Các chất ô nhiễm hữu cơ halogen cần quan tâm trong cá hồ Great Lakes: một bài tổng quan

Klecka G, Persoon C, Currie R (2010) Chemicals of emerging concern in the Great Lakes Basin: an analysis of environmental exposures. In: Whitacre DM (ed) Reviews of Environmental Contamination and Toxicology, Vol 207, vol 207. Reviews of Environmental Contamination and Toxicology. pp 1–93. doi:10.1007/978-1-4419-6406-9_1 Cole DC, Kearney J, Sanin LH, Leblanc A, Weber JP (2004) Blood mercury levels among Ontario anglers and sport-fish eaters. Environ Res 95(3):305–314. doi:10.1016/j.envres.2003.08.012 Dellinger JA (2004) Exposure assessment and initial intervention regarding fish consumption of tribal members of the Upper Great Lakes Region in the United States. Environ Res 95(3):325–340. doi:10.1016/j.envres.2003.07.012 Imm P, Knobeloch L, Anderson HA (2005) Great Lakes Sport Fish consumption advisory awareness in the Great Lakes Basin. Environ Heal Perspect 113(10):1325–1329. doi:10.1289/ehp.7980 Cole DC, Sheeshka J, Murkin EJ, Kearney J, Scott F, Ferron LA, Weber JP (2002) Dietary intakes and plasma organochlorine contaminant levels among Great Lakes fish eaters. Arch Environ Heal 57(5):496–509 Gilbertson M, Carpenter DO (2004) An ecosystem approach to the health effects of mercury in the Great Lakes basin ecosystem - Introduction. Environ Res 95(3):240–246. doi:10.1016/j.envres.2004.02.015 Carson R (1962) Silent spring. Houghton Mifflin, Boston Lovelock JE (1958) A sensitive detector for gas chromatography. J Chromatogr 1(1):35–46. doi:10.1016/s0021-9673(00)93398-3 Stockholm Convention Secretariat (2001) The United Nations Stockholm Convention on Persistent Organic Pollutants list. UNEP. http://chm.pops.int/. Accessed March 14, 2012 Reiner EJ, Boden AR, Chen T, MacPherson KA, Muscalu AM (2010) Advances in the analysis of persistent halogenated organic compounds. In: LC GC Europe, February:60–70 Murphy CA, Bhavsar SP, Gandhi N (In press) Contaminants in Great Lakes Fish: historic, current, and emerging concerns. In: Taylor WW, Lynch AJ, Leonard NJ (eds) Great Lakes Fisheries: policy and management, a binational perspective. 2nd Edition edn. Michigan State University Press, East Lansing, USA Baumann PC, Whittle DM (1988) The status of selected organics in the Laurentian Great Lakes - an overview of DDT, PCBs, dioxins, furans, and aromatic hydrocarbons. Aquat Toxicol 11(3–4):241–257 Borgmann U, Whittle DM (1991) Contaminant concentration trends in Lake Ontario lake trout (Salvelinus namaycush) - 1977 to 1988. J Great Lakes Res 17(3):368–381 Borgmann U, Whittle DM (1992) DDE, PCB, and mercury concentration trends in Lake Ontario rainbow smelt (Osmerus mordax) and slimy sculpin (Cottus cognatus) - 1977 to 1988. J Great Lakes Res 18(2):298–308 Huestis SY, Servos MR, Whittle DM, Dixon DG (1996) Temporal and age-related trends in levels of polychlorinated biphenyl congeners and organochlorine contaminants in Lake Ontario Lake trout (Salvelinus namaycush). J Great Lakes Res 22(2):310–330 Huestis SY, Servos MR, Whittle DM, vanden Heuvel M, Dixon DG (1997) Evaluation of temporal and age-related trends of chemically and biologically generated 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents in Lake Ontario lake trout, 1977 to 1993. Environ Toxicol Chem 16(2):154–164 DeVault D, Dunn W, Bergqvist PA, Wiberg K, Rappe C (1989) Polychlorinated dibenzofurans and polychlorinated dibenzo-para-dioxins in Great-Lakes fish - a baseline and interlake comparison. Environ Toxicol Chem 8(11):1013–1022 Bhavsar SP, Gewurtz SB, McGoldrick DJ, Keir MJ, Backus SM (2010) Changes in mercury levels in great lakes fish between 1970s and 2007. Environ Sci Technol 44(9):3273–3279. doi:10.1021/es903874x Gewurtz SB, Backus SM, Bhavsar SP, McGoldrick DJ, de Solla SR, Murphy EW (2011) Contaminant biomonitoring programs in the Great Lakes region: review of approaches and critical factors. Environ Rev 19:162–184. doi:10.1139/a11-005 Bhavsar SP, Awad E, Fletcher R, Hayton A, Somers KM, Kolic T, MacPherson K, Reiner EJ (2008) Temporal trends and spatial distribution of dioxins and furans in lake trout or lake whitefish from the Canadian Great Lakes. Chemosphere 73(1):S158–S165. doi:10.1016/j.chemosphere.2007.05.100 Bhavsar SP, Jackson DA, Hayton A, Reiner EJ, Chen T, Bodnar J (2007) Are PCB levels in fish from the Canadian Great Lakes still declining? J Great Lakes Res 33(3):592–605. doi:10.3394/0380-1330(2007)33[592:apliff]2.0.co;2 Gewurtz SB, Bhavsar SP, Jackson DA, Fletcher R, Awad E, Moody R, Reiner EJ (2010) Temporal and spatial trends of organochlorines and mercury in fishes from the St. Clair River/Lake St. Clair corridor, Canada. J Great Lakes Res 36(1):100–112. doi:10.1016/j.jglr.2009.12.008 Monson BA, Staples DF, Bhavsar SP, Holsen TM, Schrank CS, Moses SK, McGoldrick DJ, Backus SM, Williams KA (2011) Spatiotemporal trends of mercury in walleye and largemouth bass from the Laurentian Great Lakes Region. Ecotoxicology 20(7):1555–1567. doi:10.1007/s10646-011-0715-0 Carlson DL, De Vault D, Swackhamer D (2010) On the rate of decline of persistent organic contaminants in lake trout (Salvelinus namaycush) from the Great Lakes, 1970–2003. Environ Sci Technol 44(6):2004–2010 U.S.EPA (2011) Great Lakes Restoration Initiative. U.S.EPA. http://www.epa.gov/glnpo/glri/. Accessed March 14, 2012 Environment Canada (2010) Great Lakes Action Plan. http://www.ec.gc.ca/grandslacs-greatlakes/default.asp?lang=En&n=DF30B51A-1. March 14, 2012 Bhavsar SP, Awad E, Mahon CG, Petro S (2011) Great Lakes fish consumption advisories: is mercury a concern? Ecotoxicology 20(7):1588–1598. doi:10.1007/s10646-011-0731-0 French TD, Petro S, Reiner EJ, Bhavsar SP, Jackson DA (2011) Thirty-year time series of PCB concentrations in a small invertivorous fish (Notropis Hudsonius): an examination of Post-1990 trajectory shifts in the Lower Great Lakes. Ecosystems 14(3):415–429. doi:10.1007/s10021-011-9419-9 Sadraddini S, Azim ME, Shimoda Y, Mahmood M, Bhavsar SP, Backus SM, Arhonditsis GB (2011) Temporal PCB and mercury trends in Lake Erie fish communities: a dynamic linear modeling analysis. Ecotoxicol Environ Saf 74(8):2203–2214. doi:10.1016/j.ecoenv.2011.07.031 Azim ME, Kumarappah A, Bhavsar SP, Backus SM, Arhonditsis G (2011) Detection of the spatiotemporal trends of mercury in lake erie fish communities: a bayesian approach. Environ Sci Technol 45(6):2217–2226. doi:10.1021/es103054q Azim ME, Letchumanan M, Abu Rayash A, Shimoda Y, Bhavsar SP, Arhonditsis GB (2011) Detection of temporal trends of alpha- and gamma-chlordane in Lake Erie fish communities using dynamic linear modeling. Ecotoxicol Environ Saf 74(5):1107–1121. doi:10.1016/j.ecoenv.2011.04.019 Sadraddini S, Azim ME, Shimoda Y, Bhavsar SP, Drouillard KG, Backus SM, Arhonditsis GB (2011) A Bayesian assessment of the PCB temporal trends in Lake Erie fish communities. J Great Lakes Res 37(3):507–520. doi:10.1016/j.jglr.2011.06.005 Hogan L, Marschall E, Folt C, Stein R (2007) How non-native species in Lake Erie influence trophic transfer of mercury and lead to top predators. J Great Lakes Res 33(1):46–61 French TD, Campbell LM, Jackson DA, Casselman JM, Scheider WA, Hayton A (2006) Long-term changes in legacy trace organic contaminants and mercury in Lake Ontario salmon in relation to source controls, trophodynamics, and climatic variability. Limnol Oceanogr 51(6):2794–2807 Sandheinrich MB, Bhavsar SP, Bodaly RA, Drevnick PE, Paul EA (2011) Ecological risk of methylmercury to piscivorous fish of the Great Lakes region. Ecotoxicology 20(7):1577–1587. doi:10.1007/s10646-011-0712-3 Wiener JG, Sandheinrich MB, Bhavsar SP, Bohr JR, Evers DC, Monson BA, Schrank CS (2012) Toxicological significance of mercury in yellow perch in the Laurentian Great Lakes region. Environ Pollut 161:350–357. doi:10.1016/j.envpol.2011.09.025 Howard PH, Muir DCG (2010) Identifying new persistent and bioaccumulative organics among chemicals in commerce. Environ Sci Technol 44(7):2277–2285. doi:10.1021/es903383a Hoh E, Zhu LY, Hites RA (2006) Dechlorane plus, a chlorinated flame retardant, in the Great Lakes. Environ Sci Technol 40(4):1184–1189. doi:10.1021/es051911h Jensen S (1972) The PCB story. Ambio 1:123–131 Xia X, Hopke PK, Crimmins BS, Pagano JJ, Milligan MS, Holsen TM (In press) Toxaphene trends in the Great Lakes fish. J Great Lakes Res. doi:10.1016/j.jglr.2011.11.001 Gouteux B, Lebeuf M, Trottier S, Gagne JP (2002) Analysis of six relevant toxaphene congeners in biological samples using ion trap MS/MS. Chemosphere 49(2):183–191. doi:10.1016/s0045-6535(02)00289-8 Kucklick JR, Helm PA (2006) Advances in the environmental analysis of polychlorinated naphthalenes and toxaphene. Anal Bioanal Chem 386(4):819–836. doi:10.1007/s00216-006-0757-y Xia X, Crimmins BS, Hopke PK, Pagano JJ, Milligan MS, Holsen TM (2009) Toxaphene analysis in Great Lakes fish: a comparison of GC-EI/MS/MS and GC-ECNI-MS, individual congener standard and technical mixture for quantification of toxaphene. Anal Bioanal Chem 395(2):457–463. doi:10.1007/s00216-009-2988-1 Ballesteros-Gomez A, Rubio S (2011) Recent advances in environmental analysis. Anal Chem 83(12):4579–4613. doi:10.1021/ac200921j LeDoux M (2011) Analytical methods applied to the determination of pesticide residues in foods of animal origin. A review of the past two decades. J Chrom A 1218(8):1021–1036. doi:10.1016/j.chroma.2010.12.097 Muir D, Sverko E (2006) Analytical methods for PCBs and organochlorine pesticides in environmental monitoring and surveillance: a critical appraisal. Anal Bioanal Chem 386(4):769–789. doi:10.1007/s00216-006-0765-y Ahmed FE (2003) Analysis of polychlorinated biphenyls in food products. Trac-Trends Anal Chem 22(3):170–185. doi:10.1016/s0165-9936(03)00305-4 van Leeuwen SPJ, de Boer J (2008) Advances in the gas chromatographic determination of persistent organic pollutants in the aquatic environment. J Chromatogr A 1186(1–2):161–182. doi:10.1016/j.chroma.2008.01.044 Erickson MD (1997) Analytical chemistry of PCBs, 2nd edn. CRC Lewis Publishers, Boca Raton Reiner EJ (2010) The analysis of dioxins and related compounds. Mass Spectrom Rev 29(4):526–559. doi:10.1002/mas.20255 Reiner EJ, Clement RE, Okey AB, Marvin CH (2006) Advances in analytical techniques for polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and dioxin-like PCBs. Anal Bioanal Chem 386(4):791–806. doi:10.1007/s00216-006-0479-1 Muir DC, Stern GA, Tomy GT (2000) Chlorinated paraffins. In: Paasivirta J (ed) New types of persistent halogenated compounds, vol 3 Part K. The handbook of environmental chemistry. Springer-Verlag, Berlin Fiedler H (2010) Short-chain chlorinated paraffins: production, use and international regulations. In: DeBoer J (ed) Chlorinated Paraffins, vol 10. Handbook of environmental chemistry. pp 1–40. doi:10.1007/698_2010_58 Tomy GT, Fisk AT, Westmore JB, Muir DC (1998) Environmental chemistry and toxicology of polychlorinated n-alkanes. Rev Environ Contam Toxicol 158:53–128 Tomy GT (2010) Analysis of chlorinated paraffins in environmental matrices: the ultimate challenge for the analytical chemist. In: DeBoer J (ed) Chlorinated Paraffins, vol 10. Handbook of environmental chemistry. pp 83–106. doi:10.1007/698_2009_39 Tomy GT, Westmore JB, Stern GA, Muir DCG, Fisk AT (1999) Interlaboratory study on quantitative methods of analysis of C-10-C-13 polychloro-n-alkanes. Anal Chem 71(2):446–451. doi:10.1021/ac9807215 Ramos L (2009) Comprehensive two dimensional gas chromatography. Elsevier, Oxford Adahchour M, Beens J, Vreuls RJJ, Brinkman UAT (2006) Recent developments in comprehensive two-dimensional gas chromatography (GC X GC) I. Introduction and instrumental set-up. Trac-Trends Anal Chem 25(5):438–454. doi:10.1016/j.trac.2006.03.002 Panic O, Gorecki T (2006) Comprehensive two-dimensional gas chromatography (GC×GC) in environmental analysis and monitoring. Anal Bioanal Chem 386(4):1013–1023. doi:10.1007/s00216-006-0568-1 Korytar P, Leonards PEG, de Boer J, Brinkman UAT (2005) Group separation of organohalogenated compounds by means of comprehensive two-dimensional gas chromatography. J Chromatogr A 1086(1–2):29–44. doi:10.1016/j.chroma.2005.05.087 Muscalu AM, Reiner EJ, Liss SN, Chen T, Ladwig G, Morse D (2011) A routine accredited method for the analysis of polychlorinated biphenyls, organochlorine pesticides, chlorobenzenes and screening of other halogenated organics in soil, sediment and sludge by GC×GC-mu ECD. Anal Bioanal Chem 401(8):2403–2413. doi:10.1007/s00216-011-5114-0 Korytar P, Parera J, Leonards PEG, Santos FJ, de Boer J, Brinkman UAT (2005) Characterization of polychlorinated n-alkanes using comprehensive two-dimensional gas chromatography-electron-capture negative. ionisation time-of-flight mass spectrometry. J Chromatogr A 1086(1–2):71–82. doi:10.1016/j.chroma.2005.05.003 Tomy GT, Stern GA, Muir DCG, Fisk AT, Cymbalisty CD, Westmore JB (1997) Quantifying C-10-C-13 polychloroalkanes in environmental samples by high-resolution gas chromatography electron capture negative ion high resolution mass spectrometry. Anal Chem 69(14):2762–2771. doi:10.1021/ac961244y Houde M, Muir DCG, Tomy GT, Whittle DM, Teixeira C, Moore S (2008) Bioaccumulation and trophic magnification of short- and medium-chain chlorinated paraffins in food webs from Lake Ontario and Lake Michigan. Environ Sci Technol 42(10):3893–3899. doi:10.1021/es703184s Helm PA, Kannan K, Bidleman TF (2006) Polychlorinated naphthalenes in the Great Lakes. In: Hites RA (ed) Handbook of environmental chemistry, vol 5. Handbook of environmental chemistry. pp 267–306. doi:10.1007/698_5_043 Wiedmann T, Ballschmiter K (1993) Quantification of chlorinated naphthalenes with gc-ms using the molar response of electron-impact ionization. Fresen J Anal Chem 346(6–9):800–804. doi:10.1007/bf00321293 Fayez L, Reiner E, Kolic T, Brunato R, MacPherson K, Lega R, Crozier P (2008) An automated extraction/sample preparation method for the determination of PCDD/F, DLPCBs, BDEs AND PCNs in biota in a single analysis. In: organohalogen compounds. pp 1296–1299 Yang S, Reiner EJ, Kolic TM, Lega R, Harrison RO (2010) A rapid and simple cleanup method for analysis of Dioxins/Furans, Dioxin-like PCBs, PBDEs and PCNs. In: organohalogen compounds. pp 1788–1791 Helm PA, Gewurtz SB, Whittle DM, Marvin CH, Fisk AT, Tomy GT (2008) Occurrence and biomagnification of polychlorinated naphthalenes and non- and mono-ortho PCBs in Lake Ontario sediment and biota. Environ Sci Technol 42(4):1024–1031. doi:10.1021/es071819g Kannan K, Yamashita N, Imagawa T, Decoen W, Khim JS, Day RM, Summer CL, Giesy JP (2000) Polychlorinated naphthalenes and polychlorinated biphenyls in fishes from Michigan waters including the Great Lakes. Environ Sci Technol 34(4):566–572. doi:10.1021/es990966e Gewurtz SB, Lega R, Crozier PW, Whittle DM, Fayez L, Reiner EJ, Helm PA, Marvin CH, Tomy GT (2009) Factors influencing trends of polychlorinated naphthalenes and other dioxin-like compounds in lake trout (salvelinus namaycush) from Lake Ontario, North America (1979–2004). Environ Toxicol Chem 28(5):921–930. doi:10.1897/08-307.1 Ieda T, Ochiai N, Miyawaki T, Ohura T, Horii Y (2011) Environmental analysis of chlorinated and brominated polycyclic aromatic hydrocarbons by comprehensive two-dimensional gas chromatography coupled to high-resolution time-of-flight mass spectrometry. J Chromatogr A 1218(21):3224–3232. doi:10.1016/j.chroma.2011.01.013 Horii Y, Khim JS, Higley EB, Giesy JP, Ohura T, Kannan K (2009) Relative potencies of individual chlorinated and brominated polycyclic aromatic hydrocarbons for induction of aryl hydrocarbon receptor-mediated responses. Environ Sci Technol 43(6):2159–2165. doi:10.1021/es8030402 Alaee M, Arias P, Sjodin A, Bergman A (2003) An overview of commercially used brominated flame retardants, their applications, their use patterns in different countries/regions and possible modes of release. Environ Int 29(6):683–689. doi:10.1016/s0160-4120(03)00121-1 Kolic TM, Shen L, MacPherson K, Fayez L, Gobran T, Heim PA, Marvin CH, Arsenault G, Reiner EJ (2009) The analysis of halogenated flame retardants by GC-HRMS in environmental samples. J Chromatogr Sci 47(1):83–91 Covaci A, Harrad S, Abdallah MAE, Ali N, Law RJ, Herzke D, de Wit CA (2011) Novel brominated flame retardants: a review of their analysis, environmental fate and behaviour. Environ Int 37(2):532–556. doi:10.1016/j.envint.2010.11.007 Covaci A, Voorspoels S, Abdallah MA-E, Geens T, Harrad S, Law RJ (2009) Analytical and environmental aspects of the flame retardant tetrabromobisphenol-A and its derivatives. J Chromatogr A 1216(3):346–363. doi:10.1016/j.chroma.2008.08.035 Marvin CH, Tomy GT, Armitage JM, Arnot JA, McCarty L, Covaci A, Palace V (2011) Hexabromocyclododecane: current understanding of chemistry, environmental fate and toxicology and implications for global management. Environ Sci Technol 45(20):8613–8623. doi:10.1021/es201548c Morris S, Bersuder P, Allchin CR, Zegers B, Boon JP, Leonards PEG, de Boer J (2006) Determination of the brominated flame retardant, hexabromocyclodocane, in sediments and biota by liquid chromatography-electrospray ionisation mass spectrometry. Trac-Trends Anal Chem 25(4):343–349. doi:10.1016/j.trac.2005.11.006 Sverko E, Tomy GT, Reiner EJ, Li Y-F, McCarry BE, Arnot JA, Law RJ, Hites RA (2011) Dechlorane plus and related compounds in the environment: a review. Environ Sci Technol 45(12):5088–5098. doi:10.1021/es2003028 Covaci A, Voorspoels S, Ramos L, Neels H, Blust R (2007) Recent developments in the analysis of brominated flame retardants and brominated natural compounds. J Chromatogr A 1153(1–2):145–171. doi:10.1016/j.chroma.2006.11.060 de Boer J, Wells DE (2006) Pitfalls in the analysis of brominated flame retardants in environmental, human and food samples - including results of three international interlaboratory studies. Trac-Trends Anal Chem 25(4):364–372. doi:10.1016/j.trac.2006.01.008 Koeppen R, Becker R, Jung C, Nehls I (2008) On the thermally induced isomerisation of hexabromocyclododecane stereoisomers. Chemosphere 71(4):656–662. doi:10.1016/j.chemosphere.2007.11.009 Zhou SN, Reiner EJ, Marvin CH, Helm PA, Brindle ID (2011) Liquid chromatography/tandem mass spectrometry for analysis of 1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane (TBECH) and 1,2,5,6-tetrabromocyclooctane (TBCO). Rapid Comm Mass Spectrom 25(3):443–448. doi:10.1002/rcm.4878 Stapleton HM (2006) Instrumental methods and challenges in quantifying polybrominated diphenyl ethers in environmental extracts: a review. Anal Bioanal Chem 386(4):807–817. doi:10.1007/s00216-006-0400-y Wang D, Li QX (2010) Application of mass spectrometry in the analysis of polybrominated diphenyl ethers. Mass Spectrom Rev 29(5):737–775. doi:10.1002/mas.20263 de Boer J, Allchin C, Law R, Zegers B, Boon JP (2001) Method for the analysis of polybrominated diphenylethers in sediments and biota. Trac-Trends Anal Chem 20(10):591–599. doi:10.1016/s0165-9936(01)00097-8 Gewurtz SB, Shen L, Reiner EJ, Kolic TM, MacPherson KA, Helm PA, Howell ET, Burniston DA, Brindle ID, Marvin C (2009) Spatial trends of PBDEs in sediment of the Great Lakes. In: organohalogen compounds. pp 2283–2287 Shen L, Gewurtz S, Reiner E, Kolic T, MacPherson K, Helm P, Howell T, Burniston D, Brindle I, Marvin C (2008) PBDEs in surfical sediments of the Great Lakes: Lake Superior, Huron and Michigan. In: organohalogen compounds. pp 129–132 Thomsen C, Leknes H, Lundanes E, Becher G (2001) Brominated flame retardants in laboratory air. J Chromatogr A 923(1–2):299–304. doi:10.1016/s0021-9673(01)01004-4 Covaci A, Voorspoels S, de Boer J (2003) Determination of brominated flame retardants, with emphasis on polybrominated diphenyl ethers (PBDEs) in environmental and human samples - a review. Environ Int 29(6):735–756. doi:10.1016/s0160-4120(03)00114-4 Hahm J, Manchester-Neesvig JB, DeBord D, Sonzogni WC (2009) Polybrominated diphenyl ethers (PBDEs) in Lake Michigan forage fish. J Great Lakes Res 35(1):154–158. doi:10.1016/j.jglr.2008.12.001 Hickey JP, Chernyak SM, Begnoche LJ, Quintal RT (2002) Concentration trends of polybrominated diphenyl ethers (PBDEs) in Great Lakes fish. IAGLR Conf Program Abstr 45:54 Valters K, Li HX, Alaee M, D'Sa I, Marsh G, Bergman A, Letcher RJ (2005) Polybrominated diphenyl ethers and hydroxylated and methoxylated brominated and chlorinated analogues in the plasma of fish from the Detroit River. Environ Sci Technol 39(15):5612–5619. doi:10.1021/es0506410 Batterman S, Chernyak S, Gwynn E, Cantonwine D, Jia C, Begnoche L, Hickey JP (2007) Trends of brominated diphenyl ethers in fresh and archived Great Lakes fish (1979–2005). Chemosphere 69(3):444–457. doi:10.1016/j.chemosphere.2007.04.066 Rice CP, Chernyak SM, Begnoche L, Quintal R, Hickey J (2002) Comparisons of PBDE composition and concentration in fish collected from the Detroit river, MI and Des Plaines River, IL. Chemosphere 49(7):731–737. doi:10.1016/s0045-6535(02)00398-3 Manchester-Neesvig JB, Valters K, Sonzogni WC (2001) Comparison of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in Lake Michigan salmonids. Environ Sci Technol 35(6):1072–1077. doi:10.1021/es001422b Luross JM, Alaee M, Sergeant DB, Cannon CM, Whittle DM, Solomon KR, Muir DCG (2002) Spatial distribution of polybrominated diphenyl ethers and polybrominated biphenyls in lake trout from the Laurentian Great Lakes. Chemosphere 46(5):665–672. doi:10.1016/s0045-6535(01)00230-2 Zhu LY, Hites RA (2004) Temporal trends and spatial distributions of brominated flame retardants in archived fishes from the Great Lakes. Environ Sci Technol 38(10):2779–2784. doi:10.1021/es035288h Ismail N, Gewurtz SB, Pleskach K, Whittle DM, Helm PA, Marvin CH, Tomy GT (2009) Brominated and chlorinated flame retardants in Lake Ontario, Canada, lake trout (salvelinus namaycush) between 1979 and 2004 and possible influences of food-web changes. Environ Toxicol Chem 28(5):910–920. doi:10.1897/08-162.1 Gandhi N, Bhavsar SP, Gewurtz SB, Tomy GT (2011) Can biotransformation of BDE-209 in lake trout cause bioaccumulation of more toxic, lower-brominated PBDEs (BDE-47,-99) over the long term? Environ Int 37(1):170–177. doi:10.1016/j.envint.2010.08.013 Zhou SN, Reiner EJ, Marvin C, Kolic T, Riddell N, Helm P, Dorman F, Misselwitz M, Brindle ID (2010) Liquid chromatography-atmospheric pressure photoionization tandem mass spectrometry for analysis of 36 halogenated flame retardants in fish. J Chromatogr A 1217(5):633–641. doi:10.1016/j.chroma.2009.11.096 Poole SK, Dean TA, Oudsema JW, Poole CF (1990) Sample preparation for chromatographic separations - an overview. Anal Chim Acta 236(1):3–42. doi:10.1016/s0003-2670(00)83297-3 Kloskowski A, Chrzanowski W, Pilarczyk M, Namiesnik J (2007) Modern techniques of sample preparation for determination of organic analytes by gas chromatography. Crit Rev Anal Chem 37(1):15–38. doi:10.1080/10408340600976663 Papachlimitzou A, Barber JL, Losada S, Bersuder P, Law RJ (2012) A review of the analysis of novel brominated flame retardants. J ChromatogrA 1219:15–28. doi:10.1016/j.chroma.2011.11.029 (2012) http://www.bsef.com/our-substances/tbbpa/about-tbbpa. Accessed March 4, 2012 Tomy GT, Budakowski W, Halldorson T, Whittle DM, Keir MJ, Marvin C, Macinnis G, Alaee M (2004) Biomagnification of alpha- and gamma-hexabromocyclododecane isomers in a Lake Ontario food web. Environ Sci Technol 38(8):2298–2303. doi:10.1021/es034968h Sverko E, Tomy GT, Marvin CH, Zaruk D, Reiner E, Helm PA, Hill B, McCarry BE (2008) Dechlorane plus levels in sediment of the lower Great Lakes. Environ Sci Technol 42(2):361–366. doi:10.1021/es0710104 Tomy GT, Pleskach K, Ismail N, Whittle DM, Helm PA, Sverko E, Zaruk D, Marvin CH (2007) Isomers of dechlorane plus in Lake Winnipeg and Lake Ontario food webs. Environ Sci Technol 41(7):2249–2254. doi:10.1021/es062781v Shen L, Reiner EJ, Macpherson KA, Kolic TM, Sverko E, Helm PA, Bhavsar SP, Brindle ID, Marvin CH (2010) Identification and screening analysis of halogenated norhornene flame retardants in the Laurentian Great Lakes: dechloranes 602, 603, and 604. Environ Sci Technol 44(2):760–766. doi:10.1021/es902482b Shen L, Reiner EJ, Helm PA, Marvin CH, Hill B, Zhang XM, MacPherson KA, Kolic TM, Tomy GT, Brindle ID (2011) Historic Trends of dechloranes 602, 603, 604, dechlorane plus and other norbornene derivatives and their bioaccumulation potential in Lake Ontario. Environ Sci Technol 45(8):3333–3340. doi:10.1021/es104328r Tomy GT, Palace V, Marvin C, Stapleton HM, Covaci A, Harrad S (2011) Biotransformation of HBCD in biological systems can confound temporal-trend studies. Environ Sci Technol 45(2):364–365. doi:10.1021/es1039369 Bhavsar SP, Gandhi N, Gewurtz SB, Tomy GT (2008) Fate of PBDEs in juvenile lake trout estimated using a dynamic multichemical fish model. Environ Sci Technol 42(10):3724–3731. doi:10.1021/es0717010 Kierkegaard A, Balk L, Tjarnlund U, De Wit CA, Jansson B (1999) Dietary uptake and biological effects of decabromodiphenyl ether in rainbow trout (Oncorhynchus mykiss). Environ Sci Technol 33(10):1612–1617 Stapleton HM, Alaee M, Letcher RJ, Baker JE (2004) Debromination of the flame retardant decabromodiphenyl ether by juvenile carp (Cyprinus carpio) following dietary exposure. Environ Sci Technol 38(1):112–119. doi:10.1021/es034746j Gandhi N, Bhavsar SP, Gewurtz SB, Diamond ML, Evenset A, Christensen GN, Gregor D (2006) Development of a multichemical food web model: application to PBDEs in Lake Ellasjoen, Bear Island, Norway. Environ Sci Technol 40(15):4714–4721. doi:10.1021/es052064l Benskin JP, De Silva AO, Martin JW (2010) Isomer Profiling of Perfluorinated Substances as a tool for source tracking: a review of early findings and future applications. In: Whitacre DMDP (ed) Reviews of environmental contamination and toxicology, Vol 208: perfluorinated alkylated substances, vol 208. Reviews of Environmental Contamination and Toxicology. pp 111–160. doi:10.1007/978-1-4419-6880-7_2 D'Eon JC, Crozier PW, Furdui VI, Reiner EJ, Libelo EL, Mabury SA (2009) Observation of a commercial fluorinated material, the polyfluoroalkyl phosphoric acid diesters, in human sera, wastewater treatment plant sludge, and paper fibers. Environ Sci Technol 43(12):4589–4594. doi:10.1021/es900100d van Leeuwen SPJ, de Boer J (2007) Extraction and clean-up strategies for the analysis of poly- and perfluoroalkyl substances in environmental and human matrices. J Chromatogr A 1153(1–2):172–185. doi:10.1016/j.chroma.2007.02.069 Villagrasa M, de Alda ML, Barcelo D (2006) Environmental analysis of fluorinated alkyl substances by liquid chromatography-(tandem) mass spectrometry: a review. Anal Bioanal Chem 386(4):953–972. doi:10.1007/s00216-006-0471-9 Houde M, De Silva AO, Muir DCG, Letcher RJ (2011) Monitoring of perfluorinated compounds in aquatic biota: an updated review PFCs in Aquatic Biota. Environ Sci Technol 45(19):7962–7973. doi:10.1021/es104326w Buck RC, Franklin J, Berger U, Conder JM, Cousins IT, de Voogt P, Jensen AA, Kannan K, Mabury SA, van Leeuwen SPJ (2011) Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr Environ Assess Manag 7(4):513–541 Guo R, Reiner E, Bhavsar SP, Helm PA, Mabury S, Braekevelt E, Tittlemier SA (In press) Determination of polyfluoroalkyl phosphate diesters, perfluorophosphonates, perfluorophosphinates, perfluorocarboxylic acids and perfluorosulfonic acids in Lake Trout from the Great Lakes Region. Anal Bioanal Chem. doi:10.1007/s00216-012-6125-1 De Silva AO, Spencer C, Scott BF, Backus S, Muir DCG (2011) Detection of a cyclic perfluorinated acid, perfluoroethylcyclohexane sulfonate, in the Great Lakes of North America. Environ Sci Technol 45(19):8060–8066. doi:10.1021/es200135c Furdui V, Helm P, Crozier P, Lucaciu C, Reiner E, Marvin C, Whittle D, Mabury S, Tomy G (2008) Temporal trends of perfluoroalkyl compounds with isomer analysis in lake trout from Lake Ontario (1979–2004). Environ Sci Technol 42(13):4739–4744 Furdui V, Stock N, Ellis D, Butt C, Whittle D, Crozier P, Reiner E, Muir D, Mabury S (2007) Spatial distribution of perfluoroalkyl contaminants in lake trout from the Great Lakes. Environ Sci Technol 41(5):1554–1559 Gruber L, Schlummer M, Ungewiss J, Wolz G, Moeller A, Weise N, Fromme H (2007) Analysis of sub-ppb Levels of PFOA and PFOS in food and fish. In: organohalogen compounds. pp 142–145 Bethem R, Boison J, Gale J, Heller D, Lehotay S, Loo J, Musser S, Price P, Stein S (2003) Establishing the fitness for purpose of mass spectrometric methods. J Am Soc Mass Spectrom 14(5):528–541 Van den Berg M, Birnbaum L, Bosveld ATC, Brunstrom B, Cook P, Feeley M, Giesy JP, Hanberg A, Hasegawa R, Kennedy SW, Kubiak T, Larsen JC, van Leeuwen FXR, Liem AKD, Nolt C, Peterson RE, Poellinger L, Safe S, Schrenk D, Tillitt D, Tysklind M, Younes M, Waern F, Zacharewski T (1998) Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife. Environ Heal Perspect 106(12):775–792. doi:10.1289/ehp.98106775 Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walker N, Peterson RE (2006) The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol Sci 93(2):223–241. doi:10.1093/toxsci/kfl055 Bhavsar SP, Reiner EJ, Hayton A, Fletcher R, MacPherson K (2008) Converting Toxic Equivalents (TEQ) of dioxins and dioxin-like compounds in fish from one Toxic Equivalency Factor (TEF) scheme to another. Environ Int 34(7):915–921. doi:10.1016/j.envint.2008.02.001 Puzyn T, Falandysz J, Jones PD, Giesy JP (2007) Quantitative structure - activity relationships for the prediction of relative in vitro potencies (REPs) for chloronaphthalenes. J Environ Sci Health Part a-Toxic/Hazard Subst Environ Eng 42(5):573–590. doi:10.1080/10934520701244326 Olsman H, Engwall M, Kammann U, Klempt M, Otte J, van Bavel B, Hollert H (2007) Relative differences in aryl hydrocarbon receptor-mediated response for 18 polybrominated and mixed halogenated dibenzo-p-dioxins and -furans in cell lines from four different species. Environ Toxicol Chem 26(11):2448–2454. doi:10.1897/07-004r.1 Mason G, Zacharewski T, Denomme MA, Safe L, Safe S (1987) Polybrominated dibenzo-para-dioxins and related-compounds - quantitative in-vivo and in-vitro structure-activity-relationships. Toxicology 44(3):245–255. doi:10.1016/0300-483x(87)90027-8 Wiberg K, Rappe C, Haglund P (1992) Analysis of bromo-dibenzo-para-dioxins, chloro-dibenzo-para-dioxins and mixed bromo chloro-dibenzo-para-dioxins and dibenzofurans in salmon, osprey and human-milk. Chemosphere 24(10):1431–1439. doi:10.1016/0045-6535(92)90265-s Buser HR (1987) Brominated and brominated chlorinated dibenzodioxins and dibenzofurans - potential environmental contaminants. Chemosphere 16(8–9):1873–1876. doi:10.1016/0045-6535(87)90180-9 Taguchi VY, Nieckarz RJ, Clement RE, Krolik S, Williams R (2010) Dioxin Analysis by Gas Chromatography-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (GC-FTICRMS). J Am Soc Mass Spectrom 21(11):1918–1921. doi:10.1016/j.jasms.2010.07.010 Myers A, Mabury S, Reiner EJ (In press) Analysis of mixed halogenated dibenzo-p-dioxins and dibenzofurans (PXDD, PXDFs) in soil by gas chromatography tandem mass spectrometry. Chemosphere. doi:10.116/j.chemosphere.201202.013 Bhavsar SP, Fletcher R, Hayton A, Reiner EJ, Jackson DA (2007) Composition of dioxin-like PCBs in fish: an application for risk assessment. Environ Sci Technol 41(9):3096–3102. doi:10.1021/es062402y Bhavsar SP, Hayton A, Jackson DA (2008) Uncertainty analysis of dioxin-like polychlorinated biphenyls-related toxic equivalents in fish. Environ Toxicol Chem 27(4):997–1005. doi:10.1897/07-460.1 Bhavsar SP, Hayton A, Reiner EJ, Jackson DA (2007) Estimating dioxin-like polychlorinated biphenyl toxic equivalents from total polychlorinated biphenyl measurements in fish. Environ Toxicol Chem 26(8):1622–1628. doi:10.1897/06-621r.1 Babut M, Miege C, Villeneuve B, Abarnou A, Duchemin J, Marchand P, Narbonne JF (2009) Correlations between dioxin-like and indicators PCBs: potential consequences for environmental studies involving fish or sediment. Environ Pollut 157(12):3451–3456. doi:10.1016/j.envpol.2009.06.016 Harrad S, Diamond M (2006) New directions: exposure to polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs): current and future scenarios. Atmos Environ 40(6):1187–1188. doi:10.1016/j.atmosenv.2005.10.006 Bhavsar SP, Gewurtz SB, Helm PA, Labencki TL, Marvin CH, Fletcher R, Hayton A, Reiner EJ, Boyd D (2010) Estimating sediment quality thresholds to prevent restrictions on fish consumption: application to polychlorinated biphenyls and dioxins-furans in the canadian great lakes. Integr Environ Assess Manag 6(4):641–652. doi:10.1002/ieam.102 OMOE (2011) 2011–2012 Guide to eating Ontario sport fish. Ontario Ministry of the Environment, Toronto Delinsky AD, Strynar MJ, McCann PJ, Varns JL, McMillan L, Nakayama SF, Lindstrom AB (2010) Geographical distribution of perfluorinated compounds in fish from Minnesota Lakes and Rivers. Environ Sci Technol 44(7):2549–2554. doi:10.1021/es903777s MDH (2011) Overview of Perfluorochemicals and Health. Minnesota Department of Health. http://www.health.state.mn.us/divs/eh/hazardous/topics/pfcshealth.html. Accessed March 20, 2012 CCME (2012) Canadian Environmental Quality Guidelines Summary Table. Canadian Council of Ministers of the Environment. http://st-ts.ccme.ca/. Accessed March 20, 2012 U.S.EPA (2012) Aquatic Life Criteria. U.S.EPA. http://water.epa.gov/scitech/swguidance/standards/criteria/aqlife/index.cfm. Accessed March 20, 2012 Environment Canada (2010) Planning for a sustainable future: a federal sustainable development strategy for Canada United Nations (1992) Report of the United Nations conference on environment and development. United Nations. http://www.un.org/documents/ga/conf151/aconf15126-1annex1.htm. Accessed March 20, 2012 International Programme on Chemical Safety Environmental Health Criteria 192, Flame Retardants: a general introduction. http://www.inchem.org/documents/ehc/ehc/ehc192.htm. Accessed March 15, 2012 Georlette P (2001) Applications of halogen flame retardants. In: Horrocks AR, Price D (eds) Fire retardant materials. Woodhead Publishing, Cambridge, pp 264–292 Bocchini S, Camino G (2010) Halogen-containing flame retardants. In: Wilkie CA, Morgan AB (eds) Fire retardancy of polymeric materials. CRC Press, Boca Raton, pp 75–106 Tomy GT, Stern GA (1999) Analysis of C-14-C-17 polychloro-n-alkanes in environmental matrixes by accelerated solvent extraction-high-resolution gas chromatography/electron capture negative ion high-resolution mass spectrometry. Anal Chem 71(21):4860–4865. doi:10.1021/ac990458n