Osteoporosis was associated with severe abdominal aortic calcification based on a cross-sectional study
Tóm tắt
Abdominal aortic calcification and osteoporosis are age-related diseases. Based on a nationally representative US population, we concluded that osteoporosis may be independently associated with severe abdominal aortic calcification, which could improve our insights into the prevention and management of vascular disease. Abdominal aortic calcification (AAC) and osteoporosis are age-related diseases and share similar pathological mechanisms. However, the association between osteoporosis and AAC is uncertain. A total of 3134 participants with complete record of AAC score calculated from dual-energy X-ray absorptiometry (DXA) were enrolled from the National Health and Nutrition Examination Survey (NHANES) 2013–2014. The diagnosis of osteoporosis was obtained from self-reported interview. The baseline covariates were compared between participants with and without osteoporosis. Multivariable logistic regression was performed to examine the association between abdominal aortic calcification and osteoporosis. Compared with those without osteoporosis, participants with osteoporosis had higher AAC scores. Osteoporosis was positively associated with higher odds of severe AAC (OR = 2.65; 95%CI, 1.89–3.71; P < 0.001), and the association was not altered (OR = 2.17; 95%CI, 1.23–3.83; P = 0.008) after adjusting for numerous covariates. Our findings suggest that osteoporosis may be independently associated with severe abdominal aortic calcification.
Tài liệu tham khảo
Kauppila LI, Polak JF, Cupples LA, Hannan MT, Kiel DP, Wilson PW (1997) New indices to classify location, severity and progression of calcific lesions in the abdominal aorta: a 25-year follow-up study. Atherosclerosis 132:245–250
Cox AJ, Hsu FC, Agarwal S, Freedman BI, Herrington DM, Carr JJ, Bowden DW (2014) Prediction of mortality using a multi-bed vascular calcification score in the diabetes heart study. Cardiovasc Diabetol 13:160
Jepsen DB, Ryg J, Hansen S, Jorgensen NR, Gram J, Masud T (2019) The combined effect of parathyroid hormone (1-34) and whole-body vibration exercise in the treatment of postmenopausal osteoporosis (PaVOS study): a randomized controlled trial. Osteoporos Int 30:1827–1836
Lampropoulos CE, Kalamara P, Konsta M, Papaioannou I, Papadima E, Antoniou Z, Andrianopoulou A, Vlachoyiannopoulos PG (2016) Osteoporosis and vascular calcification in postmenopausal women: a cross-sectional study. Climacteric 19:303–307
Adragao T, Herberth J, Monier-Faugere MC, Branscum AJ, Ferreira A, Frazao JM, Dias Curto J, Malluche HH (2009) Low bone volume--a risk factor for coronary calcifications in hemodialysis patients. Clin J Am Soc Nephrol 4:450–455
Reddy J, Bilezikian JP, Smith SJ, Mosca L (2008) Reduced bone mineral density is associated with breast arterial calcification. J Clin Endocrinol Metab 93:208–211
Chen W, Eisenberg R, Mowrey WB, Wylie-Rosett J, Abramowitz MK, Bushinsky DA, Melamed ML (2020) Association between dietary zinc intake and abdominal aortic calcification in US adults. Nephrol Dial Transplant 35:1171–1178
Malluche HH, Blomquist G, Monier-Faugere MC, Cantor TL, Davenport DL (2015) High Parathyroid hormone level and osteoporosis predict progression of coronary artery calcification in patients on dialysis. J Am Soc Nephrol 26:2534–2544
Sumino H, Ichikawa S, Kasama S, Takahashi T, Sakamoto H, Kumakura H, Takayama Y, Kanda T, Murakami M, Kurabayashi M (2007) Relationship between brachial arterial endothelial function and lumbar spine bone mineral density in postmenopausal women. Circ J 71:1555–1559
Chen JS, Hogan C, Lyubomirsky G, Sambrook PN (2011) Women with cardiovascular disease have increased risk of osteoporotic fracture. Calcif Tissue Int 88:9–15
Osako MK, Nakagami H, Koibuchi N, Shimizu H, Nakagami F, Koriyama H, Shimamura M, Miyake T, Rakugi H, Morishita R (2010) Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification. Circ Res 107:466–475