Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions

Feige U, Polla BS: Heat shock proteins: the hsp70 family. Experientia 50: 979–986, 1994

Little E, Ramakrishnan M, Roy B, Gazit G, Lee AS: The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. Crit Rev Eukaryot Gene Expr 4: 1–18, 1994

Haas IG: Bip (GRP78), an essential hsp70 resident protein in the endoplasmic reticulum. Experientia 50: 1012–1020, 1994

Munro S, Pelham HRB: An Hsp70-like protein in the ER: identity with the 78 kd glucose regulated protein and immunoglobulin heavy chain binding proteins. Cell 46: 291–300, 1986

Lee AS: Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells. Trends Biochem 12: 20–23, 1987

Dorner AJ, Wasley LC, Kaufman RJ: Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels. Proc Natl Acad Sci USA 87: 7429–7432, 1990

Rothman JE: Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells. Cell 59: 591–601, 1989

Haas IG: BiP - a heat shock protein involved in immunoglobulin heavy chain assembly. Curr Topics Microbiol Immun 167: 71–82, 1991

Gething M-J, Sambrook J: Protein folding in the cell. Nature 355: 33–45, 1992

Kuznetsov G, Chen LB, Nigam SK: Multiple molecular chaperones complex with misfolded large oligomeric glycoproteins in the endoplasmic reticulum. J Biol Chem 272: 3057–3063, 1997

Gething M-J, McCammon K, Sambrook J: Expression of wildtype and mutant forms of influenza hemagglutinin: The role of folding in intracellular transport. Cell 46: 939–950, 1986

Silva AMD, Balch WE, Helenius A: Quality control in the endoplasmic reticulum: folding of vesicular stomatitis virus G protein in cells in vitro. J Cell Biol 111: 857–866, 1990

Vogel JP, Misra LM, Rose MD: Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast. J Cell Biol 110: 1885–1895, 1990

Nicchitta CV, Blobel G: Luminal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation. Cell 73: 989–998, 1993

Lyman SK, Schekman R: Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP. Cell 88: 85–96, 1997

Knittler MR, Dirks S, Haas IG: Molecular chaperones involved in protein degradation in the endoplasmic reticulum: quantitative interaction of the heat shock cognate protein BiP with partially folded immunoglobulin light chains that are degraded in the endoplasmic reticulum. Proc Natl Acad Sci USA 92: 1764-1768, 1995

Lee AS, Delegeane AM, Baker V, Chow PC: Transcriptional regulation of two genes specifically induced by glucose starvation in a hamster mutant fibroblast cell line. J Biol Chem 258: 597–603, 1983

Lee AS: Mammalian stress response: induction of the glucose regulated protein family. Curr Opin Cell Biol 4: 267–273, 1992

Resendez EJ, Attenello JW, Grafsky A, Chang CS, Lee AS: Calcium ionophore A23187 induces expression of glucoseregulated genes and their heterologous fusion genes. Mol Cell Biol 5: 1212–1219, 1985

Watowich SS, Morimoto RI: Complex regulation of heat shock and glucose-responsive genes in human cells. Mol Cell Biol 8: 393–405, 1988

Dorner AJ, Wasley LC, Raney P, Haugejorden S, Green M, Kaufman RJ: The stress response in Chinese hamster ovary cells. J Biol Chem 265: 22029–22033, 1990

Liu ES, Ou J-h, Lee AS: Brefeldin A as a regulator of grp78 gene expression in mammalian cells. J Biol Chem 267: 7128–7133, 1992

Price BD, Mannheim-Rodman LA, Calderwood SK: Brefeldin A, Thapsigargin, and AlF4-stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis. J Cell Physiol 152: 545–552, 1992

Shen J, Hughes C, Chao C, Cai J, Bartels C, Gessner T, Subjeck J: Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells. Proc Natl Acad Sci USA 84: 3278–3282, 1987

Hughes CS, Shen JW, Subjeck JR: Resistance to etoposide induced by three glucose-regulated stresses in Chinese hamster ovary cells. Cancer Res 49: 4452–4454, 1989

Vichi PJ, Tritton TR: Protection from adriamycin cytotoxicity in L1210 cells by brefeldin A. Cancer Res 53: 5237–5243, 1993

Chatterjee S, Cheng M-F, Berger SJ, Berger NA: Induction of Mr 78, 000 glucose-regulated stress protein in poly(adenosine diphosphate-ribose) polymerase-and nicotinamide adenine dinucleotide-deficient V79 cell lines and its relation to resistance to the topoisomerase II inhibitor etoposide. Cancer Res 54: 4405–4411, 1994

Chatterjee S, Cheng M-F, Berger RB, Berger SJ, Berger NA: Effect of inhibitors of poly(ADP-ribose) polymerase on the induction of GRP78 and subsequent development of resistance to etopiside. Cancer Res 55: 868–873, 1995

Yun J, Tomida A, Nagata K, Tsuruo T: Glucose-regulated stresses confer resistance to VP-16 in human cancer cells through a decreased expression of DNA topoisomerase II. Oncology Res 7: 583–590, 1995

Sacchi CM, Schiaffonati L: The effect of etopiside (VP-16) on mouse L fibroblasts: modulation of stress response, growth and apoptosis genes. Anticancer Res 16: 3659–3664, 1996

Sugawara S, Takeda K, Lee A, Dennert G: Suppression of stress protein GRP78 induction in tumor B/C10ME eliminates resistance to cell mediated cytotoxicity. Cancer Res 53: 6001–6005, 1993

Li L-J, Li X, Ferrario A, Rucker N, Liu ES, Wong S, Gomer CJ, Lee AS: Establishment of a Chinese hamster ovary cell line that expresses GRP78 antisense transcripts and suppresses A23187 induction of both GRP78 and GRP94. J Cell Physiol 153: 575–582, 1992

Koong AC, Chen EY, Lee AS, Brown JM, Giaccia AJ: Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction. Int J Radiat Oncol Biol Phys 28: 661–666, 1994

Chatterjee S, Hirota H, Belfi CA, Berger SJ, Berger NA: Hypersensitivity to DNA cross-linking agents associated with upregulation of glucose-regulated stress protein GRP78. Cancer Res 57: 5112–5116, 1997

Kennedy KA: Hypoxic cells as specific drug targets for chemotherapy. Anti-Cancer Drug Design 2: 181–194, 1987

Vaupel P, Kallinowski F, Okunieff P: Blood flow, oxygen, and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res 49: 6449–6465, 1989

Pahl HL, Baeuerle PA: The ER-overload response: activation of NF-κB. Trends Biochem Sci 22: 63–67, 1997

Pahl HL, Baeuerle PA: Endoplasmic-reticulum-induced signal transduction and gene expression. Trends Cell Biol 7: 50–55, 1997

Kozutsumi Y, Segal M, Normington K, Gething M-J, Sambrook J: The presence of malfolded proteins in the endo plasmic reticulum signals the induction of glucose-regulated proteins. Nature 332: 462–464, 1988

Patierno SR, Tuscano JM, Kim KS, Landolph JR, Lee AS: Increased expression of the glucose-regulated gene encoding the Mr 78, 000 glucose-regulated protein in chemically and radiation-transformed C3H 10T 1/2 mouse embryo cells. Cancer Res 47: 6220–6224, 1987

Cai JW, Henderson BW, Shen JW, Subjeck JR: Induction of glucose regulated proteins during growth of a murine tumor. J Cell Physiol 154: 229–237, 1993

Jamora C, Dennert G, Lee AS: Inhibition of tumor progression by suppression of stress protein GRP78/BiP induction in fibrosarcoma B/C10ME. Proc Natl Acad Sci USA 93: 7690–7694, 1996

Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156–159, 1987

Manning FCR, Xu J, Patierno SR: Transcriptional inhibition by carcinogenic chromate: relationship to DNA damage. Mol Carcinogenesis 6: 156–159, 1992

Lee AS, Delegeane A, Scharff D: Highly conserved glucoseregulated protein in hamster and chicken cells: preliminary characterization of its cDNA clone. Proc Natl Acad Sci USA 78: 4922–4925, 1981

Feinberg AP, Vogelstein B: A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 132: 6–13, 1983

Dive C, Hickman JA: Drug target interactions: only the first step in the commitment of a cell to a programmed cell death. Br J Cancer 64: 192–196, 1991

Dive C: Avoidance of apoptosis as a mechanism of drug resistance. J Int Med 242 (Suppl. 740): 139–145, 1997

McCormick TS, McColl KS, Distelhorst CW: Mouse lymphoma cells destined to undergo apoptosis in response to thapsigargin treatment fail to generate a calcium-mediated grp78/grp94 stress response. J Biol Chem 272: 6087–6092, 1997

Kaufmann S: Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemic cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res 49: 5870–5878, 1989

Liu X, Kim CN, Yang J, Jemmerson R, Wang, X: Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86: 147–157, 1996

Rizzuto R, Pinton P, Carrington W, Fay FS, Fogarty KE, Lifshitz LM, Tuft RA, Pozzan T: Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Science 280: 1763–1766, 1998

Ciocca DR, Oesterreich S, Chamness GC, McGuire WL, Fuqua S AW: Biological and clinical significance of heat shock protein 27, 000 (Hsp27): a Review. J Natl Cancer Inst 85: 1558–1570, 1993

Edwards DP, Adams DJ, McGuire WL: Estradiol stimulates synthesis of a major intracellular protein in a human breast cancer cell line (MCF-7). Breast Cancer Res Treat 1: 209–223, 1981

Ramachandran C, Catelli MG, Schneider W, Shyamala G: Estrogenic regulation of uterine 90-kilodalton heat shock protein. Endocrinology 123: 956–961, 1988

Storm FK, Gilchrist KW, Warner TF, Mahvi DM: Distribution of Hsp-27 and HER-2/neu in in situ and invasive ductal breast carcinomas. Ann Surg Oncol 2: 43–48, 1995

Storm FK, Mahvi DM, Gilchrist KW: Lack of association between tumor necrosis and Hsp-27 expression in primary breast cancer. J Surg Oncol 61: 14–16, 1996

Fuqua SAW, Oesterreich S, Hilsenbeck SG, Von Hoff DD, Eckardt J, Osborne, CK: Heat shock proteins and drug resistance. Breast Cancer Res Treat, 32: 67-71, 1994

Oesterreich S, Weng C-N, Qiu M, Hilsenbeck SG, Osborne CK, Fuqua SAW: The small heat shock protein Hsp27 is correlated with growth and drug resistance in human breast cancer cell lines. Cancer Res 53: 4443-4448, 1993

Ciocca DR, Fuqua SAW, Lock-Lim S, Toft DO, Welch, WJ, McGuire WL: Response of human breast cancer cells to heat shock and chemotherapeutic drugs. Cancer Res 52: 3648-3654, 1992

Ciocca DR, Green S, Elledge RM, Clark GM, Pugh R, Ravdin P, Lew D, Martino S, Osborne CK: Heat shock proteins Hsp27 and Hsp70: Lack of correlation with response to tamoxifen and clinical course of disease in estrogen receptor-positive metastatic breast cancer (A Southwest Oncology Group Study). Clin Cancer Res 5: 1263-1266, 1998

Lin ZP, Boller YC, Amer SM, Russell RL, Pacelli KA, Patierno SR, Kennedy KA: Prevention of brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: involvement of NF-κB activation in drug resistance. Cancer Res 58: 3059–3065, 1998

Lin ZP, Patierno SR, Kennedy KA: Activation of NF-κB is involved in hypoxia-induced drug resistance to topoisomerase II-directed agents. (submitted), 1999