Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells

Kai Zhao1, Yuxin Zhou1, Chunxia Qiao1, Ting Ni1, Zhiyu Li2, Xiaotang Wang3, Qing Guo1, Na Lu1, Libin Wei1
1State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, The People’s Republic of China
2Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, The People’s Republic of China
3Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA

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