Orotic Aciduria and Increased Nitrogen Catabolism in Rats

Smith, 1961, Pyrimidine metabolism in man. IV. The enzymatic defect of orotic aciduria, J. Clin. Invest.1, 40, 656, 10.1172/JCI104298 Maclead, 1972, Partial ornithine carbamyl transferase deficiency an inborn error of the urea cycle presenting as orotic aciduria in a male infant, Can. Med. Assoc. J, 107, 405 Kelley, 1970, Allopurinol: Alteration in pyrimidine metabolism in man, Science, 169, 388, 10.1126/science.169.3943.388 Wood, 1973, The orotic aciduria of pregnancy, Am. J. Obstet. Gynecol, 116, 57, 10.1016/0002-9378(73)90883-1 Milner, 1975, Urinary metabolites characteristic of urea cycle amino acid deficiencies, Metabolism, 24, 643, 10.1016/0026-0495(75)90144-4 Kesner, 1965, Effect of ammonia administration on orotic acid excretion in rats, J. Biol. Chem, 240, 1722, 10.1016/S0021-9258(18)97495-8 Hatchwell, 1978, Amino acid induced orotic aciduria, J. Nutr, 108, 578, 10.1093/jn/108.4.578 Hatchwell, 1978, Factors affecting amino acid induced orotic aciduria, J. Nutr, 108, 1976, 10.1093/jn/108.12.1976 Milner, 1973, Orotic aciduria and arginine deficiency, Nature, 245, 211, 10.1038/245211a0 Natale, 1969, On the availability of intramitochondrial carbamyl phosphate for the extramitochondrial biosynthesis of pyrimidine, Biochem. Biophys. Res. Commun, 37, 512, 10.1016/0006-291X(69)90945-0 Tremblay, 1977, Orotic acid biosynthesis in rat liver studies on the origin of carbamyl phosphate, Arch. Biochem. Biophys, 178, 264, 10.1016/0003-9861(77)90191-6 Schimke, 1963, Studies on factors affecting the level of urea cycle enzymes in rat liver, J. Biol. Chem, 238, 1012, 10.1016/S0021-9258(18)81251-0 Schimke, 1962, Adaptive characteristics of urea cycle enzymes in the rat, J. Biol. Chem, 237, 459, 10.1016/S0021-9258(18)93943-8 Freedjand, 1967, Effects of diet and hormones on two urea cycle enzymes, Proc. Soc. Exp. Biol. Med, 109, 394, 10.3181/00379727-109-27215 Mclean, 1965, Influence of pancreatic hormones on enzymes concerned with urea biosynthesis in rat liver, Biochem. J, 94, 410, 10.1042/bj0940410 Milner, 1978, Dietary protein intake and arginine requirement in rats, J. Nutr, 108, 382, 10.1093/jn/108.3.382 Foster, 1971, A single reagent manual method for directly determining urea nitrogen in the serum, Clin. Chem, 17, 921, 10.1093/clinchem/17.9.921 Stajner, 1968, The determination of orotic acid in the serum by means of a spectrophotometric method, Experientia, 15, 116, 10.1007/BF02146929 Steel, R. & Torrie J (1960) Principles and Procedures of Statistics, McGraw-Hill Book Co., Inc., New York. Hassan, 1979, Orotic acid biosynthesis in arginine deficient rats, Arch. Biochem. Biophys, 194, 24, 10.1016/0003-9861(79)90591-5 Raiha, 1968, Factors influencing the development of ureasynthesizing enzymes in rat liver, Biochem. J, 107, 793, 10.1042/bj1070793 Kretchmer, 1966, Some aspects of urea and pyrimidine metabolism during development, Biol. Neonat, 9, 187, 10.1159/000239989 Cahill, 1977, Starvation in man. Clinics in Endocrinology and Metabolism, 5, 397