Off-target effects of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel-pamoate, and albendazole plus oxantel-pamoate on the human gut microbiota

Pierre H.H. Schneeberger1,2, Jean T. Coulibaly1,2,3,4, Morgan Gueuning5, Wendelin Moser1,2, Bryan Coburn6,7, Jürg E. Frey5, Jennifer Keiser1,2
1Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland
2University of Basel, Basel, Switzerland
3Unité de Formation et de Recherche Biosciences, Université Felix Houphouët-Boigny, Abidjan, Cote d’Ivoire
4Centre Suisse de Recherches Scientifiques en Côte d’Ivoire, Abidjan, Cote d’Ivoire
5Agroscope, Department of Method Development and Analytics, Research Group Molecular Diagnostics, Genomics and Bioinformatics, Wädenswil, Switzerland
6Departments of Medicine and Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Canada
7Department of Medicine, Division of Infectious Diseases, University Health Network, Toronto, Canada

Tài liệu tham khảo

Abou-Zeid, 2012, Schistosomiasis and soil-transmitted helminths among an adult population in a war affected area, Southern Kordofan state, Sudan, Parasites Vectors, 5, 133, 10.1186/1756-3305-5-133 Alexander, 2017, Gut microbiota modulation of chemotherapy efficacy and toxicity, Nat. Rev. Gastroenterol. Hepatol., 14, 356, 10.1038/nrgastro.2017.20 Arumugam, 2011, Enterotypes of the human gut microbiome, Nature, 473, 174, 10.1038/nature09944 Benjamini, 1995, Controlling the false discovery rate - a practical and powerful approach to multiple testing, J. Roy. Stat. Soc. B, 57, 289 Bethony, 2006, Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm, Lancet, 367, 1521, 10.1016/S0140-6736(06)68653-4 Cantacessi, 2014, Impact of experimental hookworm infection on the human gut microbiota, J. Infect. Dis., 210, 1431, 10.1093/infdis/jiu256 Caporaso, 2010, QIIME allows analysis of high-throughput community sequencing data, Nat. Methods, 7, 335, 10.1038/nmeth.f.303 Cheng, 2013, Metagenomic analysis of the pinewood nematode microbiome reveals a symbiotic relationship critical for xenobiotics degradation, Sci. Rep., 3, 1869, 10.1038/srep01869 Clayton, 2009, Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism, Proc. Natl. Acad. Sci. U. S. A., 106, 14728, 10.1073/pnas.0904489106 2016, Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015, Lancet, 388, 1603, 10.1016/S0140-6736(16)31460-X Grayson, 2010 Horton, 2003, Global anthelmintic chemotherapy programs: learning from history, Trends Parasitol., 19, 405, 10.1016/S1471-4922(03)00171-5 Hotez, 2009, Rescuing the bottom billion through control of neglected tropical diseases, Lancet, 373, 1570, 10.1016/S0140-6736(09)60233-6 2012, Structure, function and diversity of the healthy human microbiome, Nature, 486, 207, 10.1038/nature11234 Jourdan, 2017, Soil-transmitted helminth infections, Lancet, 391, 252, 10.1016/S0140-6736(17)31930-X Kay, 2015, Differences in the faecal microbiome in Schistosoma haematobium infected children vs. uninfected children, PLoS Neglected Trop. Dis., 9, 10.1371/journal.pntd.0003861 Keiser, 2008, Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis, JAMA, 299, 1937, 10.1001/jama.299.16.1937 Klatt, 2017, Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women, Science, 356, 938, 10.1126/science.aai9383 Langille, 2013, Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences, Nat. Biotechnol., 31, 814, 10.1038/nbt.2676 Lindgreen, 2016, An evaluation of the accuracy and speed of metagenome analysis tools, Sci. Rep., 6, 19233, 10.1038/srep19233 Lozupone, 2012, Diversity, stability and resilience of the human gut microbiota, Nature, 489, 220, 10.1038/nature11550 Magnúsdóttir, 2015, Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes, Front. Genet., 6, 148, 10.3389/fgene.2015.00148 Marti, 1996, A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children, Am. J. Trop. Med. Hyg., 55, 477, 10.4269/ajtmh.1996.55.477 Maurice, 2013, Xenobiotics shape the physiology and gene expression of the active human gut microbiome, Cell, 152, 39, 10.1016/j.cell.2012.10.052 Morris, 2007, Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification, Am. J. Clin. Nutr., 85, 193, 10.1093/ajcn/85.1.193 Moser, 2017, Lancet Infect. Dis., 17, 1162, 10.1016/S1473-3099(17)30487-5 Ndyomugyenyi, 2008, Efficacy of ivermectin and albendazole alone and in combination for treatment of soil-transmitted helminths in pregnancy and adverse events: a randomized open label controlled intervention trial in Masindi district, western Uganda, Am. J. Trop. Med. Hyg., 79, 856, 10.4269/ajtmh.2008.79.856 Nicholson, 2005, Gut microorganisms, mammalian metabolism and personalized health care, Nat. Rev. Microbiol., 3, 431, 10.1038/nrmicro1152 Ormerod, 2016, Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals, Microbiome, 4, 36, 10.1186/s40168-016-0181-2 Parks, 2014, STAMP: statistical analysis of taxonomic and functional profiles, Bioinformatics, 30, 3123, 10.1093/bioinformatics/btu494 Puddu, 1965, The effect of vitamin B(12) and biotin on the metabolism of vitamin B(12) in biotin-deficient rats, Biochem. J., 96, 24, 10.1042/bj0960024 Pullan, 2014, Global numbers of infection and disease burden of soil transmitted helminth infections in 2010, Parasites Vectors, 7, 37, 10.1186/1756-3305-7-37 Rizkallah, 2010, The Human Microbiome Project, personalized medicine and the birth of pharmacomicrobiomics, Curr. Pharmacogenomics Personalized Med. (CPPM), 8, 182, 10.2174/187569210792246326 Roy, 2017, Microbiota: a key orchestrator of cancer therapy, Nat. Rev. Canc., 5, 271, 10.1038/nrc.2017.13 Schneeberger, 2016, Metagenomic diagnostics for the simultaneous detection of multiple pathogens in human stool specimens from Côte d'Ivoire: a proof-of-concept study, Infect. Genet. Evol., 40, 389, 10.1016/j.meegid.2015.08.044 Schneeberger, 2018, Investigations on the interplays between Schistosoma mansoni, praziquantel and the gut microbiome, Parasites Vectors, 11, 168, 10.1186/s13071-018-2739-2 Selhub, 2009, Folate–vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency, Am. J. Clin. Nutr., 89, 702S, 10.3945/ajcn.2008.26947C Speich, 2014, Oxantel pamoate–albendazole for Trichuris trichiura infection, N. Engl. J. Med., 370, 610, 10.1056/NEJMoa1301956 Turnbaugh, 2007, The human microbiome project: exploring the microbial part of ourselves in a changing world, Nature, 449, 804, 10.1038/nature06244 W. H. O. Expert Committee, 2002, Prevention and control of schistosomiasis and soil-transmitted helminthiasis, World Health Organ. Tech. Rep. Ser., 912, 1 Wang, 2011, Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease, Nature, 472, 57, 10.1038/nature09922 Wen, 2008, A randomized, double-blind, multicenter clinical trial on the efficacy of ivermectin against intestinal nematode infections in China, Acta Trop., 106, 190, 10.1016/j.actatropica.2008.03.007 Wilson, 2009, The role of gut microbiota in drug response, Curr. Pharmaceut. Des., 15, 1519, 10.2174/138161209788168173 Wilson, 2017, Gut microbiome interactions with drug metabolism, efficacy, and toxicity, Transl. Res., 179, 204, 10.1016/j.trsl.2016.08.002 Xiao, 2013, Advances with the Chinese anthelminthic drug tribendimidine in clinical trials and laboratory investigations, Acta Trop., 126, 115, 10.1016/j.actatropica.2013.01.009 Zaman, 1975, Clinical trial with a new anti-Trichuris drug, trans-1, 4, 5, 6 tetrahydro-2-(3-hydroxystyryl)-l-methyl pyrimidine (CP-14,445), Southeast Asian J. Trop. Med. Publ. Health, 6, 103 Ōmura, 2017, Ivermectin and malaria control, Malar. J., 16, 172, 10.1186/s12936-017-1825-9