Optimum b value for resolving crossing fibers: a study with standard clinical b value using 1.5-T MR

We sought to investigate the optimum b value for resolving crossing fiber using high-angular resolution diffusion imaging (HARDI)-based multi-tensor tractography. The study tested the standard b values that are commonly used in the routine clinical setting. Ten normal volunteers (five men and five women) with a mean age of 26.3 years (range, 22–32 years) were scanned using a 1.5-T clinical magnetic resonance unit. Single-shot echo-planar imaging was used for diffusion-weighted imaging with a diffusion-sensitizing gradient in 32 orientations. The b values of 700, 1,400, 2,100, and 2,800 s/m2 were used. Data postprocessing was performed using multi-tensor methods. The depiction of the optic nerves, optic tracts, and decussation of superior cerebellar peduncles were assessed. The depictions of the nerve fibers were independent of the b values tested. The depiction of crossing fibers by HARDI-based multi-tensor tractography is not substantially influenced by b values ranging from 700 to 2,800 s/m2. Thus, the optimum b value within this range may be the lowest one considering the higher signal to noise ratio.