Optic nerve histopathology in a case of Wolfram Syndrome: A mitochondrial pattern of axonal loss
Fred N. Ross-Cisneros1, Billy X. Pan1, Ruwan A. Silva2, Neil R. Miller3, Thomas A. Albini2, Lisbeth Tranebjaerg4,5, Nanna D. Rendtorff5, Marianne Lodahl5, Milton N. Moraes-Filho6, Milton N. Moraes6, Solange R. Salomao7, Adriana Berezovsky7, Rubens Belfort7, Valerio Carelli8,9, Alfredo A. Sadun1
1Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
2Bascom Palmer Eye Institute and Department of Ophthalmology, Miller School of Medicine, University of Miami, Miami, FL, USA
3Wilmer Eye Institute and Department of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD, USA
4Department of Audiology, Bispebjerg Hospital, Copenhagen, Denmark
5Wilhelm Johannsen Center for Functional Genome Research, Department of Cellular and Molecular Medicine, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
6Instituto de Olhos de Colatina, Colatina, Brazil
7Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
8Department of Biomedical Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy
9IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy