Optimal antibody-radionuclide combinations for clinical radioimmunotherapy: a predictive model based on mouse pharmacokinetics

Ellen D. Yorke1, Paul L. Beaumier2, Barry W. Wessels1, Alan R. Fritzberg2, A.Charles Morgan2
1Division of Radiation Oncology & Biophysics, The George Washington University Medical Center, 901 23rd Street, N.W., Washington, DC 20037 USA
2NeoRx Corporation, 410 West Harrison Street, Seattle, WA 98119, U.S.A.

Tài liệu tham khảo

Beaumier, 1986, Immunoreactivity assay for labeled anti-melanoma monoclonal antibodies, J. Nucl. Med., 27, 824 Bigler, 1988, Radioimmunotherapy for micro metastases: treatment plan for Astatine 211 (alpha emitter), J. Nucl. Med., 29, 858 Brady, 1987, Therapeutic and diagnostic uses of modified monoclonal antibodies, Int. J. Radiat. Oncol. Biol. Phys., 13, 1535, 10.1016/0360-3016(87)90322-1 Buchegger, 1986, Radioimmunotherapy of human colon carcinoma by I-131 labeled monoclonal anti CEA antibodies in a nude mouse model, Cancer, 58, 655, 10.1002/1097-0142(19860801)58:3<655::AID-CNCR2820580310>3.0.CO;2-E Carasquillo, 1988, Radioimmunoscintigraphy of colon cancer with I-131 labeled B72.3 monoclonal antibody, J. Nucl. Med., 29, 1022 Cloutier, 1973, Calculating the radiation dose to an organ, J. Nucl. Med., 14, 53 Covell, 1986, Pharmacokinetics of monoclonal immunoglobulin G1, F(ab′)2 and Fab′ in mice, Cancer Res., 46, 3969 DeNardo, 1987, Treatment of a patient with B-cell lymphoma by I-131 LYM-1 monoclonal antibodies, Int. J. Biol. Markers, 2, 49, 10.1177/172460088700200107 Dillman, 1975 Fowler, 1990, Radiobiological aspects of low dose rates in radioimmunotherapy, Int. J. Radiat. Oncol. Biol. Phys., 18, 1261, 10.1016/0360-3016(90)90467-X Friguet, 1985, Measurements of the true affinity constant in solution of antigen-antibody complexes by enzyme-linked immunoabsorbent assays, J. Immunol. Methods, 77, 305, 10.1016/0022-1759(85)90044-4 Fritzberg, 1988, Approaches to radiolabeling of antibodies for diagnosis and therapy of cancer, Pharmaceut. Res., 5, 325, 10.1023/A:1015995208444 Hanelin, 1989, Preliminary clinical evaluation of Re-186 labeled NR-CO-02 anti CEA F(ab)2 antibody fragment as a potential radioimmunotherapeutic agent, J. Nucl. Med., 30, 799 Johnstone, 1980, 48 Kunkler, 1952, The limit of renal tolerance to x-ray: an investigation into renal damage occurring following treatment of tumors of the testis by abdominal baths, Br. J. Radiat., 25, 190, 10.1259/0007-1285-25-292-190 Kunz, 1990, Microdistribution of 186Re radioimmunoconjugates in human metastatic tumor foci and human tumor xenografts in nude mice, Antibody Immunoconj. Radiopharm., 3, 75 Larson, 1985, Radiolabeled monoclonal anti-tumor antibodies in diagnosis and therapy, J. Nucl. Med., 26, 538 Lederer, 1978 Lee, 1988, Therapeutic efficacy of antiglioma mesenchymal extra-cellular matrix I-131 radiolabeled murine monoclonal antibody in a human glioma xenograft model, Cancer Res., 48, 559 Leichner, 1981, Dosimetry of 131I-labeled anti-ferritin in hepatoma: a model for radioimmunoglobulin dosimetry, Int. J. Radiat. Oncol. Biol. Phys., 7, 323, 10.1016/0360-3016(81)90105-X Miraldi, 1986, Diagnostic imaging of human neuroblastoma with radiolabeled antibody, Radiology, 161, 413, 10.1148/radiology.161.2.3763911 Moldofsky, 1983, Metastatic colon carcinoma detected with radiolabeled F(ab′)2 monoclonal antibody fragments, Radiology, 149, 549, 10.1148/radiology.149.2.6622704 Murray, 1987, Clinical parameters related to optimal tumor localization of In-III labeled mouse antimelanoma monoclonal antibody ZME-018, J. Nucl. Med., 28, 25 Order, 1986, Yttrium 90 antiferritin-A new therapeutic radiolabeled antibody, Int. J. Radiat. Oncol. Biol. Phys., 12, 277, 10.1016/0360-3016(86)90110-0 Order, 1988, A phase I study of yttrium 90 antiferritin: dose escalation and tumor dose, Antibody Immunoconj. Radiopharm., 1, 163 Schroff, 1991, Rhenium-186 labeled antibody in patients with cancer: report of pilot phase I study, Antibody Immunoconj. Radiopharm. Shah, 1991, Preclinical models for the study of the efficacy of radiolabeled monoclonal antibodies in cancer diagnosis and therapy Siegel, 1990, Bone marrow dosimetry and toxicity for radioimmunotherapy, Antibody Immunoconj. Radiopharm., 3, 213 Snyder, 1978 Tom, 1977, Human colon adenocarcinoma cells II. Tumorigenic and organoid expression in vivo and in vitro, J. Natl Cancer Inst., 58, 1507, 10.1093/jnci/58.5.1507 Vessella, 1988, Radioiodinated monoclonal antibodies in the imaging and treatment of human renal cell carcinoma xenografts in nude mice, 245 Wessels, 1990, Current status of animal radioimmunotherapy, Cancer Res., 50, 970s Wessels, 1984, Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies, Med. Phys., 11, 638, 10.1118/1.595559 Wilbur, 1989, Development of a stably radioiodinating reagent to label monoclonal antibodies for radiotherapy of cancer, J. Nucl. Med., 30, 216 Zalutsky, 1988, Influence of circulating antigen on blood pool activity of a radioiodinated monoclonal antibody, Nucl. Med. Biol., 15, 431