Overexpression of transforming growth factor‐β3 immunohistochemical staining in extramammary Paget's disease, but downregulated expression in Bowen's disease

International Journal of Dermatology - Tập 40 Số 4 - Trang 262-267 - 2001
Tamihiro Kawakami1, Yoshinao Soma1, M. Mizoguchi1, Ryuzo Saito2
1From the Department of Dermatology, St. Marianna University School of Medicine, Kanagawa and
2Second Department of Dermatology, Toho University School of Medicine, Tokyo, Japan

Tóm tắt

AbstractBackground  The role of transforming growth factor‐β (TGF‐β) in carcinogenesis is complex, with some reports indicating a tumor inhibition role and others indicating a tumor promotion role. In particular, TGF‐β3 is thought to play a key role in controlling epithelial homeostasis. Immunopositive p53 has been demonstrated in a variety of human malignant tumors and its role in oncogenesis and tumor progression is thought to be important. Extramammary Paget's disease (EPD) and Bowen's disease are skin cancers of unknown histogenesis.Objective  To clarify the role of TGF‐β3 and p53 in EPD and Bowen's disease and to better understand the origin of these disorders.Methods  Specimens were obtained from 12 patients with EPD and 12 patients with Bowen's disease seen at our clinic between 1993 and 2000. TGF‐β3 and p53 immunohistochemical staining was performed.Results  In three of the 12 EPD patients and five of the 12 Bowen's disease patients, positive p53 staining was detected. In contrast, TGF‐β3 overexpression was detected in all EPD patients, whereas downregulated TGF‐β3 expression was detected in all Bowen's disease patients.Conclusions  The present data suggest different roles for TGF‐β3 in abnormal epidermal cells in EPD and Bowen's disease. Thus, TGF‐β3 expression may be modulated differently via a p53‐dependent or ‐independent pathway in the pathogenesis of EPD and Bowen's disease. Moreover, high TGF‐β expression appears to be a useful indicator of tumor activity in EPD.

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International Journal of Dermatology

Tập 40 Số 4

262-267

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