Tính Chất Tạo Xương Của Các Hợp Kim Titan Ti6Al4V-Hydroxyapatite Được Chế Tạo Bằng Phương Pháp Nung Chảy Laser Chọn Lọc

Lin, Yujing1,2, Balbaa, Mohamed3, Zeng, Wenyi1,2, Yang, Yang1,2, Mahmoud, Dalia3,4, Elbestawi, Mohamed3, Deng, Feilong1,2, Chen, Jianyu1,2
1Department of Oral Implantology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangzhou, People’s Republic of China
2Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, People’s Republic of China
3Department of Mechanical Engineering, McMaster University, Hamilton, Canada
4Production Engineering Department, Faculty of Engineering, Alexandria University, Alexandria, Egypt

Tóm tắt

Hydroxyapatite (HA) đã được sử dụng rộng rãi để phủ cácImplant xương bằng kim loại. Tuy nhiên, lớp phủ HA có thể bị tách ra khỏi các nền kim loại, dẫn đến hiệu suất kém như các phản ứng viêm có thể cuối cùng dẫn đến việc mất chức năng của implant. Việc phân tán HA vào nền kim loại có thể là một giải pháp khả thi nhưng loại composite này có thể bị yếu về độ bền cơ học. Do đó, một vật liệu có độ nghiêng chức năng (FGM) với việc phân tán HA trong nền kim loại theo các dải biến đổi được giới thiệu để tăng cường khả năng tạo xương bề mặt và đồng thời duy trì độ bền cơ học tốt của implant xương. Trong nghiên cứu này, composite Ti6Al4V(Ti64)-HA với thành phần HA khác nhau và các FGM tương ứng của chúng đã được chế tạo bằng phương pháp nung chảy laser chọn lọc (SLM). Kết quả cho thấy so với Ti64 nguyên chất và composite Ti64-2.5%HA, composite Ti64-1%HA dường như có khả năng thúc đẩy tạo xương tốt hơn trong môi trường nuôi cấy ống nghiệm. Cả hai FGM đều đã thúc đẩy hoạt động tạo xương của Ti64 nguyên chất trong điều kiện in vivo. Hơn nữa, cấu trúc có độ nghiêng chức năng đã cải thiện tính chất chống nén của các hợp chất.

Từ khóa

#Hydroxyapatite #Ti6Al4V #Nung chảy laser chọn lọc #Hợp kim titan #Tạo xương

Tài liệu tham khảo

citation_journal_title=J. Biomed. Mater. Res. A; citation_title=Bioactivity of Novel Functionally Structured Titanium-Ceramic Composites in Contact with Human Osteoblasts; citation_author=GM Peñarrieta-Juanito, M Costa, M Cruz, G Miranda, B Henriques, J Marques, R Magini, A Mata, J Caramês, F Silva, JCM Souza; citation_volume=106; citation_issue=7; citation_publication_date=2018; citation_pages=1923-1931; citation_doi=10.1002/jbm.a.36394; citation_id=CR1 citation_journal_title=ACS Biomater. Sci. Eng.; citation_title=Titanium Coatings and Surface Modifications: Toward Clinically Useful Bioactive Implants; citation_author=A Civantos, E Martínez-Campos, V Ramos, C Elvira, A Gallardo, A Abarrategi; citation_volume=3; citation_issue=7; citation_publication_date=2017; citation_pages=1245-1261; citation_doi=10.1021/acsbiomaterials.6b00604; citation_id=CR2 citation_journal_title=ACS Appl. Mater. Interfaces; citation_title=Nitrilotriacetic acid Improves Plasma Electrolytic Oxidation of Titanium for Biomedical Applications; citation_author=S Kyrylenko, M Sowa, A Kazek-Kęsik, A Stolarczyk, M Pisarek, Y Husak, V Korniienko, V Deineka, R Moskalenko, I Matuła, J Michalska, A Jakóbik-Kolon, O Mishchenko, M Pogorielov, W Simka; citation_volume=15; citation_issue=16; citation_publication_date=2023; citation_pages=19863-19876; citation_doi=10.1021/acsami.3c00170; citation_id=CR3 citation_journal_title=Mater. Sci. Eng. C Mater. Biol. Appl.; citation_title=Hybrid Bioactive Hydroxyapatite/Polycaprolactone Nanoparticles for Enhanced Osteogenesis; citation_author=SE El-Habashy, HM Eltaher, A Gaballah, EI Zaki, RA Mehanna, AH El-Kamel; citation_volume=119; citation_publication_date=2021; citation_pages=111599; citation_doi=10.1016/j.msec.2020.111599; citation_id=CR4 citation_journal_title=Biomaterials; citation_title=Bone Bonding Behavior of the Hydroxyapatite Containing Glass-Titanium Composite Prepared by the Cullet Method; citation_author=K Yamada, K Imamura, H Itoh, H Iwata, S Maruno; citation_volume=22; citation_issue=16; citation_publication_date=2001; citation_pages=2207-2214; citation_doi=10.1016/s0142-9612(00)00402-6; citation_id=CR5 citation_journal_title=J. Mater. Chem. B; citation_title=Substituted Hydroxyapatite Coatings of Bone Implants; citation_author=D Arcos, M Vallet-Regí; citation_volume=8; citation_issue=9; citation_publication_date=2020; citation_pages=1781-1800; citation_doi=10.1039/c9tb02710f; citation_id=CR6 citation_journal_title=Mater. Sci. Eng. C Mater. Biol. Appl.; citation_title=Novel Hydroxyapatite/Graphene Oxide/Collagen Bioactive Composite Coating on Ti16Nb Alloys by Electrodeposition; citation_author=E Yılmaz, B Çakıroğlu, A Gökçe, F Findik, HO Gulsoy, N Gulsoy, Ö Mutlu, M Özacar; citation_volume=101; citation_publication_date=2019; citation_pages=292-305; citation_doi=10.1016/j.msec.2019.03.078; citation_id=CR7 citation_journal_title=Nanomedicine; citation_title=Biomimetic Titanium Implant Coated with Extracellular Matrix Enhances and Accelerates Osteogenesis; citation_author=Y Wu, H Tang, L Liu, Q He, L Zhao, Z Huang, J Yang, C Cao, J Chen, A Wang; citation_volume=15; citation_issue=18; citation_publication_date=2020; citation_pages=1779-1793; citation_doi=10.2217/nnm-2020-0047; citation_id=CR8 citation_journal_title=ACS Appl. Mater. Interfaces; citation_title=Improved Biocompatible, Flexible Mesh Composites for Implant Applications Via Hydroxyapatite Coating with Potential for 3-Dimensional Extracellular Matrix Network and Bone Regeneration; citation_author=A Naderi, B Zhang, JA Belgodere, K Sunder, G Palardy; citation_volume=13; citation_issue=23; citation_publication_date=2021; citation_pages=26824-26840; citation_doi=10.1021/acsami.1c09034; citation_id=CR9 citation_journal_title=Ceram. Int.; citation_title=A Comprehensive Review of Hydroxyapatite-Based Coatings Adhesion on Metallic Biomaterials; citation_author=W Harun, R Asri, J Alias, F Zulkifli, K Kadirgama, S Ghani, J Shariffuddin; citation_volume=44; citation_issue=2; citation_publication_date=2018; citation_pages=1250-1268; citation_doi=10.1016/j.ceramint.2017.10.162; citation_id=CR10 citation_journal_title=Colloids Surf. B Biointerfaces; citation_title=Porous Titanium-Hydroxyapatite Composite Coating Obtained on Titanium by Cold Gas Spray with High Bond Strength for Biomedical Applications; citation_author=J Guillem-Marti, N Cinca, M Punset, IG Cano, FJ Gil, JM Guilemany, S Dosta; citation_volume=180; citation_publication_date=2019; citation_pages=245-253; citation_doi=10.1016/j.colsurfb.2019.04.048; citation_id=CR11 citation_journal_title=J. Biomed. Mater. Res. A; citation_title=Microstructure and Biocompatibility of Composite Biomaterials Fabricated from Titanium and Tricalcium Phosphate by Spark Plasma Sintering; citation_author=D Mondal, L Nguyen, IH Oh, BT Lee; citation_volume=101; citation_issue=5; citation_publication_date=2013; citation_pages=1489-1501; citation_doi=10.1002/jbm.a.34455; citation_id=CR12 citation_journal_title=J. Biomech.; citation_title=A Three-Dimensional Finite Element Study on the Biomechanical Behavior of an FGBM Dental Implant in Surrounding Bone; citation_author=J Yang, HJ Xiang; citation_volume=40; citation_issue=11; citation_publication_date=2007; citation_pages=2377-2385; citation_doi=10.1016/j.jbiomech.2006.11.019; citation_id=CR13 citation_journal_title=J. Mech. Behav. Biomed. Mater.; citation_title=Microstructure and Property Evolutions of Titanium/Nano-Hydroxyapatite Composites In-Situ Prepared by Selective Laser Melting; citation_author=C Han, Q Wang, B Song, W Li, Q Wei, S Wen, J Liu, Y Shi; citation_volume=71; citation_publication_date=2017; citation_pages=85-94; citation_doi=10.1016/j.jmbbm.2017.02.021; citation_id=CR14 citation_journal_title=Materials; citation_title=Investigation of SLM Process in Terms of Temperature Distribution and Melting Pool Size: Modeling and Experimental Approaches; citation_author=MJ Ansari, DS Nguyen, HS Park; citation_publication_date=2019; citation_doi=10.3390/ma12081272; citation_id=CR15 citation_journal_title=Materials; citation_title=Ultrasonic Measurement of Stress in SLM 316L Stainless Steel Forming Parts Manufactured Using Different Scanning Strategies; citation_author=X Yan, J Pang, Y Jing; citation_publication_date=2019; citation_doi=10.3390/ma12172719; citation_id=CR16 citation_journal_title=J. Mech. Behav. Biomed. Mater.; citation_title=Laser powder Bed Fusion of Titanium-Tantalum Alloys: Compositions and Designs for Biomedical Applications; citation_author=S Huang, SL Sing, G Looze, R Wilson, WY Yeong; citation_volume=108; citation_publication_date=2020; citation_pages=103775; citation_doi=10.1016/j.jmbbm.2020.103775; citation_id=CR17 citation_journal_title=Biomed. Mater. Eng.; citation_title=In Vivo Study on Biocompatibility and Bonding Strength of Hydroxyapatite-20vol%Ti Composite with Bone Tissues in the Rabbit; citation_author=CL Chu, XY Xue, JC Zhu, ZD Yin; citation_volume=16; citation_issue=3; citation_publication_date=2006; citation_pages=203-213; citation_id=CR18 citation_journal_title=J. Tissue Eng. Regen. Med.; citation_title=Direct 3-D Printing of Ti-6Al-4V/HA Composite Porous Scaffolds for Customized Mechanical Properties and Biological Functions; citation_author=T Yi, C Zhou, L Ma, L Wu, X Xu, L Gu, Y Fan, G Xian, H Fan, X Zhang; citation_volume=14; citation_issue=3; citation_publication_date=2020; citation_pages=486-496; citation_doi=10.1002/term.3013; citation_id=CR19 citation_journal_title=J. Aust. Ceram. Soc.; citation_title=Studying the Effect of Hydroxyapatite Particles in Osteoconductivity of Ti-HA Bioceramic; citation_author=D Bovand, MR Allazadeh, S Rasouli, E Khodadad, E Borhani; citation_volume=55; citation_issue=2; citation_publication_date=2019; citation_pages=395-403; citation_doi=10.1007/s41779-018-0247-7; citation_id=CR20 citation_journal_title=Acta Biomater.; citation_title=Hydroxyapatite Reinforced Ti6Al4V Composites for Load-Bearing Implants; citation_author=JD Avila, K Stenberg, S Bose, A Bandyopadhyay; citation_volume=123; citation_publication_date=2021; citation_pages=379-392; citation_doi=10.1016/j.actbio.2020.12.060; citation_id=CR21 citation_journal_title=J. Biomed. Mater. Res. B Appl. Biomater.; citation_title=In Vitro Bioactivity and Cytocompatibility Properties of Spark Plasma Sintered HA-Ti Composites; citation_author=A Kumar, S Dhara, K Biswas, B Basu; citation_volume=101; citation_issue=2; citation_publication_date=2013; citation_pages=223-236; citation_doi=10.1002/jbm.b.32829; citation_id=CR22 citation_journal_title=J. Mech. Behav. Biomed. Mater.; citation_title=Incorporation of HA into Porous Titanium to Form Ti-HA Biocomposite Foams; citation_author=M Shbeh, ZJ Wally, M Elbadawi, M Mosalagae, H Al-Alak, GC Reilly, R Goodall; citation_volume=96; citation_publication_date=2019; citation_pages=193-203; citation_doi=10.1016/j.jmbbm.2019.04.043; citation_id=CR23 citation_journal_title=J. Mater. Sci. Mater. Med.; citation_title=Fabrication of Porous-Ti6Al4V alloy by Using Hot Pressing Technique and Mg Space Holder for Hard-Tissue Biomedical Applications; citation_author=N Aslan, B Aksakal, F Findik; citation_volume=32; citation_issue=7; citation_publication_date=2021; citation_pages=80; citation_doi=10.1007/s10856-021-06546-2; citation_id=CR24 citation_journal_title=Materials; citation_title=Nonlinear Finite Element Model for Bending Analysis of Functionally-Graded Porous Circular/Annular Micro-Plates under Thermomechanical Loads Using Quasi-3D Reddy Third-Order Plate Theory; citation_author=J Kim, E Nava, S Rakici; citation_publication_date=2023; citation_doi=10.3390/ma16093505; citation_id=CR25 citation_journal_title=Acta Biomater.; citation_title=Compositionally Graded Hydroxyapatite/Tricalcium Phosphate Coating on Ti by Laser and Induction Plasma; citation_author=M Roy, VK Balla, A Bandyopadhyay, S Bose; citation_volume=7; citation_issue=2; citation_publication_date=2011; citation_pages=866-873; citation_doi=10.1016/j.actbio.2010.09.016; citation_id=CR26 citation_journal_title=Mater. Des.; citation_title=Titanium/hydroxyapatite (Ti/HA) Gradient Materials with Quasi-Continuous Ratios Fabricated by SLM: Material Interface and Fracture Toughness; citation_author=C Han, Y Li, Q Wang, D Cai, Q Wei, L Yang, S Wen, J Liu, Y Shi; citation_volume=141; citation_publication_date=2018; citation_pages=256-266; citation_doi=10.1016/j.matdes.2017.12.037; citation_id=CR27 citation_journal_title=J. Mater. Eng. Perform.; citation_title=Production and Characterization of a Bone-Like Porous Ti/Ti-Hydroxyapatite Functionally Graded Material; citation_author=E Yilmaz, F Kabatas, A Gokce, F Findik; citation_volume=29; citation_issue=10; citation_publication_date=2020; citation_pages=6455-6467; citation_doi=10.1007/s11665-020-05165-2; citation_id=CR28 citation_journal_title=Biomaterials; citation_title=Integration of a Calcined Bovine Bone and BMSC-Sheet 3D Scaffold and the Promotion of Bone Regeneration In Large Defects; citation_author=Y Liu, L Ming, H Luo, W Liu, Y Zhang, H Liu, Y Jin; citation_volume=34; citation_issue=38; citation_publication_date=2013; citation_pages=9998-10006; citation_doi=10.1016/j.biomaterials.2013.09.040; citation_id=CR29 citation_journal_title=Int. J. Nanomed.; citation_title=Different Cell and Tissue Behavior of Micro-/Nano-Tubes and Micro-/Nano-Nets Topographies on Selective Laser Melting Titanium to Enhance Osseointegration; citation_author=X Yu, R Xu, Z Zhang, Q Jiang, Y Liu, X Yu, F Deng; citation_volume=16; citation_publication_date=2021; citation_pages=3329-3342; citation_doi=10.2147/ijn.S303770; citation_id=CR30 citation_journal_title=Mater. Sci. Eng. C Mater. Biol. Appl.; citation_title=Effect of Calcium Pyrophosphate on Microstructural Evolution and In Vitro Biocompatibility of Ti-35Nb-7Zr Composite by Spark Plasma Sintering; citation_author=L Zhang, J Tan, ZY He, YH Jiang; citation_volume=90; citation_publication_date=2018; citation_pages=8-15; citation_doi=10.1016/j.msec.2018.04.042; citation_id=CR31 citation_journal_title=Mater. Res.; citation_title=Microstructure Development on Sintered Ti/HA Biocomposites Produced by Powder Metallurgy; citation_author=P Balbinotti, E Gemelli, G Buerger, SAD Lima, JD Jesus, NHA Camargo, VAR Henriques, GDDA Soares; citation_volume=14; citation_issue=3; citation_publication_date=2011; citation_pages=384-393; citation_doi=10.1590/S1516-14392011005000044; citation_id=CR32 citation_journal_title=J. Mater. Process. Technol.; citation_title=Selective laser Melting of a Stainless Steel and Hydroxyapatite Composite for Load-Bearing Implant Development; citation_author=L Hao, S Dadbakhsh, O Seaman, M Felstead; citation_volume=209; citation_issue=17; citation_publication_date=2009; citation_pages=5793-5801; citation_doi=10.1016/j.jmatprotec.2009.06.012; citation_id=CR33 citation_journal_title=J. Mater. Sci. Technol.; citation_title=Microstructure and Mechanical Properties of Ti-6Al-4V-5% Hydroxyapatite Composite Fabricated Using Electron Beam Powder Bed Fusion; citation_author=CA Terrazas, LE Murr, D Bermudez, E Arrieta, DA Roberson, RB Wicker; citation_volume=35; citation_issue=2; citation_publication_date=2019; citation_pages=309-321; citation_doi=10.1016/j.jmst.2018.10.025; citation_id=CR34 citation_journal_title=J. Biomed. Mater. Res. A; citation_title=In Vitro Effects of Nanophase Hydroxyapatite Particles on Proliferation and Osteogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells; citation_author=Y Liu, G Wang, Y Cai, H Ji, G Zhou, X Zhao, R Tang, M Zhang; citation_volume=90; citation_issue=4; citation_publication_date=2009; citation_pages=1083-1091; citation_doi=10.1002/jbm.a.32192; citation_id=CR35 citation_journal_title=J. Biomed. Mater. Res. A; citation_title=Increased Osteoblast Adhesion on Titanium-Coated Hydroxylapatite that Forms CaTiO3; citation_author=TJ Webster, C Ergun, RH Doremus, WA Lanford; citation_volume=67; citation_issue=3; citation_publication_date=2003; citation_pages=975-980; citation_doi=10.1002/jbm.a.10160; citation_id=CR36 citation_journal_title=Stem Cells Int.; citation_title=In Vitro Uptake of Hydroxyapatite Nanoparticles and Their Effect on Osteogenic Differentiation of Human Mesenchymal Stem Cells; citation_author=X Yang, Y Li, X Liu, R Zhang, Q Feng; citation_volume=2018; citation_publication_date=2018; citation_pages=2036176; citation_doi=10.1155/2018/2036176; citation_id=CR37 citation_journal_title=Channels; citation_title=Molecular Determinants of Sensitivity and Conductivity of Human TRPM7 to Mg2+ and Ca2+; citation_author=T Numata, Y Okada; citation_volume=2; citation_issue=4; citation_publication_date=2008; citation_pages=283-286; citation_doi=10.4161/chan.2.4.6695; citation_id=CR38 citation_journal_title=Nature; citation_title=Asymmetric Activation of the Calcium-Sensing Receptor Homodimer; citation_author=Y Gao, MJ Robertson, SN Rahman, AB Seven, C Zhang, JG Meyerowitz, O Panova, FM Hannan, RV Thakker, H Bräuner-Osborne, JM Mathiesen, G Skiniotis; citation_volume=595; citation_issue=7867; citation_publication_date=2021; citation_pages=455-459; citation_doi=10.1038/s41586-021-03691-0; citation_id=CR39 citation_journal_title=Acta Biomater.; citation_title=Extracellular Calcium and CaSR Drive Osteoinduction in Mesenchymal Stromal Cells; citation_author=A González-Vázquez, JA Planell, E Engel; citation_volume=10; citation_issue=6; citation_publication_date=2014; citation_pages=2824-2833; citation_doi=10.1016/j.actbio.2014.02.004; citation_id=CR40 citation_journal_title=Nanoscale Res. Lett.; citation_title=Black Phosphorus Nanoparticles Promote Osteogenic Differentiation of EMSCs Through Upregulated TG2 Expression; citation_author=N Lu, X Wang, W Shi, L Bian, X Zhang, G Yang, X Tang, J Wang, Y Zou, Y Weng; citation_volume=16; citation_issue=1; citation_publication_date=2021; citation_pages=154; citation_doi=10.1186/s11671-021-03610-2; citation_id=CR41 citation_journal_title=Mater. Sci. Eng. A; citation_title=In Vivo Study on Biocompatibility and Bonding Strength of Ti/Ti–20 vol% HA/Ti–40 vol% HA Functionally Graded Biomaterial with Bone Tissues in the Rabbit; citation_author=C Chu, X Xue, J Zhu, Z Yin; citation_volume=429; citation_issue=1–2; citation_publication_date=2006; citation_pages=18-24; citation_doi=10.1016/j.msea.2006.03.099; citation_id=CR42 citation_journal_title=Biomed. Res. Int.; citation_title=In Vivo and In Vitro Analyses of Titanium-Hydroxyapatite Functionally Graded Material for Dental Implants; citation_author=X Wang, C Wan, X Feng, F Zhao, H Wang; citation_volume=2021; citation_publication_date=2021; citation_pages=8859945; citation_doi=10.1155/2021/8859945; citation_id=CR43 citation_journal_title=Beilstein J. Nanotechnol.; citation_title=Characterization and Influence of Hydroxyapatite Nanopowders on Living Cells; citation_author=P Oberbek, T Bolek, A Chlanda, S Hirano, S Kusnieruk, J Rogowska-Tylman, G Nechyporenko, V Zinchenko, W Swieszkowski, T Puzyn; citation_volume=9; citation_publication_date=2018; citation_pages=3079-3094; citation_doi=10.3762/bjnano.9.286; citation_id=CR44 citation_journal_title=Redox Biol.; citation_title=Hyperoside Alleviates Toxicity of β-Amyloid Via Endoplasmic Reticulum-Mitochondrial Calcium Signal Transduction Cascade in APP/PS1 Double Transgenic Alzheimer's Disease Mice; citation_author=LL Song, YQ Qu, YP Tang, X Chen, HH Lo, LQ Qu, YX Yun, VKW Wong, RL Zhang, HM Wang, MH Liu, W Zhang, HX Zhang, JTW Chan, CR Wang, JH Wu, BYK Law; citation_volume=61; citation_publication_date=2023; citation_pages=102637; citation_doi=10.1016/j.redox.2023.102637; citation_id=CR45 citation_journal_title=Cell Calcium; citation_title=Mitochondrial Ca2+ and Apoptosis; citation_author=C Giorgi, F Baldassari, A Bononi, M Bonora, E Marchi, S Marchi, S Missiroli, S Patergnani, A Rimessi, JM Suski, MR Wieckowski, P Pinton; citation_volume=52; citation_issue=1; citation_publication_date=2012; citation_pages=36-43; citation_doi=10.1016/j.ceca.2012.02.008; citation_id=CR46 citation_journal_title=J. Alloy Compd.; citation_title=Analysis of Factors Influencing Bone Ingrowth into Three-Dimensional Printed Porous Metal Scaffolds: A Review; citation_author=Z Wang, C Wang, C Li, Y Qin, L Zhong, B Chen, Z Li, H Liu, F Chang, J Wang; citation_volume=717; citation_publication_date=2017; citation_pages=271-285; citation_doi=10.1016/j.jallcom.2017.05.079; citation_id=CR47 citation_journal_title=J. Adv. Res.; citation_title=Pre-Oxidation Induced In Situ Interface Strengthening in Biodegradable Zn/nano-SiC Composites Prepared by Selective Laser Melting; citation_author=C Gao, M Yao, S Peng, W Tan, C Shuai; citation_volume=38; citation_publication_date=2022; citation_pages=143-155; citation_doi=10.1016/j.jare.2021.09.014; citation_id=CR48 citation_journal_title=J. Alloy Compd.; citation_title=A Study on Selective Laser Melting (SLM) of TiC and B4C Reinforced IN718 Metal Matrix Composites (MMCs); citation_author=V Mandal, P Tripathi, A Kumar, SS Singh, J Ramkumar; citation_volume=901; citation_publication_date=2022; citation_pages=17; citation_doi=10.1016/j.jallcom.2021.163527; citation_id=CR49