Organic Compounds Detected in Deciduous Teeth: A Replication Study from Children with Autism in Two Samples

Journal of Environmental and Public Health - Tập 2015 - Trang 1-9 - 2015
Raymond F. Palmer1, Lynne Heilbrun1, David Camann2, Alice Yau2, Stanley G. Schultz1, Viola Elisco1, Beatriz Tapia1, Noe Garza1, Claudia S. Miller1
1Department of Family and Community Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA
2Department of Analytical and Environmental Chemistry, Southwest Research Institute, 6220 Culebra Road, San Antonio, TX 78238-5166, USA

Tóm tắt

Biological samples are an important part of investigating toxic exposures and disease outcomes. However, blood, urine, saliva, or hair can only reflect relatively recent exposures. Alternatively, deciduous teeth have served as a biomarker of early developmental exposure to heavy metals, but little has been done to assess organic toxic exposures such as pesticides, plastics, or medications. The purpose of our study was to determine if organic chemicals previously detected in a sample of typically developing children could be detected in teeth from a sample of children with autism. Eighty-three deciduous teeth from children with autism spectrum disorders (ASD) were chosen from our tooth repository. Organic compounds were assessed using liquid chromatography tandem mass spectrometry and gas chromatography methods. Consistent with a prior report from Camann et al., (2013), we have demonstrated that specific semivolatile organic chemicals relevant to autism etiology can be detected in deciduous teeth. This report provides evidence that teeth can be useful biomarkers of early life exposure for use in epidemiologic case-control studies seeking to identify differential unbiased exposures during development between those with and without specific disorders such as autism.

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Journal of Environmental and Public Health

Tập 2015

1-9

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