One year prospective survey of Candida bloodstream infections in Scotland

Journal of Medical Microbiology - Tập 56 Số 8 - Trang 1066-1075 - 2007
Frank C. Odds1, Mary Hanson2, Amanda D. Davidson1, Martin Jacobsen1, P Wright3, Julie A. Whyte1, Neil A. R. Gow1, B Jones3
1Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK
2Department of Medical Microbiology, Western General Hospital, Edinburgh EH4 10XU, UK
3Department of Medical Microbiology, Royal Infirmary, Glasgow G4 OSF, UK

Tóm tắt

A 12 month survey of candidaemia in Scotland, UK, in which every Scottish hospital laboratory submitted all blood isolates of yeasts for identification, strain typing and susceptibility testing, provided 300 isolates from 242 patients, generating incidence data of 4.8 cases per 100 000 population per year and 5.9 cases per 100 000 acute occupied bed days; 27.9 % of cases occurred in intensive care units. More than half the patients with candidaemia had an underlying disease involving the abdomen, 78 % had an indwelling intravenous catheter, 62 % had suffered a bacterial infection within the 2 weeks prior to candidaemia and 37 % had undergone a laparotomy.Candida albicanswas the infecting species in 50 % of cases, followed byCandida glabrata(21 %) andCandida parapsilosis(12 %). Seven cases of candidaemia were caused byCandida dubliniensis, which was more prevalent even thanCandida lusitaniaeandCandida tropicalis(six cases each). AmongC. glabrataisolates, 55 % showed reduced susceptibility to fluconazole, but azole resistance among other species was extremely low. Multilocus sequence typing showed isolates with high similarity came from different hospitals across the country, and many different types came from the hospitals that submitted the most isolates, indicating no tendency towards hospital-specific endemic strains. Multiple isolates ofC. albicansandC. glabratafrom individual patients were of the same strain type with single exceptions for each species. The high prevalence of candidaemia in Scotland, relative to other population-based European studies, and the high level of reduced fluconazole susceptibility of ScottishC. glabrataisolates warrant continued future surveillance of invasiveCandidainfections.

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Journal of Medical Microbiology

Tập 56 Số 8

1066-1075

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