Olfactory systems and neural circuits that modulate predator odor fear

Alberini, 2009, Transcription factors in long-term memory and synaptic plasticity, Physiol. Rev, 89, 121, 10.1152/physrev.00017.2008

Apfelbach, 2005, The effects of predator odors in mammalian prey species: a review of field and laboratory review of field and laboratory studies, Neurosci. Biobehav. Rev, 29, 1123, 10.1016/j.neubiorev.2005.05.005

Asok, 2013, Immediate early gene and neuropeptide expression following exposure to the predator odor 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), Behav. Brain Res, 248, 85, 10.1016/j.bbr.2013.03.047

Ayers, 2013, Freezing to the predator odor 2,4,5 dihydro 2,5 trimethylthiazoline (TMT) is disrupted by olfactory bulb removal but not trigeminal deafferentation, Behav. Brain Res, 253, 54, 10.1016/j.bbr.2013.06.034

Ben-Shaul, 2010, In vivo vomeronasal stimulation reveals sensory encoding of conspecific and allospecific cues by the mouse accessory olfactory bulb, Proc. Natl. Acad. Sci. U.S.A, 107, 5172, 10.1073/pnas.0915147107

Blanchard, 2005, Lesions of structures showing FOS expression to cat presentation: effects on responsivity to a Cat, Cat odor, and nonpredator threat, Neurosci. Biobehav. Rev, 29, 1243, 10.1016/j.neubiorev.2005.04.019

Blanchard, 2011, Risk assessment as an evolved threat detection and analysis process, Neurosci. Biobehav. Rev, 35, 991, 10.1016/j.neubiorev.2010.10.016

Blanchard, 2003a, Dorsal premammillary nucleus differentially modulates defensive behaviors induced by different threat stimuli in rats, Neurosci. Lett, 345, 145, 10.1016/S0304-3940(03)00415-4

Blanchard, 2003b, Failure to produce conditioning with low-dose trimethylthiazoline or cat feces as unconditioned stimuli, Behav. Neurosci, 117, 360, 10.1037/0735-7044.117.2.360

Blanchard, 2001, Cue and context conditioning of defensive behaviors to cat odor stimuli, Neurosci. Biobehav. Rev, 26, 587, 10.1016/S0149-7634(01)00043-4

Bouwknecht, 2007, The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: A review of pharmacological and genetic studies in the mouse, Neurosci. Biobehav. Rev, 31, 41, 10.1016/j.neubiorev.2006.02.002

Brechbühl, 2008, Grueneberg ganglion cells mediate alarm pheromone detection in mice, Science, 321, 1092, 10.1126/science.1160770

Brechbühl, 2013, Mouse alarm pheromone shares structural similarity with predator scents, Proc. Natl. Acad. Sci. U.S.A, 110, 4762, 10.1073/pnas.1214249110

Breer, 2006, The sense of smell: multiple olfactory subsystems, Cell. Mol. Life Sci, 63, 1465, 10.1007/s00018-006-6108-5

Brennan, 1997, Neural mechanisms of mammalian olfactory learning, Prog. Neurobiol, 51, 457, 10.1016/S0301-0082(96)00069-X

Britton, 2011, Development of anxiety: the role of threat appraisal and fear learning, Depress. Anxiety, 28, 5, 10.1002/da.20733

Buck, 1991, A novel multigene family may encode odorant receptors: a molecular basis for odor recognition, Cell, 65, 175, 10.1016/0092-8674(91)90418-X

Bytheway, 2013, Risk vs. reward: how predators and prey respond to aging olfactory cues, Behav. Ecol. Sociobiol, 67, 715, 10.1007/s00265-013-1494-9

Canteras, 2002, The medial hypothalamic defensive system: hodological organization and functional implications, Pharm. Biochem. Behav, 71, 481, 10.1016/S0091-3057(01)00685-2

Canteras, 1997, Severe reduction of rat defensive behavior to a predator by discrete hypothalamic chemical lesions, Brain Res. Bull, 44, 297, 10.1016/S0361-9230(97)00141-X

Canteras, 2008, Sensing danger through the olfactory system: the role of the hypothalamic dorsal premammillary nucleus, Neurosci. Biobehav. Rev, 32, 1228, 10.1016/j.neubiorev.2008.05.009

Canteras, 1995, Organization of projections from the medial nucleus of the amygdala: a PHAL study in the rat, J. Comp. Neurol, 360, 213, 10.1002/cne.903600203

Carobrez, 1983, Neuroeffector mechanisms of the defense reaction in the rat, Physiol. Behav, 31, 439, 10.1016/0031-9384(83)90063-X

Catterelli, 1979, Influence of some biologically meaningful odorants on the vigilance states of the rat, Physiol. Behav, 23, 831, 10.1016/0031-9384(79)90186-0

Cavaggioni, 2000, Major urinary proteins, α(2U)-globulins and aphrodisin, Biochim. Biophys. Acta, 1482, 218, 10.1016/S0167-4838(00)00149-7

Cezario, 2008, Hypothalamic sites responding to predator threats – the role of the dorsal premammillary nucleus in unconditioned and conditioned antipredatory defensive behavior, Eur. J. Neurosci, 28, 1003, 10.1111/j.1460-9568.2008.06392.x

Chan, 2011, The role of the medial prefrontal cortex in innate fear regulation in infants, juveniles, and adolescents, J. Neurosci, 31, 4991, 10.1523/JNEUROSCI.5216-10.2011

Charney, 2004, Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress, Am. J. Psychiatry, 161, 195, 10.1176/appi.ajp.161.2.195

Cho, 2011, The pattern of glomerular map formation defines responsiveness to aversive odorants in mice, J. Neurosci, 31, 7920, 10.1523/JNEUROSCI.2460-10.2011

Clinchy, 2011, The neurological ecology of fear: insights neuroscientists and ecologists have to offer one another, Front. Behav. Neurosci, 4, 10.3389/fnbeh.2011.00021

Cohen, 2006, Blunted HPA axis response to stress influences susceptibility to posttraumatic stress response in rats, Biol. Psychiatry, 59, 1208, 10.1016/j.biopsych.2005.12.003

Collins, 2011, Synthetic versus natural cat odorant effects on rodent behavior and medial amygdala plasticity, Behav. Neurosci, 125, 124, 10.1037/a0021955

Corley, 2012, Stress-induced enhancement of fear conditioning and sensitization facilitates extinction-resistant and habituation-resistant fear behaviors in a novel animal model of posttraumatic stress disorder, Physiol. Behav, 105, 408, 10.1016/j.physbeh.2011.08.037

Davis, 2000, The role of the amygdala in conditioned and unconditioned fear and anxiety, The Amygdala: a Functional Analysis, 2nd Edn., 213, 10.1093/oso/9780198505013.003.0006

Day, 2004, The pattern of brain c-fos mRNA induced by a component of fox odor, 2,5-dihydro-2,4,5-trimethylthiazoline (TMT), in rats, suggests both systemic and processive stress characteristics, Brain Res, 1025, 139, 10.1016/j.brainres.2004.07.079

Dayas, 1999, Neuroendocrine responses to an emotional stressor: evidence for involvement of the medial but not the central amygdala, Eur. J. Neurosci, 11, 2312, 10.1046/j.1460-9568.1999.00645.x

Depaulis, 1992, Longitudinal neuronal organization of defensive reactions in the midbrain periaqueductal gray region of the rat, Exp. Brain Res, 90, 307, 10.1007/BF00227243

Dewan, 2013, Non-redundant coding of aversive odours in the main olfactory pathway, Nature, 497, 486, 10.1038/nature12114

Dicke, 2001, Chemical detection of natural enemies by arthroponds: An ecological perspective, Annu. Rev. Ecol. Syst, 32, 1, 10.1146/annurev.ecolsys.32.081501.113951

Dielenberg, 2004, Effect of dorsal periaqueductal gray lesions on cardiovascular and behavioral responses to cat odor exposure in rats, Behav. Brain Res, 153, 487, 10.1016/j.bbr.2004.01.015

Dielenberg, 2001, Defensive behavior in rats towards predatory odors: a review, Neurosci. Biobehav. Rev, 25, 597, 10.1016/S0149-7634(01)00044-6

Do Monte, 2008, New perspectives on β-adrenergic mediation of innate and learned fear responses to predator odor, J. Neurosci, 28, 13296, 10.1523/JNEUROSCI.2843-08.2008

Dulac, 2003, Molecular detection of pheromone signals in mammals: from genes to behaviour, Nat. Rev. Neurosci, 4, 551, 10.1038/nrn1140

Endres, 2005, Behavioral changes induced in rats by exposure to trimethylthiazoline, a component of fox odor, Behav. Neurosci, 119, 1004, 10.1037/0735-7044.119.4.1004

Endres, 2007, Conditioned behavioral responses to a context paired with the predator odor trimethylthiazoline, Behav. Neurosci, 121, 594, 10.1037/0735-7044.121.3.594

Fan, 2009, The organization of feedback projections in a pathway important for processing pheromonal signals, Neuroscience, 161, 489, 10.1016/j.neuroscience.2009.03.065

Fanselow, 2005, The neuroscience of mammalian associative learning, Annu. Rev. Psychol, 56, 207, 10.1146/annurev.psych.56.091103.070213

Fendt, 2003, Temporary inactivation of the bed nucleus of the stria terminalis but not of the amygdala blocks freezing induced by trimethylthiazoline, a component of fox feces, J. Neurosci, 23, 23, 10.1523/JNEUROSCI.23-01-00023.2003

Fendt, 2005a, TMT-induced autonomic and behavioral changes and the neural basis of its processing, Neurosci. Biobehav. Rev, 29, 1145, 10.1016/j.neubiorev.2005.04.018

Fendt, 2005b, Noradrenaline transmission within the ventral bed nucleus of the stria terminalis is critical for fear behavior induced by trimethylthiazoline, a component of fox odor, J. Neurosci, 25, 5998, 10.1523/JNEUROSCI.1028-05.2005

Ferrero, 2011, Detection and avoidance of a carnivore odor by prey, Proc. Natl. Acad. Sci. U.S.A, 108, 11235, 10.1073/pnas.1103317108

File, 1993, Dissociation between behavioral and corticosterone responses on repeated exposures to cat odor, Physiol. Behav, 54, 1109, 10.1016/0031-9384(93)90333-B

Firestein, 2001, How the olfactory system makes sense of scents, Nature, 413, 211, 10.1038/35093026

Fitzpatrick, 2011, Inactivation of the prelimbic cortex enhances freezing induced by trimethylthiazoline, a component of fox feces, Behav. Brain Res, 221, 320, 10.1016/j.bbr.2011.03.024

Fleischer, 2010, The Grueneberg ganglion: a novel sensory system in the nose, Histol. Histopathol, 25, 909

Fortes-Marco, 2013, Of pheromones and kairomones: what receptors mediate innate emotional responses?, Anat. Rec, 296, 1346, 10.1002/ar.22745

Funk, 2000, Circadian modulation of Fos responses to odor of the red fox, a rodent predator, in the rat olfactory system, Brain Res, 866, 262, 10.1016/S0006-8993(00)02249-6

Fuss, 2005, The Grueneberg ganglion of the mouse projects axons to glomeruli in the olfactory bulb, Eur. J. Neurosci, 22, 2649, 10.1111/j.1460-9568.2005.04468.x

Gabbott, 2005, Prefrontal cortex in the rat: projections to subcortical autonomic, motor, and limbic centers, J. Comp. Neurol, 492, 145, 10.1002/cne.20738

Galliot, 2012, Fear-like behavioral responses in mice in different odorant environments: Trigeminal versus olfactory mediation under low doses, Behav. Proc, 90, 161, 10.1016/j.beproc.2012.01.002

Giannetti, 1995, Analysis of the possible altering function of the septal organ in rats: a lesional and behavioral study, Physiol. Behav, 58, 837, 10.1016/0031-9384(95)00127-5

Green, 2004, Social threat perception and the evolution of paranoia, Neurosci. Biobehav. Rev, 28, 333, 10.1016/j.neubiorev.2004.03.006

Gross, 2012, The many paths to fear, Nat. Rev. Neurosci, 13, 651, 10.1038/nrn3301

Hacquemand, 2013, Comparison between low doses of TMT and cat odor exposure in anxiety- and fear-related behaviors in mice, Behav. Brain Res, 238, 227, 10.1016/j.bbr.2012.10.014

Hacquemand, 2010, Comparative fear-related behaviors to predator odors (TMT and natural fox feces) before and after intranasal ZnSO4 treatment in mice, Front. Behav. Neurosci, 4, 188, 10.3389/fnbeh.2010.00188

Heale, 1994, Components of weasel and fox odors elicit fast wave bursts in the dentate gyrus of rats, Behav. Brain Res, 63, 159, 10.1016/0166-4328(94)90087-6

Herman, 2002, Role of the paraventricular nucleus microenvironment in stress integration, Eur. J. Neurosci, 16, 381, 10.1046/j.1460-9568.2002.02133.x

Horii, 2013, Order of exposure to pleasant and unpleasant odors affects autonomic nervous system response, Behav. Brain Res, 243, 109, 10.1016/j.bbr.2012.12.042

Horii, 2010, Exposure to TMT odor affects adrenal sympathetic nerve activity and behavioral consequences in rats, Behav. Brain Res, 214, 317, 10.1016/j.bbr.2010.05.047

Illig, 2003, Odor-evoked activity is spatially distributed in piriform cortex, J. Comp. Neurol, 457, 361, 10.1002/cne.10557

Isogai, 2011, Molecular organization of vomeronasal chemoreception, Nature, 478, 241, 10.1038/nature10437

Jöels, 2006, Learning under stress: how does it work?, Trends Cogn. Sci, 10, 152, 10.1016/j.tics.2006.02.002

Karlson, 1959, “Pheromones”: a new term for a class of biologically active substances, Nature, 183, 55, 10.1038/183055a0

Kass, 2013, Fear learning enhances neural responses to threat-predictive sensory stimuli, Science, 342, 1389, 10.1126/science.1244916

Kats, 1998, The scent of death: chemosensory assessment of predation risk by prey animals, Ecoscience, 5, 361, 10.1080/11956860.1998.11682468

Kessler, 2012, fMRI fingerprint of unconditioned fear-like behavior in rats exposed to trimethylthiazoline, Eur. Neuropsychopharmcol, 22, 222, 10.1016/j.euroneuro.2011.07.011

Kim, 1992, Modality-specific retrograde amnesia of fear, Science, 256, 675, 10.1126/science.1585183

Kobayakawa, 2007, Innate versus learned odour processing in the mouse olfactory bulb, Nature, 450, 503, 10.1038/nature06281

Koos, 2005, The Grueneberg ganglion projects to the olfactory bulb, Neuroreport, 16, 1929, 10.1097/01.wnr.0000186597.72081.10

Landers, 2012, The development and neurobiology of infant attachment and fear, Dev. Neurosci, 34, 101, 10.1159/000336732

Lang, 2000, Fear and anxiety: animal models and human cognitive psychophysiology, J. Affect. Disord, 61, 137, 10.1016/S0165-0327(00)00343-8

LeDoux, 2000, Emotion circuits in the brain, Annu. Rev. Neurosci, 23, 155, 10.1146/annurev.neuro.23.1.155

Leong, 2014, Exposure to predator odor influences the relative use of multiple memory systems: role of basolateral amygdala, Neurobiol. Learn. Mem, 109, 56, 10.1016/j.nlm.2013.11.015

Lèvai, 2003, Projection pattern of nerve fibers from the septal organ: DiI-tracing studies with transgenic OMP mice, Histochem. Cell. Biol, 120, 483, 10.1007/s00418-003-0594-4

Li, 2004, Medial amygdala modulation of predator odor-induced unconditioned fear in the rat, Behav. Neurosci, 118, 324, 10.1037/0735-7044.118.2.324

Liberles, 2014, Mammalian pheromones, Annu. Rev. Physiol, 76, 151, 10.1146/annurev-physiol-021113-170334

Liberles, 2006, A second class of chemosensory receptors in the olfactory epithelium, Nature, 442, 645, 10.1038/nature05066

Lima, 1998, Stress and decision making under the risk of predation: recent developments from behavioral, reproductive, and ecological perspectives, Adv. Study Behav, 27, 215, 10.1016/S0065-3454(08)60366-6

Ma, 2007, Encoding olfactory signals via multiple chemosensory systems, Crit. Rev. Biochem. Mol. Biol, 42, 463, 10.1080/10409230701693359

Mackenzie, 2010, Ability of predator odour exposure to elicit conditioned versus sensitized post traumatic stress disorder-like behaviours, and forebrain FosB expression, in rats, Neuroscience, 169, 733, 10.1016/j.neuroscience.2010.05.005

Mamasuew, 2011, Grueneberg ganglion neurons are activated by a defined set of odorants, Chem. Senses, 36, 271, 10.1093/chemse/bjq124

Marek, 2013, The amygdala and medial prefrontal cortex: partners in the fear circuit, J. Physiol, 591, 2381, 10.1113/jphysiol.2012.248575

Maren, 2013, The contextual brain: implications for fear conditioning, extinction and psychopathology, Nat. Rev. Neurosci, 14, 417, 10.1038/nrn3492

Martinez-Marcos, 2009, On the organization of olfactory and vomeronasal cortices, Prog. Neurobiol, 87, 21, 10.1016/j.pneurobio.2008.09.010

Masini, 2010, Accessory and main olfactory systems influences on predator odor-induced behavioral and endocrine stress responses in rats, Behav. Brain Res, 207, 70, 10.1016/j.bbr.2009.09.038

Masini, 2009, Disruption of neuroendocrine stress responses to acute ferret odor by medial, but not central amygdala lesions in rats, Brain Res, 1288, 79, 10.1016/j.brainres.2009.07.011

Masini, 2005, Ferret odor as a processive stress model in rats: neurochemical, behavioral, and endocrine evidence, Behav. Neurosci, 119, 280, 10.1037/0735-7044.119.1.280

Masini, 2006, Non-associative defensive responses of rats to ferret odor, Physiol. Behav, 87, 72, 10.1016/j.physbeh.2005.08.044

Matar, 2013, Translationally relevant modeling of PTSD in rodents, Cell. Tissue Res, 354, 127, 10.1007/s00441-013-1687-6

McBride, 2003, Does intranasal application of zinc sulfate produce anosmia in mouse? An olfactometric and anatomical study, Chem. Senses, 28, 659, 10.1093/chemse/bjg053

McDonald, 1998, Cortical pathways to the mammalian amygdale, Prog. Neurobiol, 55, 257, 10.1016/S0301-0082(98)00003-3

McGaugh, 2000, Memory – a century of consolidation, Science, 287, 249, 10.1126/science.287.5451.248

McGregor, 2004, Neural correlates of cat odor-induced anxiety in rats: region-specific effects of the benzodiazepine midazolam, J. Neurosci, 24, 4134, 10.1523/JNEUROSCI.0187-04.2004

McGregor, 2002, Not all ‘predator odours’ are equal: cat odour but not 2,4,5 trimethylthiazoline (TMT; fox odour) elicits specific defensive behaviours in rats, Behav. Brain Res, 129, 1, 10.1016/S0166-4328(01)00324-2

Meredith, 1991, Sensory processing in the main and accessory olfactory systems: comparisons and contrasts, J. Steroid Biochem. Mol. Biol, 39, 601, 10.1016/0960-0760(91)90258-7

Meredith, 2004, Distinctive responses in the medial amygdala to same-species and different-species pheromones, J. Neurosci, 24, 5719, 10.1523/JNEUROSCI.1139-04.2004

Moncho-Bogani, 2005, Attraction to sexual pheromones and associated odorants in female mice involves activation of the reward system and basolateral amygdala, Eur. J. Neurosci, 21, 2186, 10.1111/j.1460-9568.2005.04036.x

Morrow, 2000, The predator odor, TMT, displays a unique, stress-like pattern of dopaminergic and endocrinological activation in the rat, Brain Res, 864, 146, 10.1016/S0006-8993(00)02174-0

Mouly, 2010, Memory and plasticity in the olfactory system: from infancy to adulthood, The Neurobiology of Olfaction, 367

Müller, 2006, Temporary inactivation of the medial and basolateral amygdala differentially affects TMT-induced fear behavior in rats, Behav. Brain Res, 167, 57, 10.1016/j.bbr.2005.08.016

Munger, 2009, Subsystem organization of the mammalian sense of smell, Annu. Rev. Physiol, 71, 115, 10.1146/annurev.physiol.70.113006.100608

Muñoz-Abellán, 2011, Behavioral and endocrine consequences of simultaneous exposure to two different stressors in rats: interaction or independence?, PLoS ONE, 6, e21426, 10.1371/journal.pone.0021426

Nader, 2001, Damage to the lateral and central, but not other, amygdaloid nuclei prevents the acquisition of auditory fear conditioning, Learn. Mem, 8, 156, 10.1101/lm.38101

Nolte, 1994, Why are predator urines aversive to prey?, J. Chem. Ecol, 20, 1505, 10.1007/BF02059876

Otto, 2000, Behavioral and neuropsychological foundations of olfactory fear conditioning, Behav. Brain Res, 110, 119, 10.1016/S0166-4328(99)00190-4

Pagani, 2009, The medial hypothalamic defensive circuit and 2,5-dihydro-2,4,5-trimethylthiazoline (TMT) induced fear: comparison of electrolytic and neurotoxic lesions, Brain Res, 1286, 133, 10.1016/j.brainres.2009.06.062

Papes, 2010, The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs, Cell, 141, 692, 10.1016/j.cell.2010.03.037

Pentkowski, 2006, Effects of lesions to the dorsal and ventral hippocampus on defensive behaviors in rats, Eur. J. Neurosci, 23, 2185, 10.1111/j.1460-9568.2006.04754.x

Perrot-Sinal, 1999, Brief predator odour exposure activates the HPA axis independent of locomotor changes, Neuroreport, 10, 775, 10.1097/00001756-199903170-00021

Pessoa, 2010, Emotion processing and the amygdala: from a ‘low road’ to ‘many roads’ of evaluating biological significance, Nat. Rev. Neurosci, 11, 773, 10.1038/nrn2920

Peters, 2009, Extinction circuits for fear and addiction overlap in prefrontal cortex, Learn. Mem, 16, 279, 10.1101/lm.1041309

Petrovich, 2001, Combinatorial amygdalar inputs to hippocampal domains and hypothalamic behavior systems, Brain Res. Rev, 38, 247, 10.1016/S0165-0173(01)00080-7

Phillips, 1992, Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning, Behav. Neurosci, 106, 274, 10.1037/0735-7044.106.2.274

Pitkänen, 2000, Connectivity of the rat amygdaloid complex, The Amygdala: a Functional Analysis, 2nd Edn., 13, 10.1093/oso/9780198505013.003.0002

Price, 2005, Free will versus survival: brain systems that underlie intrinsic constraints on behavior, J. Comp. Neurol, 493, 132, 10.1002/cne.20750

Pro-Sistiaga, 2007, Convergence of olfactory and vomeronasal projections in the rat basal telencephalon, J. Comp. Neurol, 504, 346, 10.1002/cne.21455

Redburn, 1997, Accelerated breakdown and enhanced expression of c-Fos in the rat brain after noxious stimulation, Neurosci. Lett, 237, 97, 10.1016/S0304-3940(97)00820-3

Restrepo, 2004, Emerging views on the distinct but related roles of the main and accessory olfactory systems in responsiveness to chemosensory signals in mice, Horm. Behav, 46, 247, 10.1016/j.yhbeh.2004.02.009

Risold, 1997, The structural organization of connections between hypothalamus and cerebral cortex, Brain Res. Rev, 24, 197, 10.1016/S0165-0173(97)00007-6

Roberts, 2012, Pheromonal induction of spatial learning in mice, Science, 338, 1462, 10.1126/science.1225638

Rosen, 2006, Animal studies of amygdala function in fear and uncertainty: Relevance to human research, Biol. Psychol, 73, 49, 10.1016/j.biopsycho.2006.01.007

Rosen, 2008, Analysis of behavioral constraints and the neuroanatomy of fear to the predator odor trimethylthiazoline: a model for animal phobias, Neurosci. Biobehav. Rev, 32, 1267, 10.1016/j.neubiorev.2008.05.006

Samuelsen, 2009, The vomeronasal organ is required for the male mouse medial amygdala response to chemical-communication signals, as assessed by immediate early gene expression, Neuroscience, 164, 1468, 10.1016/j.neuroscience.2009.09.030

Sawchenko, 1996, The paraventricular nucleus of the hypothalamus and the functional neuroanatomy of visceromotor responses to stress, Prog. Brain Res, 107, 201, 10.1016/S0079-6123(08)61866-X

Scalia, 1975, The differential projections of the olfactory bulb and accessory olfactory bulb in mammals, J. Comp. Neurol, 161, 31, 10.1002/cne.901610105

Schenberg, 1983, GABA modulation of the defense reaction induced by brain electrical stimulation, Physiol. Behav, 31, 429, 10.1016/0031-9384(83)90062-8

Shepherd, 2006, Smells, brain and hormones, Nature, 439, 149, 10.1038/439149a

Shipley, 1984, The connections of the mouse olfactory bulb: a study using orthograde and retrograde transport of wheat germ agglutinin conjugated to horseradish peroxidase, Brain Res. Bull, 12, 669, 10.1016/0361-9230(84)90148-5

Smith, 2004, Feld 4, a cat lipocalin allergen, Clin. Exp. Allergy, 34, 1732, 10.1111/j.1365-2222.2004.02090.x

Sotres-Bayon, 2006, Brain mechanisms of fear extinction: historical perspectives on the contribution of prefrontal cortex, Biol. Psychiatry, 60, 329, 10.1016/j.biopsych.2005.10.012

Spehr, 2006, Parallel processing of social signals by the mammalian main and accessory olfactory systems, Cell. Mol. Life Sci, 63, 1476, 10.1007/s00018-006-6109-4

Staples, 2008, Cat odor, but not trimethylthiazoline (fox odor), activates accessory olfactory and defense-related brain regions in rats, Neuroscience, 151, 937, 10.1016/j.neuroscience.2007.11.039

Swanson, 1980, The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods, J. Comp. Neurol, 194, 555, 10.1002/cne.901940306

Takahashi, 2008, Predator odor fear conditioning: current perspectives and new directions, Neurosci. Biobehav. Rev, 32, 1218, 10.1016/j.neubiorev.2008.06.001

Takahashi, 2007, Predator odor-induced conditioned fear involves the basolateral and medial amygdala, Behav. Neurosci, 121, 100, 10.1037/0735-7044.121.1.100

Takahashi, 2005, The smell of danger: a behavioral and neural analysis of predator odor-induced fear, Neurosci. Biobehav. Rev, 29, 1157, 10.1016/j.neubiorev.2005.04.008

Ulrich-Lai, 2009, Neural regulation of endocrine and autonomic stress responses, Nat. Rev. Neurosci, 10, 307, 10.1038/nrn2647

Vazdarjanova, 2001, Disrupting basolateral amygdala function impairs unconditioned freezing and avoidance in rats, Eur. J. Neurosci, 14, 709, 10.1046/j.0953-816x.2001.01696.x

Wallace, 2000, Predator odor as an unconditioned fear stimulus in rats: elicitation of freezing by trimethylthiazoline, a component of fox feces, Behav. Neurosci, 114, 912, 10.1037/0735-7044.114.5.912

Wallace, 2001, Neurotoxic lesions of the lateral nucleus of the amygdala decrease conditioned fear, but not unconditioned fear of a predator odor: comparison to electrolytic lesions, J. Neurosci, 21, 3619, 10.1523/JNEUROSCI.21-10-03619.2001

Wang, 2013, Differential roles of the dorsal and ventral hippocampus in predator odor contextual fear conditioning, Hippocampus, 23, 415, 10.1002/hipo.22105

Wang, 2012, Long-term stabilization of place cell remapping produced by a fearful experience, J. Neurosci, 32, 15802, 10.1523/JNEUROSCI.0480-12.2012

Xu, 2005, Simultaneous activation of mouse main and accessory olfactory bulbs by odors or pheromones, J. Comp. Neurol, 489, 491, 10.1002/cne.20652

Xu, 2012, Inactivation of the bed nucleus of the stria terminalis suppresses the innate fear responses of rats induced by the odor of cat urine, Neuroscience, 221, 21, 10.1016/j.neuroscience.2012.06.056

Zhang, 2001, The ventral hippocampus and fear conditioning in rats: different anterograde amnesias of fear after infusion of N-methyl-D-aspartate or its noncompetitive antagonist MK-801 into the ventral hippocampus, Behav. Brain Res, 126, 159, 10.1016/S0166-4328(01)00256-X