Overcoming radioresistance in WiDr cells with heavy ion irradiation and radiosensitization by 2-deoxyglucose with photon irradiation

Torre, 2015, Global cancer statistics, 2012, CA Cancer J Clin, 65, 87, 10.3322/caac.21262 Siegel, 2016, Cancer statistics, 2016, CA Cancer J Clin, 66, 7, 10.3322/caac.21332 Fuccio, 2012, Management of intestinal complications in patients with pelvic radiation disease, Clin Gastro-enterol Hepatol, 10, 1326, 10.1016/j.cgh.2012.07.017 Sterzing, 2015, Clinical results and toxicity for short-course preoperative radiotherapy and total mesorectal excision in rectal cancer patients, J Radiat Res, 56, 169, 10.1093/jrr/rru089 Kirchheiner, 2016, Health-related quality of life in locally advanced cervical cancer patients after definitive chemoradiation therapy including image guided adaptive brachytherapy: an analysis from the EMBRACE study, Int J Radiat Oncol Biol Phys, 94, 1088, 10.1016/j.ijrobp.2015.12.363 Jensen, 2015, Pelvic radiotherapy and sexual function in women, Transl Androl Urol, 4, 186 Jiang, 2012, Particle therapy for cancers: a new weapon in radiation therapy, Front Med, 6, 165, 10.1007/s11684-012-0196-4 Aoki-Nakano, 2013, Misrepair of DNA double-strand breaks after exposure to heavy-ion beams causes a peak in the LET–RBE relationship with respect to cell killing in DT40 cells, J Radiat Res, 54, 1029, 10.1093/jrr/rrt064 Durante, 2014, New challenges in high-energy particle radiobiology, Br J Radiol, 87, 20130626, 10.1259/bjr.20130626 Takuro, 2015, Treatment outcomes of patients with FIGO Stage I/II uterine cervical cancer treated with definitive radiotherapy: a multi-institutional retrospective research study, J Radiat Res, 56, 841, 10.1093/jrr/rrv036 Noura, 2014, Irradiation with carbon ions for locally recurrent rectal cancer, Gan To Kagaku Ryoho, 41, 1713 Okada, 2014, Rectal cancer with local re-recurrence successfully treated by carbon ion radiotherapy, Gan To Kagaku Ryoho, 41, 1710 Wakatsuki, 2015, Clinical trial of prophylactic extended-field carbon-ion radiotherapy for locally advanced uterine cervical cancer (Protocol 0508), PLoS ONE, 10, 10.1371/journal.pone.0127587 Bandugula, 2013, 2-Deoxy-D-glucose and ferulic acid modulates radiation response signaling in non-small cell lung cancer cells, Tumour Biol, 34, 251, 10.1007/s13277-012-0545-6 Lin, 2003, 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism, Cancer Res, 63, 3413 Mohanti, 1996, Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas, Int J Radiat Oncol Biol Phys, 35, 103, 10.1016/S0360-3016(96)85017-6 Vander Heiden, 2011, Targeting cancer metabolism: a therapeutic window opens, Nat Rev Drug Discov, 10, 671, 10.1038/nrd3504 Kern, 1987, Inhibition of established rat fibrosarcoma growth by the glucose antagonist 2-deoxy-D-glucose, Surgery, 102, 380 Shinjo, 2013, Comparative analysis of the expression patterns of UPR-target genes caused by UPR-inducing compounds, Biosci Biotechnol Biochem, 77, 729, 10.1271/bbb.120812 Matsumura, 2014, Inhibition of cancer cell growth by GRP78 siRNA lipoplex via activation of unfolded protein response, Biol Pharm Bull, 37, 648, 10.1248/bpb.b13-00930 Blackburn, 1999, Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells, Free Radic. Biol. Med, 26, 419, 10.1016/S0891-5849(98)00217-2 Spitz, 2000, Glucose deprivation-induced oxidative stress in human tumor cells: a fundamental defect in metabolism?, Ann NY Acad Sci, 899, 349, 10.1111/j.1749-6632.2000.tb06199.x Lee, 1998, Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells, J Biol Chem, 273, 5294, 10.1074/jbc.273.9.5294 Kawata, 2017, Additive effect of radiosensitization by 2-deoxy-D-glucose delays DNA repair kinetics and suppresses cell proliferation in oral squamous cell carcinoma, J Oral Pathol Med, 46, 979 Jha, 1992, Effect of 2-deoxy-D-glucose on DNA double strand break re-pair, cell survival and energy metabolism in euoxic Ehrlich ascites tumour cells, Int J Radiat Biol, 62, 409, 10.1080/09553009214552291 Mühlenberg, 2015, Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor, PLoS One, 10, 10.1371/journal.pone.0120531 Sun, 2017, Dual inhibition of glycolysis and glutaminolysis as a therapeutic strategy in the treatment of ovarian cancer, Oncotarget, 8, 63551, 10.18632/oncotarget.18854 Chatterjee, 2015, Combined 2-deoxy glucose and metformin improves therapeutic efficacy of sodium-iodide symporter-mediated targeted radioiodine therapy in breast cancer cells, Breast Cancer (Dove Med Press), 7, 251 Steel, 1979, Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity, Int J Radiat Oncol Biol Phys, 5, 85, 10.1016/0360-3016(79)90044-0 Paganetti, 2018, Proton relative biological effectiveness – uncertainties and opportunities, Int J Particle Ther, 5, 2, 10.14338/IJPT-18-00011.1 Datta, 2005, Variations in clinical estimates of tumor volume regression parameters and time factor during external radiotherapy in cancer cervix: does it mimic the linear-quadratic model of cell survival?, Indian J Cancer, 42, 70, 10.4103/0019-509X.16695 Suwinski, 2007, Moderately low alpha/beta ratio for rectal cancer may best explain the outcome of three fractionation schedules of preoperative radiotherapy, Int J Radiat Oncol Biol Phys, 69, 793, 10.1016/j.ijrobp.2007.03.046 Schlaich, 2013, Comparison of the effects of photon versus carbon ion irradiation when combined with chemotherapy in vitro, Radiat Oncol, 8, 260, 10.1186/1748-717X-8-260 Habermehl, 2014, The relative biological effectiveness for carbon and oxygen ion beams using the raster-scanning technique in hepatocellular carcinoma cell lines, PLoS ONE, 9, 10.1371/journal.pone.0113591 van Leeuwen, 2018, The alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies, Radiat Oncol, 13, 96, 10.1186/s13014-018-1040-z Fan, 2013, Berberine combined with 2-deoxy-d-glucose synergistically enhances cancer cell proliferation inhibition via energy depletion and unfolded protein response disruption, Biochim Biophys Acta, 1830, 5175, 10.1016/j.bbagen.2013.07.010 Kalia, 2009, Modulation of cellular radiation responses by 2-deoxy-D-glucose and other glycolytic inhibitors: implications for cancer therapy, J Cancer Res Ther, 5, 57, 10.4103/0973-1482.55145 Perumal, 2009, Modification of 2-deoxy-D-glucose on radiation-and chemo-therapeutic drug-induced chromosomal aberrations, J Cancer Res Ther, 5, 48, 10.4103/0973-1482.55142 Sharma, 2012, 2-Deoxy-D-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH-mediated defense, Free Radic Res, 46, 1446, 10.3109/10715762.2012.724771 Dwarakanath, 1999, Optimization of tumour radiotherapy: Part V-radiosensitization by 2-deoxy-D-glucose and DNA ligand Hoechst-33342 in a murine tumour, Indian J Exp Biol, 37, 865 Dwarkanath, 2001, Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines, Int J Radiat Oncol Biol Phys, 50, 1051, 10.1016/S0360-3016(01)01534-6 Rashmi, 2018, Radioresistant cervical cancers are sensitive to inhibition of glycolysis and redox metabolism, Cancer Res, 78, 1392, 10.1158/0008-5472.CAN-17-2367 Harrabi, 2013, Temozolomide in combination with carbon ion or photon irradiation in glioblastoma multiforme cell lines – does scheduling matter?, Int J Radiat Biol, 89, 692, 10.3109/09553002.2013.791406 El Shafie, 2013, In vitro evaluation of photon and raster-scanned carbon ion radiotherapy in combination with gemcitabine in pancreatic cancer cell lines, J Radiat Res, 54, i113, 10.1093/jrr/rrt052 Combs, 2012, In vitro evaluation of photon and carbon ion radiotherapy in combination with chemotherapy in glioblastoma cells, Radiat Oncol, 7, 9, 10.1186/1748-717X-7-9 Ma, 2015, Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells, Radiat Oncol, 10, 225, 10.1186/s13014-015-0536-z Kubo, 2015, Radiosensitizing effect of carboplatin and paclitaxel to carbon-ion beam irradiation in the non-small-cell lung cancer cell line H460, J Radiat Res, 56, 229, 10.1093/jrr/rru085 Fujisawa, 2015, VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation, Radiat Oncol, 10, 175, 10.1186/s13014-015-0464-y Sage, 2017, Radiation-induced clustered DNA lesions: Repair and mutagenesis, Free Radic Biol Med, 107, 125, 10.1016/j.freeradbiomed.2016.12.008 Khanna, 2001, DNA double-strand breaks: signaling, repair and the cancer connection, Nat Genet, 27, 247, 10.1038/85798 Ceccaldi, 2016, Repair pathway choices and consequences at the double-strand break, Trends Cell Biol, 26, 52, 10.1016/j.tcb.2015.07.009 Zhao, 2015, A generalized target theory and its applications, Sci Rep, 28, 14568, 10.1038/srep14568 Combs, 2011, Carbon ion radiotherapy performed as re-irradiation using active beam delivery in patients with tumors of the brain, skull base and sacral region, Radiother Oncol, 98, 63, 10.1016/j.radonc.2010.10.010 Jensen, 2016, High-LET radiotherapy for adenoid cystic carcinoma of the head and neck: 15 years' experience with raster-scanned carbon ion therapy, Radiother Oncol, 118, 272, 10.1016/j.radonc.2015.05.010 Raez, 2007, Responses to the combination of the glycolytic inhibitor 2-deoxy-glucose (2DG) and docetaxel (DC) in patients with lung and head and neck (H/N) carcinomas, J Clin Oncol, 25, 14025, 10.1200/jco.2007.25.18_suppl.14025 Stein, 2010, Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies, Prostate, 70, 1388, 10.1002/pros.21172