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Tối ưu hóa quá trình vi bao metronidazole trong vi hạt alginate nhằm mục đích giải phóng kiểm soát
Tóm tắt
Để đạt được các điều kiện tối ưu cho việc bao gói metronidazole trong sodium alginate, phương pháp bề mặt phản hồi (RSM) đã được sử dụng để tìm hiểu ảnh hưởng của các biến độc lập (nồng độ alginate và tỷ lệ thuốc so với alginate) đến các biến phụ thuộc bao gồm kích thước hạt trung bình, tỷ lệ thu hồi, tải thuốc và hiệu suất bao gói. Hơn nữa, ảnh hưởng của nồng độ alginate đến hành vi trương nở của vi hạt cũng đã được đánh giá, và cơ chế giải phóng thuốc cũng đã được nghiên cứu. Dựa trên các kết quả, có thể khẳng định rằng vi hạt hình cầu với kích thước hạt trung bình từ 443–665 µm đã được thu được với các tỷ lệ thu hồi, tải thuốc và hiệu suất bao gói lần lượt gần 79.5%, 54.9% và 79.9%. Lượng metronidazole được giải phóng được phát hiện là 68% trong 7 giờ với công thức chứa tỷ lệ thuốc so với polymer là 2:1. Các giá trị tối ưu cho nồng độ alginate và tỷ lệ thuốc so với alginate được xác định lần lượt là 1.4% (w/v) và 2.85 (w/w).
Từ khóa
#metronidazole #alginate #vi hạt #tối ưu hóa #phương pháp bề mặt phản hồi #giải phóng kiểm soátTài liệu tham khảo
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