Osteocytes and Bone Metastasis

Bonewald, 2011, The amazing osteocyte, J Bone Mineral Res, 26, 10.1002/jbmr.320

Buenrostro, 2016, The Bone Microenvironment: a Fertile Soil for Tumor Growth, Curr Qsteoporos Rep, 14, 10.1007/s11914-016-0315-2

Chin, 2015, Bone Metastasis: Concise Overview. Federal practitioner : for the health care professionals of the VA, DoD PHS, 32, 24

Moore, 2014, Osteosarcoma, Cancer Treat Res, 162, 65, 10.1007/978-3-319-07323-1_4

de Azevedo, 2020, Biology and pathogenesis of human osteosarcoma, Oncol Lett, 19, 10.3892/ol.2019.11229

Terpos, 2014, Management of bone disease in multiple myeloma, Expert Rev Hematol, 7, 10.1586/17474086.2013.874943

Minnie, 2020, Immunotherapy of multiple myeloma, J Clin Invest, 130, 10.1172/JCI129205

Hernandez, 2018, Incidence of bone metastases in patients with solid tumors: analysis of oncology electronic medical records in the United States, BMC Cancer, 18, 44, 10.1186/s12885-017-3922-0

Wang, 2015, The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells, Cancer Cell, 27, 193, 10.1016/j.ccell.2014.11.017

Liu, 2016, Characteristics and Significance of the Pre-metastatic Niche, Cancer Cell, 30, 10.1016/j.ccell.2016.09.011

Kwakwa, 2017, Integrin alphavbeta3 Signaling in Tumor-Induced Bone Disease, Cancers, 9, 10.3390/cancers9070084

Pecheur, 2002, Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone, FASEB J, 16, 10.1096/fj.01-0911fje

Weidle, 2016, Molecular Mechanisms of Bone Metastasis, Cancer Genomics Proteomics, 13, 1, 10.21873/cgp.20004

Cox, 2015, The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase, Nature, 522, 10.1038/nature14492

Walker, 2018, Role of Extracellular Matrix in Development and Cancer Progression, Int J Mol Sci, 19, 10.3390/ijms19103028

Monteiro, 2013, T cells induce pre-metastatic osteolytic disease and help bone metastases establishment in a mouse model of metastatic breast cancer, PloS One, 8, 10.1371/journal.pone.0068171

Wu, 2018, Molecular Regulation of Bone Metastasis Pathogenesis, Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol, 46, 10.1159/000489184

Chen, 2010, Breast cancer metastasis to the bone: mechanisms of bone loss, Breast Cancer Res BCR, 12, 215, 10.1186/bcr2781

Pellegatti, 2011, P2X7 receptor drives osteoclast fusion by increasing the extracellular adenosine concentration, FASEB J, 25, 10.1096/fj.10-169854

Kearns, 2008, Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease, Endocr Rev, 29, 10.1210/er.2007-0014

Gralow, 2007, Managing metastatic bone pain: the role of bisphosphonates, J Pain Symptom Manage, 33, 10.1016/j.jpainsymman.2007.01.001

Kang, 2003, A multigenic program mediating breast cancer metastasis to bone, Cancer Cell, 3, 10.1016/S1535-6108(03)00132-6

Soki, 2012, The multifaceted actions of PTHrP in skeletal metastasis, Future Oncol (Lond Engl), 8, 10.2217/fon.12.76

Weilbaecher, 2011, Cancer to bone: a fatal attraction, Nat Rev Cancer, 11, 10.1038/nrc3055

Ell, 2013, Tumor-induced osteoclast miRNA changes as regulators and biomarkers of osteolytic bone metastasis, Cancer Cell, 24, 10.1016/j.ccr.2013.09.008

Colombo, 2014, Notch signaling drives multiple myeloma induced osteoclastogenesis, Oncotarget, 5, 10.18632/oncotarget.2084

Delgado-Calle, 2016, Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma, Cancer Res, 76, 10.1158/0008-5472.CAN-15-1703

Andrade, 2017, RON kinase: A target for treatment of cancer-induced bone destruction and osteoporosis, Sci Trans Med, 9, 10.1126/scitranslmed.aai9338

Knowles, 2019, The Adenosine A2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments, Cells, 8, 10.3390/cells8060624

Dirckx, 2019, The role of osteoblasts in energy homeostasis, Nat Rev Endocrinol, 15, 10.1038/s41574-019-0246-y

Weichhaus, 2015, Osteoprotegerin in breast cancer: beyond bone remodeling, Mol Cancer, 14, 117, 10.1186/s12943-015-0390-5

Tawara, 2011, Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies, Cancer Manage Res, 3, 10.2147/CMAR.S18101

Shiozawa, 2008, Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer, J Cell Biochem, 105, 10.1002/jcb.21835

Shiozawa, 2011, Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow, J Clin Invest, 121, 10.1172/JCI43414

Capulli, 2019, Notch2 pathway mediates breast cancer cellular dormancy and mobilisation in bone and contributes to haematopoietic stem cell mimicry, Br J Cancer, 121, 10.1038/s41416-019-0501-y

Widner, 2018, Interactions Between Disseminated Tumor Cells and Bone Marrow Stromal Cells Regulate Tumor Dormancy, Curr Qsteoporos Rep, 16, 596, 10.1007/s11914-018-0471-7

Sosnoski, 2015, Dormancy and growth of metastatic breast cancer cells in a bone-like microenvironment, Clin Exp Metastasis, 32, 10.1007/s10585-015-9710-9

Johnson, 2016, Erratum: Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow, Nat Cell Biol, 18, 1260, 10.1038/ncb3433

Kobayashi, 2011, Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone, J Exp Med, 208, 10.1084/jem.20110840

Yu-Lee, 2018, Osteoblast-Secreted Factors Mediate Dormancy of Metastatic Prostate Cancer in the Bone via Activation of the TGFβRIII-p38MAPK-pS249/T252RB Pathway, Cancer Res, 78, 10.1158/0008-5472.CAN-17-1051

Yumoto, 2016, Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow, Sci Rep, 6, 10.1038/srep36520

Lawson, 2015, Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche, Nat Commun, 6, 8983, 10.1038/ncomms9983

Botolin, 2007, Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice, Endocrinology, 148, 198, 10.1210/en.2006-1006

Burghardt, 2010, High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus, J Clin Endocrinol Metab, 95, 10.1210/jc.2010-0226

Vestergaard, 2007, Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes–a meta-analysis, Osteoporos Int J established as result cooperation between Eur Foundation Osteoporos Natl Osteoporos Foundation USA, 18, 10.1007/s00198-006-0253-4

Zong, 2016, Gut-derived serotonin induced by depression promotes breast cancer bone metastasis through the RUNX2/PTHrP/RANKL pathway in mice, Oncol Rep, 35, 10.3892/or.2015.4430

Campbell, 2012, Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice, PloS Biol, 10, 10.1371/journal.pbio.1001363

Katz, 2010, Osteoporosis and gastrointestinal disease, Gastroenterol Hepatol, 6

Balkwill, 2001, Inflammation and cancer: back to Virchow, Lancet (Lond Engl), 357, 10.1016/S0140-6736(00)04046-0

Lee, 1994, Effect of trauma on implantation of metastatic tumor in bone in mice, J Surg Oncol, 56, 10.1002/jso.2930560311

Alieva, 2018, Potential impact of invasive surgical procedures on primary tumor growth and metastasis, Clin Exp Metastasis, 35, 10.1007/s10585-018-9896-8

Demicheli, 2008, The effects of surgery on tumor growth: a century of investigations, Ann Oncol, 19, 10.1093/annonc/mdn386

Krall, 2018, The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy, Sci Trans Med, 10, 10.1126/scitranslmed.aan3464

Campisi, 2007, Cellular senescence: when bad things happen to good cells, Nat Rev Mol Cell Biol, 8, 10.1038/nrm2233

Alspach, 2013, Senescence and the pro-tumorigenic stroma, Crit Rev Oncogenesis, 18, 10.1615/CritRevOncog.2014010630

Luo, 2016, Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development, Cell Rep, 14, 82, 10.1016/j.celrep.2015.12.016

Li, 2014, B Cell Production of Both OPG and RANKL is Significantly Increased in Aged Mice, Open Bone J, 6, 8, 10.2174/1876525401406010008

Ottewell, 2014, Zoledronic acid has differential antitumor activity in the pre- and postmenopausal bone microenvironment in vivo, Clin Cancer Res, 20, 10.1158/1078-0432.CCR-13-1246

Schosserer, 2017, The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy, Front Oncol, 7, 10.3389/fonc.2017.00278

Lee, 2019, The dynamic nature of senescence in cancer, Nat Cell Biol, 21, 94, 10.1038/s41556-018-0249-2

Lynch, 2013, In vivo tibial compression decreases osteolysis and tumor formation in a human metastatic breast cancer model, J Bone Mineral Res, 28, 10.1002/jbmr.1966

Kothari, 2016, Osteopontin-A Master Regulator of Epithelial-Mesenchymal Transition, J Clin Med, 5, 10.3390/jcm5040039

Fan, 2020, Skeletal loading regulates breast cancer-associated osteolysis in a loading intensity-dependent fashion, Bone Res, 8, 9, 10.1038/s41413-020-0083-6

Delgado-Calle, 2014, Role of osteocytes in multiple myeloma bone disease, Curr Opin Support Palliative Care, 8, 10.1097/SPC.0000000000000090

Zhou, 2016, Osteocytic connexin hemichannels suppress breast cancer growth and bone metastasis, Oncogene, 35, 10.1038/onc.2016.101

McDonald, 2017, Sclerostin: an Emerging Target for the Treatment of Cancer-Induced Bone Disease, Curr Qsteoporos Rep, 15, 10.1007/s11914-017-0403-y

Robling, 2020, The Osteocyte: New Insights, Annu Rev Physiol, 82, 485, 10.1146/annurev-physiol-021119-034332

Delgado-Calle, 2017, Role and mechanism of action of sclerostin in bone, Bone, 96, 29, 10.1016/j.bone.2016.10.007

Xiong, 2015, Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone, PloS One, 10, 10.1371/journal.pone.0138189

D’Oronzo, 2020, Role of Bone Targeting Agents in the Prevention of Bone Metastases from Breast Cancer, Int J Mol Sci, 21, 10.3390/ijms21083022

Gnant, 2019, Adjuvant denosumab in postmenopausal patients with hormone receptor-positive breast cancer (ABCSG-18): disease-free survival results from a randomised, double-blind, placebo-controlled, phase 3 trial, Lancet Oncol, 20, 10.1016/S1470-2045(18)30862-3

Coleman, 2020, Adjuvant denosumab in early breast cancer (D-CARE): an international, multicentre, randomised, controlled, phase 3 trial, Lancet Oncol, 21, 60, 10.1016/S1470-2045(19)30687-4

Plotkin, 2015, Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor kappaB ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading, J Biol Chem, 290, 10.1074/jbc.M115.642090

McCutcheon, 2020, Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels, J Bone Mineral Res, 35, 10.1002/jbmr.3954

Kameda, 1997, Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts, J Exp Med, 186, 10.1084/jem.186.4.489

Ma, 2019, Connexin 43 hemichannels protect bone loss during estrogen deficiency, Bone Res, 7, 11, 10.1038/s41413-019-0050-2

Li, 2020, Deletion of p16 prevents estrogen deficiency-induced osteoporosis by inhibiting oxidative stress and osteocyte senescence, Am J Trans Res, 12

Kousteni, 2001, Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity, Cell, 104, 10.1016/S0092-8674(01)00268-9

Takeshita, 2014, Age-related marrow adipogenesis is linked to increased expression of RANKL, J Biol Chem, 289, 10.1074/jbc.M114.547919

Coleman, 2014, Adjuvant zoledronic acid in patients with early breast cancer: final efficacy analysis of the AZURE (BIG 01/04) randomised open-label phase 3 trial, Lancet Oncol, 15, 997, 10.1016/S1470-2045(14)70302-X

2015, Adjuvant bisphosphonate treatment in early breast cancer: meta-analyses of individual patient data from randomised trials, Lancet (Lond Engl), 386, 10.1016/S0140-6736(15)60908-4

Wang, 2019, Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion, Oncogene, 38, 10.1038/s41388-019-0736-3

Sottnik, 2015, Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases, Cancer Res, 75, 10.1158/0008-5472.CAN-14-2493

Ma, 2018, Mechanical regulation of breast cancer migration and apoptosis via direct and indirect osteocyte signaling, J Cell Biochem, 119, 10.1002/jcb.26745

Giuliani, 2012, Increased osteocyte death in multiple myeloma patients: role in myeloma-induced osteoclast formation, Leukemia, 26, 10.1038/leu.2011.381

Riquelme, 2020, The Role of Connexin Channels in the Response of Mechanical Loading and Unloading of Bone, Int J Mol Sci, 21, 10.3390/ijms21031146

Xu, 2015, Connexin 43 channels are essential for normal bone structure and osteocyte viability, J Bone Mineral Res, 30, 10.1002/jbmr.2374

Kar, 2013, Connexin 43 channels protect osteocytes against oxidative stress-induced cell death, J Bone Mineral Res, 28, 10.1002/jbmr.1917

Bellido, 2011, Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability, Bone, 49, 10.1016/j.bone.2010.08.008

Zhou, 2015, Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis, Oncogene, 34, 10.1038/onc.2014.113

Genetos, 2007, Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes, J Cell Physiol, 212, 10.1002/jcp.21021

Di Virgilio, 2018, Extracellular ATP and P2 purinergic signalling in the tumour microenvironment, Nat Rev Cancer, 18, 10.1038/s41568-018-0037-0

Feng, 2020, The yin and yang functions of extracellular ATP and adenosine in tumor immunity, Cancer Cell Int, 20, 110, 10.1186/s12935-020-01195-x

Rapaport, 1983, Growth inhibition of human tumor cells in soft-agar cultures by treatment with low levels of adenosine 5’-triphosphate, Cancer Res, 43

Beijer, 2009, Effect of adenosine 5’-triphosphate infusions on the nutritional status and survival of preterminal cancer patients, Anti-cancer Drugs, 20, 10.1097/CAD.0b013e32832d4f22

Agteresch, 2003, Randomized clinical trial of adenosine 5’-triphosphate on tumor growth and survival in advanced lung cancer patients, Anti-cancer Drugs, 14, 10.1097/00001813-200309000-00009

Agteresch, 2000, Randomized clinical trial of adenosine 5’-triphosphate in patients with advanced non-small-cell lung cancer, J Natl Cancer Institute, 92, 10.1093/jnci/92.4.321

White, 2006, P2 receptors and cancer, Trends Pharmacol Sci, 27, 10.1016/j.tips.2006.02.004

Furlow, 2015, Mechanosensitive pannexin-1 channels mediate microvascular metastatic cell survival, Nat Cell Biol, 17, 10.1038/ncb3194

Miyazaki, 2012, Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption, J Biol Chem, 287, 10.1074/jbc.M112.385369

Schenk, 2011, ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors, Sci Signaling, 4, ra12, 10.1126/scisignal.2001270

Canale, 2018, CD39 Expression Defines Cell Exhaustion in Tumor-Infiltrating CD8(+) T Cells, Cancer Res, 78, 10.1158/0008-5472.CAN-16-2684

Kazemi, 2018, Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer, J Cell Physiol, 233, 10.1002/jcp.25873

Pellegatti, 2008, Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase, PloS One, 3, 10.1371/journal.pone.0002599

Allard, 2020, On the mechanism of anti-CD39 immune checkpoint therapy, J Immunotherapy Cancer, 8, 10.1136/jitc-2019-000186

Hirata, 2018, CD150(high) Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine, Cell Stem Cell, 22, 445, 10.1016/j.stem.2018.01.017

Vijayan, 2017, Targeting immunosuppressive adenosine in cancer, Nat Rev Cancer, 17, 10.1038/nrc.2017.86