Osteoinduction of porous titanium: A comparative study between acid‐alkali and chemical‐thermal treatments

Journal of Biomedical Materials Research - Part B Applied Biomaterials - Tập 95B Số 2 - Trang 387-396 - 2010
Chaoyong Zhao1, Xiangdong Zhu1, Kailu Liang2,3, Jietao Ding1, Zhou Xiang2,3, Hongsong Fan1, Xingdong Zhang1
1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, Sichuan, China
2Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu 610064, Sichuan, China
3Institute of Stem Cell and Tissue Engineering, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610064, Sichuan, China

Tóm tắt

AbstractIn this study, a slurry foaming method was developed to fabricate porous titanium, and two different surface treatments were applied to investigate their effects on the osteoinduction of the implants. Three types of implants, that was porous titanium with no treatment, with chemical‐thermal treatment (CTPT), and with acid‐alkali treatment (AAPT), were implanted in the dorsal muscles of adult dogs for 3 and 5 months. After implantation for 3 months, new bone was only found in the inner pores of AAPT by histological analysis and field emission scanning electron microscopy observation. After implantation for 5 months, new bone was also found in CTPT, but it was absent in AAPT. This study not only confirmed that porous titanium with appropriate surface treatments could possess osteoinduction but also showed that its osteoinductive potential was tightly related to the surface treatment. As a simpler method, acid‐alkali treatment could endow porous titanium with faster osteoinduction, and AAPT might have potential in clinical application. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010.

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Tài liệu tham khảo

10.1016/0272-8842(95)00126-3

10.1002/(SICI)1097-4636(19980915)41:4<511::AID-JBM1>3.0.CO;2-F

10.1016/0142-9612(92)90054-R

10.1016/0142-9612(96)80752-6

10.1016/0142-9612(96)00044-0

10.1023/A:1008950902047

10.1016/S0142-9612(99)00075-7

10.1016/S0142-9612(00)00016-8

10.1023/A:1021191432366

10.1016/j.biomaterials.2006.04.016

10.1016/j.biomaterials.2004.09.056

10.1002/term.5

10.1016/j.biomaterials.2004.02.026

10.1002/jor.20115

10.1007/978-3-642-56486-4

10.1016/j.mser.2004.11.001

10.2106/00004623-198668090-00013

McNamara BP, 1995, Effects of implant material properties and implant‐bone bonding on stress shielding in cementless total hip‐arthroplasty, Adv Eng Mater, 99, 309

10.1016/j.biomaterials.2007.02.020

10.4028/www.scientific.net/KEM.288-289.611

10.1002/adem.200405576

10.1016/j.biomaterials.2005.12.002

10.1557/JMR.2002.0382

10.1016/j.actbio.2006.10.004

10.1016/j.actbio.2008.04.022

10.1089/ten.tea.2009.0150

10.1089/ten.tea.2009.0074

10.1016/S0142-9612(03)00551-9

10.1016/S0142-9612(00)00094-6

10.1097/00006534-200108000-00024

10.1016/j.biomaterials.2005.12.014

10.1557/JMR.2004.0349

10.1023/A:1018524731409

10.1016/S0142-9612(97)82297-1

10.1023/A:1008859417664

10.1016/j.biomaterials.2003.08.009

10.4028/www.scientific.net/KEM.288-289.363

10.1111/j.1551-2916.2004.01635.x

ZhangXD YuanHP de GrootK.Calcium phosphate biomaterials with intrinsic osteoinductivity. Presented in the 6th World Biomaterials Conference. Hawaii USA;2000.

10.1016/j.biomaterials.2006.01.017

10.1016/S0142-9612(00)00450-6

10.1016/S0142-9612(02)00511-2

10.1002/jbm.a.10454

10.1002/jbm.10304

10.1111/j.1151-2916.1996.tb08561.x

10.1016/0142-9612(89)90019-7

10.1016/j.actbio.2008.08.008

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Journal of Biomedical Materials Research - Part B Applied Biomaterials

Tập 95B Số 2

387-396

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