentiation, Dev. Cell, 3, 39, 10.1016/S1534-5807(02)00190-9
Richon, 1997, Regulation and expression of retinoblastoma proteins p107 and p130 during 3T3-L1 adipocyte differentiation, J. Biol. Chem., 272, 10117, 10.1074/jbc.272.15.10117
Wang, 2015, Mitochondrial reactive oxygen species regulate adipocyte differentiation of mesenchymal stem cells in hematopoietic stress induced by arabinosylcytosine, PLoS One, 10
Patel, 2007, Prolonged reactive oxygen species generation and nuclear factor-kappaB activation after a high-fat, high-carbohydrate meal in the obese, J. Clin. Endocrinol. Metab., 92, 4476, 10.1210/jc.2007-0778
Bondia-Pons, 2012, Oxidative stress and inflammation interactions in human obesity, J. Physiol. Biochem., 68, 701, 10.1007/s13105-012-0154-2
Chrysohoou, 2007, The implication of obesity on total antioxidant capacity in apparently healthy men and women: the ATTICA study, Nutr. Metab. Cardiovasc. Dis., 17, 590, 10.1016/j.numecd.2006.05.007
Bryan, 2013, Redox-inflammatory synergy in the metabolic syndrome, Can. J. Physiol. Pharmacol., 91, 22, 10.1139/cjpp-2012-0295
Dandona, 2005, Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation, Circulation, 111, 1448, 10.1161/01.CIR.0000158483.13093.9D
Houstis, 2006, Reactive oxygen species have a causal role in multiple forms of insulin resistance, Nature, 440, 944, 10.1038/nature04634
Matsuzawa-Nagata, 2008, Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity, Metabolism, 57, 1071, 10.1016/j.metabol.2008.03.010
Kunitomo, 2008, Beneficial effect of coenzyme Q10 on increased oxidative and nitrative stress and inflammation and individual metabolic components developing in a rat model of metabolic syndrome, J. Pharmacol. Sci., 107, 128, 10.1254/jphs.FP0072365
Boden, 1997, Role of fatty acids in the pathogenesis of insulin resistance and NIDDM, Diabetes, 46, 3, 10.2337/diab.46.1.3
Cohen, 1996, Modulation of insulin activities by leptin, Science, 274, 1185, 10.1126/science.274.5290.1185
Wojtczak, 1993, Effect of fatty acids on energy coupling processes in mitochondria, Biochim. Biophys. Acta, 1183, 41, 10.1016/0005-2728(93)90004-Y
Lenzen, 1996, Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues, Free Radic. Biol. Med., 20, 463, 10.1016/0891-5849(96)02051-5
Swenne, 1983, Effects of aging on the regenerative capacity of the pancreatic B-cell of the rat, Diabetes, 32, 14, 10.2337/diab.32.1.14
Mares, 1993, Expression of certain antiproliferative and growth-related genes in isolated mouse pancreatic islets: analysis by polymerase chain reaction, Diabète Métab., 19, 315
Chetboun, 2012, Maintenance of redox state and pancreatic beta-cell function: role of leptin and adiponectin, J. Cell. Biochem., 113, 1966, 10.1002/jcb.24065
Rane, 1999, Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia, Nat. Genet., 22, 44, 10.1038/8751
Cozar-Castellano, 2004, Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1, Diabetes, 53, 149, 10.2337/diabetes.53.1.149
Fatrai, 2006, Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity, Diabetes, 55, 318, 10.2337/diabetes.55.02.06.db05-0757
Fiaschi-Taesch, 2013, Human pancreatic β-cell G1/S molecule cell cycle atlas, Diabetes, 62, 2450, 10.2337/db12-0777
Sciacovelli, 2014, The metabolic alterations of cancer cells, Methods Enzymol., 542, 1, 10.1016/B978-0-12-416618-9.00001-7
Ceriello, 1993, Diabetes mellitus and hypertension: the possible role of hyperglycaemia through oxidative stress, Diabetologia, 36, 265, 10.1007/BF00399961
Wolff, 1991, Protein glycation and oxidative stress in diabetes mellitus and ageing, Free Radic. Biol. Med., 10, 339, 10.1016/0891-5849(91)90040-A
Medema, 2000, AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1, Nature, 404, 782, 10.1038/35008115
Schmidt, 2002, Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D, Mol. Cell. Biol., 22, 7842, 10.1128/MCB.22.22.7842-7852.2002
Nakamura, 2000, Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN, Mol. Cell. Biol., 20, 8969, 10.1128/MCB.20.23.8969-8982.2000
Furukawa-Hibi, 2002, FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress, J. Biol. Chem., 277, 26729, 10.1074/jbc.C200256200
Szczepaniak, 2003, Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging, Magn. Reson. Med., 49, 417, 10.1002/mrm.10372
Ilkun, 2013, Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies, Curr. Pharm. Des., 19, 4806, 10.2174/1381612811319270003
Singh, 2002, Pathogenesis of atherosclerosis: a multifactorial process, Exp. Clin. Cardiol., 7, 40
Aprahamia, 2011, Adiponectin in cardiovascular inflammation and obesity, Int. J. Inflamm., 2011, 376909
Kohli, 2013, Curcumin suppresses gelatinase B mediated norepinephrine induced stress in H9c2 cardiomyocytes, PLoS One, 8, 10.1371/journal.pone.0076519
Atale, 2013, Cardioprotective role of Syzygium cumini against glucose-induced oxidative stress in H9C2 cardiac myocytes, Cardiovasc. Toxicol., 13, 278, 10.1007/s12012-013-9207-1
Jain, 2015, An assessment of norepinephrine mediated hypertrophy to apoptosis transition in cardiac cells: a signal for cell death, Chem. Biol. Interact., 225, 54, 10.1016/j.cbi.2014.11.017
Karasu, 2010, Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment, Open Cardiovasc. Med. J., 4, 240, 10.2174/1874192401004010240
Giacco, 2010, Oxidative stress and diabetic complications, Circ. Res., 107, 1058, 10.1161/CIRCRESAHA.110.223545
Yamagishi, 2012, Role of advanced glycation end products (AGEs) and oxidative stress in vascular complications in diabetes, Biochim. Biophys. Acta, 1820, 663, 10.1016/j.bbagen.2011.03.014
Bitar, 2005, Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes, Eur. J. Pharmacol., 511, 53, 10.1016/j.ejphar.2005.01.014
Pechánová, 2015, Cardiac NO signalling in the metabolic syndrome, Br. J. Pharmacol., 172, 1415, 10.1111/bph.12960
Endemann, 2004, Nitric oxide, oxidative excess, and vascular complications of diabetes mellitus, Curr. Hypertens. Rep., 6, 85, 10.1007/s11906-004-0081-x
Ndisang, 2014, Oxidative stress and inflammation in obesity, diabetes, hypertension, and related cardiometabolic complications, Oxidative Med. Cell. Longev., 2014, 506948, 10.1155/2014/506948
Ho, 2013, Biological markers of oxidative stress: applications to cardiovascular research and practice, Redox Biol., 1, 483, 10.1016/j.redox.2013.07.006
Mesquita, 2010, Reactive oxygen species mediate mitogenic growth factor signaling pathways in human leiomyoma smooth muscle cells, Biol. Reprod., 82, 341, 10.1095/biolreprod.108.075887
Li, 1997, Differential effect of hydrogen peroxide and superoxide anion on apoptosis and proliferation of vascular smooth muscle cells, Circulation, 96, 3602, 10.1161/01.CIR.96.10.3602
Rao, 1992, Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression, Circ. Res., 70, 593, 10.1161/01.RES.70.3.593
Paravicini, 2006, Redox signaling in hypertension, Cardiovasc. Res., 71, 247, 10.1016/j.cardiores.2006.05.001
Fu, 2007, Non-genomic effects of 17beta-estradiol in activation of the ERK1/ERK2 pathway induces cell proliferation through upregulation of cyclin D1 expression in bovine artery endothelial cells, Gynecol. Endocrinol., 23, 131, 10.1080/09513590601181457
Burch, 2005, Redox regulation of cell-cycle re-entry: cyclin D1 as a primary target for the mitogenic effects of reactive oxygen and nitrogen species, Antioxid. Redox Signal., 7, 741, 10.1089/ars.2005.7.741
He, 2003, Redox factor-1 contributes to the regulation of progression from G0/G1 to S by PDGF in vascular smooth muscle cells, Am. J. Physiol. Heart Circ. Physiol., 285, H804, 10.1152/ajpheart.01080.2002
Qin, 2014, Inhibition of smooth muscle cell proliferation by ezetimibe via the cyclin D1-MAPK pathway, J. Pharmacol. Sci., 125, 283, 10.1254/jphs.13239FP
Park, 2015, Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells, Exp. Mol. Med., 47, 10.1038/emm.2014.113
Mathew, 2014, Involvement of the antioxidant effect and anti-inflammatory response in butyrate-inhibited vascular smooth muscle cell proliferation, Pharm. Basel Switz., 7, 1008
Bigornia, 2010, Long-term successful weight loss improves vascular endothelial function in severely obese individuals, Obesity (Silver Spring), 18, 754, 10.1038/oby.2009.482
Sofi, 2010, Accruing evidence on benefits of adherence to the Mediterranean diet on health: An updated systematic review and meta-analysis, Am. J. Clin. Nutr., 92, 1189, 10.3945/ajcn.2010.29673
Arora, 2013, Probiotics: interaction with gut microbiome and antiobesity potential, Nutrition, 29, 591, 10.1016/j.nut.2012.07.017
Mente, 2009, A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease, Arch. Intern. Med., 169, 659, 10.1001/archinternmed.2009.38
González-Castejón, 2011, Dietary phytochemicals and their potential effects on obesity: a review, Pharmacol. Res., 64, 438, 10.1016/j.phrs.2011.07.004
Calder, 2011, Dietary factors and low-grade inflammation in relation to overweight and obesity, Br. J. Nutr., 106, S5, 10.1017/S0007114511005460
Bjelakovic, 2012, Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases, Cochrane Database Syst. Rev., 3, 10.1002/14651858.CD007176.pub2
Lin, 2009, Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial, J. Natl. Cancer Inst., 10, 14, 10.1093/jnci/djn438
Sinha, 2014, Antidiabetic potential of herbal plants and polyherbal formulation, Int. J. Phytother. Res., 4, 28
Scheele, 2009, ROS and myokines promote muscle adaptation to exercise, Trends Endocrinol. Metab., 20, 95, 10.1016/j.tem.2008.12.002
Kramer, 2007, Exercise, MAPK, and NF-κB signaling in skeletal muscle, J. Appl. Physiol., 103, 388, 10.1152/japplphysiol.00085.2007
Cairns, 2013, Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities, Cancer Discov., 3, 730, 10.1158/2159-8290.CD-13-0083
Shrotriya, 2015, Grape seed extract targets mitochondrial electron transport chain complex III and induces oxidative and metabolic stress leading to cytoprotective autophagy and apoptotic death in human head and neck cancer cells, Mol. Carcinog., 54, 1734, 10.1002/mc.22246
Kim, 2015, Cancer metabolism: strategic diversion from targeting cancer drivers to targeting cancer suppliers, Biomol. Ther., 23, 99, 10.4062/biomolther.2015.013
Rysman, 2010, De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation, Cancer Res., 70, 8117, 10.1158/0008-5472.CAN-09-3871
Chen, 2012, Prevention of obesity-associated colon cancer by (−)-epigallocatechin-3 gallate and curcumin, Trans. Gastrointest. Cancer, 1, 243
Lee, 2012, Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer, Dig. Liver Dis., 44, 1042, 10.1016/j.dld.2012.06.007
Kim, 2015, Inhibitory effect of metformin therapy on the incidence of colorectal advanced adenomas in patients with diabetes, Intest. Res., 13, 145, 10.5217/ir.2015.13.2.145
Provinciali, 2015, Metformin: risk–benefit profile with a focus on cancer, Expert Opin. Drug Saf., 14, 1, 10.1517/14740338.2015.1084289
Belda-Iniesta, 2011, Metformin: a new option in cancer treatment, Clin. Transl. Oncol., 13, 363, 10.1007/s12094-011-0669-y
Lonardo, 2013, Metformin targets the metabolic achilles heel of human pancreatic cancer stem cells, PLoS One, 8, 10.1371/journal.pone.0076518
Guppy, 2011, Anticancer effects of metformin and its potential use as a therapeutic agent for breast cancer, Future Oncol., 7, 727, 10.2217/fon.11.49
Quinn, 2013, Repositioning metformin for cancer prevention and treatment, Trends Endocrinol. Metab., 24, 469, 10.1016/j.tem.2013.05.004
Malazy, 2015, Targeting metabolic disorders by natural products, J. Diabetes Metab. Disord., 14, 57, 10.1186/s40200-015-0184-8
Eddouks, 2012, Medicinal plants in the prevention and treatment of chronic diseases, Evid. Based Complement. Alternat. Med., 2012, 1
Pandey, 2009, Plant polyphenols as dietary antioxidants in human health and disease, Oxidative Med. Cell. Longev., 2, 270, 10.4161/oxim.2.5.9498
Parasuraman, 2014, Polyherbal formulation: concept of Ayurveda, Pharmacogn. Rev., 8, 73, 10.4103/0973-7847.134229
Saxena, 2013, Phytochemistry of medicinal plants, J. Pharmacogn. Phytochem., 1, 168