Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

Journal of Controlled Release - Tập 164 Số 2 - Trang 192-204 - 2012
Geeta Mehta1,2, Amy Y. Hsiao1, Marylou Ingram3, Gary D. Luker4,5, Shuichi Takayama1,6,7
1Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109‐2099, USA
2Department of Periodontics & Oral Medicine, University of Michigan School of Dentistry, The University of Michigan, Ann Arbor, MI 48109‐2099, USA
3Huntington Medical Research Institutes, 99 North El Molino Avenue, Pasadena, CA 91101‐1830, USA
4Department of Microbiology and Immunology, University of Michigan Medical School, The University of Michigan, Ann Arbor, MI 48109‐2099, USA
5Department of Radiology, The University of Michigan, Ann Arbor, MI 48109‐2099, USA
6Department of Macromolecular Science and Engineering, The University of Michigan, Ann Arbor, MI 48109‐2099, USA
7Division of Nano-Bio and Chemical Engineering WCU Project, UNIST, Ulsan, Republic of Korea

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