Kết quả của việc ghép gan sử dụng các mảnh ghép gan dương tính với kháng thể viêm gan B: Những tác động đối với biện pháp phòng ngừa

Current Hepatitis Reports - Tập 5 - Trang 33-39 - 2006
Jose M. Nieto, Sammy Saab1
1Pfleger Liver Institute, Los Angeles, USA

Tóm tắt

Số lượng bệnh nhân được ghi danh để ghép gan đã vượt quá số ca ghép có thể thực hiện. Sự chênh lệch này giữa các ứng viên ghép và khả năng cung cấp các mảnh ghép từ người hiến đã dẫn đến sự gia tăng tỷ lệ tử vong cho các bệnh nhân đang chờ ghép gan. Một chiến lược được sử dụng để tăng cường nguồn hiến tặng là việc sử dụng các mảnh ghép mở rộng, chẳng hạn như các mảnh ghép từ những người hiến có kháng thể viêm gan B lõi (anti-HBc). Tuy nhiên, việc sử dụng các mảnh ghép dương tính với anti-HBc có thể đặt người nhận vào nguy cơ nhiễm viêm gan B virus (HBV) mới sau khi ghép. Phổ bệnh lý về gan từ viêm gan B mới có thể dao động từ viêm gan nhẹ đến mất mảnh ghép. May mắn thay, nguy cơ nhiễm HBV mới có thể được giảm thiểu thông qua việc sử dụng các nucleosid hoặc nucleotide đường uống và immunoglobulin viêm gan B cho người nhận. Bài viết này tập trung vào dịch tễ học, lịch sử tự nhiên và các chiến lược phòng ngừa nhằm giảm nguy cơ viêm gan B mới cho những người nhận ghép gan nhận các mảnh ghép dương tính với anti-HBc.

Từ khóa

#Ung thư gan #ghép gan #viêm gan B #virus Hepatitis B #bệnh lý gan.

Tài liệu tham khảo

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