Optimal clinical management of children receiving dietary therapies for epilepsy: Updated recommendations of the International Ketogenic Diet Study Group

Epilepsia Open - Tập 3 Số 2 - Trang 175-192 - 2018
Eric H. Kossoff1, Beth Zupec‐Kania2, Stéphane Auvin3, Karen Ballaban‐Gil4, Anna Bergqvist5, Robyn Blackford6, Jeffrey Buchhalter7, Roberto Caraballo8, J. Helen Cross9, Maria Dahlin10, Elizabeth Donner11, Orkide Güzel12, Rana Jehle13, Joerg Klepper14, Hoon‐Chul Kang15, Danielle A.J.E. Lambrechts16, Y.M. Christiana Liu17, Janak Nathan18, Douglas R. Nordli19, Heidi H. Pfeifer20, Jong M. Rho21, Ingrid E. Scheffer22, Suvasini Sharma23, Carl E. Stafstrom24, Elizabeth A. Thiele20, Zahava Turner25, María Magdalena Vaccarezza26, Elles J.T.M. van der Louw27, Pierangelo Veggiotti28, James W. Wheless29, Elaine Wirrell30
1Departments of Neurology and Pediatrics Johns Hopkins Outpatient Center Baltimore Maryland U.S.A.
2The Charlie Foundation Santa Monica California U.S.A.
3Department of Pediatric Neurology CHU Hôpital Robert Debré Paris France
4Department of Neurology and Pediatrics Montefiore Medical Center/Albert Einstein College of Medicine Bronx New York U.S.A.
5Department of Neurology The Childrens Hospital of Philadelphia Philadelphia Pennsylvania U.S.A.
6Department of Nutrition Lurie Children's Hospital Chicago Illinois U.S.A.
7Department of Pediatrics, Alberta Children's Hospital, Calgary, Alberta, Canada
8Department of Neurology Hospital J P Garrahan, Capital Federal Buenos Aires Argentina
9Department of Clinical & Experimental Epilepsy Great Ormond Street Hospital University College London London United Kingdom
10Department of Clinical Neuroscience, Women's and Children's Health Karolinska Institute Stockholm Sweden
11Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada
12Department of Pediatric Neurology, Izmir Dr. Behcet Uz Children's Hospital, Izmir, Turkey
13Department of Neurology Montefiore Medical Center Bronx New York U.S.A.
14Department of Pediatrics and Neuropediatrics Children's Hospital Aschaffenburg Aschaffenburg Germany
15Department of Pediatrics Pediatric Epilepsy Clinic Severance Children's Hospital Seoul Korea
16Department of Neurology, Epilepsy Centre Kempenhaeghe, Heeze, The Netherlands
17Department of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada
18Department of Child Neurology Shushrusha Hospital Mumbai India
19Department of Neurology Children's Hospital of Los Angeles Los Angeles California U.S.A.
20Department of Neurology Massachusetts General Hospital Boston Massachusetts U.S.A.
21Department of Paediatrics Alberta Children's Hospital Calgary Alberta Canada
22Epilepsy Research Centre The University of Melbourne Austin Health Heidelberg Victoria Australia
23Department of Pediatrics, Lady Hardinge Medical College, New Delhi, India
24Departments of Pediatrics and Neurology Johns Hopkins Hospital Baltimore Maryland U.S.A.
25Department of Pediatrics The Johns Hopkins University Baltimore Maryland U.S.A.
26Department of Neurology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
27Department of Dietetics Sophia Children's Hospital Erasmus Medical Centre Rotterdam The Netherlands
28Infantile Neuropsychiatry Neurological Institute Foundation Casimiro Mondino Pavia Italy
29Department of Pediatric Neurology University of Tennessee Memphis Tennessee U.S.A.
30Department of Neurology, Child and Adolescent Neurology Mayo Clinic Rochester Minnesota U.S.A.

Tóm tắt

SummaryKetogenic dietary therapies (KDTs) are established, effective nonpharmacologic treatments for intractable childhood epilepsy. For many yearsKDTswere implemented differently throughout the world due to lack of consistent protocols. In 2009, an expert consensus guideline for the management of children onKDTwas published, focusing on topics of patient selection, pre‐KDTcounseling and evaluation, diet choice and attributes, implementation, supplementation, follow‐up, side events, andKDTdiscontinuation. It has been helpful in outlining a state‐of‐the‐art protocol, standardizingKDTfor multicenter clinical trials, and identifying areas of controversy and uncertainty for future research. Now one decade later, the organizers and authors of this guideline present a revised version with additional authors, in order to include recent research, especially regarding other dietary treatments, clarifying indications for use, side effects during initiation and ongoing use, value of supplements, and methods ofKDTdiscontinuation. In addition, authors completed a survey of their institution's practices, which was compared to responses from the original consensus survey, to show trends in management over the last 10 years.

Từ khóa


Tài liệu tham khảo

Wilder RM, 1921, The effect of ketonemia on the course of epilepsy, Mayo Clin Bulletin, 2, 307

10.1016/S1474-4422(08)70092-9

10.1111/j.1528-1167.2008.01740.x

10.1111/epi.12069

10.1111/ane.12592

Kossoff EH, 2016, The ketogenic and modified atkins diets: treatments for epilepsy and other disorders

Whitmer E, 2013, Fighting back with Fat: a parent's guide to battling epilepsy through the ketogenic diet and modified Atkins diet

Martenz DM, 2012, The Keto Cookbook: innovative delicious meals for staying on the ketogenic diet

10.1055/s-2004-44906

10.1111/j.1528-1167.2008.01765.x

10.1111/epi.13650

10.1016/j.eplepsyres.2015.06.015

10.1111/epi.13256

10.1016/j.ejpn.2016.07.009

10.1001/archneurpsyc.1930.02220110066004

10.1016/j.seizure.2014.02.015

10.1046/j.1528-1157.2003.57002.x

10.1111/j.1528-1167.2007.01256.x

10.1016/j.yebeh.2012.01.002

10.1212/WNL.0000000000001004

10.1016/j.yebeh.2014.06.007

10.1016/j.yebeh.2016.02.038

10.1016/j.seizure.2013.03.005

10.1111/j.1528-1167.2006.00438.x

10.1212/01.wnl.0000187071.24292.9e

10.1111/j.1469-8749.2012.04233.x

10.1111/j.1469-8749.2007.00707.x

10.1007/s10545-016-0011-5

10.1002/ana.23702

10.1177/0883073813487600

10.1016/j.seizure.2016.01.011

10.1007/s00415-014-7240-z

10.1001/jamaneurol.2014.1584

10.1055/s-2002-33675

10.1016/j.eplepsyres.2014.10.014

10.1111/j.1528-1167.2005.05705.x

Caraballo RH, 2006, Ketogenic diet in patients with myoclonic‐astatic epilepsy, Epileptic Disord, 8, 151, 10.1684/j.1950-6945.2006.tb00174.x

10.1111/j.1528-1167.2007.01186.x

10.1016/j.braindev.2006.03.011

10.1111/j.1528-1167.2010.02586.x

10.1111/j.1528-1167.2005.00266.x

10.1016/j.ejpn.2006.03.001

10.1016/j.pediatrneurol.2007.01.013

10.1111/j.1528-1167.2011.03293.x

10.15844/pedneurbriefs-29-1-2

10.1111/j.1528-1167.2010.02703.x

10.1542/peds.2013-3106

10.1016/j.pediatrneurol.2004.09.006

10.1111/j.0013-9580.2004.18504.x

10.1016/j.ebcr.2015.03.003

10.1016/j.braindev.2008.12.020

Ishii M, 2011, The ketogenic diet as an effective treatment for Ohtahara syndrome, No To Hattatsu, 43, 47

10.1212/WNL.0000000000000151

10.1016/j.seizure.2017.07.002

10.1111/j.1528-1167.2006.00906.x

10.1016/j.yebeh.2016.12.018

10.1111/j.1442-200X.2010.03118.x

10.1016/j.eplepsyres.2006.01.007

10.1177/08830738030180011801

10.1007/s00381-005-1155-z

10.1177/088307389901401102

10.1016/S1059-1311(02)00268-6

10.1016/S0022-3476(97)70048-9

10.1177/0883073811424465

10.1002/ana.20565

10.1016/j.yebeh.2012.11.007

10.1111/epi.13813

10.1684/epd.2015.0741

10.1177/0883073810376443

10.1016/j.eplepsyres.2016.09.018

Tein I, 2002, Role of carnitine and fatty acid oxidation and its defects in infantile epilepsy, J Child Neurol, 17, S57

10.1055/s-2004-820992

10.1016/j.seizure.2007.04.010

10.1542/peds.2008-0012

10.3389/fphar.2012.00059

10.1016/j.seizure.2016.12.019

10.1016/j.yebeh.2012.05.003

10.1016/j.yebeh.2005.12.002

10.1016/j.pediatrneurol.2017.01.007

10.1177/0883073817709179

10.1203/00006450-197605000-00006

Schwartz RH, 1989, Ketogenic diets in the treatment of epilepsy: short‐term clinical effects, Dev Med Child Neurol, 1, 145, 10.1111/j.1469-8749.1989.tb03972.x

10.1111/j.1528-1167.2008.01870.x

10.1542/peds.2007-2410

10.1111/j.1528-1167.2007.01025.x

10.1016/j.pediatrneurol.2004.03.007

10.1016/j.pediatrneurol.2013.08.006

Sell E, 2005, The medium‐chain triglyceride ketogenic diet for the treatment of refractory lesional epilepsy in children, Epilepsia, 46, 234

10.1111/j.1528-1167.2006.00910.x

10.1016/j.yebeh.2007.01.012

10.1016/j.eplepsyres.2016.09.002

10.1016/j.seizure.2011.08.009

10.4103/0972-2327.194463

10.1111/j.1528-1167.2008.01959.x

10.1016/j.seizure.2011.03.008

10.1016/j.seizure.2014.03.012

10.1016/j.braindev.2017.03.027

10.1177/088307380201700305

Nathan JK, 2009, Ketogenic diet in Indian children with uncontrolled epilepsy, Indian Pediatr, 46, 669

10.1111/j.1528-1167.2005.00282.x

10.1542/peds.2004-1001

10.1001/archpedi.153.9.946

10.1111/j.1528-1167.2007.01417.x

10.1016/j.seizure.2015.09.007

10.1111/j.1528-1167.2008.01864.x

10.1111/j.1528-1167.2006.00903.x

10.1016/j.pediatrneurol.2005.11.001

10.1111/j.1600-0404.2010.01359.x

10.1111/jcpt.12578

10.1111/j.1528-1167.2005.22705.x

10.1016/j.ejpn.2016.04.003

10.1016/j.pediatrneurol.2015.10.006

10.1016/j.braindev.2005.11.005

10.1046/j.1528-1157.2002.00602.x

10.1046/j.1528-1157.2002.11302.x

10.1016/j.eplepsyres.2010.04.005

10.1542/peds.2009-0217

10.1016/j.yebeh.2004.03.011

10.1017/S0317167100001542

10.1007/s40272-014-0115-z

10.1111/j.1528-1167.2006.00803.x

10.1111/j.1365-277X.2011.01172.x

10.1007/s12011-016-0897-7

10.1046/j.1528-1157.2003.26102.x

10.1016/j.pediatrneurol.2008.08.013

10.1007/s00246-012-0219-6

10.1177/0883073807301926

10.1136/bmj.1.5741.148

10.1111/j.0013-9580.2004.10004.x

10.1046/j.1528-1157.2001.18001.x

Alberti MJ, 2016, Recommendations for the clinical management of children with refractory epilepsy receiving the ketogenic diet, Arch Argent Pediatr, 114, 56

AAP Committee on Nutrition, 2013, Pediatric nutrition, 1147, 10.1542/9781581108194-part06-ch49

10.1177/0883073814535498

10.1177/088307380001501203

10.1016/j.seizure.2009.10.009

10.1002/epi4.12058

10.1001/jama.290.7.912

10.3945/ajcn.2008.26099

10.1111/j.1528-1167.2008.01769.x

10.1016/j.eplepsyres.2011.01.012

10.1177/0883073807306255

10.1111/j.1528-1157.1998.tb01160.x

10.1177/088307380101600901

10.1016/j.seizure.2011.06.009

10.1007/s13760-016-0601-x

10.1177/0883073813476140

10.1177/0883073808318061

10.1007/s10072-015-2436-2

10.1111/j.1469-8749.2006.tb01269.x

10.1177/0883073815576793

10.1016/j.pediatrneurol.2015.10.017

10.1016/j.seizure.2013.12.002

10.1016/j.ejpn.2014.03.006

10.1007/s004670000443

10.1111/j.1469-8749.2002.tb00769.x

10.1016/S0002-8223(02)90093-3

10.1016/j.jada.2005.02.009

10.1212/WNL.54.12.2328

10.1016/j.jocn.2011.05.012

10.1177/088307380101600910

10.1111/epi.12583

10.1007/s11940-014-0291-8

10.1111/j.1528-1167.2010.02940.x

10.1111/j.1528-1167.2006.00911.x

10.1016/j.eplepsyres.2011.04.003

10.1111/j.1528-1167.2009.02488.x

10.1194/jlr.R048975

Rogawski MA, 2016, Mechanisms of action of antiseizure drugs and the ketogenic diet, Cold Spring Harb Perspect Med, 2, 6

10.1038/nm.3804

10.1111/j.1528-1167.2008.01857.x

10.1038/nn1791

10.1111/epi.13634

10.1016/j.neuropharm.2012.05.012