Optimization of a Bayesian penalized likelihood algorithm (Q.Clear) for 18F-NaF bone PET/CT images acquired over shorter durations using a custom-designed phantom

EJNMMI Physics - Tập 7 Số 1 - 2020
Tokiya Yoshii1, Kazuhisa Miwa1, Masashi Yamaguchi1, Kai Shimada1, Kei Wagatsuma2, Tensho Yamao1, Yuto Kamitaka1, Seiya Hiratsuka1, Rinya Kobayashi1, Hajime Ichikawa3, Noriaki Miyaji4, Tsuyoshi Miyazaki5, Kenji Ishii2
1Department of Radiological Sciences, School of Health Science, International University of Health and Welfare, 2600-1 Kitakanemaru, Ohtawara, Tochigi, 324-8501, Japan
2Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan
3Department of Radiology, Toyohashi Municipal Hospital, 50, Aza Hachiken Nishi, Aotake-Cho, Toyohashi, Aichi, 441-8570, Japan
4Department of Nuclear Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan
5Department of Orthopaedic Surgery, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2, Sakae-cho, Itabashi-ku, Tokyo, 173-0015, Japan

Tóm tắt

AbstractBackgroundThe Bayesian penalized likelihood (BPL) algorithm Q.Clear (GE Healthcare) allows fully convergent iterative reconstruction that results in better image quality and quantitative accuracy, while limiting image noise. The present study aimed to optimize BPL reconstruction parameters for18F-NaF PET/CT images and to determine the feasibility of18F-NaF PET/CT image acquisition over shorter durations in clinical practice.MethodsA custom-designed thoracic spine phantom consisting of several inserts, soft tissue, normal spine, and metastatic bone tumor, was scanned using a Discovery MI PET/CT scanner (GE Healthcare). The phantom allows optional adjustment of activity distribution, tumor size, and attenuation. We reconstructed PET images using OSEM + PSF + TOF (2 iterations, 17 subsets, and a 4-mm Gaussian filter), BPL + TOF (β = 200 to 700), and scan durations of 30–120 s. Signal-to-noise ratios (SNR), contrast, and coefficients of variance (CV) as image quality indicators were calculated, whereas the quantitative measures were recovery coefficients (RC) and RC linearity over a range of activity. We retrospectively analyzed images from five persons without bone metastases (male,n= 1; female,n= 4), then standardized uptake values (SUV), CV, and SNR at the 4th, 5th, and 6th thoracic vertebra were calculated in BPL + TOF (β = 400) images.ResultsThe optimal reconstruction parameter of the BPL was β = 400 when images were acquired at 120 s/bed. At 90 s/bed, the BPL with a β value of 400 yielded 24% and 18% higher SNR and contrast, respectively, than OSEM (2 iterations; 120 s acquisitions). The BPL was superior to OSEM in terms of RC and the RC linearity over a range of activity, regardless of scan duration. The SUVmaxwere lower in BPL, than in OSEM. The CV and vertebral SNR in BPL were superior to those in OSEM.ConclusionsThe optimal reconstruction parameters of18F-NaF PET/CT images acquired over different durations were determined. The BPL can reduce PET acquisition to 90 s/bed in18F-NaF PET/CT imaging. Our results suggest that BPL (β = 400) on SiPM-based TOF PET/CT scanner maintained high image quality and quantitative accuracy even for shorter acquisition durations.

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