On the significance of 5α-androstane-3α,17β-diol in the peripubertal female rat

Journal of Steroid Biochemistry - Tập 19 Số 1 - Trang 887-890 - 1983
K. B. Ruf1
1Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montréal, Canada.

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Knobil, 1980, The neuroendocrine control of the menstrual cycle, Rec. Progr. Horm. Res., 36, 53

Hoffmann, 1982, The induction of puberty in men with hypogonadotropic hypogonadism: the effect of LHRH dosage

Ryan, 1980, Neuroendocrine mechanisms involved in the onset of puberty in the female: concepts derived from the lamb, 39, 2372

Andrews, 1981, A detailed analysis of the serum luteinizing hormone profile in conscious free-moving female rats during the time of puberty, Endocrinology, 109, 2032, 10.1210/endo-109-6-2032

Grumbach, 1980, The neuroendocrinology of puberty, 249

Ramirez, 1976, Endocrinology of Puberty, 1

Donovan, 1967, Intransplenic implants of oestradiol and uterine growth in infantile and pubertal rats, J. Endocr., 37, 93, 10.1677/joe.0.0370093

Eckstein, 1975, Studies on the mechanism of the onset of puberty in the female rat, J. steroid Biochem., 6, 873, 10.1016/0022-4731(75)90317-9

Eckstein, 1970, Identification of 5α-androstane-3α,17β-diol as a principal metabolite of pregnenolone in rat ovary at onset of puberty, Nature, 228, 866, 10.1038/228866a0

Karakawa, 1976, Formation of 5α-reduced C19-steroids from progesterone in vitro by a pathway through 5α-reduced C21-steroids in ovaries of late prepubertal rats, Endocrinology, 98, 571, 10.1210/endo-98-3-571

Lerner, 1976, Identification of two 5α-reduced pregnanes as major metabolites of progesterone in immature rat ovaries (1000 × supernatant) in vitro, Endocrinology, 98, 179, 10.1210/endo-98-1-179

Eckstein, 1977, Changes in ovarian 5α-steroid reductase and 20α-hydroxy-steroid dehydrogenase activity produced by induction of first ovulation with gonadotropin, Biochim. biophys. Acta, 489, 143, 10.1016/0005-2760(77)90240-5

Kraulis, 1981, 5α-androstane-3α,17β-diol: Inhibitor of sexual maturation in the female rat, Biol. Reprod., 24, 445, 10.1095/biolreprod24.2.445

Rao, 1977, Synthesis of new steroid haptens for radioimmunoassay. Part III. 15α-carboxymethylmercaptosteroid-bovine serum albumin conjugator. Specific antisera for radioimmunoassay of 5α-dihydrotestosterone, 5α-androstane-3β, 17β-diol and 5α-androstane-3α,17β-diol, Steroids, 29, 171, 10.1016/0039-128X(77)90037-X

Cohen, 1982, Plasma concentrations of androgens during spontaneous and induced sexual maturation in the female rat, Fertil. Steril., 38, 132

Kramer, 1982, Retardation of first ovulation in pubertal rats after treatment with 5α-androstane-3α,17β-diol or its 3β-epimer, J. Endocr., 92, 31, 10.1677/joe.0.0920031

Meijs-Roelofs, 1982, Possible role of 5α-androstane-3α,17β-diol in the control of follicle stimulating hormone secretion in the immature female rat, J. Endocr., 92, 37, 10.1677/joe.0.0920037

Rochefort, 1979, Mechanism of action of antiestrogens and androgens on the estrogen receptor, J. steroid Biochem., 11, 1635, 10.1016/0022-4731(79)90361-3

Rochefort, 1980, Interactions and actions of androgens on the estrogen receptor, 75

Lerner, 1978, Changes in steroidogenesis in preovulatory rat ovaries induced to ovulate with Pregnant Mare Serum Gonadotropin, Endocrinology, 103, 1039, 10.1210/endo-103-4-1039

Advis, 1981, Changes in ovarian 3α-androstanediol response to human chorionic gonadotropin during puberty in the rat: modulatorv role of prolactin, Enducrinology, 109, 223, 10.1210/endo-109-1-223

Kaushansky, 1977, Endocrine and reproductive repercussions of immunization against progesterone and estradiol in female rats, Acta endocr., 84, 795

Main, 1980, Effects of passive immunization against testosterone on serum and pituitary gonadotropins: Implications for the relative importance of androgens and inhibin in the control of gonadotropin secretion in the female rat, J. Endocr., 86, 135, 10.1677/joe.0.0860135

Arai, 1978, Synaptogenic action of estrogen on the hypothalamic arcuate nucleus (ARCN) of the developing brain and of the deafferented adult brain in female rats, 43

Brawer, 1983, Effect of long term androgen and estrogen exposure on the hypothalamus, Endocrinology, 112, 194, 10.1210/endo-112-1-194