Ossification of the Posterior Longitudinal Ligament: Etiology, Diagnosis, and Outcomes of Nonoperative and Operative Management

Global Spine Journal - Tập 6 Số 2 - Trang 195-204 - 2016
Rasheed Abiola1, Paul T. Rubery2, Addisu Mesfin2
1Department of Orthopaedic Surgery, University of Wisconsin School of Medicine, Madison, Wisconsin, United States
2Department of Orthopaedic Surgery, University of Rochester School of Medicine, Rochester, New York, United States

Tóm tắt

Study Design Narrative review. Objective To provide an overview on the diagnosis, natural history, and nonoperative and operative management of ossification of the posterior longitudinal ligament (OPLL). OPLL is a multifactorial condition caused by ectopic hyperostosis and calcification of the posterior longitudinal ligament. Familial inheritance and genetic factors have been implicated in the etiology of OPLL. The cervical spine is most commonly affected followed by the thoracic spine. The clinical manifestations range from asymptomatic to myelopathy or myeloradiculopathy. Methods Using PubMed, studies published prior to October 2014 with the keywords “OPLL, etiology”; “OPLL, genetics”; “OPLL, spinal cord injury”; “OPLL, natural history”; “OPLL, non-surgical management”; OPLL, surgical management”; “OPLL, surgical complications” were evaluated. Results The review addresses the etiology, epidemiology, classification, clinical presentation, imaging findings, and nonoperative and operative management of OPLL. Complications associated with surgical management of OPLL are also discussed. Conclusions OPLL commonly presents with myelopathy and radiculopathy. Spine providers should consider OPLL in their differential diagnosis and when reviewing images. If surgical intervention is pursued, imaging-based measurements and findings can help in choosing an anterior versus posterior surgical approach.

Từ khóa


Tài liệu tham khảo

10.1097/BRS.0b013e318241ad33

10.2214/ajr.131.6.1049

10.1371/journal.pone.0040587

10.1002/jor.21586

10.1086/378593

10.1038/ng.3045

10.1007/s00223-012-9662-x

10.1007/978-4-431-32563-5_16

10.1097/BRS.0b013e3181e9a8a6

10.1097/01.bsd.0000155033.63557.9c

10.1007/978-4-431-32563-5_3

Epstein N E, 1992, Neurosurg Q, 2, 223

10.1007/s100380170117

Ohtsuka K, 1986, Nippon Seikeigeka Gakkai Zasshi, 60, 1087

10.1097/00007632-199311000-00006

10.3171/spi.2005.3.1.0017

10.1097/01.brs.0000245870.97231.65

10.1097/BRS.0b013e31814614f3

10.1097/BRS.0b013e3181f49718

10.1227/01.NEU.0000083590.84053.CC

10.1097/BRS.0b013e31822da1d5

10.1007/s00586-012-2573-8

10.1007/s00586-013-2989-9

10.3171/spi.2007.6.4.4

10.2176/nmc.37.173

10.1227/01.neu.0000279731.21145.45

10.1097/00003086-199902000-00004

10.1097/00007632-200102010-00008

10.1097/BRS.0b013e31817f988c

Matsunaga S, 2002, J Neurosurg, 96, 168

10.1016/j.spinee.2015.01.028

10.1016/j.spinee.2014.10.001

10.3171/2011.1.FOCUS10273

Matsunaga S, 2004, J Neurosurg, 100, 245

10.1097/00002517-199712000-00012

10.3171/2010.12.FOCUS10270

10.3171/2009.7.SPINE08656

10.1097/BRS.0b013e318188b300

10.1097/01.brs.0000257560.91147.86

10.1016/j.spinee.2011.09.008

10.1097/BRS.0000000000000054

Iwasaki M, 2002, J Neurosurg, 96, 180

10.1097/BRS.0b013e318239cca0

10.1007/s00264-008-0609-9

10.3340/jkns.2010.48.4.335

10.2106/JBJS.F.01114

10.3171/foc.2001.10.4.7

10.1016/S0090-3019(97)00285-1

10.1097/00002517-199306040-00001

10.1097/01.brs.0000193940.75354.e5

10.2531/spinalsurg.13.281

10.1097/BRS.0b013e31816c913b

10.1097/BSD.0b013e318286ba39

10.3171/2012.9.SPINE12617

10.1016/j.spinee.2010.02.015

10.1097/BRS.0b013e31815e3911

10.1016/j.jocn.2011.05.025

Thông tin
Thông tin xuất bản

Global Spine Journal

Tập 6 Số 2

195-204

Thông tin tác giả