Optimal control of certain infinite dimensional systems with application to chemotherapy modelling

Proceedings of the American Control Conference - Tập 5 - Trang 3466-3471 vol.5 - 2002
J. Smieja1, A. Swierniak1
1Department of Automatic Control, Silesian University of Technology, Gliwice, Poland

Tóm tắt

This paper is concerned with modeling and control of a certain class of bilinear systems. They are described by infinite number of ODE. The form of the system matrix allows decomposing the model, which, in turn, enables addressing problems of system analysis and control optimization. The system description is transformed into a finite number of integro-differential equations. An optimal control problem is stated, with the performance index defined in l/sub 1/ space, due to particular problem applications in the fields of biomedical modeling and queuing systems. Necessary conditions for optimal control are derived and their applicability discussed.

Từ khóa

#Optimal control #Transmission line matrix methods #Matrix decomposition #Automatic control #Nonlinear systems #Control system analysis #Control system synthesis #Integrodifferential equations #Performance analysis #History

Tài liệu tham khảo

10.1016/0165-1161(93)90004-J 10.1016/0016-0032(52)90836-3 10.1006/jtbi.1994.1095 swierniak, 1998, Infinite dimensional model of evolution of drug resistance of cancer cells, Journal of Mathematical Systems Estimation and Control, 8, 1 wierniak, 1999, Qualitative analysis of controlled drug resistance model - Inverse Laplace and semigroup approach, Control and Cybernetics, 28, 61 mieja, 0, Gradient method for finding optimal scheduling in infinite dimensional models of chemotherapy, Journal of Theoretical Medicine wierniak, 1997, Asymptotic properties of infinite dimensional model of drug resistance evolution, ECC'97 Proceedings CD-ROM Brussels Summary, 1 curtain, 1995, An Introduction to Infinite-Dimensional Linear Systems Theory, 10.1007/978-1-4612-4224-6 10.1109/TAC.1972.1099857 10.1016/B978-1-4831-6713-8.50010-5 smieja, 1999, Control optimization for the infinite dimensional model of drug resistance via a gradient method, Proc of 18 IASTED Conference Modeling Identification and Control Innsbruck, 245 polanski, 1997, Qualitative analysis of the infinite-dimensional model of evolution of drug resistance, Advances in Mathematical Population Dynamics - Molecules Cells and Man World Scientific, 595 kleinrock, 1976, Queuing Systems Vol 1 Theory kimmel, 1990, Mathematical models of gene amplification with applications to cellular drug resistance and tumorigenicity, Genetics, 125, 633, 10.1093/genetics/125.3.633 gabasov, 1971, The Qualitative Theory of Optimal Processes smieja, 1999, Optimal control for the model of drug resistance resulting from gene amplification, Preprints 12th World Congress IFAC, 71 pontryagin, 1962, Mathematical Theory of Optimal Processes