Organ transplant recipients with Merkel cell carcinoma have reduced progression-free, overall, and disease-specific survival independent of stage at presentation

Kempf, 2013, Skin cancer in organ transplant recipients, Pathobiology, 80, 302, 10.1159/000350757 Albores-Saavedra, 2010, Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study, J Cutan Pathol, 37, 20, 10.1111/j.1600-0560.2009.01370.x Penn, 1999, Merkel’s cell carcinoma in organ recipients: report of 41 cases, Transplantation, 68, 1717, 10.1097/00007890-199912150-00015 Agelli, 2003, Epidemiology of primary Merkel cell carcinoma in the United States, J Am Acad Dermatol, 49, 832, 10.1016/S0190-9622(03)02108-X Buell, 2002, Immunosuppression and Merkel cell cancer, Transplant Proc, 34, 1780, 10.1016/S0041-1345(02)03065-8 Heath, 2008, Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features, J Am Acad Dermatol, 58, 375, 10.1016/j.jaad.2007.11.020 Tadmor, 2012, Increased incidence of chronic lymphocytic leukemia and lymphomas in patients with Merkel cell carcinoma–a population based study of 335 cases with neuroendocrine skin tumor, Br J Haematol, 157, 457, 10.1111/j.1365-2141.2012.09087.x Engels, 2002, Merkel cell carcinoma and HIV infection, Lancet, 359, 497, 10.1016/S0140-6736(02)07668-7 Paulson, 2013, Systemic immune suppression predicts diminished Merkel cell carcinoma–specific survival independent of stage, J Invest Dermatol, 133, 642, 10.1038/jid.2012.388 Brewer, 2012, Chronic lymphocytic leukemia is associated with decreased survival of patients with malignant melanoma and Merkel cell carcinoma in a SEER population-based study, J Clin Oncol, 30, 843, 10.1200/JCO.2011.34.9605 Tarantola, 2013, Prognostic factors in Merkel cell carcinoma: analysis of 240 cases, J Am Acad Dermatol, 68, 425, 10.1016/j.jaad.2012.09.036 Zur Hausen, 2009, The search for infectious causes of human cancers: where and why, Virology, 392, 1, 10.1016/j.virol.2009.06.001 Gandhi, 2009, Merkel cell polyomavirus: an update, J Cutan Pathol, 36, 1327, 10.1111/j.1600-0560.2009.01464.x Feng, 2008, Clonal integration of a polyomavirus in human Merkel cell carcinoma, Science, 319, 1096, 10.1126/science.1152586 Andres, 2010, Prevalence of MCPyV in Merkel cell carcinoma and non-MCC tumors, J Cutan Pathol, 37, 28, 10.1111/j.1600-0560.2009.01352.x Duncavage, 2009, Prevalence of Merkel cell polyomavirus in Merkel cell carcinoma, Mod Pathol, 22, 516, 10.1038/modpathol.2009.3 Becker, 2009, MC polyomavirus is frequently present in Merkel cell carcinoma of European patients, J Invest Dermatol, 129, 248, 10.1038/jid.2008.198 Wieland, 2011, Merkel cell polyomavirus infection and Merkel cell carcinoma in HIV-positive individuals, Curr Opin Oncol, 23, 488, 10.1097/CCO.0b013e3283495a5b Paulson, 2011, Transcriptome-wide studies of Merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival, J Clin Oncol, 29, 1539, 10.1200/JCO.2010.30.6308 Sihto, 2012, Tumor infiltrating immune cells and outcome of Merkel cell carcinoma: a population-based study, Clin Cancer Res, 18, 2872, 10.1158/1078-0432.CCR-11-3020 Kubica, 2012, Melanoma in immunosuppressed patients, Mayo Clin Proc, 87, 991, 10.1016/j.mayocp.2012.04.018 Brewer, 2011, Malignant melanoma in solid transplant recipients: collection of database cases and comparison with surveillance, epidemiology, and end results data for outcome analysis, Arch Dermatol, 147, 790, 10.1001/archdermatol.2011.159 Rodrigues, 2002, Altered clinical course of malignant melanoma in HIV-positive patients, Arch Dermatol, 138, 765, 10.1001/archderm.138.6.765 Burgi, 2005, Incidence and risk factors for the occurrence of non-AIDS-defining cancers among human immunodeficiency virus–infected individuals, Cancer, 104, 1505, 10.1002/cncr.21334 Koljonen, 2009, Incidence of Merkel cell carcinoma in renal transplant recipients, Nephrol Dial Transplant, 24, 3231, 10.1093/ndt/gfp334 Lanoy, 2010, Skin cancers associated with autoimmune conditions among elderly adults, Br J Cancer, 103, 112, 10.1038/sj.bjc.6605733 Hemminki, 2012, Kaposi sarcoma and Merkel cell carcinoma after autoimmune disease, Int J Cancer, 131, E326, 10.1002/ijc.27376 Muirhead, 2007, Partial regression of Merkel cell carcinoma in response to withdrawal of azathioprine in an immunosuppression-induced case of metastatic Merkel cell carcinoma, Clin Oncol (R Coll Radiol), 19, 96, 10.1016/j.clon.2006.10.001 Burack, 2003, Sustained remission of metastatic Merkel cell carcinoma with treatment of HIV infection, J R Soc Med, 96, 238, 10.1258/jrsm.96.5.238 Bhatia, 2011, Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer, Curr Oncol Rep, 13, 488, 10.1007/s11912-011-0197-5 Goronzy, 2007, Aging and T-cell diversity, Exp Gerontol, 42, 400, 10.1016/j.exger.2006.11.016 Teicher, 2007, Transforming growth factor-beta and the immune response to malignant disease, Clin Cancer Res, 13, 6247, 10.1158/1078-0432.CCR-07-1654 Houston, 2003, Fas ligand mediates immune privilege and not inflammation in human colon cancer, irrespective of TGF-beta expression, Br J Cancer, 89, 1345, 10.1038/sj.bjc.6601240 Khong, 2002, Natural selection of tumor variants in the generation of “tumor escape” phenotypes, Nat Immunol, 3, 999, 10.1038/ni1102-999 Rubinstein, 2004, The role of galectins in the initiation, amplification and resolution of the inflammatory response, Tissue Antigens, 64, 1, 10.1111/j.0001-2815.2004.00278.x Uyttenhove, 2003, Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase, Nat Med, 9, 1269, 10.1038/nm934 Dowlatshahi, 2013, Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T cell exhaustion in reducing T cell responses, J Invest Dermatol, 133, 1879, 10.1038/jid.2013.75 Ullrich, 2005, Mechanisms underlying UV-induced immune suppression, Mutat Res, 571, 185, 10.1016/j.mrfmmm.2004.06.059