Oncolytic Viruses as Antigen-Agnostic Cancer Vaccines

Cancer Cell - Tập 33 - Trang 599-605 - 2018
Stephen J. Russell1, Glen N. Barber2
1Department of Molecular Medicine, Mayo Clinic, Rochester, MN 55905, USA
2Department of Cell Biology, University of Miami Miller School of Medicine, Miami, FL 33136, USA

Tài liệu tham khảo

Alexander, 2016, The checkpoint immunotherapy revolution: what started as a trickle has become a flood, despite some daunting adverse effects; new drugs, indications, and combinations continue to emerge, P T, 41, 185 Alexandrov, 2013, Signatures of mutational processes in human cancer, Nature, 500, 415, 10.1038/nature12477 Alvarez-Breckenridge, 2015, Potentiating oncolytic viral therapy through an understanding of the initial immune responses to oncolytic viral infection, Curr. Opin. Virol., 13, 25, 10.1016/j.coviro.2015.03.015 Andtbacka, 2015, Talimogene laherparepvec improves durable response rate in patients with advanced melanoma, J. Clin. Oncol., 33, 2780, 10.1200/JCO.2014.58.3377 Andtbacka, 2016, Patterns of clinical response with talimogene laherparepvec (T-VEC) in patients with melanoma treated in the OPTiM phase III clinical trial, Ann. Surg. Oncol., 23, 4169, 10.1245/s10434-016-5286-0 Andtbacka, 2015, Final data from CALM: a phase II study of Coxsackievirus A21 (CVA21) oncolytic virus immunotherapy in patients with advanced melanoma, J. Clin. Oncol., 33, 10.1200/jco.2015.33.15_suppl.9030 Barber, 2005, VSV-tumor selective replication and protein translation, Oncogene, 24, 7710, 10.1038/sj.onc.1209042 Barber, 2011, Innate immune DNA sensing pathways: STING, AIMII and the regulation of interferon production and inflammatory responses, Curr. Opin. Immunol., 23, 10, 10.1016/j.coi.2010.12.015 Barber, 2015, STING: infection, inflammation and cancer, Nat. Rev. Immunol., 15, 760, 10.1038/nri3921 Bartee, 2017, In vivo and in situ programming of tumor immunity by combining oncolytics and PD-1 immune checkpoint blockade, Exp. Hematol. Oncol., 6, 15, 10.1186/s40164-017-0075-4 Bennett, 1999, Cutting edge: adenovirus E19 has two mechanisms for affecting class I MHC expression, J. Immunol., 162, 5049, 10.4049/jimmunol.162.9.5049 Brown, 2012, Eaten alive! Cell death by primary phagocytosis: 'phagoptosis', Trends Biochem. Sci., 37, 325, 10.1016/j.tibs.2012.05.002 Castello, 2011, The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases, J. Biomed. Biotechnol., 2011, 369648 Chen, 2016, Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing, Nat. Immunol., 17, 1142, 10.1038/ni.3558 Chesney, 2017, Randomized, open-label phase II study evaluating the efficacy and safety of talimogene laherparepvec in combination with ipilimumab versus ipilimumab alone in patients with advanced, unresectable melanoma, J. Clin. Oncol., 10.1200/JCO.2017.35.15_suppl.9509 Chiocca, 2014, Oncolytic viruses and their application to cancer immunotherapy, Cancer Immunol. Res., 2, 295, 10.1158/2326-6066.CIR-14-0015 Clemens, 2005, Translational control in virus-infected cells: models for cellular stress responses, Semin. Cell Dev. Biol., 16, 13, 10.1016/j.semcdb.2004.11.011 Corrales, 2017, Innate immune signaling and regulation in cancer immunotherapy, Cell Res., 27, 96, 10.1038/cr.2016.149 Dehne, 2017, Cancer cell and macrophage cross-talk in the tumor microenvironment, Curr. Opin. Pharmacol., 35, 12, 10.1016/j.coph.2017.04.007 Deng, 2014, STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors, Immunity, 41, 843, 10.1016/j.immuni.2014.10.019 Drappier, 2015, Inhibition of the OAS/RNase L pathway by viruses, Curr. Opin. Virol., 15, 19, 10.1016/j.coviro.2015.07.002 Durham, 2017, Oncolytic VSV primes differential responses to immuno-oncology therapy, Mol. Ther., 25, 1917, 10.1016/j.ymthe.2017.05.006 Elsedawy, 2013, Oncolytic vaccines, Expert Rev. Vaccines, 12, 1155, 10.1586/14760584.2013.836912 Engeland, 2014, CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy, Mol. Ther., 22, 1949, 10.1038/mt.2014.160 Farrington, 2013, Competition for antigen at the level of the APC is a major determinant of immunodominance during memory inflation in murine cytomegalovirus infection, J. Immunol., 190, 3410, 10.4049/jimmunol.1203151 Fernandes, 2016, Oncogenes: the passport for viral oncolysis through PKR inhibition, Biomark. Cancer, 8, 101, 10.4137/BIC.S33378 Finlay, 2006, Anti-immunology: evasion of the host immune system by bacterial and viral pathogens, Cell, 124, 767, 10.1016/j.cell.2006.01.034 Franz, 2017, Innate immune receptors as competitive determinants of cell fate, Mol. Cell, 66, 750, 10.1016/j.molcel.2017.05.009 Galanis, 2015, Oncolytic measles virus expressing the sodium iodide symporter to treat drug-resistant ovarian cancer, Cancer Res., 75, 22, 10.1158/0008-5472.CAN-14-2533 Gale, 1998, Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase, Pharmacol. Ther., 78, 29, 10.1016/S0163-7258(97)00165-4 Galluzzi, 2017, Immunogenic cell death in cancer and infectious disease, Nat. Rev. Immunol., 17, 97, 10.1038/nri.2016.107 Galluzzi, 2018, Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018, Cell Death Differ., 25, 486, 10.1038/s41418-017-0012-4 Gao, 2009, Recombinant vesicular stomatitis virus targeted to Her2/neu combined with anti-CTLA4 antibody eliminates implanted mammary tumors, Cancer Gene Ther., 16, 44, 10.1038/cgt.2008.55 Gordon, 2017, PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity, Nature, 545, 495, 10.1038/nature22396 Guo, 2017, Oncolytic immunotherapy: conceptual evolution, current strategies, and future perspectives, Front. Immunol., 8, 555, 10.3389/fimmu.2017.00555 Gustin, 2003, Inhibition of nucleo-cytoplasmic trafficking by RNA viruses: targeting the nuclear pore complex, Virus Res., 95, 35, 10.1016/S0168-1702(03)00165-5 Harding, 2017, Mitotic progression following DNA damage enables pattern recognition within micronuclei, Nature, 548, 466, 10.1038/nature23470 Hardy, 1994, Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect, J. Virol., 68, 7790, 10.1128/JVI.68.12.7790-7799.1994 Hewitt, 2003, The MHC class I antigen presentation pathway: strategies for viral immune evasion, Immunology, 110, 163, 10.1046/j.1365-2567.2003.01738.x Hill, 1995, Herpes simplex virus turns off the TAP to evade host immunity, Nature, 375, 411, 10.1038/375411a0 Hou, 2016, Oncolytic virus-mediated targeting of PGE2 in the tumor alters the immune status and sensitizes established and resistant tumors to immunotherapy, Cancer Cell, 30, 108, 10.1016/j.ccell.2016.05.012 Ichikawa, 2012, Epitope diversification driven by non-tumor epitope-specific Th1 and Th17 mediates potent antitumor reactivity, Vaccine, 30, 6190, 10.1016/j.vaccine.2012.07.060 Kaminskyy, 2010, To kill or be killed: how viruses interact with the cell death machinery, J. Intern. Med., 267, 473, 10.1111/j.1365-2796.2010.02222.x Kedl, 2003, Epitope dominance, competition and T cell affinity maturation, Curr. Opin. Immunol., 15, 120, 10.1016/S0952-7915(02)00009-2 Kedl, 2000, T cells compete for access to antigen-bearing antigen-presenting cells, J. Exp. Med., 192, 1105, 10.1084/jem.192.8.1105 Keller, 2016, Oncolytic viruses-immunotherapeutics on the rise, J. Mol. Med. (Berl.), 94, 979, 10.1007/s00109-016-1453-9 Kenney, 2015, Increased immune response variability during simultaneous viral coinfection leads to unpredictability in CD8 T cell immunity and pathogenesis, J. Virol., 89, 10786, 10.1128/JVI.01432-15 Kim, 2006, Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF, Mol. Ther., 14, 361, 10.1016/j.ymthe.2006.05.008 Knutson, 2005, Augmenting T helper cell immunity in cancer, Curr. Drug Targets Immune Endocr. Metabol. Disord., 5, 365, 10.2174/156800805774913006 Krysko, 2017, Necroptotic cell death in anti-cancer therapy, Immunol. Rev., 280, 207, 10.1111/imr.12583 Lichty, 2014, Going viral with cancer immunotherapy, Nat. Rev. Cancer, 14, 559, 10.1038/nrc3770 Liu, 2003, ICP34.5 deleted herpes simplex virus with enhanced oncolytic, immune stimulating, and anti-tumour properties, Gene Ther., 10, 292, 10.1038/sj.gt.3301885 Liu, 2014, Oncolytic vaccinia virotherapy for endometrial cancer, Gynecol. Oncol., 132, 722, 10.1016/j.ygyno.2014.01.009 Mackenzie, 2017, cGAS surveillance of micronuclei links genome instability to innate immunity, Nature, 548, 461, 10.1038/nature23449 Maroun, 2017, Designing and building oncolytic viruses, Future Virol., 12, 193, 10.2217/fvl-2016-0129 Mohme, 2017, Circulating and disseminated tumour cells - mechanisms of immune surveillance and escape, Nat. Rev. Clin. Oncol., 14, 155, 10.1038/nrclinonc.2016.144 Mohr, 2004, Neutralizing innate host defenses to control viral translation in HSV-1 infected cells, Int. Rev. Immunol., 23, 199, 10.1080/08830180490265600 Moresco, 2011, Toll-like receptors, Curr. Biol., 21, R488, 10.1016/j.cub.2011.05.039 Nagata, 2017, Programmed cell death and the immune system, Nat. Rev. Immunol., 17, 333, 10.1038/nri.2016.153 Naik, 2012, Curative one-shot systemic virotherapy in murine myeloma, Leukemia, 26, 1870, 10.1038/leu.2012.70 Obuchi, 2003, Development of recombinant vesicular stomatitis viruses that exploit defects in host defense to augment specific oncolytic activity, J. Virol., 77, 8843, 10.1128/JVI.77.16.8843-8856.2003 Puzanov, 2016, Talimogene laherparepvec in combination with ipilimumab in previously untreated, unresectable stage IIIB-IV melanoma, J. Clin. Oncol., 34, 2619, 10.1200/JCO.2016.67.1529 Ribas, 2017, Oncolytic virotherapy promotes intratumoral T cell infiltration and improves anti-PD-1 immunotherapy, Cell, 170, 1109, 10.1016/j.cell.2017.08.027 Rivas, 2016, Shutoff of host gene expression in influenza a virus and herpesviruses: similar mechanisms and common themes, Viruses, 8, 102, 10.3390/v8040102 Ruotsalainen, 2015, Clonal variation in interferon response determines the outcome of oncolytic virotherapy in mouse CT26 colon carcinoma model, Gene Ther., 22, 65, 10.1038/gt.2014.83 Russell, 2014, Remission of disseminated cancer after systemic oncolytic virotherapy, Mayo Clin. Proc., 89, 926, 10.1016/j.mayocp.2014.04.003 Russell, 2017, Oncolytic virotherapy: a contest between apples and oranges, Mol. Ther., 25, 1107, 10.1016/j.ymthe.2017.03.026 Russell, 2012, Oncolytic virotherapy, Nat. Biotechnol., 30, 658, 10.1038/nbt.2287 Salama, 2017, Next steps in immuno-oncology: enhancing antitumor effects through appropriate patient selection and rationally designed combination strategies, Ann. Oncol., 28, 57, 10.1093/annonc/mdw534 Samson, 2018, Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade, Sci. Transl. Med., 10, 10.1126/scitranslmed.aam7577 Schiavoni, 2013, Type I interferons as stimulators of DC-mediated cross-priming: impact on anti-tumor response, Front. Immunol., 4, 483, 10.3389/fimmu.2013.00483 Schock, 2017, Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway, Cell Death Differ., 24, 615, 10.1038/cdd.2016.153 Schumacher, 2015, Neoantigens in cancer immunotherapy, Science, 348, 69, 10.1126/science.aaa4971 Shen, 2016, Immunovirotherapy with vesicular stomatitis virus and PD-L1 blockade enhances therapeutic outcome in murine acute myeloid leukemia, Blood, 127, 1449, 10.1182/blood-2015-06-652503 Takeuchi, 2009, Innate immunity to virus infection, Immunol. Rev., 227, 75, 10.1111/j.1600-065X.2008.00737.x Toda, 2015, Clearance of apoptotic cells and pyrenocytes, Curr. Top. Dev. Biol., 114, 267, 10.1016/bs.ctdb.2015.07.017 Topalian, 2015, Immune checkpoint blockade: a common denominator approach to cancer therapy, Cancer Cell, 27, 450, 10.1016/j.ccell.2015.03.001 Vyas, 2008, The known unknowns of antigen processing and presentation, Nat. Rev. Immunol., 8, 607, 10.1038/nri2368 Woller, 2015, Viral infection of tumors overcomes resistance to PD-1-immunotherapy by broadening neoantigenome-directed T-cell responses, Mol. Ther., 23, 1630, 10.1038/mt.2015.115 Woo, 2015, Innate immune recognition of cancer, Annu. Rev. Immunol., 33, 445, 10.1146/annurev-immunol-032414-112043 Xia, 2016, Recurrent loss of STING signaling in melanoma correlates with susceptibility to viral oncolysis, Cancer Res., 76, 6747, 10.1158/0008-5472.CAN-16-1404