Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

Cancer Cell - Tập 19 Số 1 - Trang 17-30 - 2011
Wei Xu1,2, Hui Yang1,2, Ying Liu3, Ying Yang2, Ping Wang2, Se Hee Kim4, Shinsuke Ito5,4, Yang Chen6, Pu Wang1,2, Meng Xiao1,2, Li Xia Liu7, Wentong Jiang1,2, Jing Liu6, Jin Ye Zhang1, Bin Wang8, Stephen V. Frye9, Yi Zhang10,5,4, Yan-hui Xu2, Qun‐Ying Lei7,1, Kun‐Liang Guan7,11,1,2, Shimin Zhao1,2, Yue Xiong10,4,1,2
1Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Shanghai Medical School, Fudan University, Shanghai 20032, China
2State Key Laboratory of Genetic Engineering, School of Life Sciences, Shanghai Medical School, Fudan University, Shanghai 20032, China
3Department of Pathology, Shanghai Medical School, Fudan University, Shanghai 20032, China
4Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA
5Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, NC 27599, USA
6Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
7Department of Biochemistry, Shanghai Medical School, Fudan University, Shanghai 20032, China
8Department of Biological Chemistry, Shanghai Medical School, Fudan University, Shanghai 20032, China
9Center for Integrative Chemical Biology and Drug Discovery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, NC 27599, USA
10Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, NC 27599, USA
11Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA

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Cancer Cell

Tập 19 Số 1

17-30

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