Origins of the ‘KNDy hypothesis’ of GnRH pulse generation

Goodman, R. L. et al. Endogenous opioid peptides control the amplitude and shape of gonadotropin-releasing hormone pulses in the ewe. Endocrinology 136, 2412–2420 (1995)

Goodman, R. L. et al. Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B. Endocrinology 148, 5752–5760 (2007)

Lehman, M. N., Coolen, L. M. & Goodman, R. L. Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion. Endocrinology 151, 3479–3489 (2010)

Moore, A. M., Coolen, L. M. & Lehman, M. N. In vivo imaging of the GnRH pulse generator reveals a temporal order of neuronal activation and synchronization during each pulse. Proc. Natl. Acad. Sci. USA 119, e2117767119 (2022)