Outcomes in pediatric asthma

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Nishiyama O, Kato K, Kume H, et al.: Asthma health status: influence of disease severity categorized by peak expiratory flow. J Asthma 2003, 40:281–287.

Greenstone M: Individualized written action plans based on peak expiratory flow improve asthma health outcomes (review). ACP J Club 2004, 141:52.

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Fuhlbrigge AL, Kitch BT, Paltiel AD, et al.: FEV(1) is associated with risk of asthma attacks in a pediatric population. J Allergy Clin Immunol 2001, 107:61–67. This paper shows the importance of FEV1 as an objective measure of clinical outcomes and how it can be used to assess risk for asthma flare-up. It is important to note that children with normal FEV1 are still at a risk for flare-up, but much less than children with poor FEV1.

Sont JK, Willems LN, Bel EH, et al.: Clinical control and histopathologic outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. The AMPUL Study Group. Am J Respir Crit Care Med 1999, 159:1043–1051.

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Jones SL, Kittelson J, Cowan JO, et al.: The predictive value of exhaled nitric oxide measurements in assessing changes in asthma control. Am J Respir Crit Care Med 2001, 164:738–743.

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Graham DM, Blaiss MS, Bayliss MS, et al.: Impact of changes in asthma severity on health-related quality of life in pediatric and adult asthma patients: results from the asthma outcomes monitoring system (in process citation). Allergy Asthma Proc 2000, 21:151–158.

Eisner MD, Ackerson LM, Chi F, et al.: Health-related quality of life and future health care utilization for asthma. Ann Allergy Asthma Immunol 2002, 89:46–55. This prospective managed care study demonstrates that quality of life measurements are helpful in predicting outcomes in asthma. It verifies the usefulness of quality of life questionnaires as useful tools for measuring outcomes in asthma.

Okelo SO, Wu AW, Krishnan JA, et al.: Emotional quality-oflife and outcomes in adolescents with asthma. J Pediatr 2004, 145:523–529.

Annett RD, Bender BG, Lapidus J, et al.: Predicting children’s quality of life in an asthma clinical trial: What do children’s reports tell us? J Pediatr 2001, 139:854–861.

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Lozano P, Sullivan SD, Smith DH, Weiss KB: The economic burden of asthma in US children: estimates from the National Medical Expenditure Survey. J Allergy Clin Immunol 1999, 104:957–963.

Gendo K, Sullivan SD, Lozano P, et al.: Resource costs for asthma-related care among pediatric patients in managed care. Ann Allergy Asthma Immunol 2003, 91:251–257.

Antonicelli L, Bucca C, Neri M, et al.: Asthma severity and medical resource utilisation. Eur Respir J 2004, 23:723–729.

Lara M, Rosenbaum S, Rachelefsky G, et al.: Improving childhood asthma outcomes in the United States: a blueprint for policy action. Pediatrics 2002, 109:919–930. This paper, funded by Robert Wood Johnson Foundation, addresses the need for a comprehensive program for improving outcomes in children with asthma. Their suggestions for both the private and public sector could make a major improvement in care for all children with asthma.

Disease Management Association of America: Definition of Disease Management. Washington, DC: DMAA; 2004.

Bonner S, Zimmerman BJ, Evans D, et al.: An individualized intervention to improve asthma management among urban Latino and African-American families. J Asthma 2002, 39:167–179.

Bratton DL, Price M, Gavin L, et al.: Impact of a multidisciplinary day program on disease and healthcare costs in children and adolescents with severe asthma: a two-year follow-up study. Pediatr Pulmonol 2001, 31:177–189.

Georgiou A, Buchner DA, Ershoff DH, et al.: The impact of a large-scale population-based asthma management program on pediatric asthma patients and their caregivers. Ann Allergy Asthma Immunol 2003, 90:308–315.

Lukacs SL, France EK, Baron AE, Crane LA: Effectiveness of an asthma management program for pediatric members of a large health maintenance organization. Arch Pediatr Adolesc Med 2002, 156:872–876.