Overexpression of human papillomavirus (HPV) type 16 oncoproteins promotes angiogenesis via enhancing HIF-1α and VEGF expression in non-small cell lung cancer cells

Brognard, 2001, Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation, Cancer Res., 61, 3986 Syrjanen, 1979, Condylomatous changes in neoplastic bronchial epithelium. Report of a case, Respiration, 38, 299, 10.1159/000194095 Ciotti, 2006, Detection and expression of human papillomavirus oncogenes in non-small cell lung cancer, Oncol. Rep., 16, 183 Wang, 2008, Human papillomavirus type 16 and 18 infection is associated with lung cancer patients from the central part of China, Oncol. Rep., 20, 333 Srinivasan, 2009, Human papillomavirus type 16 and 18 in primary lung cancers – a meta-analysis, Carcinogenesis, 30, 1722, 10.1093/carcin/bgp177 Baba, 2010, Human papillomavirus is frequently detected in gefitinib-responsive lung adenocarcinomas, Oncol. Rep., 23, 1085 Aguayo, 2010, Human papillomavirus-16 presence and physical status in lung carcinomas from Asia, Infect. Agent Cancer, 5, 20, 10.1186/1750-9378-5-20 Zhang, 2010, Variation of Human papillomavirus 16 in cervical and lung cancers in Sichuan, China, Acta Virol., 54, 247, 10.4149/av_2010_04_247 Joh, 2010, Human papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) in non-small cell lung cancer, Exp. Mol. Pathol., 89, 222, 10.1016/j.yexmp.2010.08.001 Krikelis, 2010, Frequent presence of incomplete HPV16 E7 ORFs in lung carcinomas: memories of viral infection, J. Clin. Virol., 49, 169, 10.1016/j.jcv.2010.07.020 Cheng, 2007, Human papillomavirus 16/18 E6 oncoprotein is expressed in lung cancer and related with p53 inactivation, Cancer Res., 67, 10686, 10.1158/0008-5472.CAN-07-1461 Hsu, 2009, Association between expression of human papillomavirus 16/18 E6 oncoprotein and survival in patients with stage I non-small cell lung cancer, Oncol. Rep., 21, 81 Cheng, 2008, Human papillomavirus type 16/18 upregulates the expression of interleukin-6 and antiapoptotic Mcl-1 in non-small cell lung cancer, Clin. Cancer Res., 14, 4705, 10.1158/1078-0432.CCR-07-4675 Chang, 2010, Up-regulation of interleukin-17 expression by human papillomavirus type 16 E6 in nonsmall cell lung cancer, Cancer, 116, 4800, 10.1002/cncr.25224 Cheng, 2008, Human telomerase reverse transcriptase activated by E6 oncoprotein is required for human papillomavirus-16/18-infected lung tumorigenesis, Clin. Cancer Res., 14, 7173, 10.1158/1078-0432.CCR-08-0850 Iwakawa, 2010, Prevalence of human papillomavirus 16/18/33 infection and p53 mutation in lung adenocarcinoma, Cancer Sci., 101, 1891, 10.1111/j.1349-7006.2010.01622.x Simen-Kapeu, 2010, Lack of association between human papillomavirus type 16 and 18 infections and female lung cancer, Cancer Epidemiol. Biomarkers Prev., 19, 1879, 10.1158/1055-9965.EPI-10-0356 Koshiol, 2011, Assessment of Human Papillomavirus in Lung Tumor Tissue, J. Natl. Cancer Inst., 103, 501, 10.1093/jnci/djr003 Folkman, 2002, Role of angiogenesis in tumor growth and metastasis, Semin. Oncol., 29, 15, 10.1053/sonc.2002.37263 Jackson, 2010, HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer, Expert Opin. Ther. Targets, 14, 1047, 10.1517/14728222.2010.511617 Huang, 1998, Regulation of hypoxia-inducible factor 1α is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway, Proc. Natl. Acad. Sci. USA, 95, 7987, 10.1073/pnas.95.14.7987 Ivan, 2001, HIF α targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing, Science, 292, 464, 10.1126/science.1059817 Bardos, 2005, Negative and positive regulation of HIF-1: a complex network, Biochim. Biophys. Acta, 1755, 107 Yohena, 2009, Upregulation of hypoxia-inducible factor-1alpha mRNA and its clinical significance in non-small cell lung cancer, J. Thorac. Oncol., 4, 284, 10.1097/JTO.0b013e31819852d5 Rovina, 2011, VEGF and IL-18 in induced sputum of lung cancer patients, Cytokine, 54, 277, 10.1016/j.cyto.2011.02.014 Charpidou, 2011, Bronchial washing levels of vascular endothelial growth factor receptor-2 (VEGFR2) correlate with overall survival in NSCLC patients, Cancer Lett., 304, 144, 10.1016/j.canlet.2011.02.018 Park, 2011, Prognostic implications of hypoxia-inducible factor-1α in epidermal growth factor receptor-negative non-small cell lung cancer, Lung Cancer, 72, 100, 10.1016/j.lungcan.2010.08.005 Tang, 2007, Overexpression of human papillomavirus type 16 oncoproteins enhances hypoxia-inducible factor 1alpha protein accumulation and vascular endothelial growth factor expression in human cervical carcinoma cells, Clin. Cancer Res., 13, 2568, 10.1158/1078-0432.CCR-06-2704 Romon, 2010, Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways, Mol. Cancer, 9, 157, 10.1186/1476-4598-9-157 Hellner, 2011, Human papillomaviruses as therapeutic targets in human cancer, J. Clin. Oncol., 29, 1785, 10.1200/JCO.2010.28.2186 López-Ocejo, 2000, Oncogenes and tumor angiogenesis: the HPV-16 E6 oncoprotein activates the vascular endothelial growth factor (VEGF) gene promoter in a p53 independent manner, Oncogene, 19, 4611, 10.1038/sj.onc.1203817 Semenza, 2010, Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics, Oncogene, 29, 625, 10.1038/onc.2009.441 Nakamura, 2009, Hypoxia-specific stabilization of HIF-1alpha by human papillomaviruses, Virology, 387, 442, 10.1016/j.virol.2009.02.036 Bodily, 2011, Human papillomavirus E7 enhances hypoxia-inducible factor 1-mediated transcription by inhibiting binding of histone deacetylases, Cancer Res., 71, 1187, 10.1158/0008-5472.CAN-10-2626 Stöppler, 2001, The human papillomavirus (HPV) 16 E6 oncoprotein leads to an increase in gene expression of the angiogenic switch molecule FGF-BP in non-immortalized human keratinocytes, Oncogene, 20, 7430, 10.1038/sj.onc.1204957 Toussaint-Smith, 2004, Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytes is sufficient to alter the expression of angiogenic factors, Oncogene, 23, 2988, 10.1038/sj.onc.1207442 Bequet-Romero, 2000, Angiogenesis modulators expression in culture cell lines positive for HPV-16 oncoproteins, Biochem. Biophys. Res. Commun., 277, 55, 10.1006/bbrc.2000.3628 Walker, 2011, Expression of human papillomavirus type 16 E7 is sufficient to significantly increase expression of angiogenic factors but is not sufficient to induce endothelial cell migration, Virology, 410, 283, 10.1016/j.virol.2010.11.010 Xi, 2009, The pro-angiogenic factors stimulated by human papillomavirus type 16 E6 and E7 protein in C33A and human fibroblasts, Oncol. Rep., 21, 25 Ochoa, 2011, Interleukin 6, but not T helper 2 cytokines, promotes lung carcinogenesis, Cancer Prev. Res. (Phila), 4, 51, 10.1158/1940-6207.CAPR-10-0180 Yeh, 2006, Autocrine IL-6-induced Stat3 activation contributes to the pathogenesis of lung adenocarcinoma and malignant pleural effusion, Oncogene, 25, 4300, 10.1038/sj.onc.1209464 Liu, 2011, IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma, Biochem. Biophys. Res. Commun., 407, 348, 10.1016/j.bbrc.2011.03.021 Numasaki, 2003, Interleukin-17 promotes angiogenesis and tumor growth, Blood, 101, 2620, 10.1182/blood-2002-05-1461